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Cette note de recherche examine le nationalisme identitaire de la Coalition Avenir Québec (CAQ) depuis son arrivée au pouvoir, à travers une analyse qualitative des débats parlementaires à l’Assemblée nationale du Québec (2018–2023). En s’appuyant sur les discours des élus caquistes, elle explore comment la CAQ définit et met en oeuvre son nationalisme identitaire, caractérisé par un interventionnisme fort en matière d’immigration, de laïcité et de protection de la langue française. Il s’agit de montrer que, face à une réforme du fédéralisme bloquée et au refus de la souveraineté à deux reprises par la population, la CAQ substitue aux aspirations déchues de souveraineté du Québec et aux tentatives de réforme de la fédération une affirmation franche des « frontières imaginées » de la nation québécoise, c’est-à-dire des marqueurs qui définiraient « un vrai Québécois ». Grâce à un large corpus de débats parlementaires et à un codage thématique qualitatif, l’analyse met en évidence l’ubiquité du discours identitaire dans l’action gouvernementale de la CAQ. Enfin, cette note de recherche souligne le potentiel heuristique de l’analyse des discours parlementaires pour mieux comprendre les transformations contemporaines du nationalisme québécois.
Venous thrombosis in the Fontan circulation can be a devastating complication, and its management has traditionally been surgical. Here, we present two cases of extensive Fontan thrombosis that have both been successfully medically managed, with survival beyond two years.
Given the tropicalization of a complex subvariety of the torus, we define a morphism between the tropical cohomology and the rational cohomology of their respective tropical compactifications. We say that the subvariety of the torus is cohomologically tropical if this map is an isomorphism for all closed strata of the tropical compactification.
We prove that a schön subvariety of the torus is cohomologically tropical if and only if it is wunderschön and its tropicalization is a tropical homology manifold. The former property means that the open strata in the boundary of a tropical compactification are all connected and the mixed Hodge structures on their cohomology are pure of maximum possible weight; the latter property requires that, locally, the tropicalization verifies tropical Poincaré duality.
We study other properties of cohomologically tropical and wunderschön varieties, and show that in a semistable degeneration to an arrangement of cohomologically tropical varieties, the Hodge numbers of the smooth fibers are captured in the tropical cohomology of the tropicalization. This extends the results of Itenberg, Katzarkov, Mikhalkin and Zharkov.
Enhanced environmental disinfection is linked to reduced hospital-acquired infection rates. In this study, we aimed to evaluate the efficacy of an emerging disinfection technology, a filtered far-UV-C handheld (FFUHH) device, for reducing bacterial loads on high-touch surfaces in shared clinical workrooms, and to isolate, identify and characterize clinically significant environmental pathogens.
Methods:
We compared samples from high-touch items (dictation device, mouse, armchair, desk, and keyboard) before and after FFUHH treatment. Samples were collected weekly: contact plates for colony counts and swabs before and after intervention on standardized adjacent areas for each surface, respectively. The swabs were enriched and cultured on selective media to isolate pathogens. Environmental samples, as well as clinical samples collected from patients during the study period, were validated using MALDI-TOF and whole genome sequencing.
Results:
Among the 440 collected plates (220 before and 220 after treatment), the highest mean colony count pre-treatment was detected from armchairs, and the lowest from keyboards. The mean reduction of colony-forming units ranged 53% and 83% and was statistically significant (P < 0.05) across all surfaces except for the keyboard. We characterized multidrug-resistant Staphylococcus epidermidis ST5 and ST16 strains, a carbapenem-resistant Acinetobacter baumannii, and a Klebsiella pneumoniae genetically related to a clinical isolate with a rare sequence type not previously detected in our institution.
Conclusion:
The FFUHH effectively reduced the microbial burden on high-touch surfaces. It can offer an advantage for surface disinfection and an alternative to routinely used biocides.
