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Left atrial appendage aneurysms are uncommon cardiac anomalies often discovered incidentally, with potential to cause arrhythmias or thromboembolic events, prompting surgical correction. Herein, we present the successful surgical treatment of a left atrial appendage aneurysm identified in a 7-year-old asymptomatic patient.
The desegregation of Dallas Theological Seminary (DTS) offers a critical case study for scholars of American religious history, illuminating how white evangelical institutions responded to the racial transformations of the post-civil rights era. Unlike southern evangelical colleges that defended segregation on overt theological grounds, DTS never explicitly framed its exclusion of Black students within a scriptural mandate. Instead, the seminary’s shift from racial exclusion to intentional Black student recruitment in the 1970s reflects what Martin Luther King Jr. once described as a “more cautious than courageous” approach. Anchored in biblical literalism, DTS president John Walvoord’s reluctance to use scripture to justify segregation played a key role in the school’s transformation. This article fills a gap in the historiography by examining how institutional culture, theological commitments, and broader cultural pressures converged to produce a quiet and incremental model of desegregation—neither overtly racist nor actively prophetic—offering a more complex portrait of evangelicalism and race in the second half of the twentieth century.
Let a group Γ act on a paracompact, locally compact, Hausdorff space M by homeomorphisms and let 2M denote the set of closed subsets of M. We endow 2M with the Chabauty topology, which is compact and admits a natural Γ-action by homeomorphisms. We show that for every minimal Γ-invariant closed subset $\mathcal{Y}$ of 2M consisting of compact sets, the union $\bigcup \mathcal{Y}\subset M$ has compact closure.
As an application, we deduce that every compact uniformly recurrent subgroup of a locally compact group is contained in a compact normal subgroup. This generalizes a result of Ušakov on compact subgroups whose normalizer is compact.
This study discusses the intersection between Black/African Digital Humanities, and computational methods, including natural language processing (NLP) and generative artificial intelligence (AI). We have structured the narrative around four critical themes: biases in colonial archives; postcolonial digitization; linguistic and representational inequalities in Lusophone digital content; and technical limitations of AI models when applied to the archival records from Portuguese-colonized African territories (1640–1822). Through three case studies relating to the Africana Collection at the Arquivo Histórico Ultramarino, the Dembos Collection, and Sebestyén’s Caculo Cangola Collection, we demonstrate the infrastructural biases inherent in contemporary computational tools. This begins with the systematic underrepresentation of African archives in global digitization efforts and ends with biased AI models that have not been trained on African historical corpora.
Surgical site infections (SSIs) are among the most common postoperative complications in colorectal surgery, and associate with increased morbidity, prolonged recovery, and higher healthcare costs. Most studies combine all SSI categories, potentially overestimating economic burden due to higher severity of organ/space infections. The specific cost impact of incisional SSIs—superficial and deep infections—remains underexplored, despite its prevention potential. This study aimed to evaluate hospital costs associated with incisional SSIs following colorectal resection.
Methods:
A retrospective cohort study was conducted at a tertiary oncologic center, including patients who underwent surgical resection for primary neoplasms of the colon, rectum, or anal canal between 2018 and 2023. Patients with incisional SSIs were matched 1:1 to controls without SSI using propensity scores based on demographic and surgical variables. Total hospital costs within 60 days postoperatively were analyzed using real-world, institution-specific cost data. Multivariate regression was used to identify independent cost predictors.
Results:
Among 985 eligible patients, 176 (17.9%) developed an incisional SSI. After matching, 346 patients (173 pairs) were included in the cost analysis. Mean hospital costs were significantly higher in the SSI group (€6,065.93 vs €5,089.97; P < 0.001), primarily due to prolonged hospitalization and increased outpatient care use (medical and nursing consultations). Incisional SSI was an independent predictor of higher costs, along with open surgery, comorbidities and stoma presence.
Conclusions:
Incisional SSIs associated with higher hospital costs after colorectal surgery. These findings support the implementation of targeted SSI prevention strategies to reduce complications and optimize healthcare resource use.
The Darband Wall in southern Uzbekistan marks an important political border in the Classical world, yet the dating of its construction is largely relative and contested. Presenting 10 new radiocarbon dates from the wall, the authors argue that construction began in the early or middle third century BC, likely under Seleucid or early Greco-Bactrian rule, while later reconstruction efforts coincide with Kushan expansion around the first and second centuries AD. Early Hellenistic-style fortifications reveal a defensive, and possibly an orientational, shift during Kushan rule that underscores both the strategic significance of the wall and the need for more extensive investigation.
