Integrating metabolic syndrome (MetS) screening procedures into routine care remains challenging. Traditional anthropometric and body composition assessments, while useful, have drawbacks that limit their application. However, automated anthropometrics produced from smartphone scanning applications may offer a solution. This study aimed to determine whether smartphone-derived anthropometrics could effectively predict both MetS and its severity. A total of 281 participants underwent a MetS screening assessment to determine fasting blood pressure, lipids, glucose and waist circumference and completed a smartphone scanning assessment (MeThreeSixty®) to collect digital anthropometrics. Actual MetS classification and MetS severity (MetSindex), a continuous estimate of MetS progression, were determined using MetS screening data. Then, least absolute shrinkage and selection operator regression was used to develop a new MetSindex prediction equation in a subset of participants (n 226), which was subsequently tested in the remaining participants (n 55), and MetS classification was predicted from the retained variables using logistic regression. The following equation was produced: Smartphone-predicted MetSindex: −0·8880 + 0·1493(medication use = 1; 0 = no medication use) + 0·0089(weight) + 0·0079(bust circumf.) + 0·0140 (thigh circumf.) – 0·6247(appendage-to-trunk circumf. index), where medication use includes medications for hypertension, dyslipidaemia or hyperglycaemia. The newly developed MetSindex prediction model demonstrated equivalence with actual MetSindex and revealed acceptable agreement (R2:0·72; root mean squared error: 0·42; se of the estimate: 0·22) when evaluated in the testing sample (n 55), although proportional bias was observed (P < 0·001). Smartphone-predicted MetS classification demonstrated acceptable diagnostic performance with an accuracy of 92·7 % and an AUC of 0·89. Smartphone scanning applications can accurately assess MetS prevalence and severity, presenting new possibilities for health screening beyond clinical environments.

A significant association between tomato consumption and a lower risk of developing hypertension has been reported. In this study, we aimed to investigate the relationship between tomato intake and prehypertension risk among Korean adults. Hypertension was defined according to the criteria established by the Korean Society of Hypertension. The study participants were selected from the Health Examinees cohort study. Tomato consumption was measured using an FFQ and categorised into quintiles based on the amount consumed. Higher tomato consumption was associated with a lower risk of prehypertension in men (hazard ratio (HR) 0·86, 95 % CI 0·80, 0·92, Pfor trend 0·0005). Women in the highest quintile also showed a similar trend (HR 0·94, 95 % CI 0·90, 0·99, Pfor trend 0·0091). Stratified analyses revealed a reduced risk of prehypertension across all subgroups, except underweight individuals and those with a history of alcohol consumption (all Pfor interaction < 0·05). These findings indicate that higher tomato intake may offer potential advantages for managing blood pressure levels.

To examine the association between snack characteristics (snack frequency, snack energy density and snack nutritional quality) with diet quality and cardiometabolic risks among US adolescents from the 2009–2016 National Health and Nutrition Examination Survey. Cross-sectional dietary data collected using a 24-h dietary recall from the 2011–2016 National Health and Nutrition Examination Survey (1999 boys and 1897 girls aged 12–19 years) were analysed. Associations between snack characteristics with diet quality, fasting blood glucose, TAG, total cholesterol, HDL, LDL, blood pressure, waist circumference and metabolic syndrome risk score using multiple linear regression were analysed stratified by sex. Higher snack nutritional quality (β (95 % CI): boys 0·31 (0·09, 0·52); girls 0·44 (0·30, 0·57)) was linked to better overall diet quality, whereas snack energy density excluding beverages (β (95 % CI): boys –1·82 (–2·52, –1·12); girls –1·75 (–2·69, –0·82)) was linked to poorer overall diet quality. Among girls, higher snack frequency was associated with lower waist circumference and lower fasting blood glucose (–0·67 (–1·28, −0·05)). Additionally, higher snack energy density and nutritional quality were associated with lower waist circumference and TAG, respectively. No associations between snack characteristics and cardiometabolic indicators or metabolic syndrome risk score were observed for boys. Findings suggest that strategies to improve adolescent snack nutritional quality and energy density may enhance overall diet quality. However, limited associations were observed between snack characteristics and cardiometabolic risk indicators among girls only. Prospective studies are needed to further investigate the relationship between snack characteristics and adolescent health outcomes.

