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Children with CHDs are exposed to ionising radiation during diagnostic and interventional cardiac catheterisation procedures. Data regarding radiation doses a child is exposed to during these procedures are scarce. We aimed to investigate the radiation dose and other related parameters for paediatric cardiac catheterisation and propose these as local reference levels.
Methods and Materials:
We collected radiation exposure data for all diagnostic and interventional cardiac catheterisation cases (excluding electrophysiology procedures) utilising fluoroscopy at “Anonymized for review” between January 1, 2021 and November 30, 2021. Direct measures of radiation usage, i.e. fluoroscopy time, dose-area product value, and air kerma, were reported for each case by the INNOVA 2100 manufactured by Wipro GE Healthcare. The absorbed radiation dose was measured using a Bhabha Atomic Research Centre dosimeter, which was placed directly on the patients’ chests. Differences in measures of radiation exposure across procedural and interventional types were tested using the normality of continuous data by Kolmogorov–Smirnov test. Spearman’s correlation coefficient was calculated when the data violated normality.
Results:
The overall median dose-area product, fluoroscopy time, air kerma, and absorbed dose measured using a Bhabha Atomic Research Centre dosimeter were 300 mg.m2, 10.5 mins, 37 mGy, and 2.4 mSv, respectively. We have further categorised the median exposure parameters into 5 age groups and propose them as local dose reference levels. There was a strong correlation between fluoroscopy time with the absorbed radiation dose (Rho = 0.942). Fluoroscopy time showed fair correlation with air kerma (Rho = 0.65) and dose-area product (Rho = 0.59). Absorbed radiation dose showed fair correlation with dose-area product ( Rho = 0.56).
Conclusion:
Fluoroscopy time alone is not a sufficient metric to monitor radiation exposure. Even when fluoroscopy times were comparable, air kerma and dose-area product levels were quite different. Therefore, the local dose reference levels proposed can be used as a benchmark for future studies aimed at process optimisation and further reducing the radiation exposure in paediatric patients.
This study aimed to compare long-term audiological outcomes of diode laser stapedotomy, microdrill stapedotomy and combined potassium titanyl phosphate laser–microdrill stapedotomy, and to identify predictors of surgical success.
Methods
Surgical, audiological and complications data were collected. Surgical success was analysed via the measurement of post-operative air–bone gap, air conduction gain.
Results
A total of 615 patients were included; median follow-up was 16 months (range 1–1319). Overall, the 94.3 per cent achieved surgical success (air–bone gap < 15 dB). Median air–bone gap closure was 5 dB (interquartile range: 2.50–8.12), and median air conduction gain was 27.5dB (interquartile range: 19.37–36.25).
Compared across techniques, success rates were similar; however, post-operative air–bone gap was significantly better with laser techniques than with microdrill alone (p = 0.016). Longer prostheses were associated with improved outcomes.
Conclusion
All the examined techniques showed excellent audiological results. Laser use was associated with better post-operative air–bone gap than stapedotomy with microdrill only.
Early placement of a ventricular access device (VAD) in premature post-hemorrhagic ventricular dilatation based on ventricular size criteria, coupled with an aggressive tapping regimen to control ventricular size, may improve developmental outcomes. As this treatment paradigm represents a significant departure from traditional care, we present results of an institutional quality improvement protocol implementation study focusing on safety and resource use for those seeking to implement a similar care pathway.
Methods:
Infants treated under the new ventricular size-driven protocol were retrospectively compared to a historical cohort managed according to clinical symptomatology. Process and compliance measures related to protocol implementation were tracked, as were complications and measures of resource use.
Results:
Ventricular access device (VAD) placement occurred earlier and at a smaller ventricle size, but beyond the protocol-mandated timeframe. Although more resource-intensive than customary care, compliance with protocol-directed screening ultrasounds and VAD aspirations by trained clinicians was high. Intensive ultrasound surveillance altered the management of only one infant during their treatment course. An increased rate of complications related to earlier and more aggressive treatment in these fragile infants was not observed.
Conclusions:
Protocol compliance was satisfactory and no safety issues were noted. Although VAD placement occurred sooner, a majority of infants received intervention outside of the mandated timeframe and at a ventricular size above the desired intervention threshold. Minimizing transfer delays from peripheral neonatal intensive care units and improving access to the operating room were identified as areas for improvement. It appears possible to decrease the frequency of ultrasound surveillance without compromising safety.
The homology of the free and the based loop space of a compact globally symmetric space can be studied through explicit cycles. We use cycles constructed by Bott and Samelson and by Ziller to study the string topology coproduct and the Chas-Sullivan product on compact symmetric spaces. We show that the Chas-Sullivan product for compact symmetric spaces is highly non-trivial for any rank and we prove that there are many non-nilpotent classes whose powers correspond to the iteration of closed geodesics. Moreover, we show that the based string topology coproduct is trivial for compact symmetric spaces of higher rank and we study the implications of this result for the string topology coproduct on the free loop space.
The idea of decentering the human from our understanding of the world is under discussion across the globe. Behind this lies the question of anthropocentrism and the social sciences formed around it. In what follows, I outline what is involved in decentering humans and how this process is linked to materiality. This is not a new issue: an extensive tradition of materialist critiques of anthropocentrism stretches from eleventh-century Iran to sixteenth-century Rome, post-war Germany, and Indigenous knowledges passed down across generations. We need to access these histories and understand how they have interacted with, pushed back against, and been reconfigured by colonialism and empire. Dealing with such matters raises conceptual problems about power and agency, structure and change, and nature and the social. But this work also leads to questions about global knowledge production, including who gets to theorize, who is theorized, and how different regions—such as Iran—are rendered intelligible. While there is no single blueprint for change, there is scope for invention and experiment. In this article, I contribute to the nexus of new materialism, postcolonialism, and Iranian studies by exploring these questions and providing an overview of the special issue: “Materiality in Iran.”