This paper examines American public attitudes toward corrective measures against uncooperative security allies through a preregistered survey experiment on a nationally representative sample of 1,502 American citizens. The findings demonstrate strong public support for corrective measures, particularly coercive strategies such as economic sanctions and military aid reduction, against allies whose policies conflict with the dominant power’s interests. While alliance discord also triggers demands for reduced American contributions to the alliance, public response varies substantially based on the nature of the misalignment and the characteristics of the uncooperative ally. Notably, the ally regime type significantly moderates support for corrective measures, with Americans demonstrating marked reluctance to endorse punitive actions against democratic allies. However, neither the ally’s military capabilities nor the presence of formal treaty arrangements significantly moderates public preferences. These findings contribute to our understanding of alliance management and the domestic foundations of international cooperation while offering insights into the pressures leaders face when addressing alliance noncompliance.
In this paper, the upper bounds of non-real eigenvalues of indefinite Sturm–Liouville (S-L) problems with boundary conditions depend on the eigenparameter are studied. The upper bounds of real parts, imaginary parts and absolute values of non-real eigenvalues are given under the condition that the coefficients are integrable.
Research finds genetic predisposition for depression is associated with increases in depression across adolescence and adulthood. In turn, depressive symptoms in adolescence are associated with substance use. However, there has been modest examination of genetic predisposition for depression, growth in depressive symptoms, and substance use from late childhood through adolescence, and mostly in White samples. Also, psychosocial interventions can attenuate associations between genetic predisposition and psychopathology, a genotype by intervention (GxI) effect. We examined associations among polygenic risk for depression, growth in depressive symptoms from age 7 to 16, and substance use at age 16, as well as moderation by a family-based preventive intervention. Participants were African-ancestry (n = 154) and European-ancestry (n = 219) youth from the Early Steps Multisite Study, half of whom participated in the Family Check-Up intervention. A small polygenic by intervention effect was found on reductions in depressive symptoms for African-ancestry youth, and growth in depressive symptoms was positively associated with substance use at age 16. In sensitivity analyses, a small GxI effect was detected in European-ancestry youth on reductions in depressive symptom slopes from age 10 to 16. These findings highlight how early intervention can buffer genetic effects on depressive symptoms over time.
We numerically investigate the hydrodynamics of an actively heaving flexible foil flapping under a wave surface. The coupled level set and volume-of-fluid method is used to capture the air–water interface, and the immersed-boundary method is used to capture the fluid–structure interaction. A sinusoidal heaving motion is imposed at the foil’s leading edge, and its posterior parts oscillate passively according to its flexible characteristics, allowing dynamic interactions with the wave-induced flow. The propulsive performance of the foil is examined for the influence of three main factors: the ratio of the heaving frequency ($f_{\!f}$) to the wave frequency ($f_w$), the phase difference between the heaving motion and the incident wave ($\mathit \varPhi$) and the submergence depth of the foil ($D$). At $\mathit \varPhi = 0$, the results reveal that the propulsion of the flexible foil benefits from flapping near the wave surface when $f_{\!f}/f_w = 0.5$, and the propulsive efficiency is optimised at $D/L = 1$, where $L$ is the foil’s length. However, when $f_{\!f}/f_w$ = 1.0 and 2.0, the propulsion of the flexible foil is hindered near the wave surface. This hydrodynamic hindrance is closely related to vortex splitting and roll-up phenomena, which induce the formation of a drag wake. By adjusting the phase difference $\mathit \varPhi$, the hindrance in the flexible foil propulsion can be mitigated to enhance propulsive performance. To further understand the relationship between the flapping kinematics and propulsive dynamics, we perform a scaling analysis based on lift force and added mass force, offering good quantification of propulsive performance.
This study outlines the investigation into an outbreak of Mycobacterium fortuitum infections involving 17 cases undergoing hip or knee surgeries at two ambulatory surgery centers (ASCs) in Tennessee from January 2023 to November 2024. Notably, the outbreak could not be attributed to contaminated water sources, which are typically associated with non-tuberculous mycobacteria (NTM) outbreaks, presenting a unique challenge.
Methods:
Outbreak investigation steps included Infection Prevention (IP) assessments, case-control study, environmental sampling, whole genome sequencing, and a healthcare personnel (HCP) exposure questionnaire.
