Equitable access to medicines is vital for people with disabilities to receive effective, affordable, and quality treatment, helping preserve functionality, prevent further disability, and promote social and economic inclusion. This paper explores the specific medicine needs of people with disabilities in low- and middle-income countries (LMICs), focusing on the European Union’s (EU) extraterritorial legal obligations under the Convention on the Rights of Persons with Disabilities (CRPD). As the first regional international organization to accede to a UN human rights treaty, the EU offers a unique case for examining how international legal commitments extend beyond its borders. The paper outlines a legal framework based on the CRPD to assess the EU’s responsibilities for ensuring access to medicines globally. This framework is applied to two case studies: the EU’s internal joint COVID-19 vaccine procurement strategy and its external BioNTainer initiative for vaccine production in Africa under Team Europe. The analysis finds that the EU falls short of its CRPD obligations, particularly in areas of technology transfer and intellectual property sharing, which are essential for equitable global vaccine access. The paper concludes that the EU’s current actions do not fulfill its human rights commitments to people with disabilities in LMICs.

The concept of parity due to Fitzpatrick, Pejsachowicz and Rabier is a central tool in the abstract bifurcation theory of nonlinear Fredholm operators. In this paper, we relate the parity to the Evans function, which is widely used in the stability analysis for traveling wave solutions to evolutionary PDEs.

In contrast, we use Evans function as a flexible tool yielding general sufficient condition for local bifurcations of specific bounded entire solutions to (Carathéodory) differential equations. These bifurcations are intrinsically nonautonomous in the sense that the assumptions implying them cannot be fulfilled for autonomous or periodic temporal forcings. In addition, we demonstrate that Evans functions are strictly related to the dichotomy spectrum and hyperbolicity, which play a crucial role in studying the existence of bounded solutions on the whole real line and therefore the recent field of nonautonomous bifurcation theory. Finally, by means of non-trivial examples we illustrate the applicability of our methods.

Word processing during reading is known to be influenced by lexical features, especially word length, frequency, and predictability. This study examined the relative importance of these features in word processing during second language (L2) English reading. We used data from an eye-tracking corpus and applied a machine-learning approach to model word-level eye-tracking measures and identify key predictors. Predictors comprised several lexical features, including length, frequency, and predictability (e.g., surprisal). Additionally, sentence, passage, and reader characteristics were considered for comparison. The analysis found that word length was the most important variable across several eye-tracking measures. However, for certain measures, word frequency and predictability were more important than length, and in some cases, reader characteristics such as proficiency were more significant than lexical features. These findings highlight the complexity of word processing during reading, the shared processes between first language (L1) and L2 reading, and their potential to refine models of eye-movement control.

This study applies Bayesian chronological modeling to 16 new AMS radiocarbon dates on short-lived botanical remains and wood-charcoal recovered from the archaeological site Ahatsistari, a seventeenth-century Huron-Wendat village located in Simcoe County in Ontario, Canada. The modeled radiocarbon dates provide an independent time frame for understanding site phase and sequence, compatibility with historically documented events of a known date, and assessment of the socioeconomic and political influences affecting the composition of European trade good assemblages from different sites. We argue that Ahatsistari is likely Carhagouha, the principal village of the northern Attignawantan who were members of the Huron-Wendat Confederacy, and home to Samuel de Champlain and Joseph Le Caron from 1615 to 1616. In addition, Ahatsistari is contemporary with the archaeological site Warminster, which is believed to be Champlain’s Cahiagué. Radiocarbon dates from the archaeological sites of Ahatsistari, Warminster, and Ball are consistent with earlier suppositions for the beginning and end of Glass Bead Period 2 (AD 1600–1625), whereas differences in the composition of the glass trade bead assemblages speak to the prominent role of Ahatsistari in trade with the French and to variable trade relations among other early seventeenth-century Huron-Wendat villages.

