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The dissertation consists of an introductory chapter and eight published articles centered around the following topics: (1) calibration of the interpretability strength of weak first-order theories; (2) determination of the (un)decidability of fine-grained fragments of the intended models of the aforementioned theories; and (3) investigation of algebraic properties of the lattice of interpretability degrees of computably enumerable essentially undecidable theories.
1. J. Murwanashyaka, A weak theory of building blocks. Mathematical Logic Quarterly, vol. 70 (2024), pp. 233–254. doi: 10.1002/malq.202300015
2. J. Murwanashyaka, Hilbert’s tenth problem for term algebras with a substitution operator. Computability, vol. 13 (2024), nos. 3–4, pp. 433–457. doi: 10.3233/COM-230444
3. J. Murwanashyaka, Weak essentially undecidable theories of concatenation, part II. Archive for Mathematical Logic, vol. 63 (2024), pp. 353–390. doi: 10.1007/s00153-023-00898-y
4. J. Murwanashyaka, F. Pakhomov, and A. Visser, There are no minimal essentially undecidable theories. Journal of Logic and Computation, vol. 34 (2024), no. 6, pp. 1159–1171. doi: 10.1093/logcom/exad005
5. J. Murwanashyaka, Weak essentially undecidable theories of concatenation. Archive for Mathematical Logic, vol. 61 (2022), nos. 7–8, pp. 939–976. doi: 10.1007/s00153-022-00820-y.
6. J. Murwanashyaka, Weak sequential theories of finite full binary trees, Revolutions and Revelations in Computability (U. Berger, J. N. Y. Franklin, F. Manea, and A. Pauly, editors), CiE 2022, Lecture Notes in Computer Science, Vol. 13359, Springer International Publishing, 2022, pp. 208–219. doi: 10.1007/978-3-031-08740-0_18.
7. L. Kristiansen and J. Murwanashyaka, First-order concatenation theory with bounded quantifiers. Archive for Mathematical Logic, vol. 60 (2021), nos. 1–2, pp. 77–104. doi: 10.1007/s00153-020-00735-6.
8. L. Kristiansen and J. Murwanashyaka, On interpretability between some weak essentially undecidable theories, Beyond the Horizon of Computability (M. Anselmo, G. Della Vedova, F. Manea, and A. Pauly, editors), CiE 2020, Lecture Notes in Computer Science, Vol. 12098, Springer International Publishing, 2020, pp. 63–74. doi: 10.1007/978-3-030-51466-2_6.
The crystal structures of two arylcyclohexylamine derivatives – methoxmetamine·HCl (2-(3-methoxyphenyl)-2-(methylamino)cyclohexan-1-one hydrochloride, MMXE·HCl) and methoxetamine·HCl (2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one hydrochloride, MXE·HCl) – have been determined using laboratory X-ray powder diffraction data contained in the Powder Diffraction File™. MMXE·HCl and MXE·HCl exhibit anesthetic and sedative effects and have been illicitly used as recreational drugs due to their dissociative hallucinogenic and euphoriant effects. The structure determination of MMXE·HCl and MXE·HCl was carried out with DASH, and the Rietveld refinements were performed with TOPAS Academic in monoclinic unit cells. The parameters obtained for MMXE·HCl were a = 15.0429(5) Å, b = 14.0721(5) Å, c = 6.5716(2) Å, β = 90.9864(14)°, and V = 1,390.91(8) Å3, with Z = 4 and space group P21/n. The parameters obtained for MXE·HCl were a = 8.7772(5) Å, b = 9.9528(7) Å, c = 8.5841(6) Å, β = 100.276(3)°, and V = 737.86(8) Å3, with Z = 2 and space group P21. The structures were validated by dispersion-corrected DFT calculations. Hirshfeld surface analysis and fingerprint plots calculations are also reported.
A large-scale parametric study of the flow over the prolate spheroid is presented to understand the effect of Reynolds number and angle of attack on the separation, the wake formation and the loads. Large-eddy simulation is performed for six Reynolds numbers ranging from ${\textit{Re}} = 0.15\times 10^6$ to $4 \times 10^6$ and for eight angles of attack ranging from $\alpha = 10^\circ$ to $\alpha = 90^\circ$. For all the cases considered, the boundary layer separates symmetrically and forms a recirculation region. Several distinct flow topologies are observed that can be grouped into three categories: proto-vortex, coherent vortex and recirculating wake. In the proto-vortex state, the recirculation does not have a distinct centre of rotation, instead, a two-layer detached flow structure is formed. In the coherent vortex state, the separated shear layer rolls into a three-dimensional vortex that is aligned with the axis of the spheroid. This vortex has a clear centre of rotation corresponding to a minimum of pressure and transforms the transverse momentum from the separated shear layer into axial momentum. In the recirculating wake regime, the recirculation is incoherent and the primary separation forms a dissipative shear layer that is convected in the direction of the free stream. This symmetric pair of shear layers bounds a low-momentum recirculating cavity on the leeward side of the spheroid. The properties of these states are not constant, but evolve along the axis of the spheroid and are dictated by the characteristics of the boundary layer at separation. The variation of the flow with Reynolds number and angle of attack is described, and its connection to the loads on the spheroid are discussed.