Mandibular and dental material of hyaenids from the Central Asian localities of Zasukhino-3 (Russia) and Nalaikha (Mongolia), dating to the late Early Pleistocene (0.9–0.78 Ma) was identified as giant hyena Pachycrocuta brevirostris based on morphological and size similarities. Comparative analysis of Eurasian P. brevirostris from different stratigraphic levels (from 2.1 to 0.5 Ma) revealed two evolutionary stages of the lower cheek teeth of the giant hyenas. The stages are determined as morphotypes A and B, directed toward the differentiation of the function of premolar and enhancing the cutting function of m1. We traced the microprocesses that occurred during the transition from the primitive structure of the m1 talonid to its more advanced state. This event occurred during the transition from the late Villafranchian to the Epivillafranchian (ca. 1.1–0.9 Ma). The stabilized advanced morphotype B was found in samples from Zasukhino-3, Nalaikha, and other close-in-age localities such as Lakhuti-2. The new finds from Asian Russia and Mongolia suggest that P. brevirostris from these regions represent a single giant hyena population occupying the northernmost part of their Asian range.
Fields of sandy paleodunes have been identified in Brazil, Colombia, Venezuela, and Guyana north of the South American continent. In this study, geochronological data obtained by optically stimulated luminescence (OSL) for paleodunes in the Middle Rio Negro region (Brazil) allowed the identification of two stages of dune deposition: the older from 169.74 ± 1.01 ka to 124.38 ± 0.91 ka and the younger from 18.89 ± 0.88 ka to 14.75 ± 0.77 ka. The older interval is the first reported in the Amazon; no correlated sediment has been documented. In contrast, the more recent depositional interval correlates to the interval of paleodune fields of the region called “dry corridor” in the Late Pleistocene–Holocene. In this study, we associated the genesis of paleodunes with the reworking of alluvial deposits from the Negro and Demini rivers, driven by river seasonality during the Pleistocene–Holocene, as evidenced by characteristic microtextural data.
Catheter-related bloodstream infections (CRBSI) or central line-associated bloodstream infections (CLABSI) occur frequently with long-term indwelling catheters. EDTA (Ethylenediaminetetraacetic acid) and other catheter lock solutions can prevent CRBSI/CLABSI. This study aimed to identify the role of EDTA lock solution in preventing CRBSI/CLABSI compared to the non-EDTA lock solutions.
Materials and Methods:
Eligible studies comparing the effectiveness of EDTA versus a control group on averting CRBSI or CLABSI were identified through searches across PubMed, Embase, Scopus, Cochrane CENTRAL, medRxiv, bioRxiv, and ClinicalTrials.gov. The secondary outcomes were catheter colonization, catheter survival, and catheter thrombosis. The relative risk for all the outcomes was calculated.
Results:
This meta-analysis included eight studies (403 EDTA vs 425 control patients) and demonstrated a significant reduction in CRBSI/CLABSI with EDTA (15 vs 71 events; RR: 0.18; 95% CI: 0.10–0.33; P < 0.00001). Catheter colonization also decreased significantly (8 vs 38 events; OR: 0.11; 95% CI: 0.05–0.29). EDTA improved catheter survival in hemodialysis patients (OR: 3.77; 95% CI: 1.23–11.61; P < 0.02) but showed no significant effect on thrombolytic treatment or all-cause mortality. Subgroup analyses supported these findings, with no publication bias detected.
Conclusion:
EDTA significantly reduces CRBSI/CLABSI and catheter colonization, improves catheter survival, but does not affect thrombolytic treatment or mortality. Evidence certainty varies across outcomes.
This article offers principles to be followed when editing οὔκουν and οὐκοῦν. The distinction between these words is supported by the ancient grammarians, but manuscript readings oscillate to such a degree that modern editors often do not trust them. The most common principles thus far available are those established by Kühner–Gerth and Denniston. Some are so subjective, however, that editors do not always agree on the accentuation of a non-negligible number of instances. This article takes into account the pragmatic contexts in which the particle is used in Attic drama to effect a distinction by applying a conversation analytic methodology to their interpretation. All instances appearing in the extant plays of Aeschylus, Sophocles, Euripides and Aristophanes have been analysed.