The growing body of literature on corporate purpose has underscored its potential as a strategic driver for firms. However, its practical implementation remains challenging due to the concept’s multifaceted and often abstract nature. By reviewing 118 articles, this systematic literature review develops a process framework on how corporate purpose can be translated into concrete organizational strategies across three dimensions: antecedents, management, and consequences. Specifically, we identify the foundational conditions that shape a purpose statement in firms, examine how purpose is embedded and shared within them, and assess the multilevel outcomes of an effective purpose. The review highlights actionable levers to align purpose with strategy and practice, discussing how firms can implement their ‘reason why’. In doing so, the study provides contributions to better understand corporate purpose from both a theoretical and managerial perspective, within the broader field of strategic management.

Anaesthesia methods play a crucial role in ensuring the integrity of the animal during experimental studies. This study investigates the impact of two anaesthesia methods, CO₂ and cold treatment, on an insect antennal response to synthetic alarm pheromone compounds. Adult worker hornets were anesthetised, and their antennae excised and tested using an electroantennography set-up with controlled stimulation of alarm pheromone components. Results showed that CO₂-anesthetised hornets exhibited robust antennal responses, while cold-anesthetised individuals displayed none. This result suggests that freezing may impair the functionality of olfactory receptors. In contrast, CO₂ anaesthesia preserves receptor integrity, offering reliable and interpretable results. This study highlights the importance of selecting appropriate anaesthesia techniques to avoid artefacts in insect sensory physiology research and underscores the ecological relevance of studying Vespa velutina nigrithorax alarm signalling.

The current administration has disproportionately targeted transgender, nonbinary, and gender nonconforming people, despite accounting for less than 1% of the population (Jones, 2024). Though there has been a flurry of executive orders issued restricting the rights of this population, Executive Order 14168 (i.e., Defending Women from Gender Ideology Extremism and Restoring Biological Truth to the Federal Government) and Executive Order 14151 (Ending Radical and Wasteful Government DEI Programs and Preferencing) are likely to be particularly impactful for workplaces. This is because Executive Order 14168 challenges the existing federal protections of the Civil Rights Act of 1964 extended through Bostock v. Clayton County (2020), by declaring sex as binary and biological and denying the existence of transgender people. In addition, EO14151 eliminates federal diversity, equity, and inclusion programs and practices, which limits organizational practices and policies that might otherwise create inclusive and equitable environments for transgender employees. Therefore, this policy brief aims to discuss these executive orders, the existing protections they aim to alter, and the potential implications for transgender employees, organizations, and industrial-organizational professionals.

We consider the Perron–Frobenius operator defined on the space of functions of bounded variation for the beta-map $\tau _\beta (x)=\beta x$ (mod $1$) for $\beta \in (1,\infty )$, and investigate its isolated eigenvalues except $1$, called non-leading eigenvalues in this paper. We show that the set of $\beta $ such that the corresponding Perron–Frobenius operator has at least one non-leading eigenvalue is open and dense in $(1,\infty )$. Furthermore, we establish the Hölder continuity of each non-leading eigenvalue as a function of $\beta $ and show in particular that it is continuous but non-differentiable, whose analogue was conjectured by Flatto, Lagarias and Poonen in [The zeta function of the beta transformation. Ergod. Th. & Dynam. Sys. 14 (1994), 237–266]. In addition, for an eigenfunctional of the Perron–Frobenius operator corresponding to an isolated eigenvalue, we give an explicit formula for the value of the functional applied to the indicator function of every interval. As its application, we provide three results related to non-leading eigenvalues, one of which states that an eigenfunctional corresponding to a non-leading eigenvalue cannot be expressed by any complex measure on the interval, which is in contrast to the case of the leading eigenvalue $1$.

Increasing senior leadership diversity and decentralizing decision-making have become imperatives for many organizations, supported by a growing normative literature. However, mixed empirical evidence suggests that these may hinder the decision-making processes required to deliver value to firms and their stakeholders. We argue that diversity and decentralization should instead be viewed as means of organizing towards these ends, and theorize the conditions under which they may harm performance – specifically, the nature of the knowledge problems faced by leaders. Analyzing a 19-year panel of 922 U.S. firms, we find that diversity and decentralization are associated with stronger financial and market performance in uncertain environments but become liabilities under ambiguity, where speed and strategic clarity are critical and homogeneous, centralized leadership is more effective. Stakeholder outcomes are similarly affected, particularly employee wellbeing and ethical political activity. These findings challenge normative claims, with implications for theory, proscriptions, and practice.

