The presence of parkinsonism is required for the diagnosis of certain clinical syndromes and, together with demographic, clinical, and genetic features, can be highly predictive of underlying pathology, usually α-synuclein or tau aggregation. Nevertheless, parkinsonian features may be present in clinical syndromes not typically associated with parkinsonism and, therefore, complicate differential diagnosis. On the other hand, certain tauopathies have a variable frequency of associated parkinsonian disturbances, further challenging clinical to pathologic diagnostic accuracy. In this chapter, we briefly describe less-common clinical syndromes that may present with, or eventually manifest, extrapyramidal symptoms characteristic of parkinsonism but for which parkinsonism is not typically considered a core clinical feature. Although some of these clinical syndromes are primarily associated with tauopathies (frontotemporal degeneration with parkinsonism linked to chromosome 17, primary progressive apraxia of speech and traumatic encephalopathy syndrome), tauopathy is seldom the underlying pathology in cases of primary progressive aphasia.

Dystonia, defined as a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal, often repetitive, movements, postures, or both, results in patterned, twisted, and sometimes tremulous movements. When dystonia is the sole manifestation, it is known as primary dystonia. Primary dystonia is an uncommon disorder and includes genetic forms of dystonia as well as idiopathic dystonia. Dystonia can involve one body part, when it is called focal; more than one contiguous body part, when it is known as segmental; or involving the trunk and more than two body parts, when it is called generalized. This chapter reviews primary dystonia: the epidemiology, the current theories of pathophysiology, the clinical description, and available treatments of genetic as well as the various forms of focal dystonia, including blepharospasm, oromandibular dystonia, laryngeal dystonia, cervical dystonia, focal hand dystonia and truncal dystonia.

This chapter summarizes current knowledge concerning illicit drugs and specific toxins, such as some street drugs, organic solvents, pesticides and herbal extracts like Cycas circinalis, known to induce signs and symptoms of motor parkinsonism. Special attention is given to differential diagnosis and therapeutical strategies. Marketed drugs such as antipsychotics, anti-emetics, calcium channel blockers, selective serotonin reuptake inhibitors, antiepileptics, antidepressants, antiarrhythmics, immunosuppressants, statins, and trimeazidine, also identified to cause drug-induced parkinsonism, are also dealt with in this chapter.

Petrarch initiated ruin-tourism, and that flowered in the period of the eighteenth-century Grand Tour. Arguably, the ruins of Rome were the first to generate the production of a considerable variety of souvenirs, portable objects manufactured expressly for visitors to take away. Now a souvenir is only desirable if the object it represents is deemed attractive: the ruin-aesthetic was so well established by the time of the Grand Tour that ruins moved from the background of paintings into the foreground; they became the subject. In the engravings of Piranesi the ruins of Rome reached their peak of aesthetic appeal. The aesthetic validation of ruins is to the fore, since the English decorated the interiors of their houses with scenes of ruination. They also brought home architectural models of ruins in cork or marble for display; their porcelain and fans were decorated with ruin motifs.

The clinical and pathologic hallmarks of Parkinson’s disease (PD) are motor parkinsonism due to underlying progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta accompanied by an accumulation of intracytoplasmic protein inclusions known as Lewy bodies and Lewy neurites. The diagnostic criteria/guidelines based on the UK Parkinson’s Disease Society Brain Bank clinical diagnostic criteria have guided clinicians and researchers in the diagnosis of PD for many decades. This chapter discusses whether this description represents our current understanding of PD, and why it is time to integrate new research findings and accommodate our definition and diagnostic criteria of PD, such as Parkinson-associated non-motor symptoms, genetics, biomarkers, imaging findings, or heterogeneity of phenotypes and underlying molecular mechanisms. In 2015, the International Parkinson and Movement Disorder Society published clinical diagnostic criteria for Parkinson’s disease, which were designed specifically for use in research but also as a general guide to clinical diagnosis of PD. These criteria and some of their limitations are also discussed.

This chapter shows that the pointed free construction from Chapter 4 is a nonsymmetric multifunctor. Furthermore, it provides equivalences of homotopy theories between categories of nonsymmetric algebras in pointed multicategories and permutative categories. This is the basis for applications to enriched diagrams in Chapter 12.

Chapter 6 turns to the attack on the Whig view of the state, and especially to the rejection of the Whig contention that no arbitrary or despotic power is any longer being exercised. The chapter focuses on two major challenges to this complacency. One line of criticism pointed out that, with the creation and rapid growth of the national debt, enormous sums were now being paid directly to the crown, thereby bringing an obvious danger of despotism. The second and epoch- making challenge came from the American colonies. When the British government resolved in 1764 to tax them directly, the colonists denounced this innovation as an obvious act of despotism. They argued that, because they had no representation in the British Parliament, they had no means of expressing or withholding their consent. They were thus being subjected to a wholly arbitrary form of power, and were consequently being treated as slaves. The chapter traces the development of this patriot case in the writings of Otis, Hopkins, Dulany, Dickinson, Jefferson and other colonists, and concludes with the defence of the patriot cause by Price and Paine and the publication of the Declaration of Independence.

While the traditional vertical understanding of rights remains rooted in an older liberalism, the horizontal model possesses affinities with republican thought. This chapter makes these connections between constitutional practice and some of the core texts in the history of political thought. In addition to different understandings of the relationship between spheres, or the individual and community, liberal and republican thought generally conceive of liberty differently, a distinction that also maps onto the vertical and horizontal models in important ways. Rights in a horizontal understanding take on a new significance as more than mere rights, but ends as well, that potentially implicate the polity as a whole. Thus, horizontal application gives rise to new calls for parity between public and private spaces, which, in turn, amounts to a new source for understanding the duties of private actors. Such concepts as the common good and duty, integral to republican thought, come to the fore and offer a baseline for conceptualizing the parity and duties to which horizontal application gives rise. The chapter illustrates how these republican concepts occur in the context of actual cases and larger constitutional discourses, drawing examples from Germany, India, and South Africa.