Biomarkers alone cannot resolve psychiatry’s diagnostic challenges, particularly the boundary between normal variation and pathology. Diagnosis should prioritise the subjective, phenomenological experiences of patients rather than solely relying on biological evidence, emphasising a framework centred on suffering, debilitation and societal impact.

We describe caudal analgesia agent, dose, reported adverse events, and outcomes in a single-centre, retrospective cohort study of 200 patients undergoing cardiac surgery from October 2020 to April 2023. Median (interquartile range) doses of clonidine and morphine were 2.7 (2.1–3) mCg/kg and 0.12 (0.1–1.12) mg/kg, respectively. Our findings suggest that a clonidine/morphine caudal was tolerated in cardiac surgical patients.

Original accounts of feminist standpoint theory emphasize its fundamentally critical stance toward situated knowledge (Smith 1974; Hartsock 1983; Collins 1986). The function of a critical standpoint is not to carelessly accept the beliefs of marginalized people, but instead to interpret those beliefs in light of thoroughgoing and pervasive ideological distortions. Some formulations of standpoint theory capture this critical function in the achievement thesis. It claims that a standpoint is not obtained automatically but must be achieved through a struggle against a dominant ideology. Contrary to the standard acceptance of the achievement thesis, Bright has recently argued that the requirement of achievement can warrant the dogmatic exclusion of some perspectives from becoming standpoints. In turn, he advances an account of standpoint theory which abandons the achievement thesis. Against Bright’s non-achievement account of standpoint theory, I argue that doing away with the achievement thesis abandons standpoint theory’s original aim of being critical of the social structures which construct and legitimize situated knowledge. Further, I argue that Bright’s concern with the possible dogmatism of the achievement thesis is better addressed by a commitment to the classic account of standpoint theory rather than a revision of it.

International law has been predominantly shaped by the West. Despite decolonization, insufficient attention has been paid to non-Western civilizations’ practices, including Asian civilizations. This article examines this insufficiency in relation to treaty interpretation and customary international law identification. To do so, it uses the notion of conscientious objection to military service as a case study. Despite particularly adverse state practice, chiefly in Asia, the International Covenant on Civil and Political Rights (ICCPR) treaty body and UN organs began affirming in the 1990s that the Covenant includes a right to conscientious objection to military service. The first part analyzes whether such a right can be implied from the ICCPR, inter alia, by assessing the practice of Asian states. The second part endeavours to explain the gap between the international human rights machinery’s pronouncements and non-Western practice by discussing the Western-centrism and individual-centrism of interpretations adopted by human rights bodies and organs.

This study evaluated the effects of combining Bacillus species with hydrolysed and inactive Torula yeast on rumen fermentation of tropical forages in vitro. Exp. 1 assessed different combinations of direct-fed microbials (DFM) and hydrolysed/inactive yeast on the ruminal fermentation of Urochloa brizantha hay in a randomised block design (3×3 factorial scheme). Treatments included: 1) Negative control, no DFM inclusion (NC); 2) B. subtilis and B. licheniformis (SL); 3) B. subtilis, B. licheniformis, B. amyloliquefaciens and B. coagulans (SLAC); 4) Hydrolysed Torula yeast (HY); 5) dry inactive Torula yeast (IY); 6) B. subtilis, B. licheniformis and dry inactive Torula yeast (SL+IY); 7) B. subtilis, B. licheniformis and hydrolysed Torula yeast (SL+HY); 8) B. subtilis, B. licheniformis, B. amyloliquefaciens, B. coagulans and dry inactive Torula yeast (SLAC+IY) and 9) B. subtilis, B. licheniformis, B. amyloliquefaciens, B. coagulans and hydrolysed Torula yeast (SLAC+HY). Bacillus and yeast interaction affected the total short-chain fatty acids (SCFA) and SCFA profile. In treatments without Bacillus, IY resulted in higher isovalerate compared to treatments without yeast (NC). The no yeast treatment also had lower isovalerate concentration than other treatments (HY, IY). Exp. 2 and Exp. 3 evaluated NC, SL, SLAC, SL+HY and SLAC+IY plus SLAC+HY in low- and medium-quality forage. For low-quality forage, SLAC+IY + SLAC+HY had the highest NH3-N concentration, while SL+HY yielded the highest total SCFA. In medium-quality forage, SL+HY showed the highest total SCFA. The combination of Bacillus species and HY may enhance total SCFA and NH3-N in the rumen, improving nutrient utilisation in grazing beef cattle.

