To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Based on the generalised Saint-Venant equations for granular flow on an inclined chute, we show how to generate solitary waves from localised perturbations at the inlet. Such perturbations usually give rise to a group of roll waves, but by choosing the system parameters appropriately, the formation of all but the first wave can be suppressed, thus turning this first one into a solitary wave. This calls for a highly diffusive flow, which is realised for inclination angles close to the minimal angle required to keep the granular material flowing.
Different types of biocompatibility testing such as cytotoxicity; sensitization; irritation acute, subacute, subchronic, and chronic systemic toxicity; pyrogenicity; genotoxicity; implantation; hemocompatibility; carcinogenicity; reproductive and developmental toxicity are discussed in this chapter.
This introductory chapter provides a brief history of biomaterials, and the emphasis over the years on ensuring the viability of implants for the desired time and their interaction with the biology of the body. It discusses the importance of first understanding the type of chemical bonds that hold atoms together and how these bonds impart physical, chemical, and mechanical properties to the materials. These properties render biomaterials more or less appropriate for different medical applications as well as determine the body’s response to them.
Different surface modification techniques to modify surfaces of medical devices including principles underlying these surface modification techniques and advantages and limitations of each technique are discussed in this chapter.
The bipolar junction transistor is introduced and its operation is explained. DC and switching applications are given. The need for DC biasing for AC amplification is illustrated and then satisfied by the Universal DC bias circuit. The thermal stability of this circuit is discussed and resulting constraints on resistor selection are developed. Amplifier gain, input impedance, and output impedance are defined and their usefulness is explained. The AC equivalents for the bipolar transistor are developed and then used to derive the properties of the common-emitter, common-collector, and common-base amplifiers. The concepts of distortion and feedback are introduced.
In the previous chapters, and in Chapters 4 and 6 in particular, we already encountered methods for testing hypotheses. We used these statistical tests to determine if a given empirical correlation corresponds to the real key, or to an incorrect key. This chapter takes a more systematic look at statistical testing and derives methods that are—in some particular sense—best possible.
The recirculating flow at the rear of a flat-base three-dimensional body with ground proximity is investigated for different body attitudes defined by the pitch angle varying in the range $-1.5^\circ \lt \alpha \lt +2.6^\circ$ and the yaw angle in the range $0^\circ \lt \beta \lt +12^\circ$. Experiments measuring the three components of the mean velocity field in two perpendicular planes intersecting the recirculation area as well as the base pressure distribution are conducted for 50 different attitudes. They provide a clear correlation between the orientation of the spatially averaged reversed flow and the gradient at the centre of the base pressure distribution. Both vectors are found to be in the same so-called w-plane, that is perpendicular to the base of which the azimuthal position changes with the body attitude due to either the flow orientation at the base separation or sometimes to a ground separation for large nose-up pitch. Numerical simulations of the same geometry realised for 10 attitudes show satisfactory agreement with the force coefficients measured in the experiment. Base flow variations induced by attitude changes are also well captured, particularly that of the w-plane. The full three-dimensional simulation data are used to show that the inner structure of the separation bubble is always a tilted recirculation torus, where the tilt orientation is given by the base pressure gradient. At the bubble closure, a pair of longitudinal vortices symmetrically located on both sides of the w-plane are permanently observed with circulations consistent with the circulation of the dividing streamline separation in the w-plane.
Key components of the extracellular space together with the principal proteins and pathways that cells utilize to interact, different adhesion mechanisms, and the role of cell material environment are discussed in this chapter.
This chapter presents the cellular environment and encompasses a diverse population of control systems that range from biomolecular phenomena to a remarkably complex coordination of signaling pathways. Discussions include the principal functions of the plasma membrane, major classes and operation of cell junctions, cell signaling pathways, and secondary messengers. In addition, common biological testing techniques in biology–biomaterial interactions are also discussed.
The success of cooperative unmanned aerial vehicle (UAV) missions relies on effective multi-UAV path planning. To address the issues of limited individual diversity and susceptibility to local optima during the population initialisation phase of the traditional grey wolf optimiser (GWO), this paper proposes an improved chaotic grey wolf optimiser (CGWO). The algorithm enhances population diversity by introducing chaotic initialisation to generate more uniformly distributed initial solutions. Combined with a chaotic local search strategy, it employs a dynamic balancing mechanism that allows individuals in the population to strike a balance between global exploration and local refinement, thereby breaking free from local optima constraints and accelerating optimal solution convergence. The algorithm was validated by using the CEC2017 benchmark functions and simulations of multi-UAV mission scenarios. The results clearly demonstrate that the improved algorithm significantly outperforms the original GWO and other common optimisation algorithms in terms of convergence accuracy and speed during benchmark testing. In multi-UAV mission scenarios, the enhanced algorithm excels in trajectory planning, flexibly avoiding obstacles while maintaining smooth flight paths for UAVs. Overall, this research provides a practical solution for coordinated multi-UAV operational path planning.
The operational amplifier is introduced and the basic rules for its operation are given. Nonlinear operation is explained and the golden rules for linear operation are derived. Several examples of linear operation are given, including amplifiers, buffer, adder, differential amplifier, integrator, and differentiator. Practical considerations for using op-amps are discussed, including bias currents, offset voltages, slew rate limits, and frequency response. As a final non-linear example, an oscillator circuit, the astable multivibrator, is presented and analyzed.
Ice shelves that spread into the ocean can develop rifts that can trigger iceberg calving and enhance ocean-induced melting. Fluid mechanically, this system is analogous to an extensionally dominated radial spreading of a non-Newtonian fluid into a relatively inviscid and denser ambient fluid. Laboratory experiments have shown that rift patterns can emerge when the spreading fluid is shear thinning. Linear stability analysis supports these findings, predicting that while the instability mechanism is active in Newtonian fluids, it is suppressed by stabilising secondary-flow cellular vortices. Here, we explore the fully nonlinear evolution of a radially spreading Newtonian fluid, assessing whether large-amplitude perturbations could drive an instability. We use a quasi-three-dimensional numerical simulation that solves the full nonlinear shallow-shelf approximation, tracing the evolving fluid front, and validate it with known axisymmetric solutions and predictions from linear-stability theory. We find that large-amplitude perturbations induce nonlinear effects that give rise to non-axisymmetric patterns, including cusp-like patterns along the fluid front and complex secondary-flow eddies, which have neither been predicted theoretically nor observed experimentally. However, despite these nonlinear effects, large-amplitude perturbations alone are insufficient to induce rift-like patterns in Newtonian fluids. Strain-rate peaks at the troughs of the fluid front suggest that shear-thinning fluids may become more mobile in these regions, potentially leading to rift formation. This coincides with the likely weakening of stabilising forces as the fluid becomes more shear-thinning. These findings elucidate the critical role of nonlinear viscosity on the formation of rift-like patterns, which is the focus of Part 2 of this study.
In this chapter, thrombus formation on biomaterial surfaces and other biological responses are presented. Information discussed includes details on platelets structure and function, platelet–material interactions, contact activation, and pathways of blood coagulation. In addition, the complement system and its activation through different pathways, including activation in the presence of biomaterials, are discussed. The occurrence of acute and chronic inflammation, the role of biomaterials in causing inflammation as well as foreign body reactions, and the formation of fibrous encapsulation around a biomaterial are also covered in this chapter.