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Though ubiquitous in many engineering applications, including drug delivery, the compound droplet hydrodynamics in confined geometries have been barely surveyed. For the first time, this study thoroughly investigates the hydrodynamics of a ferrofluid compound droplet (FCD) during its migration in a microchannel under the presence of a pressure-driven flow and a uniform external magnetic field (UEMF) to manipulate its morphology and retard its breakup. Finite difference and phase-field multiple-relaxation time lattice Boltzmann approaches are coupled to determine the magnetic field and ternary flow system, respectively. First, the influence of the magnetic Bond number (${Bo}_m$) on the FCD morphology is explored depending on whether the core or shell is ferrofluid when the UEMF is applied along $\alpha =0^\circ$ and $\alpha =90^\circ$ relative to the fluid flow. It is ascertained that imposing the UEMF at $\alpha =0^\circ$ when the shell is ferrofluid can postpone the breakup. Intriguingly, when the core is ferrofluid, strengthening the UEMF enlarges the shell deformation. Afterwards, the effects of the capillary number (${Ca}$), density ratio, viscosity ratio, radius ratio and surface tension coefficients are scrutinised on the FCD deformation and breakup. The results indicate that augmenting the core-to-shell viscosity and density ratios accelerates the breakup process. Additionally, surface tension between the core and shell suppresses the core deformation. Moreover, increasing the ${Ca}$ intensifies the viscous drag force exerted on the shell, flattening its rear side, which causes a triangular-like configuration. Ultimately, by varying ${Bo}_m$ and ${Ca}$, five distinct regimes are observed, whose regime map is established.
To describe the mitigation strategies for a Candida auris outbreak in a cardiothoracic transplant intensive care unit (CTICU) and its implications for infection prevention practices.
Design:
Retrospective cohort study from July 2023 to February 2024.
Setting:
A large academic medical center.
Methods:
A multidisciplinary team convened to conduct the outbreak investigation and develop mitigation strategies in the CTICU.
Results:
From July 2023 to February 2024, 34 possible hospital-onset cases of C. auris were identified in our CTICU. Whole-genome sequencing and phylogenetic analysis based on pairwise single nucleotide polymorphism (WG-SNP) distance revealed two distinct outbreak clusters. Of the 34 patients, 11 (32.3%) were solid organ transplant recipients and 12 (35.3%) had a mechanical circulatory support device. Of the cohort, only 11/34 (32.3%) had prior exposure to high-risk healthcare facilities within six months prior to admission, as follows: acute inpatient rehabilitation facilities (AIRs) (n = 5, 14.7%), skilled nursing facilities (SNFs) (n = 3, 8.8%), and long-term acute care hospitals (LTACHs) (n = 3, 8.8%). The cohort had a median of 22.0 antibiotic-days prior to their positive results. Five (14.7%) patients had C. auris candidemia, three of whom expired likely due to infection. Infection Prevention (IP) interventions addressed several modes of transmission, including healthcare personnel hands, shared patient equipment, and the environment.
Conclusion:
Our experience suggests that the epidemiology of C. auris may be changing, pointing towards a rising prevalence in acute care settings. IP interventions targeting hand hygiene behavior and promoting centralizing cleaning and disinfection of shared patient equipment may have contributed to outbreak resolution.
In the recent case of Ezuame Mannan v Attorney General and Speaker of Parliament,1the Ghanaian Supreme Court in a 5-4 decision struck down the Narcotics Control Commission Act, 2020 (Act 1019), on grounds that the parliamentary processes leading to its enactment were unconstitutional. In arriving at this decision, the court strived to define the limits of Parliament’s legislative powers. While some clarity was achieved, difficult contradictions emerged. Prominent among these was the extent to which the constitutional power of judicial review over legislative actions should interfere with the autonomy of Parliament. In this article, I propose that a proper understanding and application of the purposive approach to interpretation offers an effective tool for reconciling these seemingly conflicting constitutional values.