Results:
IP assessment highlighted several concerns, including no formal facility water management program (WMP), a lack of dedicated IP personnel and certified sterile processing staff, the absence of a formalized system for tracking surgical site infections, and a notable gap in understanding the requirements for reporting diseases. The case-control findings revealed a significant association between the presence of a surgical technologist in the operating room during the procedures and the occurrence of NTM infections, indicated by an odds ratio of 55.77 (95% CI [3.16–985.44]; P = 0.0097). Thirteen clinical isolates collected at one ASC and three additional isolates collected at a second ASC were highly related by whole genome sequencing.
Conclusion:
The study further elucidates valuable insights gained from the outbreak response, including the gaps in surveillance within the ambulatory surgical setting and systematic collection of cultures from environmental sources. It emphasizes the importance of thorough vetting, onboarding, continuing education, and practice monitoring for HCP.
While increasing seafood consumption may help address micronutrient deficiencies and metabolic disorders, evidence supporting this recommendation in the Indian context remains limited and inconclusive. Using the nationally representative cross-sectional 2019-2021 National Family Health Survey dataset, we investigated the association of fish consumption frequency with anemia and metabolic disorders (overweight/obesity, hypertension, and hyperglycemia) among adult men (aged 15-54 years) and women (aged 15-49 years) in India. A control function (CF) method was employed to examine the association in individuals who consumed fish daily and those who reported consuming fish daily/weekly. The analysis was restricted to conformed non-vegetarians (who reported ever consuming egg, fish, or meat). Overall, 86.9% of men and 74.7% of women were conformed non-vegetarian. CF analysis revealed that both daily and daily/weekly fish consumption were associated with a reduced risk of anemia among both men and women. Daily fish consumers exhibited increased likelihood of overweight/obesity (men: β: 0.405, 95%CI: 0.074, 0.735, p:0.017; women: β: 0.248, 95%CI 0.125, 0.370, p<0.001). Conversely, daily/weekly fish intake was associated with a reduced risk of overweight/obesity in men (β: -0.041, 95%CI: -0.069, -0.013; p:0.004). Daily/weekly fish consumption was associated with a reduced risk of hypertension and increased odds of hyperglycemia among men. Fish consumption demonstrated a potentially protective relationship against hypertension in women, regardless of how often they consumed fish, while also being associated with a higher prevalence of hyperglycemia. Indian adults can improve their health by eating more fish, which can help fight anemia and may also reduce overweight/obesity and high blood pressure.
Space–time correlations of velocity and high-Schmidt-number ($Sc \approx 2000$) passive scalar fields are investigated in turbulent pipe flow using particle image velocimetry and planar laser-induced fluorescence, respectively. Both the velocity and scalar fields exhibit characteristic elliptical patterns in their respective space–time correlations. The elliptic approximation model, originally developed for the velocity field, is applied to estimate convection and sweeping velocities for both fields. In both fields, the convection velocity decreases, while the sweeping velocity increases, along the pipe radius. The convection velocity ratio between the scalar and velocity fields shows that high-Schmidt-number scalar fluctuations are advected faster than the velocity fluctuations. Similarly, the sweeping velocity of the scalar fluctuations is found to be larger than that of the velocity fluctuations. Furthermore, the high-Schmidt-number scalar is found to decorrelate more rapidly than the corresponding velocity, with the scalar Taylor microscale distinctly smaller than the velocity Taylor microscale.
Like many newer EU Free Trade Agreements, the Trade and Cooperation Agreement (TCA) includes commitments concerning labour and social standards and environment and climate policy under the title the ‘Level Playing Field’. This title includes non-regression provisions, which prohibit reducing or weakening certain standards ‘in a manner affecting trade’, and novel rebalancing provisions, which allow the parties to take unilateral measures if material impacts on trade are arising as a result of significant divergences in levels of protection in specific areas of regulation. Although terminology linking trade to labour and environmental issues is becoming reasonably common in trade agreements, there has only been limited consideration as to what trade effects or impacts actually need to be demonstrated. This paper argues that the language of ‘manner affecting trade’ and ‘material impact on trade’ in the TCA denotes a ‘conditions of competition’ test as opposed to a stricter, and relatively more difficult to satisfy, trade remedies model. It further considers the possible application of the provisions in the context of the UK’s 2022 strikes measures, highlighting that even if a conditions of competition test is used, there are serious questions as to whether the non-regression and rebalancing provisions in the TCA are efficacious in achieving values-based objectives.
