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Half of people living in the USA do not consume tap water. Surveys have assessed perceptions of water and water utilities, but less is known about how these perceptions relate to the preference for tap or bottled water. The present analysis examined whether beliefs about tap water and the water utility were associated with drinking water preferences.
Design:
In a cross-sectional survey, six water beliefs were measured: trust in tap water, the water utility, and the local government; perceived safety and quality of tap water; and awareness that the water utility frequently tests tap water. Regression models adjusted for sociodemographic characteristics were used to estimate the odds of preferring tap over bottled water dependent on respondents’ beliefs about their tap water.
Setting:
Virginia, USA.
Participants:
Adults aged 18 years and older (n 808).
Results:
More than two-thirds of respondents had positive beliefs about their tap water, but only 54 % reported tap as their preferred drinking water source. All water beliefs, except for awareness of the frequency of water testing, were associated with higher odds of preferring tap water over bottled (adjusted OR range: 1·56–3·2).
Conclusions:
Our findings suggest that favourable tap water beliefs may be necessary, but not sufficient, to motivate people to drink from the tap. There remains a critical need for future research to bridge the gap between tap water perceptions and consumption, which should include enhancing the trustworthiness of tap water and the water utility as well as improving consumers’ perceptions of water quality and safety.
Dicamba-resistant soybean was developed and commercialized by Monsanto in 2016, and in recent years, barnyardgrass has become more troublesome for growers who use residual herbicides with dicamba technology. Field studies were conducted from 2019 to 2021 in Stoneville, Mississippi, to evaluate barnyardgrass control after applications of glyphosate or glyphosate + dicamba, when mixed with residual herbicides, and when applied sequentially. In the first field study, glyphosate (1,120 g ae ha−1) and glyphosate + dicamba (560 g ae ha−1) were applied in combination with common residual herbicides. The second field study included an initial treatment with glyphosate (1,120 g ha−1), glyphosate + dicamba (560 g ha−1), and glyphosate + dicamba + S-metolachlor (1,064 g ai ha−1) followed by a sequential treatment of glyphosate or glyphosate + dicamba at 3 and 7 d after an initial herbicide treatment. Results indicated that glyphosate alone provided greater barnyardgrass control than glyphosate + dicamba. Additionally, at 28 d after treatment, pyroxasulfone, pyroxasulfone + fluthiacet, dimethenamid-P, and S-metolachlor did not affect postemergence control of barnyardgrass after glyphosate + dicamba treatments. Furthermore, sequential herbicide treatments of glyphosate or glyphosate + dicamba led to no difference in barnyardgrass control 28 d after the sequential treatment. These results indicate that options exist for adding residual herbicides to glyphosate + dicamba treatments and that sequential treatments of glyphosate or glyphosate + dicamba are important for optimizing barnyardgrass control.
To examine how school food policies and perceived barriers influence food provision in New Zealand primary school canteens, using the ‘Healthy Food and Drink Guidance for Schools’.
Design:
Cross-sectional analyses of school food menus and school food policy and practices surveys completed by school leaders/principals.
Setting:
New Zealand primary schools.
Participants:
239 primary schools completed the school food policies and practices survey, and eighty schools provided canteen menus.
Results:
Most schools reported having a healthy food and drink policy in their school (76·2 %) and promoted healthy eating during school hours (87·4 %). Two-thirds (69·5 %) identified barriers to healthy food and drink provision, most commonly the convenience of ready-made foods (39·3 %), and resistance from parents (34·3 %). The number of reported barriers was not a significant predictor for the presence of a school food policy (OR-1·034, P = 0·841). School menus (n 80) consisted of 16·4 % ‘green’ items, 34·7 % ‘amber’ items and 36·8 % ‘red’ items. There was no relationship between the percentage of ‘green’, ‘amber’ and ‘red’ items and the presence of a school food policy or reported barriers. More than a third (38·9 %) of menus from schools that reported they had a ‘Plain Milk and Water’ only policy still contained sugar-sweetened beverages.
Conclusions:
Although most New Zealand primary schools had healthy food policies, this was not consistently reflected in healthy food items on canteen menus. Further research is needed to understand how systemic barriers, such as cost, convenience and parental influence, affect policy implementation and school food provision.
