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The breakup and coalescence of particle aggregates confined at the interface of turbulent liquid layers are investigated experimentally and theoretically. In particular, we consider conductive fluid layers driven by Lorentz forces and laden with millimetre-scale floating particles. These form aggregates held together by capillary attraction and disrupted by the turbulent motion. The process is fully characterised by imaging at high spatio-temporal resolution. The breakup frequency $\varOmega$ is proportional to the mean strain rate and follows a power-law scaling $\varOmega \sim D^{3\text{/}2}$, where $D$ is the size of the aggregate, attributed to the juxtaposition of particle-scale strain cells. The daughter aggregate size distribution exhibits a robust U-shape, which implies erosion of small fragments as opposed to even splitting. The coalescence kernel $\varGamma$ between pairs of aggregates of size $D_{1}$ and $D_{2}$ scales as $\varGamma \sim ( D_{1} + D_{2} )^{2}$, which is consistent with gas-kinetic dynamics. These relations, which apply to regimes dominated both by capillary-driven aggregation and by drag-driven breakup, are implemented into the population balance equation for the evolution of the aggregate number density. Comparison with the experiments shows that the framework captures the observed distribution for aggregates smaller than the forcing length scale.
Synbiotic beverages have become a boon for health-conscious people as these beverages can offer a variety of health benefits. The present study aimed to produce a novel synbiotic beverage from browntop millet (Urochloa ramosa, previously Brachiaria ramosa). Lacticaseibacillus rhamnosus was used for the fermentation of the browntop millet. Multi-response methodology optimization was performed, and maximum ferric-reducing antioxidant power (FRAP) concentration, reducing sugar and protein concentration was observed at 757.42 µ mol Fe (II)/ml, 90.38 mg/ml, and 1.31 mg/ml, respectively. The study also observed an excellent cell hydrophobicity (85.7%) of the probiotic strain. Thus, the final product obtained had a DPPH value of 54.89 ± 2.2 %.
This study aimed to develop a predictive model to investigate the effect of temperature, pH, NaCl concentration, initial inoculum concentration and time on enterotoxin A (SEA) production by Staphylococcus aureus. Combinations of three levels of temperature (10, 15 and 25°C ), five levels of pH (5.3, 5.5, 6.0, 6.5 and 6.7), five levels of NaCl (0.8, 1.0, 1.5, 2.0 and 2.2%), three levels of inoculum concentration (0, 3 and 5 log CFU/mL) in brain heart infusion (BHI) broth were studied. Colonies were counted and SEA production was assessed at 24 h intervals for up to 240 h. A probabilistic logistic regression model was used to describe the production of SEA by Staphylococcus aureus. SEA production was influenced by all factors, except NaCl concentration. S. aureus produced SEA in all samples at 25°C, while the temperature of 10°C delayed the growth and SEA production of S. aureus at initial contamination levels of 3 log CFU/mL and 5 log CFU/mL and prevented it at 0 log CFU/mL. The model was statistically and experimentally validated, demonstrating a good fit, with a high percentage agreement, Nagelkerke's R2 and the Hosmer and Lemeshow test for the SEA production model. The experimental validation confirmed the effectiveness of the models for predicting the probability of SEA production by S. aureus in Minas Frescal cheese.
Coarctation of the aorta accounts for approximately 6–8% of CHDs, typically manifesting as narrowing of the proximal thoracic aorta. Clinical and haemodynamic effects vary depending on the severity and associated anomalies. We aimed to compare the outcomes of surgical versus percutaneous interventions in patients with coarctation of the aorta and to identify factors influencing the choice of treatment strategy.
Methods:
We retrospectively analysed the medical records of 120 patients diagnosed and treated for coarctation of the aorta at Ankara University Faculty of Medicine, Department of Pediatric Cardiology over a 12-year period. Patients were grouped by age (0–4 months and >4 months). Clinical and echocardiographic data were reviewed. Treatment selection was based on American Heart Association 2011 guidelines, considering age, weight, and anatomy. Surgical repair was preferred in infants <4 months; balloon angioplasty or stent implantation was used in older patients. Procedural success and complications were assessed.
Results:
A total of 62% were male, the median age at diagnosis was 1.1 months, and 67% were diagnosed before 4 months of age. The most common symptom was a cardiac murmur (62.5%). Initially, balloon angioplasty was performed in 50%, surgical repair in 45%, and stent implantation in 5%. The acute success rate was 98.3%. Complications occurred in 13.3%, including thrombosis (7.5%) and aneurysm (2.5%). Recoarctation developed in 43% and was significantly higher after balloon angioplasty compared to surgery (55% vs. 29.6%, p = 0.004), and in patients <4 months (52.2% vs. 25.5%, p = 0.014). Management strategies typically included surgical repair in infants <4 months, balloon angioplasty in older children, and stenting in those ≥25 kg, while treatment was ultimately individualised.
