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The topic of this thesis lies in the intersection between proof theory and algebraic logic. The main object of discussion, constructive reasoning, was introduced at the beginning of the twentieth century by Brouwer, who followed Kant’s explanation of human intuition of spacial forms and time points: these are constructed step by step in a finite process by certain rules, mimicking constructions with straightedge and compass and the construction of natural numbers, respectively.
The aim of the present thesis is to show how classical reasoning, which admits some forms of indirect reasoning, can be made more constructive. The central tool that we are using are induction principles, methods that capture infinite collections of objects by considering their process of generation instead of the whole class. We start by studying the interplay between certain structures that satisfy induction and the calculi for some non-classical logics. We then use inductive methods to prove a few conservation theorems, which contribute to answering the question of which parts of classical logic and mathematics can be made constructive.
Capitalism is in trouble, or so we have been told. I argue that Adam Smith has a lot to teach us about the future of capitalism. I first examine recent discussions about the current challenges and criticisms against capitalism such as the productivity slowdown, waning competition, the role of globalization, rising inequality, and climate change. I emphasize that there are some global trends, but there are also important national and regional differences reflecting differences in institutions and policy. Not only natural-scientific technology, but also social-scientific technology—that is, governance, policy, and institutions—matter. Then, I explain what Smith can teach us. First, Adam Smith conceives a truly inclusive capitalism: he takes income distribution into account when he argues for the desirability of economic development. Second, inclusive capitalism requires broad formation and sharing of knowledge among people. Third, the expansion of exchange and trade has beneficial effects, but we should be aware of its distributional consequences. Fourth, institutions matter. Fifth, proper law and institutions—the “system of natural liberty”—are essential to a well-functioning market economy. However, the “system of natural liberty” is not automatically achieved. Policy and institutions are history-dependent; therefore, history matters.
Since 2014, transcatheter paravalvular leak closure with the Occlutech Paravalvular Leak Device has been successfully accomplished in adults with high technical success. We describe the first successful use of the Occlutech Paravalvular Leak Device in the left atrio-ventricular valve in the United States in a 5-year-old child with a history of previously repaired atrio-ventricular septal defect.
To deconstruct the multiple levels of risk factors for Clostridioides difficile infection, using multilevel models (MLMs) accounting for patient movement.
Study Design and Setting:
Case-control study of patients hospitalized in three acute care Delaware hospitals, December 2019–December 2023.
Patients:
Cases were patients aged ≥18 years who tested positive for hospital-onset C. difficile infection. Controls were patients aged ≥18 years hospitalized more than 72 hours, who did not test positive for C. difficile infection.
Methods:
Hierarchical and cross-classified MLMs were used to calculate odds of C. difficile infection based on patient-level risk factors and to evaluate the variation in odds of infection attributable to environmental risk factors using the hospital unit(s) a patient was assigned to during hospitalization.
Results:
Our study included 1,223 patients (249 cases, 974 controls). In both models, greater odds of infection were associated with antibiotic exposure [adjusted odds ratio (aOR) = 11.20, 95% confidence interval (CI) = 7.19, 17.40; aOR = 12.80, 95% CI = 8.46, 19.40 for hierarchical and cross-classified models respectively] and health insurance (aOR = 1.74, 95% CI = 1.12, 2.68; aOR = 1.62, 95% CI = 1.03, 2.53; public vs. private). Median odds ratios (MOR) for both models indicated greater relevance of between-unit heterogeneity in the outcome than health insurance but less than antibiotic exposure (MOR = 1.83, 95% CI = 1.56, 2.30 and 2.71 95% CI = 2.10, 4.06).
Conclusion:
Using multilevel methods accounting for patient movement, we found that while antibiotic use is the most important risk factor in patients that developed C. difficile infection, environmental risk factors are additionally important and should be considered in research involving hospitalized patients and healthcare-associated infections.
Wolff-Parkinson-White syndrome, characterised by accessory pathways, is rarely seen with dextrocardia. We present a case of situs inversus-dextrocardia with Wolff-Parkinson-White syndrome successfully treated via catheter ablation using 3D mapping (EnSite Precision®). Adjustments included reversed electrocardiogram (ECG) electrode placement, EnSite patch positioning, and fluoroscopic views. Coronary sinus access required counterclockwise manoeuvers. Mapping identified a left-sided accessory pathway, necessitating transseptal puncture with mirror-image adjustments. Ablation at the optimal site resulted in success. This case highlights the feasibility of catheter ablation in dextrocardia with tailored procedural modifications.