The Malvaceae is the 12th largest angiosperm family with ten subfamilies, 243 genera and c. 4000 species of trees, shrubs, herbs and a few climbers. Subfamilies originated in the Upper Cretaceous-Palaeocene, and their divergence times range from 71.6 to 33.0 Ma. Seeds have a folded, investing or spatulate embryo, and they may be nondormant (ND) or have physical (PY) and/or physiological (PD) dormancy. Of the 365 species for which dormancy/germination data were found, 34.0% had ND seeds and 46.6% PY; 1.6%, PD&ND; 13.1%, PY&ND; and 4.7% PY+PD. Seeds with PY have a palisade layer of Malpighian cells (with a light line) in the outer epidermis of the inner integument, and a chalazal plug is the water gap. Seeds of 168 species of wet tropical trees, in all ten subfamilies, were ND (57.2%) or had PY (19.7%), but seed collections of many species were a mixture of ND & PY (20.2%); 2.9% had PD&ND. We found 13 tree species in wet tropics with recalcitrant seeds and 57 species in 28 genera in seven subfamilies in various habitats with persistent soil seed banks. Malvoideae is the most species rich and widely distributed subfamily and is found in tropical and temperate regions but rarely in subalpine/boreal or Arctic/alpine tundra vegetation. Few if any Malvaceae, in particular Malvoideae, grow as herbaceous perennials in tundra vegetation; possible reasons for this are considered.
This paper examines the recent rejection of the ‘Anthropocene’ as a formal geological epoch to explore how climate anxiety shapes scientific research. While there is broad agreement among scientists about climate change, political and legal action lag behind. Scientists bridge this gap by communicating their findings in ways that influence policy. This effort reflects the broader condition of ‘polycrisis’: multiple overlapping global challenges. I argue that terms like ‘Anthropocene’ and ‘polycrisis’ are not fixed truths, but strategies for taming uncertainty. Scientists, accordingly, are increasingly coming to replace legislators by encouraging certain kinds of present-day action towards more desirable futures.
Technical summary
This paper examines the Anthropocene Working Group's (AWG) effort to formalise a new geological epoch and interprets its 2024 rejection as a case study in the politics of polycrisis. Drawing on ethnographic research with the AWG, it shows how scientific observation is increasingly driven by anticipatory anxiety and a performative impulse to orient action towards uncertain futures. Through the concepts of the technofossil and procedural precedent, the article illustrates how geoscientific methods both generate and respond to normative expectations. The paper argues that polycrisis is not merely descriptive, but constitutes a second-order mode of engaging with the future, wherein political urgency animates what and how scientists observe. In the context of climate change, scientific actors are not only producing knowledge but also seeking to shape policy and social response by innovating within disciplinary protocols. Terms like ‘Anthropocene’ and ‘polycrisis’ are powerful abstractions whose utility lies in their imaginative capacity to narrate contingency and complexity, and imagine solutions by orienting action in the present towards desirable outcomes in the future, rather than in any fixed claim to objectivity.
Social media summary
Anxiety about the future is reshaping science, law, and the way we understand today's overlapping global crises.
Invasive non-native species proceed through the Invasion Process upon introduction to a new location, with stages comprising establishment, growth, spread, and invasive impact. High fecundity, driven by fast growth, short lifespan, and a long reproduction period, can lead to high population densities, facilitating stage progression. The Asian date mussel (Arcuatula senhousia) is a marine intertidal–subtidal species, recently established in the UK. Given its potential to impact ecosystem services in Northern Europe, understanding the Invasion Process stage it has reached is imperative for assessing potential invasiveness and informing management. Therefore, population parameters of subtidal A. senhousia in the UK were evaluated from April 2021 to March 2022 to assess invasion stage. Specimens were collected (n = 1,029) via dredging and processed for condition index, gonadosomatic index, gonad index, length-frequency distribution, and electronic length-frequency analyses. While densities were low (<1 individuals per m2), maximum lifespan was high (23 months) and growth rate was high (1.8 mm per month), relative to other populations within the species’ global range. Results confirmed June to October spawning as previously reported in the UK and France but also evidenced secondary spawning (in November) for the first time in Northern Europe. Successful recruitment from primary and secondary spawning in 2020 was also apparent. Findings indicate A. senhousia has reached the Growth stage, and that further spread within the UK and Northern Europe is likely. Climate change will likely increase larval survivorship and individual and population fecundity, facilitating progression to invasive impact, potentially within the next decade.