Acute effects of a daily dose of red wine may cause deterioration of visual function; however, there is limited information on healthy individuals. This study aims to investigate acute effects of daily red wine consumption on visual function and retinal microvasculature in healthy young adults through a randomised self-controlled design and to explore the molecular mechanisms using an animal model. In healthy young adults’ study, twenty-seven adults with follow-up at baseline, 0·5 h and 2 h after consuming 300 ml of either red wine or water underwent blood biochemistry, visual function, morphology and blood flow of retinal and choroidal vasculatures, and cerebral blood flow (CBF) evaluation. Acute red wine consumption caused abnormal changes in retinal function (multifocal visual electrophysiology) that preceded changes in vision. Macular vessel diameter index (VDI) increased significantly at 0·5 h but decreased significantly at 2 h, despite increased regional CBF following red wine consumption, which was consistent with increased choroidal thickness and decreased retinal thickness. Animal experiments conducted on Brown Norway rats demonstrated a significant decrease in retinal VDI and vessel area density (VAD) associated with increased reactive oxygen species production following red wine administration, as well as decreased endothelial nitric oxide synthase (eNOS) and increased endothelin-1 (ET-1) levels in the retina. Consequently, red wine consumption caused abnormal changes in retinal function and microvascular constriction in healthy young adults, and an animal model suggested that the underlying mechanism may involve the regulation of eNOS and ET-1 levels in the retina. These findings imply the potential detrimental effects of drinking habits on individuals with retinal ischaemic diseases.

This study aimed to investigate the effects of caffeic acid (CA) on the inflammatory response induced by hydrogen peroxide (H2O2) in porcine small intestinal epithelial cells (IPEC-J2 cells) and to elucidate the potential molecular mechanisms involved. Firstly, we treated IPEC-J2 cells with different concentrations of H2O2 to establish the inflammation model caused by oxidative stress. Subsequently, we treated IPEC-J2 cells with CA and/or H2O2 to investigate the effect of CA on the inflammatory response of IPEC-J2 cells induced by H2O2. In addition, IPEC-J2 cells were treated with a nuclear factor kappa-B (NF-κB) inhibitor and a Nucleotide-binding Oligomerization Domain (NOD)-like receptor thermal protein domain associated protein 3 (NLRP3) inhibitor, so as to investigate the molecular mechanism by which CA alleviates H2O2-induced damage in porcine intestinal epithelial cells. The changes in cell morphology, intestinal epithelial cell damage and the expression of genes related to the NF-κB/NLRP3 signalling axis were examined. The results showed that CA attenuated H2O2-induced intestinal epithelial cell injury, and the mechanism may be related to the inhibition of NF-κB-mediated NLRP3 inflammasome activation. These findings were expected to provide a theoretical basis for more reasonable and effective application of CA, and provide new ideas for nutritional regulation measures to alleviate intestinal inflammation in piglets.

This study evaluated the effect of different medium-chain to long-chain fatty acid (MCFA:LCFA, M:L) ratios on growth performance, intestinal function, antioxidant capacity and gut microbiota in piglets. A total of 250 piglets were randomly assigned to five groups with five replicates, each containing ten pigs. The diets, containing varying amounts of MCFA-rich coconut oil and LCFA-rich soyabean oil, resulted in M:L ratios of 0, 2·1, 4·2, 8·8 and 33·8 %. Results showed that both final body weight and average daily weight gain increased as the M:L ratio increased (P < 0·05), while the 8·8 % M:L ratio diet exhibited the lowest feed:gain ratio (P < 0·05). As the M:L ratio increased, the contents of superoxide dismutase and glutathione peroxidase were increased, and MDA was decreased in serum (P < 0·05). The 8·8 and 33·8 % M:L diets improved ileal and jejunal morphology (P < 0·05), as indicated by greater villus height and villus height:crypt depth ratios. Furthermore, increasing M:L ratios from 0 to 33·8 % increased expression of tight junction proteins occludin and ZO-1 in the jejunum (P < 0·05). The 33·8 % M:L ratio reduced microbial α-diversity (P < 0·05), while 8·8 % M:L diet significantly increased the abundance of beneficial bacteria (e.g. Lactobacilli, Prevotella) and decreased harmful bacteria (e.g. Escherichia-Shigella, Enterococcus) in the cecum (P < 0·05). In summary, our study found that 8·8 % of dietary M:L ratios significantly improved growth performance, likely through modulating intestinal function, antioxidant activity and gut microbial composition.

