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106116 results in Materials Science

Page 95 of 5306

  • Loss in acoustic metasurfaces: a blessing in disguise – ERRATUM

  • Nikhil JRK Gerard, Yun Jing
  • Journal:
    MRS Communications / Volume 10 / Issue 4 / December 2020
    Published online by Cambridge University Press:
    29 January 2020, p. 705
    Print publication:
    December 2020
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  • A de novo theranostic nanomedicine composed of PEGylated graphene oxide and gold nanoparticles for cancer therapy

  • Hadi Samadian, Rahim Mohammad-Rezaei, Rana Jahanban-Esfahlan, Bakhshali Massoumi, Mojtaba Abbasian, Abbas Jafarizad, Mehdi Jaymand
  • Journal:
    Journal of Materials Research / Volume 35 / Issue 4 / 28 February 2020
    Published online by Cambridge University Press:
    29 January 2020, pp. 430-441
    Print publication:
    28 February 2020

  • A de novo drug delivery nanosystem based on gold nanoparticles (GNPs), decorated poly(ethylene glycol) (PEG), and folate (FA)-conjugated graphene oxide (GO) was designed and developed successfully. Initially, the graphite (G) powder was oxidized to the GO, and then functionalized with chloroacetic acid to afford a carboxylated graphene oxide (GO–COOH). The obtained GO–COOH was functionalized with an amine end-caped PEG, FA, as well as 3-amino-1-propanethiol to produce a GO–PEG–FA–SH. In another experimental section, GNPs were synthesized through a citrate-mediated reduction approach, and subsequently decorated onto/into GO–PEG–FA–SH through the formation of Au–S bond to afford a GO–PEG–FA/GNP nanosystem. The resultant nanosystem was loaded with doxorubicin hydrochloride (DOX) as a model anticancer drug, and its drug-loading capacity as well as pH-dependent drug release behavior were investigated. The anticancer activity of the developed theranostic nanomedicine was extensively evaluated using MTT assay against human breast cancer cells (MCF7). The developed GO–PEG–FA/GNPs–DOX theranostic nanomedicine exhibited an excellent cancer chemotherapy feature. In addition, this nanomedicine can be used in chemo-photothermal therapy of solid tumors because of the presence of GO and GNPs in its structure.

  • Hyaluronan-coated meta-organic framework loaded with cisplatin and oleanolic acid for synergetic chemotherapy of colorectal cancer

  • Qin Huang, En Wang, Weigang Gu, Wencong Ma, Yifeng Zhou
  • Journal:
    Journal of Materials Research / Volume 35 / Issue 22 / 30 November 2020
    Published online by Cambridge University Press:
    29 January 2020, pp. 3106-3115
    Print publication:
    30 November 2020

  • Effective cancer therapy is usually limited by the off target distribution of chemotherapeutic drugs and multidrug resistance (MDR) of cancer cells. As a result, the development of a drug delivery system (DDS) capable of targeting cancer cells while at the same time delivering two or more chemotherapeutic drugs is believed to be a good solution to this dilemma. Herein, a hyaluronan-coated meta-organic framework nanoparticles (HM) were fabricated as a DDS in our study to deliver cisplatin (PDD) and oleanolic acid (Ola). Positive results were obtained in our study which reveal that the DDS (HM/PDD/Ola) is favorable in colorectal cancer (HCT116) therapy by enhancing targeted apoptosis and reversing MDR. Compared with applying free drugs or mono DDS, the dual loaded HM/PDD/Ola showed synergistic effects and better performance, which might be a future alternative for the chemotherapy of colorectal cancer.

Page 95 of 5306