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Using serum biomarkers that reflect fruit and vegetable (FV) intake offers a significant advantage over traditional dietary assessments by providing a more objective, accurate measure, meaningfully minimising recall bias and misreporting common in self-reported dietary data. This study investigated the relationship between these serum biomarkers and mortality risk using data from 19 168 adults aged 30 years and older who participated in the National Health and Nutrition Examination Survey from 1988 to 2006. Mortality follow-up was determined by linkage to the National Death Index through 31 December 2019 and diet by 24-h recalls. Cox proportional hazards models were employed to calculate hazard ratios (HR) and 95 % CI for mortality outcomes by tertiles of serum biomarkers of FV intake. Higher serum concentrations of total carotenoids were associated with a reduced risk of all-cause (tertile 3 v. tertile 1 HR = 0·69, 95 % CI = 0·61, 0·78) and cancer mortality (HR = 0·53, 95 % CI = 0·39, 0·71). Greater serum concentrations of individual carotenoids, such as α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin, were also linked to lower risks of all-cause and cancer mortality. Higher serum potassium concentrations showed a trend towards an association with a greater risk of all-cause mortality. No significant associations were found between serum vitamin C concentrations and mortality outcomes in the overall analysis; however, in sex-stratified analyses, higher vitamin C concentrations were associated with reduced risk of all-cause and cancer mortality in women. These findings suggest that specific serum biomarkers of FV intake, particularly carotenoids and vitamin C, may serve as indicators of reduced mortality risk.
We construct efficient topological cobordisms between torus links and large connected sums of trefoil knots. As an application, we show that the signature invariant $\sigma_\omega$ at $\omega=\zeta_6$ takes essentially minimal values on torus links among all concordance homomorphisms with the same normalisation on the trefoil knot.
Christian Connection women – Deborah Peirce, Harriet Livermore, and Rebecca Miller – who penned three of America’s earliest defenses of a woman’s right to preach from 1820 to 1841, conceived of themselves not only as exhorters, evangelists, and preachers but also as interpreters of the Bible. This analysis of their distinctive hermeneutical strategies demonstrates how they interpreted Philippians 4:2–3 as ballast for Christian Connection female laborers to preach and how they exploited the church’s distinction between worship and business meetings to limit Paul’s injunction to silence (1 Corinthians 14:34–35) to business meetings only. It illuminates their distinctive contributions as biblical interpreters by setting their defenses alongside influential commentaries written by men, Sarah Grimké’s defense of women’s preaching (1838), and memoirs authored by early American women preachers. Without the writings of Peirce, Livermore, and Miller, it might be possible to draw an artificial bifurcation in antebellum Christianity between interpretation and experience, that is, between commentaries and Grimké’s Letters, whose primary purpose is to interpret the Bible without explicit reference to experience, and the memoirs of women called to preach, for whom the ascendant attribute of their call was an experience that no text or interpretation could invalidate. These Christian Connection defenses mitigate such a dichotomy.
The French poet Henri Chopin (1922–2008) was one of a generation of experimental young artists around 1955 who recognised new possibilities for innovation in the realm of expanded sonic assemblage that is at once viscerally embodied and highly mediated. The catalyst: the newfound availability and affordability of the portable reel-to-reel tape recorder. This article examines the relation between Chopin’s recorded ‘audiopoems’, which were built up over time by means of distortion, layering and looping, and the artist’s unusual approach to performing live with these recorded compositions. Through strategies of aural assemblage, including physically tampering with the tape, randomly cutting and splicing the reels, and accentuating feedback, Chopin circulated the voice in new ways, both intimate and collective. This article considers how he experimented with live performance as mediation par excellence, harmoniously juxtaposing live improvisation with the preceding mediation of sound recording technology, to create a ‘double extension’ that generated feedback as well as improvisatory spaces of encounter. This article examines several projects – both realised and speculative – as well as archival accounts of performances in the 1960s and 1970s to reflect on Chopin’s unwavering commitment to the very human scale, individual and collective, of mediated expression.
