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The study aimed to explore the causal effect of maternal prepregnancy body mass index (BMI) on congenital malformations of intestine (CMI). The genome-wide association data of BMI and CMI were obtained via the Mendelian randomization (MR) base platform. Single nucleotide polymorphisms (SNPs) significantly associated with BMI in females were identified and used as instrumental variables, and the causal relationship between BMI in females and CMI was examined using the bidirectional two-sample MR analyses research method. Three statistical methods including inverse-variance weighted (IVW) method, weighted median estimator, and MR-Egger regression were employed. A total of 36 SNPs significantly associated with BMI in females were identified in the study (P < 5 × 10−8; linkage disequilibrium r2 < 0.001). Consistent association between BMI in females and CMI was observed when evaluated by different methods (IVW: odds ratio (OR) 0.364, 95% confidence interval (CI) 0.144–0.922; weighted median estimator: OR 0.395, 95% CI 0.096–1.619; MR-Egger Method: OR 0.244, 95% CI 0.020–2.974), which suggests that BMI in females is negatively associated with increased risk of CMI. The MR analysis provided the strong evidence to indicate that decreasing BMI in females might be causally associated with the risk of CMI.
The burgeoning critical scholarship on space in International Relations (IR) overwhelmingly recognises space as a socially produced set of performances, practices, and discourses, converging into meaningful organisations of located experience. Drawing on the writings of Deleuze and Guattari on the related concepts of nomadism and the war machine, I argue that this productive emphasis betrays a continued statist methodology that proceeds by binding, or partitioning, space into finished outcomes. I present a conceptual challenge to the normative emphasis on socially produced space by following nomadism, the immanent tendency to variation in the process of spatial becoming. Working with nomadic potentials brings to the fore smooth space, which includes the continuous possibilities and intensities existing unencumbered beneath concretised productions of organised space. I follow the spatial movement of violence in Punjab during the Indian Partition of 1947 as the emergence of a war machine which deployed the nomadism of smooth space to decompose and upend striations. My objectives are first, to argue for spatial possibilities beyond the normative positivity of produced space, and secondly, to register the fundamental methodological and analytical shifts that these possibilities demand. These shifts can in turn deepen ongoing disciplinary inquiries into indeterminacy.
Developmental Gerstmann’s Syndrome (DGS) is a proposed neurological disorder characterized by finger agnosia, acalculia, right-left disorientation, agraphia, and in some cases, constructional dyspraxia. Case studies of DGS are limited, particularly those reporting on assessments in adults. The present case study demonstrates the presence of DGS symptoms in a young female adult with an autoimmune disorder but no clear history of neurological damage.
Method:
This client sought academic accommodations for her undergraduate math classes. She was administered a comprehensive neuropsychological assessment, during which she demonstrated difficulties with mathematical concepts, right-left disorientation, inverted writing, mild finger agnosia, andimpairments in fine motor abilities and visual motor coordination.
Results:
The client’s symptoms were consistent with DGS, though variability in her performance on assessments suggests compensatory strategies she may have developed throughout her life.
Conclusion:
Our client demonstrated similarities with previously reported accounts of DGS as assessed in adults. This case proposes further evidence for DGS as a syndrome and presents challenges to assessing DGS in high-functioning adults. The case highlights a need for a standardized testing battery to assess DGS.