Studies on tillering dynamics are essential to understand the aspects underlying the persistence and adaptation pathways of grass communities, especially in more complex multispecific pastures. This study aimed to assess the tillering dynamics and population stability of Andropogon gayanus cv. Planaltina (PG), Megathyrsus maximus cv. Massai (MG) and Urochloa brizantha cv. BRS Piatã (PP) grown as monocultures and as a mixture. The treatments corresponded to three grasses described above. Sixteen 180 m2 plots were randomly assigned and managed intermittently under manual harvest at pre- and post-harvest heights of 35 and 17.5 cm, respectively, for two years. During autumn/winter/early spring, when resource availability is limited by abiotic factors, pasture population stability was ensured by the conservation strategy of all species, mainly through the high tiller survival rate (85.5 ± 0.32). In late spring and summer, the capture strategy was prioritized for all species, with stability ensured through high tiller appearance rates (30.3 ± 0.80 and 40.4 ± 1.47, respectively), which compensated for the high tiller death rate (28.7 ± 1.10) and resulted in greater species turnover during these both seasons. The association among PG, MG and PP in a mixture allows species to coexist with relatively stable populations and tillering dynamics, similar to their monocultures. These findings represent a step forward in our understanding of mixed swards stability and indicate that such associations could be viable alternatives to palisadegrass monocultures in tropical regions. Further research should test this mixed sward under grazing, during medium to long-term.
This article argues that a pervasive but confused theory of free will is driving unwarranted resistance to behavioral genetic research and undermining the concept of personal responsibility enshrined in our moral and legal conventions. We call this the theory of ‘free-will-by-subtraction’. A particularly explicit version of this theory has been propounded by the psychologist Eric Turkheimer, who has proposed that human agency can be scientifically quantified as the behavioral variation that remains unexplained after known genetic and environmental causes have been accounted for. This theory motivates resistance to research that suggests genetic differences substantially account for differences in human behavior because that is seen to reduce the scope of human freedom. In academic philosophy, free-will-by-subtraction theory corresponds to a position called ‘libertarian incompatibilism’, which holds that human beings are not responsible for behavior that has antecedent causes yet maintains that free will nonetheless exists because some fraction of human behavioral variation is self-caused. However, this position is rejected by most professional philosophers. We argue that libertarian incompatibilism is inconsistent with a secular materialist outlook in which all human behavior is understood to have antecedent causes whether those causes are known to science or not — an outlook Turkheimer shares. We show that Turkheimer sustains this contradiction by adopting an untenable position we call ‘epistemic libertarianism’, which holds that antecedent causes of our behavior only infringe on our freedom if we know about them. By contrast, the overwhelming majority of secular materialist philosophers support a position called ‘compatibilism’, which maintains that free will is compatible with the comprehensive causation of human behavior. We show that compatibilism neutralizes the threat that genetic explanation poses to human agency and rescues a generous conception of personal responsibility that aligns with our moral intuitions.
Nutrition plays a key role in shaping children’s eating behaviours, which can be influenced by environment and social interactions, making careful management essential at home and school. This cross-sectional study aimed to evaluate the perceptions of caregivers in these settings regarding the consumption and eating behaviours of children aged 3–6 years. Food preferences and frequency questionnaires were administered to children, and their teachers and caregivers, supplemented by free drawing and colouring activities. The results revealed discrepancies between parents and teachers, with parents recognising the importance of fruits and vegetables for health and reporting that children have access to these foods at home. Although parents recognised the importance of vegetable consumption, teachers did not share this perception, as they observed limited access to these foods among children and even reported difficulties in introducing them into the school environment. The most consumed foods during main meals were rice, beans, vegetables and meats, while fruits and dairy products were predominant in breakfast and snacks. Children frequently mentioned fruits such as watermelon, strawberry, and apple using free drawing and colouring activities. These findings highlight significant differences in perceptions between parents and teachers regarding children’s access to healthy foods, underscoring the need for improved communication to promote healthier eating habits.