The aerodynamic performance of an ultra-high aspect ratio strut-braced wing design is assessed for flight at cruise. The sensitivity of a selected airframe design from a recent CleanSky2 project to operating conditions around the design point is quantified using the adaptive-cut high-dimensional model representation (HDMR) method, which allows for the decomposition of the parameter space into smaller subdomains to isolate the parameter interactions and influence on the aerodynamic forces. A comparative analysis with a cantilever wing configuration is performed to identify the role of the strut on the sensitivity of the design. Insight into the transonic performance is gained by characterisation of buffet limits and drag rise. Results show that, for the selected optimised airframe configuration, small changes in freestream parameters can lead to significant reduction in performance due to drag divergence triggered by the shock wave generated at the strut-wing junction and at the fuselage-strut intersection. Cruise conditions can be achieved without buffet onset throughout much of the parameter space. Safety margins associated with buffeting are satisfied, but sensible limits are imposed on the flight envelope for this configuration.
Research on mortality and admissions for physical health problems across eating disorder diagnoses in representative settings is scarce. Inequalities in these outcomes across a range of sociodemographic characteristics have rarely been investigated.
Aims
We investigated whether people with eating disorders had greater all-cause mortality and physical health-related in-patient admissions compared with those without eating disorders, and whether associations varied by sex, ethnicity, deprivation, age and calendar year at diagnosis.
Method
Using primary care Clinical Research Practice Datalink linked to Hospital Episode Statistics, we matched people with an incident eating disorder diagnosis (any, anorexia nervosa, bulimia nervosa, eating disorders not otherwise specified, generic eating disorder or a referral code) from primary care Read codes to four people without eating disorders (1:4 matching) on year of birth, sex, primary care practice, year of registration and index date. We used univariable and multivariable Cox (mortality) and Poisson (admissions) models, and fitted interactions to investigate whether associations varied by sociodemographic characteristics.
Results
We included 58 735 people (90.1% female, 91.6% White). People with any eating disorders had higher all-cause mortality (hazard ratio: 2.15, 95% CI: 1.73–2.67). Anorexia nervosa had the highest mortality (hazard ratio: 3.49, 95% CI: 2.43–5.01). People with any eating disorders had higher rates of planned (incidence rate ratio (IRR): 1.80, 95% CI: 1.4–1.87) and emergency admissions for physical health problems (IRR: 2.35. 95% CI: 2.35–2.46) and emergency admissions for injuries, accidents and substance misuse (IRR: 5.26, 95% CI: 5.24–5.29). Mortality and admission rate ratios were greater in males.
Conclusions
People with eating disorders have high rates of mortality and physical health-related admissions. Observed inequalities call for an understanding of why such inequalities exist. These findings highlight the need for prompt and effective treatment for eating disorders, and for improved guidance on primary care management of people with eating disorders.
To identify changes in emergency department (ED) use in Houston, TX during the mid-summer Hurricane Beryl-induced power outage to inform future targeted public health interventions.
Methods
Syndromic surveillance system ED visit daily counts for total visits, heat-related illness, carbon monoxide poisoning, acute cardiac condition, stroke, dialysis, and medication refills post-hurricane were statistically compared to the 2 weeks prior and plotted alongside the percentage of the population with power outage.
Results
Daily ED visits post-storm were statistically higher (P< 0.05) than the 2 weeks prior for total visits and acute cardiac events (Day 1, 2); heat-related illness (Day 1-3); dialysis (Day 0-3); and carbon monoxide poisoning and medication refill (Day 1-9).
Conclusions
While 50% of the city experienced power outages from high winds, total ED visits, acute cardiac events, and heat-related illness were statistically higher in the first 3 days after Beryl than expected. Houston developed targeted messaging to mitigate these events in future disasters.
The gastrointestinal microbiota of mammals plays a crucial role in host health, influencing nutrient absorption, lipid metabolism, and immune system regulation. This study examines the current state of research on gut microbiota in pinnipeds and cetaceans, significant indicators of ocean health. To this end, a bibliometric and an in-depth analysis was conducted using the Scopus database. A total of 83 articles published between 1994 and 2023 were found on this topic. In this period, publications showed a 6.9% annual increase, reflecting a growing interest in this field. The USA and China lead in research output, reflecting their high investment in research funding. Study topics were classified in characterization, characterization and comparison, bacterial isolation, and others. Regarding the origin of the samples, faecal samples predominated over gastrointestinal tissues and oral swabs. The most abundant bacterial phyla were Firmicutes, Proteobacteria, Fusobacteria, and Bacterioidetes. The research also highlights the presence of pathogenic bacteria underscoring the need to better understand the health implications for these species. The analysis also reveals that studies focus on a few species, such as Phoca vitulina (Harbor seal) and Tursiops truncatus (Bottlenose dolphin), reflecting a bias towards more accessible and studied species. To advance in this area, it is recommended to broaden the range of species and countries studied, improve sampling methodologies, and foster international collaborations. Research on marine mammal gut microbiota remains an expanding field, offering significant insights into the biology and ecology of these animals.