For any integers x and y, let $(x, y)$ and $[x, y]$ stand for the greatest common divisor and the least common multiple of x and y, respectively. Let $a,b$ and n be positive integers, and let $S=\{x_1, \ldots , x_n\}$ be a set of n distinct positive integers. We denote by $(S^a)$ and $[S^a]$ the $n\times n$ matrices having the ath power of $(x_i,x_j)$ and $[x_i,x_j]$, respectively, as the $(i,j)$-entry. Bourque and Ligh [‘On GCD and LCM matrices’, Linear Algebra Appl.174 (1992), 65–74] showed that if S is factor closed (that is, S contains all positive divisors of any element of S), then the GCD matrix $(S)$ divides the LCM matrix $[S]$ (written as $(S)\mid [S]$) in the ring $M_n({\mathbb Z})$ of $n\times n$ matrices over the integers. Hong [‘Divisibility properties of power GCD matrices and power LCM matrices’, Linear Algebra Appl.428 (2008), 1001–1008] proved that $(S^a)\mid (S^b)$, $(S^a)\mid [S^b]$ and $[S^a]\mid [S^b]$ in the ring $M_{n}({\mathbb Z})$ when $a\mid b$ and S is a divisor chain (namely, there is a permutation $\sigma $ of order n such that $x_{\sigma (1)}\mid \cdots \mid x_{\sigma (n)}$). In this paper, we show that if $a\mid b$ and S is factor closed, then $(S^a)\mid (S^b)$, $(S^a)\mid [S^b]$ and $[S^a]\mid [S^b]$ in the ring $M_{n}({\mathbb Z})$. The proof is algebraic and p-adic. Our result extends the Bourque–Ligh theorem. Finally, several interesting conjectures are proposed.
Since the early 1950s, national statisticians have regarded unpaid work as non-economic, excluding it from GDP. Feminist scholars argue this exclusion reflects a gender-biased view of progress that renders women’s non-market productivity invisible. As what gets measured drives policy priorities and resource allocation, breastfeeding highlights the need to account for women’s unpaid care work in economic statistics. This paper advances the Beyond GDP agenda by demonstrating how market-derived prices can improve the measurement and recognition of women’s lactation labour. We first trace the historical displacement of breastfeeding by commercial formula and identify key economic drivers. Next, we review critiques of GDP and debates over including non-market household services in the UN’s System of National Accounts. We then present novel estimates of breast milk’s economic value in selected countries. Our analysis shows that existing market prices can robustly proxy for breastfeeding work, correcting GDP’s gender bias and realigning policy priorities. Including human milk production in core economic indicators not only reflects its true contribution but also promotes women’s and children’s rights and supports sustainable development through comprehensive true-cost accounting.
The present study describes a new Ditylenchoides species, isolated from Meknès, Morocco, during nematode surveys conducted to investigate the biodiversity of plant-parasitic nematodes in Mediterranean olive groves and adjacent patches of natural vegetation. Application of integrative taxonomical approaches clearly verified that it is a new species designated herein as Ditylenchoides morocciensis sp. nov., also representing the first report of the genus in Morocco. The new species is parthenogenetic, characterised by a short body 460 (373–528 μm); stylet delicate, relatively short, 8.7 (8.0–9.0) μm long with rounded basal knobs; six lines in the lateral fields; median bulb of pharynx oval, muscular and valvate; secretory-excretory pore located at the level of basal pharyngeal bulb region; vulva located at 79.9 (76.9–81.3) % of body length; relatively long post-vulval uterine sac 29.1 (20.0–39.0) μm; and a subcylindrical tail 24.4 (22.0–28.0) μm long, with a bluntly rounded tip. The results of molecular analysis of D2-D3 28S rRNA, ITS rRNA, partial 18S rRNA, and cytochrome oxidase c subunit 1 (COI) gene sequences support for the new species status and clearly separated D. morocciensis sp. nov. from all other species within Ditylenchoides. Phylogenetic analyses of ribosomal markers (D2-D3 28S rRNA and partial 18S rRNA) of this study confirms that Ditylenchoides is a monophyletic genus, clearly separated from other genera within Anguinoidea.
We developed a compact, ultra-wideband radar demonstrator for measurements of snow thickness. We designed the radar to be capable of reconfigurable operation over Ku- and S/C bands, and with a size, weight, and power compatible with a C-3 class unmanned aircraft system (UAS). We implemented the radar’s radio frequency frontend using low-cost laminate materials and employed 3D printed antennas for an inexpensive implementation. To demonstrate its performance and capabilities, we first conducted a series of laboratory tests, followed by tests of opportunity in Antarctica using a sled-based setup. Next, we integrated the radar demonstrator into an Aurelia X6 Pro system and completed a series of local flight tests over areas including grass-covered land and a wooded section with different seasonal foliage conditions. Lastly, we used our UAS-borne radar test bed to map seasonal snow accumulation to a depth close to ∼30 m in Greenland from 100-m altitude. In this paper, we offer a succinct description of the radar test bed electronics, a discussion of laboratory tests and integration considerations, and present sample results from various field scenarios.