Spodoptera frugiperda is a notorious pest that has been recorded attacking over 353 crop species worldwide. Excessive insecticide exposure can lead to resistance and has adverse impacts on the environment and beneficial organisms. Long-lasting pest control methods like entomopathogenic fungi may be used to prevent the negative impact of synthetic insecticides. In the current research, effectiveness of Cordyceps fumosorosea was analysed by applying a sub-lethal dose (LC15 = 2.09 × 106 spores mL−1) and a lethal dose (LC50 = 2.17 × 107 spores mL−1) on filial (F0) and first filial (F1) generations of S. frugiperda to estimate both lethal and sub-lethal effects. The LC15 was used to keep a significant proportion of larvae alive to permit determination of sublethal effects on S. frugiperda. After treatment with the LC15 and LC50, S. frugiperda progeny displayed shorter larval duration, lower fecundity, and shorter adult female and male longevities relative to untreated controls. Likewise, the adult pre-oviposition period, total pre-oviposition period, oviposition days (Od), net reproductive rates (Ro), and mean generation times (T) were reduced in fungal-infected groups. Furthermore, activities of key detoxifying enzymes, i.e. acetylcholinesterase (AChE), glutathione S-transferases (GST), and esterases (EST), were also evaluated. Substantial differences of AChE, GST, and EST (24.3, 18.34, and 10.09 µmol/min/mg protein), respectively, were observed at the LC50 in contrast to the LC15 and controls. The current study showed pathogenicity of C. fumosorosea, which negatively affected insect development and changed the activities of detoxifying enzymes, thereby increasing the effectiveness and eco-friendly management of S. frugiperda.

Traditional legal scholarship has long focused on the exercise of discretion in all its forms; however, by borrowing from the analytical toolkit of science and technology studies (STS), we begin to take an ‘ontological turn’ into the courtroom by documenting a new tool of judicial discretion invoked by criminal justice adjudicators: what we call ontological discretion. By examining three objects from our own research – sleep, death, and intoxication—we show how their lack of a universal, singular ontology may necessitate that adjudicators use their discretion to either choose a coherent ontology in a given case, or else avoid opining on ‘what things are’ altogether. We therefore start to move beyond those important but now rather mainstream sociolegal inquiries into legal knowledges, instead shifting our focus toward what legal actors say the objects of their various knowledges actually are, as well as the widespread legal effects of the court’s ontological games.

The dynamics surrounding the legislative process of the Indonesian Criminal Procedure Code (Kitab Undang-Undang Hukum Acara Pidana, KUHAP) from 1979 to 1981 were shaped by a clash between two opposing ideologies. On one side stood proponents of a rights-based approach, advocating for legal protections for the accused; on the other, supporters of an authoritarian approach emphasised the primacy of state authority in maintaining security and public order. In the end, Indonesian lawmakers were able to strike a balance by establishing several procedural safeguards that purported to protect the rights of the accused. This article offers a detailed account and analysis of this debate, illuminating how resistance and compromise emerged from the struggle. Drawing on these historical insights, the article explores the potential for reform in the contemporary Indonesian legal and political landscape, highlighting current challenges. The main dataset for this article was collected from official records of the meetings that took place during the legislative process of the KUHAP, as well as public opinion at the time. Although this debate took place more than four decades ago, revisiting the historical context of the KUHAP remains crucial to understanding its ongoing relevance and potential future for reform.