Marriage rates in Korea have been declining at an unprecedented pace in the recent two decades. Drawing on the classical economic theory of marriage as a rational choice, we compute local aggregate economic values of prime-age working men and women to examine the relationship between the relative values of men and marriage rates. The relative values of men fell dramatically by 40% during this period, undermining the economic justification of marriage under unequal allocation of housework. The two-way fixed effects estimation using region-year transitory variations shows that a 1% decrease in the relative values of men was associated with a 0.088% decrease in marriage rates. To explain the precipitous convergence of economic values between the two genders, we decompose the changes in the relative values into four components – (gender-neutral) structural changes, (gender-specific) industrial segregation, (gender-neutral) wage growth, and (gender-specific) wage gaps within industries – to measure their contributions to secular marriage decline. In the 2000s, both the alleviated industrial segregation and the structural changes toward industries with higher female proportions played a major role. On the other hand, the impact of reduced gender wage gaps within industries also became prominent in the 2010s.
Emerging reports show that personal listening device usage causes vestibular impairment. This study aims to investigate the effect of personal listening device usage on vestibular impairment.
Methods
Subjects between 13 and 25 years were recruited. Each subject underwent a personal listening device usage questionnaire and quantification of sound exposure level, followed by a series of vestibular tests. Statistical analyses were performed to identify the association between personal listening device characteristics, sound exposure level and vestibular function.
Results
A total of 131 participants were recruited, with a mean age of 20 ± 2.55 years. The mean duration of personal listening device usage per day was 5.53 ± 2.76 hours. Noise exposure from personal listening device usage was noted to cause more saccular damage in adolescents. A correlation was found between the preferred listening level, the 40-hour equivalent continuous exposure level (r = 0.406, p = 0.029) and the latency right p13 among adolescents.
Conclusion
Sound exposure levels among adolescents are higher than among young adults. Personal listening device usage resulted in saccular damage among adolescents.
Giant cell arteritis (GCA), a form of large vessel vasculitis, carries the risk of irreversible loss of vision due to involvement of arteries supplying optic nerve, retina and choroid. As such, timely diagnosis of GCA is crucial. The study examines the presenting symptoms among suspected GCA patients with both positive and negative biopsy results and the association of computed tomography angiography (CTA) findings of the suspected GCA patients with superficial temporal artery (STA) biopsy results.
Materials and Methods:
A retrospective study involving 22 patients who underwent STA biopsy and CTA at Kingston Health Science Center. The CTA images of the patients were analyzed for the following imaging signs: blurred STA wall, perivascular enhancement, presence of stenosis or occlusion of STA and calcification. The association between imaging signs and STA biopsy results was assessed using odds ratios (ORs). Additionally, the final alternative diagnosis for the patients with negative biopsy results was also investigated.
Results:
There was a strong association between the presence of two CTA imaging findings : blurred STA wall and perivascular enhancement, and positive STA biopsy results (OR: 29, p: 0.001). Suspected GCA patients with negative STA biopsy results had no single unifying alternative diagnosis.
Conclusion:
This study provides evidence for the potential role of CTA in the initial assessment of suspected GCA patients.
This paper introduces the Chinese Learner English Corpus (CLEC), comprising argumentative texts written by Chinese lower and upper secondary school students. CLEC expands learner corpus research by including texts from intermediate-level learners and rich metadata on their backgrounds, including engagement with self-initiated, so-called Extramural English (EE) activities outside the classroom. To illustrate potential uses, two case studies are presented. The first uses a keyword analysis to reveal thematic and stylistic differences between CLEC and its Swedish counterpart, SLEC, highlighting linguistic priorities related to distinct learning contexts. The second investigates lexical bundles associated with gaming, demonstrating how EE engagement might influence learners’ use of multiword units. Freely available online, CLEC facilitates contrastive interlanguage analysis and supports further research into L2 learning and use, particularly regarding the role of language exposure. The corpus is also a valuable resource for teacher trainees aiming to deepen their understanding of SLA processes.
Tricuspid valve repair in paediatric infective endocarditis using a right axillary thoracotomy approach has never been reported. This report describes the minimally invasive treatment of infective endocarditis using this approach in a previously healthy paediatric patient. The patient underwent successful tricuspid valve repair and was discharged with an outpatient antibiotic regimen. He remains well seven months postoperatively.
