The interaction between a turbulent flow and a porous boundary is analysed with focus on the sensitivity of the roughness function,
$\Delta U^+$, to the upscaled coefficients characterizing the wall. The study is aimed at (i) demonstrating that imposing effective velocity boundary conditions at a virtual plane boundary, next to the physical one, can efficiently simplify the direct numerical simulations (DNS); and (ii) pursuing correlations to estimate
$\Delta U^+$ a priori, once the upscaled coefficients are calculated. The homogenization approach employed incorporates near-interface advection via an Oseen-like linearization, and the macroscopic coefficients thus depend on both the microstructural details of the wall and a slip-velocity-based Reynolds number,
$Re_{slip}$. A set of homogenization-simplified DNS is run to study the channel flow over transversely isotropic porous beds, testing values of the grains’ pitch within
$0\lt \ell ^+\lt 40$. Reduction of the skin-friction drag is attainable exclusively over streamwise-aligned inclusions for
$\ell ^+$ values up to
$20{-}30$. The drag increase over spanwise-aligned inclusions (or streamwise-aligned ones at large
$\ell ^+$) is accompanied by enhanced turbulence levels, including intensified sweep and ejection events. The root-mean-square of the transpiration velocity fluctuations at the virtual plane,
$\tilde V_{rms}$, is the key control parameter of
$\Delta U^+$; our analysis shows that, provided
$\tilde V_{rms} \lesssim 0.25$, then
$\tilde V_{rms}$ is strongly correlated to a single macroscopic quantity,
$\Psi$, which comprises the Navier-slip and interface/intrinsic permeability coefficients. Fitting relationships for
$\Delta U^+$ are proposed, and their applicability is confirmed against reference results for the turbulent flow over impermeable walls roughened with three-dimensional protrusions or different geometries of riblets.