We give a construction of integral local Shimura varieties which are formal schemes that generalise the well-known integral models of the Drinfeld p-adic upper half spaces. The construction applies to all classical groups, at least for odd p. These formal schemes also generalise the formal schemes defined by Rapoport-Zink via moduli of p-divisible groups, and are characterised purely in group-theoretic terms.
More precisely, for a local p-adic Shimura datum $(G, b, \mu)$ and a quasi-parahoric group scheme ${\mathcal {G}} $ for G, Scholze has defined a functor on perfectoid spaces which parametrises p-adic shtukas. He conjectured that this functor is representable by a normal formal scheme which is locally formally of finite type and flat over $O_{\breve E}$. Scholze-Weinstein proved this conjecture when $(G, b, \mu)$ is of (P)EL type by using Rapoport-Zink formal schemes. We prove this conjecture for any $(G, \mu)$ of abelian type when $p\neq 2$, and when $p=2$ and G is of type A or C. We also relate the generic fibre of this formal scheme to the local Shimura variety, a rigid-analytic space attached by Scholze to $(G, b, \mu , {\mathcal {G}})$.
This article offers an intersectional and temporospatial analysis of female visibility during religious activity in urban spaces in Republican Rome. The focus is on the regular religious activity of prominent female religious officials – Vestals, flaminica Dialis, and regina sacrorum – and collectives of women – married and enslaved women – as religious activity and roles could empower some women, and provide regular opportunities for visibility in the city. I argue that such an approach and focus reshape our understanding of the visibility of women in urban spaces, challenging traditional scholarly views of female domesticity and invisibility. A temporospatial lens reveals that women of various roles and statuses were regularly visible in a wide array of urban spaces, seemingly irrespective of their public, private, or sacred nature. There appears to have been limited spatial segregation by gender. Instead, a woman’s intersectional statuses and temporality were key dimensions differentiating female visibility. There was no singular gendered rhythm, but plural rhythms in interaction and conflict, and female religious officials played key roles in directing these rhythms and bringing harmony to the religious calendar. Futurity and the preservation of the community lay at the core of this female religious activity. Ultimately, time’s place was pivotal.
Sheath-ends are poorly represented in works regarding weaponry of the Cimmerian period (10th–7th century BC), despite forming an important component, particularly among the melee weapons of the time. There are several reasons for this neglect: until recently, the number of known sheath-ends was quite small, thus making it impossible to speak of types, variants or cultural affiliations; also, most of the previously published sheath-ends are spread over a large territory and were published many decades ago. Therefore, some of them may be unknown to researchers due to the age of publications, as well as linguistic and cultural barriers. Over the past few years, a larger number of new sheath-ends has emerged. Some of them belong to previously known types, others are completely new. Their analysis is here conducted using the comparative method. The total number of sheath-ends now known makes it possible to begin a discussion about their types, chronology and origins, which will undoubtedly develop as new finds appear.
The essence of the Metaverse lies in the inter-subjectivity revealed by phenomenology. The many-worlds model reveals the significance of interaction and communication for digital human existence. The Metaverse exhibits a rhizomatic structure of narrative from multiple small universe interpretations, particularly the cross-embedding and close coupling between digital relational orders and analog legal orders formed through interface revolution. Virtuality-reality interfacing permits rational design based on exchange concepts, yielding twelve fundamental digital-age juridical propositions from subject interaction ordering mechanisms. These propositions indicate that with consumer sovereignty and distributed autonomous organizations, the Metaverse will transform order principles. A corridor system connecting cyberspace to off-chain society will be built using code and smart contracts as dual interfaces, producing varied relationship-law combinations.
Recently, autonomous aerial systems have received unparalleled popularity and applications as varied as they are innovative in the civil domain. The unmanned aerial vehicle (UAV) is now the subject of intensive research in both aeronautical and automotive engineering.
This paper presents a new, robust gain-scheduled adaptive control strategy for a class of UAV with linear parameter varying (LPV) models. The proposed controller synthesis involves a set of pre-tuned linear quadratic regulator (LQR) combined with fractional-order PID controllers supervised with an adaptive switching law. The main innovation in this work is the enhancement of the classical gain-scheduling adaptive control robustness for systems with LPV models by combining a set of robust LQR + fractional-order PID compensators. The stability of the resulting controller is demonstrated and its efficiency is validated using a numerical simulation example on a civilian UAV system airspeed and altitude control to illustrate its practical efficiency and achieved robustness.