Conclusion:
Recoarctation was the most frequent complication, especially among infants under four months and after balloon angioplasty. Surgical repair was associated with a lower risk of recoarctation in early infancy. Percutaneous stent implantation for coarctation is an effective and safe procedure, but it is limited by the patient’s weight. Individualised treatment based on age, anatomy, and clinical status is essential to optimise outcomes.
This study examines foraminifers from limestone horizons of the mainly Brigantian Lower Limestone Formation across the Midland Valley of Scotland (MVS), to determine more precisely the correlation of the limestone beds throughout the region and with the marine bands. Three quantitative biostratigraphical methods were applied to the foraminiferal dataset. The Ranking and Scaling method produced unusual mixed associations and a ranked optimum sequence, making it the least reliable. In contrast, the Unitary Associations (UA) and Constrained Optimization (CONOP) methods yielded more consistent sequences and correlations, especially the latter. The main conclusions drawn were: (i) The West Kirkton, First Abden and St Monans Brecciated limestones of the eastern MVS are considered the base of the Lower Limestone Formation; (ii) The Petershill Limestone is considered as the likely lateral equivalent of the Blackhall Limestone; (iii) the Seafield Tower, Charlestown Main and Middle Skateraw limestones can be correlated in the eastern MVS; (iv) the Abden Fauna (marine band) in central Fife, is confirmed just below the base of the Lower Limestone Formation in most sections; and (v) correlation of limestones below the Neilson Shell Band (marine band) in the eastern region is confirmed with the CONOP method, and in the western region with the Unitary Associations.
This systematic review and meta-analysis aimed to review existing measures of subjective cognition during menopause and to estimate the correlation between subjective and objective cognition in perimenopausal and postmenopausal women.
Method:
Eligible studies reported scores for at least one subjective and objective measure of cognition for perimenopausal or postmenopausal women. EMBASE, Medline, and PsycINFO were searched for eligible studies on November 22nd 2024. The risk of bias in individual studies was evaluated using a modified QUADAS-2 form. The results of the review were summarized in narrative form. Studies that reported correlations between subjective and objective cognition were synthesized using a multilevel meta-analysis.
Results:
The sample included 5629 participants over 24 studies, including 295 perimenopausal women, 5086 postmenopausal women, and 248 women across mixed peri- and post-menopausal samples. Twelve measures of subjective cognition were used across studies. Six studies were included in the meta-analysis. A small significant correlation was observed between subjective cognition and objective measures of learning efficiency (r = .12; CI = .02 to .23). Correlations across other cognitive domains were non-significant.
Conclusions:
Our findings suggest subjective cognition may be associated with performance on measures of learning efficiency, offering a starting point for further research on menopausal brain fog. The present findings highlight the need for a reliable measure of subjective cognitive symptoms associated with menopause. Additionally, a better characterization of the neuropsychological profile of menopausal brain fog is needed to progress research in this field and ultimately improve clinical support for women experiencing these symptoms.
To improve the compactness, broadband, high gain and wide coverage performance of the shortwave antenna (array), this paper introduces the array technology from the LPDA unit antenna, establishes the compact optimization model of the 2×3 elements LPDA fan-shaped array, and proposes an optimization method applied to the broadband decoupling and grating lobe suppression for LPDA fan-shaped phased array, taking the broadband low coupling and non-grating lobe as constraints; By using phased array technology, the wide scanning characteristics of LPDA fan-shaped array are analysed, and the influence of antenna parameters on the mutual coupling is studied when LPDA phased array widely scan. Finally, the feasibility of the truss based 2×3 elements LPDA fan-shaped phased array with a scale of 1:60 is verified through tests. The fan-shaped phased array has a frequency coverage of 13~28 MHz, an average gain of 17.5 dBi in the band, an average beam width of ≥ 30 °, and a scanning range of ≥ 90 °. The proposed array has the characteristics of broadband, low coupling, high gain, wide scanning and compactness. The proposed joint optimization method provides a very promising technical means for the optimization design of complex multi-dimensional phased arrays.
Pediatric cancer survivors are at increased risk for neurocognitive challenges that can impact academic achievement and attainment. Educational supports via accommodations or special education can promote better outcomes for these youth; however, barriers often stand in the way of appropriate supports being implemented. Neuropsychological evaluation reports highlight a child’s neurocognitive strengths and needs, but an additional tool to assist parents and educators in understanding the extent to which a child’s neurocognitive needs are addressed by their educational supports may help ensure appropriate supports.
Method:
The present study piloted a novel neurocognitive needs-to-educational supports alignment rubric in a referred sample of pediatric survivors of cancer, bone marrow transplant, and cancer predisposition syndromes (i.e., neurofibromatosis).