A mechanical heart valve is a durable device used to replace damaged ones inside a living heart, aiming for regulated blood flow to avoid the risks of cardiac failure or stroke. The modern bileaflet designs, featuring two semicircular leaflets, aim to improve blood flow control and minimise turbulence as compared to the older models. However, these valves require lifelong anticoagulation therapy to prevent blood clots, increasing bleeding risks and necessitating regular monitoring. Turbulence within the valve can lead to complications such as haemolysis (damage to red blood cells), thrombosis, platelet activation and valve dysfunction. It also contributes to energy loss, increased cardiac workload, and endothelial damage, potentially impairing the valve efficiency and increasing the risk of infective endocarditis. To address these challenges, a design-modified St Jude Medical (SJM) valve with streamlined edges was conceptualised and assessed using direct numerical simulations. Results show that the streamlined design minimises abrupt blood flow alterations and reduces turbulence-inducing vortices. Compared to existing SJM valves, the new design ensures smoother flow transitions, reduces flow disturbances, and reduces pressure drop. It significantly decreases shear stress, drag and downstream turbulence, enhancing haemodynamic efficiency. These improvements lower the risk of complications such as haemolysis and thrombosis, offering a safer and more efficient option for valve replacement, establishing the potential of edge streamlining in advancing mechanical heart valve technology, and favouring patient outcomes.
Unhealthy diets are a leading cause of preventable ill health. Healthy diets tend to be more expensive than less healthy diets and as such are more likely to be consumed by individuals with a higher income. This review paper discusses the development of the Eatwell Guide, evaluates the affordability of a diet consistent with the Eatwell Guide (“the Eatwell Guide diet”), and explores how food pricing can be leveraged to encourage and support healthier dietary choices.
The Eatwell Guide is the UK’s food-based dietary guidelines. It provides healthy eating advice that is intended to facilitate policy cohesion but is also used as a public facing health promotion tool.
The cost of food has increased and recent estimates suggest that the Eatwell Guide diet is now more expensive than the current average diet. There is strong evidence that subsidies would be effective at increasing the uptake of healthy diets. Monitoring the cost of a healthy diet is important for policy development; however, we should exercise caution when considering how to incorporate costs into food-based dietary guidelines and be mindful of the limitations of the data that could support this.
This study connected flow structure and morphological changes in and around a rectangular vegetation patch. The emergent patch was constructed in an 8 cm sand bed. Two patch densities were tested, using a regular configuration of rigid dowels. Near the leading edge of the patch, enhanced turbulence levels produced sediment erosion. Some of the eroded sediment was carried into the patch, forming an interior deposition dune. The denser patch resulted in a smaller dune due to stronger lateral flow diversion and weaker interior streamwise velocity. After the leading-edge dune, in the fully developed region of the patch, vortices formed in the shear layers along the patch lateral edges. Elevated turbulence at the patch edge produced local erosion. For the dense patch, material eroded from the edge was transported into the patch to form a flow-parallel ridge, and there was no net sediment loss/gain by the patch. For the sparse patch, material eroded from the edge was transported away from the patch, resulting in a net loss of sediment from the patch. In the wake of both patches, deposition occurred near the wake edges and not at the wake centreline, which was attributed to the weak lateral transport associated with the weakness of the von Kármán vortex street. Specifically, the lateral transport length scale was less than half the width of the patch. The increasing bedform height within the wake progressively weakened and narrowed the von Kármán vortex street, illustrating an important feedback from morphological evolution to the flow structure. Despite significant local sediment redistribution, the patch did not induce channel-scale sediment transport.
The crystal structure of a new form of racemic reboxetine mesylate has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Reboxetine mesylate crystallizes in space group P21/c (#14) with a = 14.3054(8), b = 18.0341(4), c = 16.7924(11) Å, β = 113.4470(17)°, V = 3,974.47(19) Å3, and Z = 8 at 298 K. The crystal structure consists of double columns of anions and cations along the a-axis. Strong N–H···O hydrogen bonds link the cations and anions into zig-zag chains along the a-axis. The powder pattern has been submitted to the International Centre for Diffraction Data (ICDD®) for inclusion in the Powder Diffraction File™ (PDF®).