Thomas Schelling’s 1966 classic, Arms and Influence, became one of the major strategic works of the Cold War, and it remains the clearest argument for the implicit logic of American and Russian coercive forms of diplomacy. Schelling is incisive about the credibility of deterrence, but the credibility of leadership is reduced to the Cold War assumption that power is decisive. While the rise of China and Putin’s invasion of Ukraine have rekindled interest in Schelling’s approach, the diffusion of agency and the interrelationship of issues in the current multinodal era have undermined the efficacy of hegemonic coercion. Rather than restoring Cold War bipolarity, the rise of China has created an asymmetric parity with the United States in which overlapping interdependencies inhibit the formation of camps. In the new era, the pursuit of strategic advantage by any state, large or small, must aim at securing its multidimensional welfare in a complex and unpredictable environment. The global powers are not hegemonic contenders, but rather the largest powers in a multinodal matrix of autonomous states in which each confronts uncertainty. A strategy based on coercion is likely to be less effective against its targets and more costly in its collateral effects. In a post-hegemonic era, Schelling’s premise that arms are the primary path to influence must be reexamined.
This paper develops a parallel between prudence and population ethics. I argue that developing a standard guiding the evaluation of the comparative prudential value of different lives is challenging because it shares a similarity with population ethics: In both contexts, we assess the comparative value of populations of person-stages/people, which may vary in number and level of well-being. Based on this analogy, I show that Arrhenius’ fifth impossibility theorem can be applied to prudence. I develop and compare five possible escape routes: Critical-Level Views, Totalism, Limited Aggregation, Nebel’s Lexical Threshold View and what I call the Negative Lexicality View.
Lawyers play a central role in every political system in the United States. However, although lawyers are overrepresented in political office, women lawyers are underrepresented. We argue that, for men, attending law school and seeking political office aligns with broader career goals and gendered socialization patterns. We use an original survey of undergraduate social science majors to show that agentic career goals, or interest in influence, prestige, and wealth, are associated with attending law school. Data from a panel study of lawyers demonstrates that agentic goals predict political ambition. Women lawyers are less politically ambitious; agentic goals mediate this relationship.
Community crime against older people is of increasing concern but the relationship between safety-seeking behaviours and continued psychological distress has not been examined. As existing assessment tools have limited validity, we aimed to investigate this by designing a novel person-reported safety-seeking behaviour measure (PRSBM) and conducting preliminary evaluation of its wider applicability.
Method:
We collected mixed-methods data from n=100 initially distressed older victims at 3 months post-crime, using the PRSBM. This asked older victims how often they engaged in six behaviours (checking, reassurance-seeking, rumination, avoidance, rituals, hypervigilance), what these were, how often, and how much they had changed since the crime. We measured continued distress using the two-item General Anxiety Disorder and Patient Health Questionnaires. We analysed qualitative behaviour data using codebook thematic analysis, quantitative data on behaviour frequency and change using logistic regression adjusted for gender, age and crime type, and explored the PRSBM psychometric structure using unique variable analysis.
Results:
Older victims reported a wide range of safety-seeking behaviours conceptually consistent with their experiences. Some were highly restrictive; others may help maintain independence. The frequency of checking, avoidance, and hypervigilance, and a change in avoidance, were most strongly associated with continued distress. The PRSBM was acceptable, comprehensive, and captured differences and commonalities in safety-seeking.
Conclusions:
As older victims identified as avoidant appear at risk of losing their independence, referral for treatment is recommended. The PRSBM appears promising as a research and clinical tool in a range of settings, suggesting further testing in different populations would be worthwhile.
Major shifts underway in US vaccine policies reflect widespread misinformation, notably including unproven claims of harms from vaccines. Vaccination misconceptions also include an array of falsities about the scope and extent of governmental powers and protections. Exposing these “legal myths” clarifies existing foundations of vaccine laws and policies, providing guidance on appropriate responses to quell vaccine hesitancy.
Due to frailty, chronic health issues, limited mobility, dependence on assistive devices, and polypharmacy, the geriatric population is more susceptible to the adverse effects of earthquakes. The aim of this study was to determine the factors affecting the quality of life of older adults who experienced the Kahramanmaraş-centered earthquakes in Türkiye on February 6, 2023.
Methods
This cross-sectional interview-based study was conducted with 340 older adults who experienced the earthquakes on February 6, 2023, and visited outpatient departments in Gaziantep. Data were gathered using a demographic form, Modified Fried Frailty Index, and WHO Quality of Life Instrument for Older Adults.
Results
Participants’ average age was 71.37 ± 6.56 years, and 56.6% were women. Among them, 20.9% lost a first-degree relative, 15.3% were injured, and 45.3% were displaced. WHOQOL-OLD scores differed significantly by age, marital status, education, chronic illness, polypharmacy, living arrangements, and frailty.
Conclusions
This study highlights the factors influencing the quality of life of older adults in Türkiye after an earthquake. Living with a spouse and having primary or secondary education improved quality of life, while chronic illnesses and displacement had negative impacts. These findings emphasize the importance of considering the specific needs of older adults in disaster preparedness and response.