An understanding of bird movement and habitat use in breeding and non-breeding areas is critical for the conservation of migratory birds. Latham’s Snipe Gallinago hardwickii breeds in Japan and Russia then migrates more than 6,000 km to its non-breeding sites in Australia. It is at risk because it favours areas under pressure from urban development. We investigated the movement patterns of Latham’s Snipe at a key non-breeding site – Jerrabomberra Wetlands, in Canberra, Australia. We tracked 32 Latham’s Snipe using GPS telemetry devices in the 2022/3 and 2023/4 seasons. The tracked birds remained at Jerrabomberra Wetlands for their non-breeding season and formed distinctive and predictable patterns of roosting and foraging. The distance range between roosting and foraging sites was similar across both the 2022/3 and 2023/4 seasons, with 75% of birds travelling less than 2.5 km and the majority of birds travelling <6 km. Approximately one third (31%) of birds travelled up to 30 km overnight before returning to the wetlands, and two birds (6%) travelled up to 140 km for up to three days. Home range sizes averaged 19 ha and did not significantly differ among individuals in either season. The relatively small size of the home ranges and short foraging trip distances suggest that conservation of non-breeding habitat in urbanised areas can be achieved through the protection of small areas, providing the habitat is suitable. However, individuals varied in their use of the broader landscape and therefore their susceptibility to threats may vary. From an urban planning perspective, habitat protection should prioritise roost sites while ensuring a diversity of foraging habitat within 6 km.
To co-design a systems approach aimed at promoting the wide-scale adoption of whole-school approaches to food in UK primary schools to improve school food environments, food provision and dietary intake in children.
Design:
A systems framework (Action Scales Model) was used to guide the co-design of the systems approach. The process involved identifying leverage points within the UK primary school food system that, if influenced, could alter the way in which the system functions. Actions were then agreed upon to influence those leverage points.
Setting:
Co-design workshops were held online between September 2021 and February 2022.
Participants:
Members of the co-design team comprised twelve school stakeholders (headteachers, school food improvement officers, catering leads, representatives of UK school food organisations and a dietician) and a team of researchers with expertise in school food, systems thinking and intervention development. Our partnership board included decision-makers and advocates of the whole-school approach to food in England and Northern Ireland.
Results:
Identified leverage points included the priorities of headteachers, who are instrumental in instigating whole-school approach to food adoption. Direction from local and national policymakers was also identified. Actions to influence these leverage points included providing direct support to schools (through an online resource) and encouraging policymakers to monitor the adoption of the approach.
Conclusion:
The methods described here can be replicated by others to promote the adoption of whole-school approaches to food in other contexts and contribute to the growing literature on developing systems-wide approaches to promote the adoption of public health initiatives.
Traditional diets are culturally accepted and adapted to local environments, but globalisation has shifted towards unhealthy, unsustainable eating habits. This study aims to assess the literature on the effects of traditional, place-based diets on health and sustainability and examines the suitability of common tools used to evaluate them.
Design:
A systematic search was conducted using the PRISMA 2020 guidelines across seven databases (CINAHL, Cochrane Library, MEDLINE, Scopus, Web of Science, PubMed and Google Scholar), and the protocol was registered with PROSPERO (CRD42023445750). The inclusion criteria were traditional place-based diets, studies examining the nutritional, health benefits and sustainability impacts of traditional food consumption, published in English, with no date restriction.
Results:
Eleven studies from Spain, Romania, Portugal, Mexico, Chile, Japan, Uganda and India met the criteria. Assessment tools included carbon footprints (via LCA), nitrogen footprints, NRF9.3, Nutri-Score and EAT-Lancet; some incorporated qualitative methods. Mediterranean, Atlantic and Japanese diets aligned well with health and sustainability, whereas meat-heavy or nutrient-deficient patterns raised concerns. Most studies relied on standardised tools and secondary datasets, with limited use of region-specific environmental data or qualitative insights. Only one intervention study was identified.