Latin American and South European countries share a common policy legacy of public Pay-As-You-Go (PAYG) pension systems, yet reform paths taken over the past decades between and within the two regions have varied. Latin American countries opted for the full or partial privatization of their public pension systems, yet subsequent reforms have challenged the public–private mix. Meanwhile, countries in Southern Europe opted for a less radical path, entailing different degrees of reform of their public pillars and the introduction of supplementary private ones. Our analysis focuses on Argentina, Chile, and Uruguay – in Latin America – and Spain, Italy, and Greece – in Southern Europe – and the reforms implemented since 1990. In understanding reform variation, we argue that by focusing on the role of political institutions and policy legacies, it is possible to identify reform mechanisms.

Dr. Tom Beauchamp wrote multiple seminal articles that influenced bioethics, research ethics, and animal ethics. But his influence extends beyond his academic scholarship. Here we honor Dr. Beauchamp’s contributions as a scholar, mentor, and teacher.

Utilizing data on household consumption expenditure patterns and sectorial greenhouse gas emissions, we study the extent of inequality over Turkish households’ differentiated carbon footprint incidences. We harmonize the household budget survey data of the Turkish Statistical Institute (TURKSTAT) with production-based gas emissions data from EXIOBASE3 and investigate both the direct and indirect emissions across household-level income strata. Our calculations reveal that the households in the highest income decile alone are responsible for 19.4 percent of the overall (direct and indirect) emissions, whereas the bottom 10 percent of households are responsible for 4.3 percent. We also find that for direct emissions, the per-household average of the highest income decile exceeds that of the lowest income decile by a factor of 11.2. Notably, 87 percent of the indirect emissions budget for the poorest decile is linked to food and housing expenses, underscoring their susceptibility to climate policies. We confer that in designing the net-zero emission pathways to combat climate change, it would not suffice to study the technological transition of decarbonization solely and that the successful implementation of an indigenous environmental policy will ultimately depend upon the socio-economic factors of income distribution strata, indicators of consumption demand, and responsiveness of the individual households to react to price signals.

I offer a critique of the method of analysis employed in Carl-Johan Palmqvist’s article The Mirror Account of Hope and Fear when arguing against the co-variation thesis (CVT). I show that the analysis of CVT—which uses the notational convention of representing a hope as “p’ and its supposed corresponding fear as “¬p’—is problematic in that it potentially obscures the divergent propositional content of hopes and fears. As an antidote, I suggest representing the propositional content of hopes and fears with distinct placeholders p, q, and etc. and I show how this refinement in method allows us to make progress on the issue of co-variation.

Effects of variations in parents’ control styles, especially the amount of power assertion they deploy, have long been a central question in socialization research. Although severe, harsh control is unanimously considered harmful, research on effects of far more common low-to-moderate power assertion is inconsistent. Drawing from attachment and social cognition traditions, we examined whether children’s representations of parents (Internal Working Models, IWMs) moderated associations between parental power assertion and children’s socialization (violating or embracing rules and values, responsiveness to parents). In two studies of community families (Family Study, FS, N = 102, and Children and Parents Study, CAPS, N = 200), employing observations and reports, we assessed parental power assertion at age 4.5, children’s IWMs at ages 8 in FS and 4.5 in CAPS, and socialization outcomes at ages 10 and 12 in FS and 4.5 in CAPS. In FS, children’s IWMs of the parent moderated effects of parental power assertion on socialization outcomes in mother- and father-child dyads (βs = 0.47, 0.41, respectively): Power assertion had detrimental effects only for children with negative IWMs of their parents. In CAPS, findings were replicated for mother-child dyads (β = 0.24). We highlight origins of multifinality in socialization sequelae of parental control.

Middle aortic syndrome is rare cause of secondary hypertension, typically manifesting in childhood or early adolescence. It involves obstructive narrowing of the aorta, often occurring in the distal thoracic and abdominal aorta and its major branches. While the exact cause of middle aortic syndrome is not fully understood, it has been linked to hereditary genetic conditions such as Williams syndrome. This case report describes a 16-year-old female with Williams syndrome who presented with abdominal pain and hematochezia. CT angiography revealed moderate narrowing of the abdominal aorta, consistent with a diagnosis of middle aortic syndrome.