The reproductive efficiency of dairy cows decreases significantly in hot climates. Exposure to heat stress causes damage to different stages of the reproductive cycle including a decrease in the quality of oocytes. Antioxidant supplementation has been introduced as one of the main approaches to alleviate the effects of free radical damage associated with heat stress. Gamma-oryzanol (ORY), a component of rice bran oil, is introduced as a novel antioxidant. As a supplement of culture media for maturation, the effect of ORY on the development of heat-shocked bovine cumulus–oocyte complexes was evaluated in this study. At the end of maturation in vitro using the heat-shock model, a higher proportion of metaphase II oocytes (0.78 ± 0.03 vs 0.42 ± 0.03) and lower metaphase I and germinal vesicle breakdown (0.10 ± 0.02 vs 0.38 ± 0.03) were recorded for the treated group (N = 205) in comparison with the control (N = 203) (P < 0.05). Moreover, the treatment exerted upregulation of NRF2, SOD, CAT and GPX transcripts in matured oocytes and GPX in CCs, along with a considerable increase in the cleavage (0.52 ± 0.04 vs 0.33 ± 0.03) and total blastocyst rates (0.30 ± 0.03 vs 0.14 ± 0.02) (P < 0.05). These results showed that ORY increased the mRNA expression of the transcripts associated with antioxidant enzymes and enhanced the developmental potential of heat-shocked bovine oocytes and warranted further studies to explore this antioxidant’s influence on improving dairy cattle’s reproductive efficiency during heat stress.
Putting the work of the poet Nathaniel Mackey into correspondence with that of the singer, composer, performance and video artist M. Lamar offers a unique perspective on the complex relationship between automation and possession. Mackey’s Andoumboulou and Mu move in and through M. Lamar so that possession and automation are destabilized and replaced by molecular distintegrations of plantation worlds and the sonic apertures of a Black Afrofuturist Android.
Vertically bounded, horizontally propagating internal waves may become unstable through triad resonant instability, in which two sibling waves in background noise draw energy from a parent internal tide. If the background stratification is uniform, then the condition for pure resonance between the parent and sibling wave frequencies and horizontal and vertical wavenumbers can be found semi-analytically from the roots of a polynomial expression. In non-uniform stratification, determining the frequencies and horizontal wavenumbers for which resonance occurs is less straightforward. We develop a theory for near-resonant excitation of a pair of sibling waves from a low-mode internal wave in which the proximity to pure resonance is characterised by the discrepancy between the forced sibling wave frequencies and the natural frequency of these modes. Knowing this discrepancy can be used methodically to determine pure resonance conditions. This inviscid theory is compared with numerical simulations of effectively inviscid waves. For comparison with laboratory experiments, the theory is adapted to include viscous effects both in the bulk of the fluid and at the side walls of the tank. We find that our theoretical predictions for frequencies and wavenumbers of the fastest growing sibling waves are generally consistent between theory, simulations and experiments, though theory overpredicts the growth rate observed in experiments. In all cases, the growth rate of sibling waves decreases with decreasing parent wave frequency, becoming negligibly small in experiments if the parent wave has frequency less than $\approx 0.7$ of the buoyancy frequency at the surface.
In 2019 British choreographer Seke Chimutengwende began research on a new project exploring horror, haunted houses, and the hauntings of colonial history. It begins in darkness (2022) emerged in collaboration with the dancers who perform each iteration. Working through the figure of the haunted stately home, It begins in darkness excavates—and exorcises—the horror of slavery’s histories through dance.