Conclusions:
Traditional diets show promise as culturally appropriate models for sustainable and healthy eating. Current tools designed around standardised, reductionist frameworks often fail to capture the complexity of traditional food systems, including local practices, preparation methods and cultural meaning. To better assess traditional diets, future research should develop regionally adapted indicators and integrate quantitative measures with qualitative insights from local communities.
Sitotroga cerealella (Olivier) (Lepidoptera: Gelechiidae) is one of the most serious pests of rice. The variations in phytoconstituents of rice cultivars (Miniket, Cottondora Sannalu, Gobindobhog, Swarna, and Tulaipanji) that led to differences in population growth of S. cerealella were studied. Fitness of the moth was approximated in terms of mean generation time (Tc), net reproductive rate (NRR or R0), intrinsic rate of population increase (rm), etc. Considering potential fecundity (Pf), growth rates, mortality coefficient (MC), and expected population size in the second generation (PF2), we classified the susceptibility of the rice cultivars to S. cerealella in the order as M > C > G > S > T. This was despite the higher concentrations of all the tested primary metabolites (PMs) in C and T. The least susceptibility of T and lower susceptibility of C than M can be attributed to their higher levels of secondary metabolites (SMs). M was highly susceptible due to its lowest SM content and sufficient levels of PMs. Now, G and S contained lower amounts of SMs, but they were moderately susceptible owing to the lower PM content. This emphasises the role of SMs, such as phenols, flavonoids, tannins, saponins, alkaloids, phytates, and oxalates, in determining the susceptibility of crop cultivars. Although none of the rice cultivars were entirely resistant, it can be stated that Miniket requires more protection measures against S. cerealella during storage than the others.
The crucifer flea beetle, Phyllotreta cruciferae (Goeze), and the striped flea beetle, P. striolata (Fabricius) (Coleoptera: Chrysomelidae), are invasive pests to canola, Brassica napus (Linnaeus) (Brassicaceae), in North America. Understanding how temperature and predators influence flea beetle damage in canola is critical for improving current management strategies, yet these factors are rarely studied. We examined the prevalence (proportion of plants damaged), intensity (defoliation of damaged plants), and overall damage (mean defoliation = prevalence × intensity) caused by flea beetles on canola seedlings at different temperatures, plant densities, and with or without generalist predators. Flea beetles preferred to feed on the abaxial (undersides) of cotyledons rather than the typically assessed adaxial (top) side, regardless of temperature, and produced more stem and cotyledon damage at higher temperatures, regardless of the species. Predators Pardosa spp. (Araneae: Lycosidae) and Pterostichus melanarius (Illiger) (Coleoptera: Carabidae) reduced flea beetle abundance and the intensity of cotyledon defoliation. Pterostichus melanarius also reduced overall stem damage, whereas Pardosa spp. reduced stem damage intensity. Under constant flea beetle densities, canola sustained less damage at a higher plant density. These results suggest that reducing the number of flea beetles per seedling, through predation or higher plant density, may help reduce Phyllotreta damage to canola.
Obesity is characterised by chronic low-grade inflammation, which is a key factor in the development of obesity-related co-morbidities. Intake of n-3 long-chain PUFAs is associated with anti-inflammatory effects. Recent studies suggest that also n-11 long-chain MUFAs may reduce the concentrations of inflammatory markers, possibly by increasing the biosynthesis of EPA. The primary aim was to investigate if diets added herring oil containing cetoleic acid (CA, C22:1n-11) or a CA concentrate (CECO) affected the fatty acid composition in tissues from obese rats with chronic inflammation. Secondary aims included investigating the effects on inflammatory markers. Thirty male obese Zucker fa/fa rats were fed diets containing herring oil (HERO) or a CECO, containing 0·70 or 1·40 wt% CA, respectively, with a comparable content of EPA (0·17 and 0·20 wt%, respectively), or a control diet with soyabean oil for 5 weeks. Data were analysed using one-way ANOVA. CA from HERO and CECO diets were recovered in liver, adipose tissue, muscle and blood cells. The EPA concentration was similar between HERO and CECO groups in tissues, whereas the hepatic concentrations of fatty acid desaturases were lower or similar to Controls. The concentrations of TNFα, matrix metalloproteinase-3, IL6, monocyte chemotactic protein 1 and integrin α M in adipose tissue, and the hepatic concentration of CD68 were lower after CECO intake but were not affected by the HERO diet. To conclude, rats fed the CECO diet had lower concentrations of inflammatory and macrophage infiltration markers, but this effect was probably not mediated through increased EPA biosynthesis.