Immersive technologies, such as augmented reality (AR) and virtual reality (VR), allow people to immerse themselves in a complete virtual environment, or enhance the physical world with digital elements. Also referred to as extended reality (XR), these technologies create experiences that feel real, whether fully or partially virtual. The impact of XR on human rights and society is linked to a large-scale consumer breakthrough, which could pose significant human rights risks. This article discusses these risks through the lens of four public values rooted in human rights instruments: privacy, autonomy, non-discrimination and a clean and healthy environment. It highlights the urgency for governments to protect and companies to respect the rights of both XR users and non-users. The aim is to initiate discussions on early interventions, avoiding missteps seen during the rise of social media, when benefits were encouraged, while risks were overlooked.
This paper investigates how Assyrian kings protected their material legacies for posterity and why in some prominent instances such protections failed, with a particular focus on the palaces of Kalḫu and Nineveh during the Sargonid Period. I approach this question through the lens of intergenerational reciprocity; Assyrian worldviews provided various channels through which past, present, and future kings could engage with one another in reciprocal and coercive relationships across time. Unlike curses and blessings, which were relatively easy for Assyrian kings to disregard, these reciprocal relationships provided more compelling incentives for rulers to honour and preserve their predecessors’ material legacies. However, practical or ideological concerns would sometimes result in the need to alter buildings in ways that damaged the material legacy of a past ruler. In some of these instances, steps were taken to symbolically compensate the past ruler in question for this damage. In this fashion, rulers were able to negotiate the ideological tension between tradition and innovation to preserve historical memory while adapting living cultural heritage to meet current needs.
CBT for psychosis is an established and evolving psychological therapy. Historical controversies about the nature of psychosis persist, and more recent debates about the outcome literature lack precision, muddying the waters further. Based on our experience as clinicians, teachers and supervisors, and following NHS and national lead roles, we describe ten common misconceptions about CBT for psychosis. These include misconceptions about the evidence, the focus of therapy, ‘thinking positively’, and the nature of collaboration and the therapeutic relationship. We refute these misconceptions based on current theory, research, and best practice guidelines. We highlight the need to get out of the clinic room, measure the impact of therapy on personal recovery and autonomy, and meet training and governance requirements. It is essential that clinicians, service leads, and our professional bodies uphold core standards of care if people with psychosis are to have access to high quality CBT of the standard we would be happy to see offered to our own family and friends.
Key learning aims
(1) To recognise common misconceptions about CBT for psychosis.
(2) To counter these misconceptions theoretically and empirically – to inform ourselves, colleagues and service leads committed to ensuring high quality CBT for psychosis.
(3) To highlight statutory and professional body responsibilities to ensure parity of esteem for people with psychosis, who deserve high quality, ‘full dose’ treatments delivered by appropriately trained clinicians, and supported by robust governance systems, just as we would expect for people with physical health conditions.
We develop a powerful tool for embedding any tree poset P of height k in the Boolean lattice which allows us to solve several open problems in the area. We show that:
• If $\mathcal {F}$ is a family in $\mathcal {B}_n$ with $|\mathcal {F}|\ge (q-1+\varepsilon ){n\choose \lfloor n/2\rfloor }$ for some $q\ge k$, then $\mathcal {F}$ contains on the order of as many induced copies of P as is contained in the q middle layers of the Boolean lattice. This generalizes results of Bukh [9] and Boehnlein and Jiang [8] which guaranteed a single such copy in non-induced and induced settings, respectively.
• The number of induced P-free families of $\mathcal {B}_n$ is $2^{(k-1+o(1)){n\choose \lfloor n/2\rfloor }}$, strengthening recent independent work of Balogh, Garcia, and Wigal [1] who obtained the same bounds in the non-induced setting.
• The largest induced P-free subset of a p-random subset of $\mathcal {B}_n$ for $p\gg n^{-1}$ has size at most $(k-1+o(1))p{n\choose \lfloor n/2\rfloor }$, generalizing previous work of Balogh, Mycroft, and Treglown [4] and of Collares and Morris [10] for the case when P is a chain.
All three results are asymptotically tight and give affirmative answers to general conjectures of Gerbner, Nagy, Patkós, and Vizer [18] in the case of tree posets.