Dieting is a global emerging trend in recent years as more people strive to adhere to food restriction plans for weight management in obese people and to achieve desired slim body. This strategy may have unforeseen repercussions in females that may affect reproductive potential. Therefore, we aimed to investigate the impact of dietary stress on reproductive hormone levels, histoarchitecture of the ovary, autophagy and apoptosis markers in the rat ovary. Data suggest that dietary stress caused due to food deprivation decreased body weight and ovary weight, luteinising hormone, follicular-stimulating hormone and estradiol-17β levels. The dietary stress reduced the number of primary follicles, altered the histoarchitecture of the ovary, increased number of fragmented and irregularly shaped oocytes. Dietary stress induced autophagy signalling by inhibiting mammalian target of rapamycin and increasing Lamp-1, LC-3 and Beclin-1 in the ovarian follicles. In addition, dietary stress induced proapoptotic signalling pathway by decreasing Bcl-2 and increasing Bax as well as cytochrome-c expressions in the ovary. Taken together, these findings suggest that dietary stress caused due to food deprivation reduced reproductive hormones levels, induced autophagy and apoptotic signalling pathways that affected histoarchitecture of the ovary, ovarian function, oocyte quality and thereby reproductive potential.

Family meals are positively associated with healthier diets among children and parents. We aimed to deepen the understanding of these relationships by exploring the associations between shared meals and dietary quality among children, fathers and mothers. A subset of parent-child dyads (296 children aged 3–6 years, 103 fathers, 293 mothers) from the DAGIS Intervention baseline assessment was included in this cross-sectional study. The parents reported how often they shared meals with the child and filled in a food frequency questionnaire assessing their child’s and their own food consumption. A Healthy Food Intake Index (HFII) describing dietary quality was calculated for all family members. We used linear regression to investigate the associations between shared meals and the HFII of the children, fathers and mothers. Models were adjusted for child’s age and gender, parent’s age and educational level and number of children in the household. Children whose fathers reported less frequently sharing a weekend lunch with the child had a lower HFII (B estimate –1·58, 95 % CI –2·66, –0·50). The association remained close to statistical significance with adjustments (B estimate –0·99, 95 % CI –2·17, 0·19). A less frequently shared weekend lunch was also borderline significantly associated with lower HFII among the fathers (adjusted model, B estimate –1·13, 95 % CI –2·30, 0·04). Fathers should be encouraged to share meals with their family, since it might have a role in the dietary quality of both children and fathers. Future studies should recognise fathers as important contributors to a healthy home food environment.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious disease and increasingly prevalent in children. MASLD is associated with health consequences such as type 2 diabetes and CVD. While vitamin E is a potent antioxidant that has been proposed to improve liver function and cardiometabolic health including liver markers, lipid profile, glycaemic control and anthropometric measurements. A comprehensive search was conducted up to March 2025. Data on anthropometric measures, liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT)), glycaemic indices (fasting blood sugar (FBS), insulin, homeostatic model assessment for insulin resistance (HOMA-IR)), lipid profiles (total cholesterol (TC), TAG, LDL-cholesterol, HDL-cholesterol) and serum vitamin E levels were extracted. Statistical analyses were performed using a random-effects model. Eleven randomised controlled trials involving 665 participants were included in this study. Vitamin E significantly reduced ALT (weighted mean difference (WMD) = −5·23 U/L; 95 % CI: −7·72, −2·75; P < 0·001) and AST (WMD = −3·00 U/L; 95 % CI: −4·59, −1·41; P < 0·001), reflecting improved liver function. It also decreased TC (WMD = −5·77 mg/dl; 95 % CI: −11·46, −0·09; P = 0·04) and HOMA-IR (WMD = −0·82; 95 % CI: −1·28, −0·37; P < 0·001), while significantly increasing serum vitamin E levels (WMD = 9·16 mg/l; 95 % CI: 3·29, 15·03; P = 0·002). No significant changes were observed in the BMI, GGT, FBS, insulin, LDL-cholesterol, HDL-cholesterol or TAG levels. Vitamin E supplementation in paediatric MASLD appears to favourably influence key liver enzymes such as ALT, AST and certain metabolic factors including TC, and HOMA-IR levels, supporting its potential role as adjunctive therapy.