Micro-UAV systems used for metric purposes are highly capable of capturing relatively high-resolution, chromatically stable aerial images at low altitudes. In micro-UAV-based aerial imaging-based structure-from-motion (a-SfM) applications, the flight mission planning problem can be customised to achieve different objectives. The requirement for minimising the time spent in the air, which is crucial for energy conservation, can be achieved by designing the shortest possible flight path. Spatial resolution in the captured aerial images can be significantly preserved by maintaining the ground sampling distance (GSD) value within a 95${\rm{\% }}$ confidence interval throughout the flight path. Fuel efficiency can be improved by minimising the number of turning manoeuvers required to follow the flight path during the flying mission. In this paper, four distinct flight mission planning processes are delineated to enable the energy-efficient and effective implementation of aerial imaging missions, with their associated parameters optimised using the colony-based search algorithm (CSA). The obtained experimental results demonstrate that the proposed flight mission planning processes are highly successful in the energy-efficient and effective execution of aerial imaging missions.
This paper presents a novel machine learning framework for reconstructing low-order gust-encounter flow field and lift coefficients from sparse, noisy surface pressure measurements. Our study thoroughly investigates the time-varying response of sensors to gust–airfoil interactions, uncovering valuable insights into optimal sensor placement. To address uncertainties in deep learning predictions, we implement probabilistic regression strategies to model both epistemic and aleatoric uncertainties. Epistemic uncertainty, reflecting the model’s confidence in its predictions, is modelled using Monte Carlo dropout – as an approximation to the variational inference in the Bayesian framework – treating the neural network as a stochastic entity. On the other hand, aleatoric uncertainty, arising from noisy input measurements, is captured via learned statistical parameters, and propagate measurement noise through the network into the final predictions. Our results showcase the efficacy of this dual uncertainty quantification strategy in accurately predicting aerodynamic behaviour under extreme conditions while maintaining computational efficiency, underscoring its potential to improve online sensor-based flow estimation in real-world applications.
Nonnative earthworm species are invading the boreal forest in North America. Oribatid mites are key detritivores in boreal forest soils, initiating litter decomposition and maintaining forest floor structure. Earthworms are also detritivores and are considered ecosystem engineers. When introduced into nonendemic environments, earthworms may alter soil biogeochemical cycling and adversely affect oribatid mite communities. However, to our knowledge, no field studies in boreal forests have investigated invasive earthworms and their impacts on oribatid mites. The present study was conducted in a boreal trembling aspen, Populus tremuloides Michaux (Salicaceae), stand near Wolf Lake, Alberta, Canada. After assessing the current state of earthworm invasion, we identified an area with a lower density of earthworms that was invaded by one species, Dendrobaena octaedra Savigny (Crassiclitellata: Lumbricidae), and an area with a higher density of earthworms that was invaded by multiple species, D. octaedra (Crassiclitellata: Lumbricidae) and Aporrectodea spp. (Crassiclitellata: Lumbricidae). The higher-density area was associated with lower understorey vegetation species richness and with thinner forest floors characterised by higher bulk density but lower total organic carbon and nitrogen stocks. Oribatid mite community composition differed between the two areas, and their richness significantly decreased with higher earthworm density. Our findings suggest that earthworm invasion is substantially disrupting habitat for oribatid mites and might affect the overall boreal ecosystem equilibrium in the long term.
We show that the Hausdorff dimension of the attractor of an inhomogeneous self-similar iterated function system (or self-similar IFS) can be well approximated by the Hausdorff dimension of the attractor of another inhomogeneous self-similar IFS satisfying the strong separation condition. We also determine a formula for the Hausdorff dimension of the algebraic product and sum of the inhomogeneous attractor.
The antibiotic spectrum index (ASI) outcome quantifies antibiotic exposure based on spectrum of activity. Our objective was to examine ASI as an exploratory outcome in the context of a recent stewardship-focused, clinical trial in childhood pneumonia that originally used a binary guideline-concordant outcome.