Results:
Inter-rater reliability across disciplines was satisfactory. Among school-aged patients who were attending public school (n = 90), mean needs-to-supports alignment was 20.3%, indicating that on average, referred patients were receiving minimal classroom supports addressing identified neurocognitive needs. Among the 42.9% with a formal support plan, proportion of needs met by a support rose to only 47%, indicating that in spite of some recognition of patient needs, supports remain inadequate to the breadth of patient needs.
Conclusions:
This alignment tool can assist parents and educators in better tailoring a child’s educational supports to meet their needs, serve as a communication tool between healthcare and education teams, and provide a quantitative metric for evaluating educationally focused interventions (e.g., school liaison programming) in youth with a variety of chronic health conditions and developmental disabilities.
Mass street protests and other highly contentious actions often capture headlines and public attention, but what remains after the news cycle moves on? Many times, grassroots initiatives crystallise during or after these intense moments of participation, leaving in their wake effective organisations that continue to make daily life more liveable in contexts of extreme vulnerability. Despite the persistence and impact of these ‘things that work’ – as we call them – they are often less visible and understudied. How do these initiatives emerge and sustain themselves in the communities in which they work? Using ethnographic methods, we investigate the case of a community centre formed in the wake of a land occupation in the urban periphery of Buenos Aires to answer these questions. We argue that grassroots initiatives build local power through everyday care-work: forming relationships, changing identities and providing valuable services and information.
This study investigates the stability characteristics of rotating-disk boundary layers in rotor–stator cavities under the frameworks of local linear, global linear and global nonlinear analyses. The local linear stability analysis uses the Chebyshev polynomial method, the global linear stability analysis relies on the linearised incompressible Navier–Stokes (N–S) equations and the global nonlinear analysis involves directly solving the complete incompressible N–S equations. In the local linear framework, the velocity profile derived from the laminar self-similar solution on the rotating-disk side of an infinite rotor–stator cavity is mapped to the Bödewadt–Ekman–von Kármán theoretical model to establish a unified analytical framework. For the global stability study, we extend the methodological framework proposed by Appelquist et al. (J. Fluid Mech.,vol 765, 2015, pp. 612–631) for the von Kármán boundary layer, implementing pulsed disturbances and constructing a radial sponge layer to effectively capture the spatiotemporal evolution of perturbation dynamics while mitigating boundary reflection effects. The analysis reveals that the rotating-disk boundary layer exhibits two distinct instability regimes: convective instability emerges at ${\textit{Re}}=r^*/\sqrt {\nu ^*/\varOmega ^*}=204$ (where $r^*$ is the radius, $\nu ^*$ is the kinematic viscosity and $\varOmega ^*$ is the rotation rate of the system) with azimuthal wavenumber $\beta =27$, while absolute instability emerges at ${\textit{Re}}=409.6$ with azimuthal wavenumber $\beta =85$. Under pulsed disturbance excitation, an initial convective instability behaviour dominates in regions exceeding the absolute instability threshold. As perturbations propagate into the sponge layer’s influence domain, upstream mode excitation triggers the emergence of a global unstable mode, characterised by a minimum critical Reynolds number ${\textit{Re}}_{\textit{end}}=484.4$. Further analysis confirms that this global mode is an inherent property of the rotating-disk boundary layer and is independent of the characteristics of the sponge layer. Frequency-domain analysis establishes that the global mode frequency is governed by local stability characteristics at ${\textit{Re}}_{\textit{end}}$, while its growth rate evolution aligns with absolute instability trends. By further incorporating nonlinear effects, it was observed that the global properties of the global nonlinear mode remain governed by ${\textit{Re}}_{\textit{end}}$. The global temporal frequency corresponds to ${\textit{Re}}_{\textit{end}}=471.8$. When ${\textit{Re}}$ approaches 517.2, the spiral waves spontaneously generate ring-like vortices, which subsequently trigger localised turbulence. This investigation provides novel insights into the fundamental mechanisms governing stability transitions in the rotating-disk boundary layer of the rotor–stator cavity.
Rural and urban environments are exposed to the same types of climate-induced disasters, but rural populations are considered particularly vulnerable to the adverse health effects associated with these disasters. This study compares individual-level public health preparedness for climate-induced disasters in rural versus urban environments and examines the impact of rurality on variables that influence preparedness attitudes and behaviors.
Methods
A national, online survey was conducted from April to June 2024. Chi-squared tests and multiple logistic regression models with interaction terms were used to compare the preparedness attitudes and behaviors reported by rural and urban populations.
Results
Rural and urban populations generally shared preparedness attitudes and behaviors, but several significant differences were observed. Regression analysis suggested that rurality interacted with age and income to play a significant role in modifying the odds of having an evacuation plan and reporting concern about the severity of future climate-induced disasters.
Conclusions
Rurality appears to influence certain attitudes and behaviors related to preparedness for climate-induced disasters. Should climate-induced behaviors become more frequent and severe in the future, dedicated efforts should be taken to ensure that these events do not exacerbate health disparities between rural and urban environments.