Nutraceuticals are increasingly of interest in nutritional psychiatry, where creatine has been investigated in several randomised trials for its effects on depressive symptoms. However, these findings have not yet been systematically synthesised. We conducted a systematic review to assess the effects of creatine supplementation on symptoms of depression. Four databases were searched up to February 2025 for trials comparing creatine with placebo in individuals with or without depression. Study selection, data extraction and risk of bias assessment (RoB 2) were conducted independently, and certainty of evidence was evaluated using Grading of Recommendations, Assessment, Development and Evaluation (GRADE). Random-effects meta-analyses with Hartung–Knapp–Sidik–Jonkman adjustment including eleven trials (1093 participants) found a standardised mean difference of −0·34 (95 % CI −0·68, −0·00; GRADE: very low quality of evidence), equivalent to 2·2 points on the seventeen-item Hamilton Depression Rating Scale, below the minimal important difference of 3·0 points. CI include non-clinically important effects, and heterogeneity was substantial (I2 = 71·3 %). While effects appeared larger in clinically depressed populations, subgroup analyses and trim-and-fill adjustments indicated substantial bias favouring creatine. Results for secondary endpoints were significant for remission (three trials, OR 3·60; 95 % CI 1·76, 7·56), but not for treatment response (two trials, OR 0·72; 95 % CI 0·28, 1·88). Our findings suggest that creatine may offer a small-to-moderate benefit for individuals with depression, but average effects were not clinically important and the true effect may be trivial or null. The evidence on which these results are based is very uncertain. Larger, more rigorous randomised trials are required to draw definitive conclusions.

Dietary patterns are key modifiable determinants in cardiovascular disease (CVD) prevention, accounting for over half of CVD-related deaths and disabilities. This study aimed to examine whether changes in diet quality and six predefined diet scores were associated with incident cardiovascular (CV) events over four years among secondary care cardiology patients. We conducted a secondary prospective analysis of participants aged ≥45 years from the Brazilian Cardioprotective Nutritional Program Trial, including 1,704, 1,629 and 1,286 individuals for the 12-, 24- and 36-month change analyses, respectively. The assessed diet scores included the Dietary Inflammatory Index (DII), Dietary Total Antioxidant Capacity (dTAC), overall, healthful and unhealthful Plant-Based Diet Index (PDI, hPDI, uPDI), and the modified Alternative Healthy Eating Index (mAHEI). The primary outcome was the incidence of new CV events in each follow-up period, adjudicated by the Clinical Endpoints Committee. Associations were estimated using Cox proportional hazards models, combining intervention and control groups. A total of 162 incident CVD cases occurred over a median follow-up of 3.25 years. After 36 months, improvements in mAHEI scores were inversely associated with CV event incidence in both crude (HR: 0.96; 95% CI: 0.92–0.99) and adjusted models (HR: 0.94; 95% CI: 0.89–1.00). No significant associations were found for changes in DII, dTAC, PDI, hPDI or uPDI across any time point. These findings suggest that, in individuals receiving secondary CV care, sustained improvements in diet quality, particularly those reflected by the mAHEI, may require longer periods to translate into measurable benefits for cardiovascular health.