Design:
Secondary analysis of a randomized clinical trial.
Setting:
Two tertiary pediatric hospitals.
Methods:
Encounters were randomly assigned to clinical decision support (CDS) or usual care treatment arm. The ASI was calculated by summing daily ASI scores for each unique antibiotic administered. It was evaluated as a continuous and ordinal measure: No Antibiotics (ASI = 0), Narrow (1-2), Intermediate (3-4), Broad (5-7), and Very Broad (≥8). Proportional odds regression modeled the ordinal ASI outcome in the first 24 hours by treatment arm and compared to the guideline-concordance outcome. Results were stratified by emergency department (ED) disposition. We also conducted a longitudinal, descriptive analysis of day-to-day ASI for those with in-hospital dispositions.
Results:
We included 1027 encounters, 549 (53%) were randomized to CDS and 478 (47%) usual care respectively. ASI Category did not differ by treatment arm overall (Odds Ratio: 0.88[95% Confidence Interval: 0.70,1.09]), which mirrored binary guideline-concordance. Mean ASI was lower for concordant encounters (2.1 vs 8.4, P < 0.001) and across all ED dispositions. In the longitudinal analysis, there were 1137 day-to-day ASI comparisons, with only 7% representing spectrum escalations.
Conclusions:
The ASI outcome yielded similar results to a dichotomous concordance outcome. However, ASI provided more granular insights into antibiotic prescribing, suggesting ASI may be a useful outcome measure in future stewardship-focused trials.
A wideband harmonic rejection (HR) voltage-domain mixer using resistive scaling is presented featuring excellent linearity and high intermediate frequency (IF) bandwidth. Thin-oxide devices with constant gate-to-source voltages (VGS) are utilized to maximize the switching linearity. A novel switching core topology providing low-impedance IF outputs is proposed to support wideband in-phase (I) and quadrature (Q) mixer outputs when capacitively loaded by an analog-to-digital converter (ADC). Eight LO clock phases, each with a 25% duty cycle, are on-chip generated for quadrature down-conversion and HR. By cleverly activating and organizing the mixer branches, the mixer's input impedance at radio frequency (RF) can be kept perfectly constant throughout all eight clock phases, enhancing the mixer’s linearity. The TSMC 40 nm-CMOS realized mixer reaches 20.9 dBm OIP3 at an IF of 50 MHz with a conversion loss of 22.5 dB. It offers an 800 MHz 3-dB IF bandwidth when connected to a differential capacitive loading of 0.15 pF, with a total power consumption of 40.7 mW drawn from a 1.1 V supply. The mixer targets linear wideband base station observation receiver applications.
We explored the dynamics of Taylor–Couette flows within square enclosures, focusing primarily on the turbulence regime and vortex behaviour at varying Reynolds numbers. Laboratory experiments were conducted using particle image velocimetry for Reynolds numbers $Re_{\varDelta }\in [0.23, 4.6]\times 10^3$ based on the minimum gap $\varDelta /d = 1/16$, $1/8$ and $1/4$, where $d$ is the cylinder diameter, or $Re\in [1.8, 9.8]\times 10^3$ based on $d/2$. At lower $Re$, the flow was dominated by well-defined Taylor and Görtler vortices, while higher $Re$ led to a turbulent state with distinct motions. Space–time radial velocity analysis revealed persistent Taylor vortices at lower $Re$, with larger gaps but increased turbulence, and irregular motions at higher $Re$, with smaller gaps. Velocity spectra reveal that the energy distribution is maintained at frequencies lower than the integral-type frequency $f_I$ across varying $\varDelta$ due to the dominance of large vortices. However, there is a monotonic increase in energy at higher frequencies beyond $f_I$. The reduced characteristic frequency $f_I\varDelta /\omega _ir_i \sim 1/10$ indicates that these motions scale linearly with angular velocity, and inversely with the gap. Proper orthogonal decomposition (POD) and spectral POD were used to distinguish between Taylor and Görtler vortices, showing the effects of gap size and the associated energy cascade. Linear stability analysis included as complementary support revealed primary instability of the Taylor vortex, which is similar to the circular enclosure, along with multiple corner modes that are unique to the geometry.