Although fundamental arguments have been presented to support the value-laden nature of all scientific research, they appear to be difficult to apply to basic research in physics. To explain this, I argue that basic research in physics is, in a very specific respect, often value-laden to a lesser degree. To spell this out, I refer to the different signal-to-noise ratios that can be achieved in different fields of research. I also argue that having a very low degree of value-ladenness in the very specific respect that I identify does not mean that the research is not value-laden at all.
The Third Reich established a new financial order in Central Europe. This article examines one aspect of these changes, namely the evolution of banking law. After the seizure of power in 1933, Nazi officials weaponized financial and legal institutions to support the rearmament campaign. They initially worked through the Credit Supervisory Office, a regulatory agency created in 1934, to enforce a standardized model of regulation. Driven by more than a desire for self-sufficiency (autarky) and expropriative control, the authorities devised a system of economic governance that perpetuated the conflict and continually supported German financial interests. The politicization and dismantling of the regulatory office, officially dissolved in 1944, reflected the evolving priorities of the Nazi regime. By reinterpreting existing laws and working with a willing state bureaucracy, officials were able to use regulation as a tool for redesigning the banking systems of Germany and the annexed territories.
Although current prescribing guidelines suggest continuation of psychotropic drugs in pregnant women, population-based evidence supporting their safety is limited.
Aims
This study aims to clarify the plausible causal links between maternal psychotropic drug exposures and obstetric complications.
Method
This cohort study investigated all births by Hong Kong residents ≥18 years of age in public hospitals between 2004 and 2022. Birth episodes were classified according to whether they were unexposed to psychotropic drugs, exposed but discontinued before conception or exposed during pregnancy. Firth’s penalised logistic regression was employed in all analysis, and negative control analysis was conducted to assess causality. False discovery rate correction and sensitivity analyses were performed.
Results
Among 587 419 births, 7182 episodes involved psychotropic prescriptions (antipsychotics, antidepressants, anticonvulsants, benzodiazepines) during pregnancy. In broad drug class analysis, all significant associations observed in the exposed group were also observed in negative control analysis (psychotropics discontinued before conception), suggesting that elevated risks could be attributed to unmeasured confounders. Nevertheless, in subclass analyses, certain psychotropic drugs showed increased risks of obstetric complications, i.e. significant associations between atypical antipsychotics and genito-urinary infection (odds ratio 2.70, 95% CI 1.46–4.83), and between valproate and low birth weight (odds ratio 1.68, 95% CI 1.16–2.37). These associations became non-significant in negative control analysis, and the high E-values (atypical antipsychotics and genito-urinary infection, 4.84; valproate and low birth weight, 2.75) suggested that the results were unlikely to have been driven by unmeasured confounders. Maternal diagnoses of schizophrenia and depression were independently associated with increased risk of obstetric complications, after controlling for the effects of psychotropics.
Conclusions
The population-based data and meticulous analyses did not support any clear causal link between broad-class psychotropic exposure during pregnancy and increased risk of obstetric/neonatal complications. However, some psychotropic subclasses may increase obstetric/neonatal complications. The limited number of episodes involving discontinuation of some psychotropic subclasses may have resulted in false negative findings in the negative control analysis.
This study examines the political participation of undocumented Mexican immigrants residing in the United States in Mexican external voting. As international mobility of people has increased globally, scholarly attention has grown concerning how overseas citizens engage in electoral processes in their countries of origin. However, previous studies based on traditional survey methods may have yielded biased results due to the underrepresentation of undocumented immigrants, who are less likely to enroll in survey company panels due to concerns about the potential compromise of their identities. To include this hard-to-reach population and conduct representative sampling, our research employs a method called respondent-driven sampling (RDS), which permits the surveying of a population devoid of a sampling frame. Our analysis of the Mexican case demonstrates that a lack of electoral information, lower levels of education, and heightened distrust of the Mexican government are associated with diminished electoral participation.