The global arms trade stands at the crossroads of security, business and human rights. While historically dominated by security narratives, increasing recognition of the arms industry’s business functions has led to calls for greater corporate accountability for the adverse human rights impacts of arms production and transfers. Business and Human Rights (BHR) provides innovative approaches for addressing regulatory and conceptual gaps in arms trade governance, and, in particular, offers two key paths forward for bringing coherency to arms trade governance and recalibrating the balance between security and business interests and human rights protection. First, as a field of practice, BHR can be utilised to develop comprehensive and coordinated due diligence that bridges silos between human rights, corruption, diversion and lack of transparency, to overcome regulatory fragmentation. Second, as a discourse, BHR introduces a conceptual foundation for reframing the status of human rights in arms trade governance and impelling corporate leadership to elevate human rights protection.