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Services related to paid domestic work in private households are an important global labor market for migrant women. The Philippines is one of the largest exporters of work-force for the international domestic work sector. In this context, the linguistic legacy of American colonization becomes a key factor: English is an official language of the Philippines alongside Filipino. In addition, several varieties of Philippine English are widespread. Against this backdrop, Filipino and Filipina workers are positioned as competent, Anglophone workers in low-wage sectors such as the global domestic work market. Based on these attributions, they are also commodified as workers who can easily learn other languages and who are versatile and compatible with all linguistic and cultural spaces – worldwide. This paper sheds light on the multilingual repertoires of Filipina domestic workers in the Spanish capital, Madrid. The study is grounded in the paradigms of critical ethnographic sociolinguistics, migration linguistics and multilingualism research. The underlying data are based on narratives of Filipinas who migrated to Spain between 1971 and 2017. The findings reveal complex tensions around English. On the one hand, English is often perceived as prestigious and therefore valuable linguistic capital that can lead to social mobility. On the other hand, English is not seen as a panacea for securing employment beyond domestic work. Extrapolating from these findings, the overall picture that emerges is that English is deeply embedded in structurally determined social inequalities, which can be observed both in the country of origin and in the destination society.
Schizophrenia is a severe psychiatric disorder characterised by positive symptoms, such as hallucinations and delusions, which are linked to dysregulated striatal connectivity. Although traditional models highlight the limbic striatum’s role in salience processing, emerging evidence suggests that the associative striatum, critical for cognitive control and habit formation, also plays a significant role. However, the structural connectivity underlying striatal subregions and its relationship to symptom severity and treatment response remains poorly understood.
Aims
This study aimed to investigate the structural connectivity of striatal subregions in first-episode schizophrenia (FE-SCZ) patients and to evaluate its association with positive symptoms and changes following antipsychotic treatment.
Method
We recruited 80 FE-SCZ patients and 80 healthy controls who underwent diffusion tensor imaging probabilistic tractography to assess white matter tract strength between the striatum and ten cortical targets. Longitudinal analysis was conducted in patients at baseline (within 2 weeks of initial antipsychotic exposure) and after ongoing treatment to evaluate changes in connectivity and their relationship to symptom improvement.
Results
FE-SCZ patients exhibited reduced connectivity between the dorsolateral prefrontal cortex (dlPFC) and associative striatum and increased connectivity between the anterior cingulate cortex (ACC) and associative striatum compared to controls. Longitudinal analysis revealed that antipsychotic treatment increased dlPFC–associative striatum connectivity and decreased ACC–associative striatum connectivity, which correlated with reductions in positive symptom severity.
Conclusions
These findings highlight the critical role of striatal subregions in the pathophysiology of schizophrenia, emphasising the associative striatum’s involvement in cognitive control and salience attribution. Changes in striatal connectivity after continued antipsychotic therapy may serve as a biomarker for symptom improvement, advancing our understanding of schizophrenia and guiding future therapeutic strategies.
Early deprivation holds far-reaching implications for academic performance in adolescence. Yet, the implicated cascading mechanisms remain under-delineated, and little is known about why children may display diverse patterns of cognitive development. To address such gaps, we leveraged long-term longitudinal data derived from the Future of Families and Child Wellbeing Study (n = 2,085). Results indicated that early deprivation (age 3, caregivers’ reports and observers’ ratings; controlling for early threat and unpredictability) was negatively associated with adolescent academic performance (age 15, adolescents’ reports) indirectly through a negative association with cognitive ability in middle childhood (age 9, standardized tests). Furthermore, such an indirect effect was less pronounced among children with higher (versus lower) negative emotionality (age 1, mothers’ ratings), given that the negative link between early deprivation and subsequent cognitive ability was weaker among children with higher (versus lower) negative emotionality. Breaking down cognitive ability into sub-components (i.e., working memory, language ability, reading comprehension, and problem-solving), both language ability and applied problem-solving were involved in the deprivation-emotionality interaction. These findings highlight the critical role of cognitive ability in accounting for the long-term academic consequences of early deprivation and the key role of negative emotionality in shaping heterogeneity in such pathways.
Inappropriate urine cultures (UCs) are common and lead to inappropriate antimicrobial use. Urinalyses (UAs) have been increasingly incorporated into diagnostic stewardship interventions, but the impact of these interventions nationally has not been assessed. We describe UA and UC utilization practices using a nationwide dataset of patients admitted to acute care hospitals.
Methods:
Design, Setting and Participants: We performed a retrospective cohort study of index UCs and their associated UAs performed for adult patients (age ≥ 18 years) admitted in U.S. acute care hospitals, participating in the PINC AI™ Healthcare Database (PHD) from January 1, 2017, through December 31, 2020. A positive UA was defined as >10 leukocytes per high power field, positive leukocyte esterase, or positive nitrite.