There is growing evidence that optimising dietary quality and engaging in physical activity (PA) can reduce dementia and cognitive decline risk and improve psychosocial health and quality of life (QoL). Multimodal interventions focusing on diet and PA are recognised as significant strategies to tackle these behavioural risk factors; however, the cost-effectiveness of such interventions is seldom reported. A limited cost consequence based on a 12-month cluster-randomised Mediterranean diet (MedDiet) and walking controlled trial (MedWalk) was undertaken. In addition, QoL data were analysed. Programme costs ($AUD2024) covered staff to deliver the MedWalk programme and foods to support dietary behaviour change. The primary outcome measure of this study was change in QoL utility score, measured using the Assessment of Quality of Life (AQoL-8D). Change scores were compared for the groups using general linear models while controlling for demographic factors associated with baseline group differences and attrition. Change in QoL (decreased, maintained or improved) was determined using a cross-tabulation test. MedWalk programme costs were estimated at $2695 AUD per participant and control group cost at $165 per person – a differential cost of $2530. Mean change in utility scores from baseline to 12 months was not statistically significant between groups. Nevertheless, the MedWalk group was significantly less likely to experience a reduction in their QoL (20·3 % MedWalk v. 42·6 % control group) (P = 0·020). A MedDiet and walking intervention may have a role in preventing decline in QoL of older Australians; however, longer-term follow-up would be beneficial to see if this is maintained.
In the summer of 2016, a case of potentially herbicide-resistant redroot pigweed (Amaranthus retroflexus L.) was reported in Saint-Louis-de-Gonzague (QC, Canada) in an identity-preserved soybean [Glycine max (L.) Merr.] field where imazethapyr and chlorimuron-ethyl were applied preemergence, two active ingredients that inhibit acetolactate synthase (ALS). A few years earlier, several A. retroflexus populations resistant to ALS-inhibiting herbicides were reported in Manitoba (MB). Amaranthus retroflexus samples from these fields were collected and analyzed to characterize the presence of a resistance mechanism and the associated level of resistance. Sequencing of the ALS gene revealed a mutation resulting in a serine to asparagine substitution at amino acid position 653. Dose–response experiments indicated resistance factors of 27.7 to 194.0 to imazethapyr (imidazolinones) among these populations, but susceptibility to members of all other ALS inhibitor families that were tested. In one MB population, a serine to isoleucine substitution at position 653 was observed for the first time in A. retroflexus in some of the plants, and this contributed to the detection of resistance to thifensulfuron-methyl when compared with most susceptible control population. The response of the two MB control populations to thifensulfuron-methyl differed, and resistance factors were influenced by the level of susceptibility of the control populations to thifensulfuron-methyl. The same was not observed with imazethapyr. Non–target site resistance (NTSR) was not detected in the MB populations when they were exposed to malathion before exposure to the herbicide. We identified two new mutations on the ALS gene in A. retroflexus that result in ALS inhibitor–specific cross-resistance patterns. Further investigation into NTSR and the mechanism behind the differential response of the control populations to thifensulfuron-methyl are warranted.