Children with coeliac disease (CD) on a gluten-free diet (GFD) often have poor dietary quality (DQ). A Gluten-Free Food Guide (GFFG) was developed to address this. This pilot randomised controlled trial evaluated the impact of GFFG dietary counselling on DQ and ultra-processed food (UPF) intake in newly diagnosed CD children. Child–parent pairs were randomised to the standard of care only (CON: n 20) or the intervention (INT: standard of care + GFFG; n 20). Primary outcomes included DQ (Healthy Eating Index-Canadian) and UPF intake (NOVA classification), assessed at baseline (BL), 3 and 6 months. In INT, dietary variety scores, a subcomponent of DQ, increased between BL and 3 months (BL: 6·7 (3·3–6·7) v. 3 months: 10 (10–10); P = 0·01) and in higher variety scores than CON at 3 months (P < 0·01). Total DQ and UPF intake remained unchanged. Increased dietary variety in INT was associated with increases in dairy products (BL: 7·5 (sd 3·6) % v. 3 months: 12·4 (sd 6·7) %; P = 0·01) and unsweetened milk (BL: 2·5 (sd 2·2) % v. 3 months: 4·7 (sd 3·0) %; P = 0·01) servings, consumed as a percentage of the total food group servings. These improvements were not observed at 6 months. A greater number of INT children met the GFFG protein recommendation at 3 months (BL: 0/19 v. 3 months: 5/19; P = 0·01), with no change in CON. A single GFFG session improved short-term dietary variety and unsweetened milk intake. Ongoing work addressing the GF food environment, dietitian access and policies to improve DQ are needed.

Nutritional status has been compromised by ongoing war and restrictions on food deliveries in the Gaza Strip. We developed a mathematical model that outputs retrospective estimates and scenario-based projections of acute malnutrition prevalence among children given caloric intake and other factors. We present here the model and its application to the crisis in Gaza. We extended an existing mechanistic model for weight change as a function of energy balance, calibrating it to represent variability in growth curves observed in pre-war Gaza. We simulated open cohorts of children exposed to time-varying caloric intake, infant exclusive breast-feeding prevalence, incidence of infectious disease and coverage of malnutrition treatment, while allowing for adult caloric sacrifice to supplement child intake in times of food scarcity. The model accurately replicates growth standards, pre-war growth patterns and expected parameter dependencies. It suggests that a considerable increase in acute malnutrition occurred in northern Gaza during early 2024. Projections for late 2024 include a serious nutritional emergency if relatively pessimistic assumptions are made about food availability. The model may hold considerable promise for informing decisions in humanitarian response but requires further validation and development.

There is growing evidence that optimising dietary quality and engaging in physical activity (PA) can reduce dementia and cognitive decline risk and improve psychosocial health and quality of life (QoL). Multimodal interventions focusing on diet and PA are recognised as significant strategies to tackle these behavioural risk factors; however, the cost-effectiveness of such interventions is seldom reported. A limited cost consequence based on a 12-month cluster-randomised Mediterranean diet (MedDiet) and walking controlled trial (MedWalk) was undertaken. In addition, QoL data were analysed. Programme costs ($AUD2024) covered staff to deliver the MedWalk programme and foods to support dietary behaviour change. The primary outcome measure of this study was change in QoL utility score, measured using the Assessment of Quality of Life (AQoL-8D). Change scores were compared for the groups using general linear models while controlling for demographic factors associated with baseline group differences and attrition. Change in QoL (decreased, maintained or improved) was determined using a cross-tabulation test. MedWalk programme costs were estimated at $2695 AUD per participant and control group cost at $165 per person – a differential cost of $2530. Mean change in utility scores from baseline to 12 months was not statistically significant between groups. Nevertheless, the MedWalk group was significantly less likely to experience a reduction in their QoL (20·3 % MedWalk v. 42·6 % control group) (P = 0·020). A MedDiet and walking intervention may have a role in preventing decline in QoL of older Australians; however, longer-term follow-up would be beneficial to see if this is maintained.