Results:
The overall rate of UCs in this study was 124.7 per 1000 discharges and annual UC rates decreased from 2017 (129.2) to 2020 (120.0). The proportion of UCs that had a positive UA increased from 60.5% in 2017 to 68.1% in 2020; UCs without a UA decreased from 19.3% to 10.5%, and UCs with a negative UA did not significantly change (20.2% to 21.5%). A multivariate multinomial logistic regression model identified male sex, age <65, and a diagnosis of cancer to be predictors of having a UC with a negative UA or no UA.
Conclusions:
UC utilization decreased over the study period. The proportion of UCs with a positive UA increased. This may suggest a positive impact of diagnostic stewardship practices at the national level although further progress is needed.
This study examines sea loans in the Portuguese Empire (1600–1800). Structured as contingent contracts, this kind of credit served as a risk-sharing agreement for financing transoceanic trade routes. Using notarial protocols and court records, the study examines how maritime regulations, international political relations, and information problems influenced the pricing of loan agreements. The study demonstrates that the introduction of the convoy system, which distinguished Portugal–Brazilian connections, coincided with a downward trend in sea loan rates, which converged with those of safer short-term lending instruments. In contrast, periods of war and free navigation increased uncertainty, making maritime insurance and sea loans complementary instruments for risk management.
The present study aimed to conduct a meta-analysis using the random-effects model to merge published genetic parameter estimates for metabolic disorders [mastitis (MA), metritis (ME), ketosis (KE), milk fever (MF), retained placenta (RP), displaced abomasum (DA), and lameness (LA)] in dairy cows. A total of 239 heritability and 355 genetic correlation estimates were extracted from 61 peer-reviewed articles published between 1991 and 2024. Heritability estimates for metabolic disorders were generally low, ranging from 0.034 for ME to 0.067 for DA and MF. These estimates were associated with small standard errors and narrow 95% confidence intervals, with all estimates being statistically significant (P < 0.05). The estimates for genetic correlations between metabolic disorders were positive, ranging from 0.038 (MA-DA) to 0.522 (KE-DA). Furthermore, only the genetic correlations for DA-LA (0.147), RP-ME (0.472), MA-LA (0.239), MA-MF (0.365), KE-DA (0.522), KE-RP (0.124), and KE-ME (0.157) were significant (P < 0.05). Positive and low genetic correlations were observed between MA-milk yield (MY), MF-MY, and LA-MY (0.291, 0.135, and 0.263, respectively; P < 0.05). Similarly, positive correlations were found between DA-fat yield (FY), MA-FY, MA-protein yield (PY), LA-FY, and LA-PY (0.121, 0.170, 0.303, 0.176, and 0.236, respectively; P < 0.05). The genetic correlations between KE-fat to protein ratio (FPR) and DA-FPR were positive and ranged from low to moderate (0.520 and 0.196, respectively; P < 0.05). Significant genetic correlations were also noted between MA-days open (DO) (0.416), MA-days from calving to first service (DCFS) (0.207), and LA-calving interval (CI) (0.210; P < 0.05). This meta-analysis provides valuable insights into the genetic contribution to metabolic disorders in dairy cows and highlights the generally low heritability and the variable genetic correlations between these disorders and performance traits. These findings may contribute to more effective breeding strategies aimed at reducing the occurrence of metabolic disorders in dairy herds.
Studies investigating motivations for political participation in receiving-state politics among immigrant groups typically follow a traditional approach to understanding the process behind political engagement. In this work, the authors argue that this approach is insufficient if we want to understand the motivations of diasporic groups, notably in cases in which they are geographically close to home and influenced by both origin and receiving-state politics. This study examines the motivations for political party engagement among members of Bosnian diaspora in Austria and elucidates the links between political party membership and receiving-country political opportunity structures which formally result in political detachment from homeland politics. It does so through twenty-five interviews with Bosnian members of Austrian political parties conducted in fourteen cities in Austria. The article focuses on motivations for engagement in political parties which result in detachment from homeland politics and an identification with receiving-state politics. The findings reveal that pre-migratory experiences of war and membership in diasporic associations do not drive the motivations for engagement. Instead, their participation evolves from motives that are embedded in local experiences, while motives related to origin-state opportunity structures are negative or feebly present.
This article surveys the life and work of Benjamin Clough (1791–1853), Wesleyan Methodist missionary to Ceylon, focusing on his contributions to the study of Pali and Buddhism. It attempts to show that he inaugurated the Western study of Pali and that he should be recognised as one of the most important early scholars of Buddhism.