This paper aims to elucidate the physical mechanisms underlying airfoil–vortex gust interaction and mitigation. The vortex gust mitigation problem consists in finding the pitch rate sequence that minimises the gust-induced lift disturbance of an NACA0012 airfoil at Reynolds number 1000. The instantaneous flow fields and resulting lift are obtained from numerical resolution of the Navier–Stokes equations. The controller is modelled as an artificial neural network and trained to minimise the lift fluctuation using deep reinforcement learning (DRL). The paper shows that DRL-trained controllers are able to mitigate medium- and high-intensity vortex gusts by more than 80 % compared to the uncontrolled scenario. It then presents a comparative analysis of the controlled and uncontrolled lift generation mechanisms using the force partitioning method (FPM). The FPM provides a quantitative assessment of the amount of lift generated by each flow region. For medium-intensity gusts, the main phenomenon is the asymmetry in the airfoil boundary layer induced by the vortex. The control strategy mitigates the gust-induced lift by restoring the flow symmetry around the airfoil. For high-intensity gusts, the boundary layer asymmetry remains, but the gust interaction with the airfoil also triggers flow separation and the formation of a strong leading-edge vortex (LEV). Consequently, the control command balances several aerodynamic phenomena such as boundary layer asymmetry, flow detachment, LEV, and secondary recirculation regions to produce a net quasi-zero lift fluctuation. Thus this work highlights the potential of DRL control, enhanced by advanced post-processing such as FPM, to discover and interpret optimal flow control mechanisms.
Using calibrated radiocarbon dates, this study investigates climate signals recorded in fluvial sedimentary archives from southern Poland, eastern Netherlands, and eastern Germany. Summed probability density functions (PDFs) were constructed and analyzed in the context of INTIMATE stratigraphy. The results indicate that fluvial sedimentation and erosion processes were closely linked to climate fluctuations, particularly during GS/GI and GI/GS transitions. The analyses indicate multi-scale relationships between regional geomorphological processes and global climate trends during the period from 50 to 15 cal kBP. This study provides a reconstruction of Late Pleistocene fluvial activity and highlights the need for more precise radiocarbon dates to refine correlations between regional and global climate events.
We prove a common refinement of theorems of Bergfalk and of Casarosa and Lambie-Hanson, showing that under certain hypotheses, the higher derived limits of a certain inverse system of abelian groups $\mathbf {A}$ do not vanish. The refined theorem has a number of interesting corollaries, including the nonvanishing of the second derived limit of $\mathbf {A}$ in many of the common models of set theory of the reals and in the Mitchell model. In particular, we disprove a conjecture of Bergfalk, Hrušák, and Lambie-Hanson that higher derived limits of $\mathbf {A}$ vanish in the Miller model.
The topic of this thesis lies in the intersection between proof theory and algebraic logic. The main object of discussion, constructive reasoning, was introduced at the beginning of the twentieth century by Brouwer, who followed Kant’s explanation of human intuition of spacial forms and time points: these are constructed step by step in a finite process by certain rules, mimicking constructions with straightedge and compass and the construction of natural numbers, respectively.
The aim of the present thesis is to show how classical reasoning, which admits some forms of indirect reasoning, can be made more constructive. The central tool that we are using are induction principles, methods that capture infinite collections of objects by considering their process of generation instead of the whole class. We start by studying the interplay between certain structures that satisfy induction and the calculi for some non-classical logics. We then use inductive methods to prove a few conservation theorems, which contribute to answering the question of which parts of classical logic and mathematics can be made constructive.
Capitalism is in trouble, or so we have been told. I argue that Adam Smith has a lot to teach us about the future of capitalism. I first examine recent discussions about the current challenges and criticisms against capitalism such as the productivity slowdown, waning competition, the role of globalization, rising inequality, and climate change. I emphasize that there are some global trends, but there are also important national and regional differences reflecting differences in institutions and policy. Not only natural-scientific technology, but also social-scientific technology—that is, governance, policy, and institutions—matter. Then, I explain what Smith can teach us. First, Adam Smith conceives a truly inclusive capitalism: he takes income distribution into account when he argues for the desirability of economic development. Second, inclusive capitalism requires broad formation and sharing of knowledge among people. Third, the expansion of exchange and trade has beneficial effects, but we should be aware of its distributional consequences. Fourth, institutions matter. Fifth, proper law and institutions—the “system of natural liberty”—are essential to a well-functioning market economy. However, the “system of natural liberty” is not automatically achieved. Policy and institutions are history-dependent; therefore, history matters.