We strengthen known results on Diophantine approximation with restricted denominators by presenting a new quantitative Schmidt-type theorem that applies to denominators growing much more slowly than in previous works. In particular, we can handle sequences of denominators with polynomial growth and Rajchmann measures exhibiting arbitrary slow decay, allowing several applications. For instance, our results yield non-trivial lower bounds on the Hausdorff dimensions of intersections of two sets of inhomogeneously well-approximable numbers (each with restricted denominators) and enable the construction of Salem subsets of well-approximable numbers of arbitrary Hausdorff dimension.

A set of 710 accessions of global durum wheat panel was obtained from the International Centre for Agricultural Research in Dryland Areas (ICARDA) and evaluated for variability in 32 agro-morphological traits at the ICAR-Indian Institute of Wheat and Barley Research, Karnal, India, during 2021–22 and 2022–23. The accessions were grouped based on the type of breeding material and geographical origin, and the Shannon–Wiener diversity index (H′) was calculated for each trait as well as each group. The H′ values ranged from 0.02 (grain crease) to 1.27 (wax of ear) with an overall mean of 0.63, when considering the entire set as a single group. Landraces exhibited higher variability (H′ = 0.64) as compared to released cultivars and evolutionary pre-breeding population lines (H′ = 0.55). Furthermore, accessions originating from West Asia exhibited the highest variability (H′ = 0.63). Traits such as coleoptile colour, plant growth habit, auricle colour and pubescence, flag leaf attitude, ear shape, presence or absence of awns, awns colour and attitude, glumes shape and pubescence, beak length, peduncle attitude, grain phenol colour, grain germ width and brush hair length were found suitable for distinguishing the present durum accessions due to their higher frequency distribution and Shannon–Wiener diversity index values. A core set of 13 accessions was developed using the programme Power Core. These accessions represent the overall variability of the entire set and can therefore serve as a potential source of new genes/alleles for the genetic enhancement of durum wheat. This durum panel may also serve as a valuable reference collection for global researchers in the characterization of durum wheat accessions.

Genebanks worldwide play a crucial role in the long-term conservation and accessibility of wide diversity of plant genetic resources (PGR). These resources are essential for addressing current and future challenges related to climate change and biodiversity loss, thereby contributing to agricultural production and sustainability. Enhancing the efficiency of genebanks requires implementing a quality management system that ensures data transparency, as well as the documentation and standardization of processes. This study proposes a set of 10 mandatory and 38 optional genebank metrics specifically designed for collections of orthodox seeds. These metrics define a set of basic parameters that are easy to calculate and collectively serve as a valuable tool for improving genebank management, enhancing performance, fostering transparency and promoting collaborations among institutions. Fourteen institutions engaged in the long-term conservation of PGR were consulted in the development of the proposed metrics. This work lays the foundation for the establishment of a widely accepted set of genebank metrics within the global genebank community. Further research and iterative development are necessary to formulate comprehensive metrics applicable to other ex situ conservation methods (such as cryopreservation, in vitro and field conservation) as well as in situ conservation strategies (including genetic reserves and on-farm conservation).

While conducting archaeological survey to document the large prehistoric canal systems in the central portion of the Tehuacán Valley, investigators recorded a mound and plaza complex that includes what appears to be an effigy mound in the shape of a scorpion. Large quantities of ceramics, including surface-decorated and polychromes, indicate a Late Classic and Postclassic occupation. The site is interpreted as being part of an intensive agricultural system as it appears centrally located in the context of highly developed agricultural and irrigation infrastructure. For the reasons described, we interpret this ca. 60 meter scorpion effigy mound as an intentional feature with possible astronomical alignments. It is hypothesized as being part of a local civic/ceremonial complex with the possible use/function of observing the summer and winter solstices. If so, it provides an insight into the integration of calendrical ritual with the surrounding complex system of fields and irrigation canals. Admittedly, these observations and explanations are relatively subjective. However, we consider them to be persuasive when the evidence is considered in its entirety.