Children are uniquely vulnerable to chemical, biological, radiological, and nuclear (CBRN) events due to anatomical, physiological, and psychological differences. Current decontamination practices are adapted from adult protocols.
Objective
To evaluate current practices, challenges, and special considerations in pediatric decontamination during CBRN events.
Method
A scoping review was conducted using six databases in accordance with PRISMA-ScR framework. Studies were eligible if they evaluated decontamination methods involving children (0-18 years) in real or simulated CBRN scenarios. Fourteen studies met the inclusion criteria, and data were thematically analyzed into four domains.
Results
Disrobing is widely recognized as a critical first step in the decontamination process, and 43% of the studies reviewed identified it as such. When done immediately and appropriately, it can remove a significant amount of contaminants. Although its effectiveness varies based on how much of the body is covered and the nature of the exposure. Dry decontamination was discussed in 21% of studies, and wet decontamination was the most commonly reported approach, appearing in 93%. Key pediatric challenges included hypothermia, psychological distress, separation from caregivers, and difficulties managing non-ambulatory or special needs populations. Few studies addressed age-specific protocols or long-term psychological impacts. The results are presented in procedural order to reflect the typical sequence of decontamination in CBRN response.
Conclusions
Current decontamination guidelines inadequately address pediatric-specific needs. There is a critical need for standardized, age-appropriate guidelines that integrate caregiver support and psychosocial considerations. A pediatric decontamination algorithm was developed to consolidate current evidence into a practical framework for CBRN mass casualty incidents.
The aim of this research is to examine student motivation to participate in general music classes. The research involves students aged 10–14 from a general education primary school in Croatia (N = 186). The results indicate that these students were motivated to engage in general music classes; however, a nonlinear decline in motivation was evident as students progressed through the school years. Girls were more motivated to participate in general music classes compared to boys, and students involved in additional musical activities reported higher levels of motivation. Furthermore, listening to music influenced students’ perceptions of general music lessons and was associated with their motivation.
The Acholla Archaeological Project is an international collaboration at the site of Acholla (Tunisia) between the Institut National du Patrimoine (INP), Dickinson College and the University of Oklahoma, with additional support from the University of Leicester and the Endangered Archaeology in the Middle East and North Africa (EAMENA) project. The first season of the project took place in June 2025, focusing on three main tasks: fieldwalking, topographic survey and architectural documentation. Over a period of two and a half weeks, an area of over 25 ha was covered by a fieldwalking team and nearly 40,000 finds were collected for study and analysis. Topographic and architectural surveys were also undertaken to begin the process of creating an updated plan of the site. The work accomplished this season has already yielded new information about Acholla and has provided a strong foundation for future fieldwork campaigns and further research at this important coastal site.
In her Time and History in Hegelian Thought and Spirit, Sally Sedgwick sets out to:
specify the extent to which we can accurately attribute to Hegel the view that human reason and the freedom it affords us are indebted for their nature to this temporal order of nature and history. Hegel’s concern with our reason’s development conveys not just his fascination with the past but his interest in how reason responds to and is anchored in and shaped by the past. (TH: 4)
In the first part of the book Sedgwick is concerned with freedom being temporally conditioned. The second part consists of the last two chapters and is concerned with the claim that ‘all our thought is indebted to this actual realm as well’ (TH: 8). Hegel repeatedly asserts, Sedgwick notes, ‘that none of us can escape our time in thought’ (TH: 143).
I am grateful to the Reviews Editor for the Hegel Bulletin, Susanne Herrmann-Sinai, for arranging this discussion of my book, Time and History in Hegelian Thought and Spirit (2023). I appreciate this opportunity to clarify and expand on some of the main ideas of the book, including those that are the most challenging to defend. I also owe thanks, of course, to each of my four critics for giving their valuable time to this project. In the context of so few pages, it is not possible to respond to every criticism; I have had to pick and choose. In the process, I may have failed to do full justice to my critics’ concerns.
This essay investigates the meaning of “nominal prices” in Adam Smith’s the Wealth of Nations, its contraposition to “real prices,” and the impact of Smith’s nominal prices upon his assessment of the prices of wheat over the centuries. I also consider measure and value in the Wealth of Nations as well as Smith’s threefold standard of measure: labor, wheat, money. Smith chose an unusual measure to investigate prices over time, with nominal prices being referred to a specific quantity of silver. This raises questions about the possible impact of centuries-old debates over debasement and the value of money on Smith’s measurement of value across times.