The objective of this study was to evaluate the impact of incorporating group-based nutritional education into usual care on adherence to nutritional counselling among outpatients with type 2 diabetes (T2DM). This parallel-group, randomised controlled superiority trial was conducted with outpatients diagnosed with T2DM and poor glycaemic control. The control group received individual usual care, while the intervention group received usual care plus group-based nutritional education, which included three sessions: ‘Let’s Go Shopping,’ ‘Healthy Plate’ and ‘Hunger and Satiety.’ Baseline and four-month follow-up assessments were conducted, and outcome measures included adherence to nutritional counselling, glycaemic control, weight and physical activity. A total of 213 participants were included: 61·9 % were women, aged 60 years (interquartile range (IQR) = 53–65), 67·6 % with low socio-economic status, 67·3 % had obesity and the glycated Hb (HbA1c) was 9·3 % (IQR = 8·3–10·2 %). The intervention did not result in superior glycaemic control; however, short-term reductions in HbA1c were observed across all participants (–0·3 % (IQR = –0·7–0·3 %)). The intervention group demonstrated an increase in physical activity levels between visits (262 metabolic equivalent tasks (IQR = 99–257); P = 0·038), but no significant difference between the groups. Participants in the intervention group adhered to 67 % of combinations, compared with 50 % in the control group (P = 0·012), and adherence to the diabetes plate method was significantly higher in this group (75·9 % v. 62·2 %; P = 0·05). In conclusion, no significant between-group differences in glycaemic control were found, although both groups improved HbA1c short-term. Group-based nutritional education increased dietary adherence, particularly to the diabetes plate method and physical activity. Long-term effects on metabolic outcomes warrant further study.
As a highly aggressive tumour of the digestive tract, pancreatic cancer has a high mortality rate and poor treatment outcomes. The five-year survival rate for patients with pancreatic cancer is distressingly low, and the recurrence chance remains unacceptably high even with successful treatment. Surgical procedures and chemotherapy are the main treatments of pancreatic cancer, and surgical procedures are the only effective treatment at present. However, these cancer cells can easily develop resistance to chemotherapy agents, which leads to low treatment efficacy and high mortality in pancreatic cancer. Additionally, early diagnosis of pancreatic cancer is challenging due to the absence of obvious symptoms, making surgical intervention unattainable in early stages. However, pancreatic cancer cells show unique changes at genetic and cellular levels, which makes them sensitive to metalrelated cell death or exhibit some characteristics related to metalrelated cell death. These changes and characteristics could be utilized for treatment and diagnosis in pancreatic cancer.
Method
Therefore, our motivation is to explain the potential of metalrelated cell death in treating this aggressive cancer. This review begins by analysing the types of metal-related cell death: ferroptosis, cuproptosis and lysozincrosis. Each form is evaluated based on its unique features and related metabolic pathways.
Results
By examining the key characteristics of metal-related cell death modalities, their primary metabolic patterns and their interactions with pancreatic cancer, our aim is to point the direction to identify potential therapies and treatments.
Conclusions
Our review expands the possibilities for utilizing metal-related cell death and instils hope for its future potential in pancreatic cancer treatment.
Sepsis affects 50 million people globally, contributing to 20 % of all deaths and significantly increasing healthcare costs due to intensive care needs. Although the role of n-3 fatty acids in reducing sepsis mortality remains debated, recent studies suggest their potential in modulating immune responses and improving outcomes. This umbrella review aims to clarify the benefits of n-3 supplementation on mortality rate, length of intensive care unit (ICU) stays and days on mechanical ventilation in patients with sepsis. Following Cochrane and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodologies, a systematic search was conducted across multiple databases up to February 2025. After independent screening, data extraction and critical appraisal, meta-analyses were reassessed using the DerSimonian and Laird model. Evidence was graded using the GRADE approach, categorising outcomes based on strength and quality. A comprehensive search identified 934 records, of which thirty-four randomised controlled trials (RCT) from twenty-one systematic reviews and meta-analyses focused on n-3 supplementation in sepsis patients. n-3 significantly reduced mortality (risk ratio: 0·79, 95 % CI 0·69, 0·90), length of ICU stays (mean difference (MD): −3·6 d, 95 % CI −4·39, −2·81) and ventilation days (MD: −2·86 d, 95 % CI −4·46, −1·26). Parenteral nutrition showed slightly better outcomes than enteral nutrition, and EPA and DHA provided superior results compared with mixed oils. These findings suggest n-3 supplementation could improve mortality, ICU stays and ventilator dependency in patients with sepsis. However, the certainty of the evidence ranges from low to very low, emphasising the need for further high-quality RCT to validate these benefits. Also, clinicians should prescribe n-3 supplements cautiously in this regard.