Since 2014, transcatheter paravalvular leak closure with the Occlutech Paravalvular Leak Device has been successfully accomplished in adults with high technical success. We describe the first successful use of the Occlutech Paravalvular Leak Device in the left atrio-ventricular valve in the United States in a 5-year-old child with a history of previously repaired atrio-ventricular septal defect.
To deconstruct the multiple levels of risk factors for Clostridioides difficile infection, using multilevel models (MLMs) accounting for patient movement.
Study Design and Setting:
Case-control study of patients hospitalized in three acute care Delaware hospitals, December 2019–December 2023.
Patients:
Cases were patients aged ≥18 years who tested positive for hospital-onset C. difficile infection. Controls were patients aged ≥18 years hospitalized more than 72 hours, who did not test positive for C. difficile infection.
Methods:
Hierarchical and cross-classified MLMs were used to calculate odds of C. difficile infection based on patient-level risk factors and to evaluate the variation in odds of infection attributable to environmental risk factors using the hospital unit(s) a patient was assigned to during hospitalization.
Results:
Our study included 1,223 patients (249 cases, 974 controls). In both models, greater odds of infection were associated with antibiotic exposure [adjusted odds ratio (aOR) = 11.20, 95% confidence interval (CI) = 7.19, 17.40; aOR = 12.80, 95% CI = 8.46, 19.40 for hierarchical and cross-classified models respectively] and health insurance (aOR = 1.74, 95% CI = 1.12, 2.68; aOR = 1.62, 95% CI = 1.03, 2.53; public vs. private). Median odds ratios (MOR) for both models indicated greater relevance of between-unit heterogeneity in the outcome than health insurance but less than antibiotic exposure (MOR = 1.83, 95% CI = 1.56, 2.30 and 2.71 95% CI = 2.10, 4.06).
Conclusion:
Using multilevel methods accounting for patient movement, we found that while antibiotic use is the most important risk factor in patients that developed C. difficile infection, environmental risk factors are additionally important and should be considered in research involving hospitalized patients and healthcare-associated infections.
Wolff-Parkinson-White syndrome, characterised by accessory pathways, is rarely seen with dextrocardia. We present a case of situs inversus-dextrocardia with Wolff-Parkinson-White syndrome successfully treated via catheter ablation using 3D mapping (EnSite Precision®). Adjustments included reversed electrocardiogram (ECG) electrode placement, EnSite patch positioning, and fluoroscopic views. Coronary sinus access required counterclockwise manoeuvers. Mapping identified a left-sided accessory pathway, necessitating transseptal puncture with mirror-image adjustments. Ablation at the optimal site resulted in success. This case highlights the feasibility of catheter ablation in dextrocardia with tailored procedural modifications.
Children are uniquely vulnerable to chemical, biological, radiological, and nuclear (CBRN) events due to anatomical, physiological, and psychological differences. Current decontamination practices are adapted from adult protocols.
Objective
To evaluate current practices, challenges, and special considerations in pediatric decontamination during CBRN events.
Method
A scoping review was conducted using six databases in accordance with PRISMA-ScR framework. Studies were eligible if they evaluated decontamination methods involving children (0-18 years) in real or simulated CBRN scenarios. Fourteen studies met the inclusion criteria, and data were thematically analyzed into four domains.
Results
Disrobing is widely recognized as a critical first step in the decontamination process, and 43% of the studies reviewed identified it as such. When done immediately and appropriately, it can remove a significant amount of contaminants. Although its effectiveness varies based on how much of the body is covered and the nature of the exposure. Dry decontamination was discussed in 21% of studies, and wet decontamination was the most commonly reported approach, appearing in 93%. Key pediatric challenges included hypothermia, psychological distress, separation from caregivers, and difficulties managing non-ambulatory or special needs populations. Few studies addressed age-specific protocols or long-term psychological impacts. The results are presented in procedural order to reflect the typical sequence of decontamination in CBRN response.
Conclusions
Current decontamination guidelines inadequately address pediatric-specific needs. There is a critical need for standardized, age-appropriate guidelines that integrate caregiver support and psychosocial considerations. A pediatric decontamination algorithm was developed to consolidate current evidence into a practical framework for CBRN mass casualty incidents.
The aim of this research is to examine student motivation to participate in general music classes. The research involves students aged 10–14 from a general education primary school in Croatia (N = 186). The results indicate that these students were motivated to engage in general music classes; however, a nonlinear decline in motivation was evident as students progressed through the school years. Girls were more motivated to participate in general music classes compared to boys, and students involved in additional musical activities reported higher levels of motivation. Furthermore, listening to music influenced students’ perceptions of general music lessons and was associated with their motivation.