The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 21 twin studies from 5 countries (Australia, Denmark, Finland, Sweden, and United States) established to explore the nature of gene–environment interplay in cognitive, physical, and emotional health across the adult lifespan. The combined data from over 145,000 participants (aged 18 to 108 years at intake) has supported multiple research projects over the three phases of development since its inception in 2010. Phases 1 and 2 focused on launching and growing the consortium and supported important developments in data harmonization, analyses of data pooled across multiple studies, incorporation of linkages to national registries and conscription data, and integration of molecular genetic and classical twin designs. IGEMS Phase 3 focuses on developing appropriate infrastructure to maximize utilization of this large twin consortium for aging research.

This review aims to highlight some of the key bioactive functionalities that a range of components in milk can potentially make to reduce risks to health at key life stages. Such functionalities cannot be adequately explained by traditional estimates of nutrient supply. The benefits of gangliosides from the milk fat globule membrane (MFGM) for neonatal neurodevelopment are examined along with milk proteins for growth stimulation of children via the proteins’ ability to stimulate insulin-like growth factor-1 (IGF-1). Exosomes in bovine milk and their miRNA are bioavailable, with an animal study indicating that placenta development and embryo survival were both enhanced. Concerning bone health, the unique characteristics of the casein micelle for supplying Ca, P and Mg to the GI tract were considered. The so-called dairy food matrix and the hypotensive effect of some peptides from milk proteins may be compensatory factors for SFA regarding CVD risk. The recent rise in use of glucagon-like peptide-1 (GLP-1) receptor agonists for adiposity reduction and improving glycaemic control is noted alongside evidence that milk proteins can stimulate GLP-1 synthesis potentially reducing GLP-1 receptor agonist need in high milk protein consumers. Other functionality included the ability of whey proteins to stimulate synthesis of skeletal muscle protein, crucial for bone protection and glycaemic control and the role of milk/Ca for reducing colorectal cancer risk. Perhaps the most exciting functionality is that of polar phospholipids in the MFGM potentially improving cognition and reducing the risk of dementia in the elderly. Clearly more human studies are needed.

Disasters and emergencies, from natural hazards to complex crises, demand a fundamental shift in traditional management paradigms. At all levels of disaster and emergency management, from frontline responders to high-level policymakers, 2 integrated concepts—situational awareness and a disaster mindset—are critical for effective response and resilience. Situational awareness is not merely the collection of data; it’s the dynamic and continuous process of perceiving, comprehending, and projecting a holistic understanding of the operational environment, including evolving threats, available resources, and stakeholder dynamics. When fused with a disaster mindset—a psychological and strategic posture characterized by proactive anticipation, radical adaptability, and decisive action under pressure—it creates a powerful framework for navigating uncertainty. This paper, presented as the Frederick M. (“Skip”) Burkle lecture, proposes a new, integrated framework that systematically applies these concepts to enhance decision-making and operational effectiveness across all managerial tiers, enabling a transition from a reactive to a proactive and resilient posture in the face of escalating global complexities.

The political representation and agency of young people in international politics is still poorly understood, notwithstanding sustained interest in the pluralisation and diversification of transnational civil society and the ‘opening up’ of IOs in international relations (IR) scholarship. In this article, we put forward a theoretical framework for the study of youth representation in IR that is at once responsive to the specificities of youth and, at the same time, contributes to theory-building on political representation of newly recognised constituencies in international institutions overall. Theoretically, we build on constructivist and performative theories of representation, and we use our empirical insights to extend and qualify these theories. Empirically, we provide the first in-depth study of youth representation in global health governance. Based on an interpretive analysis of policy documents and qualitative interviews with youth participants at three major global health events, our study explores prevalent portrayals of youth as a constituency and problematises the legitimising effects of these portrayals. Moreover, we expose how multiple barriers and intersecting inequalities constrain young people’s encounters with exclusive spaces of global health policy-making and we point to the reflective and ambiguous ways in which young people embrace, enact, and question ‘youth’ as a political category.

Food insecurity is a global issue. The objective is to summarise the literature identifying the main outcomes related to out-of-school hours interventions that provide food for low-income families with school-aged children, how they impact school-aged children and their families, and to identify gaps in knowledge. This review covered the main types and dimensions proposed in the literature. One author independently selected the studies, and an independent reviewer randomly reviewed them. Any paper meeting the inclusion criteria was considered regardless of geographical location. Papers were predominantly from the US, UK and Australia, including school-aged children from low-income families. Ninety-four articles were included relating to holiday clubs (n = 38), breakfast clubs (n = 45) and after-school clubs (n = 11). Key outcomes were healthy eating, academic, social, physical activity, nutritional education and financial outcomes. Clubs were consistent regarding the positive social and financial outcomes. There was variation in the primary aim, either to improve healthy eating or to feed children, regardless of nutritional quality. None of the studies reported children’s health outcomes. This review identified the key outcomes of interventions for low-income families outside of school hours in the literature. It highlights the consistent positive social outcomes across the three intervention types and the discrepancy in the nutritional value of the food provided. Few studies examined the attainment impact of holiday clubs, with no evidence on how they could impact term-time attendance. This highlights the need to analyse secondary data to understand further the attainment and attendance impact on children attending these interventions over time.

Social relationships provide opportunities to exchange and obtain health advice. Not only close confidants may be perceived as sources of health advice, but also acquaintances met in places outside a closed circle of family and friends, e.g., in voluntary organizations. This study is the first to analyze the structure of complete health advice networks in three voluntary organizations and compare them with more commonly studied close relationships. To this end, we collected data on multiple networks and health outcomes among 143 middle-aged and older adults (mean age = 53.9 years) in three carnival clubs in Germany. Our analyses demonstrate that perceived health advice and close relationships overlap only by 34%. Moreover, recent advances in exponential random graph models (ERGMs) allow us to illustrate that the network structure of perceived health advice differs starkly from that of close relationships. For instance, we found that advice networks exhibited lower transitivity and greater segregation by gender and age in comparison to networks of close relationships. We also found that actors with poor physical health perceive less individuals as health advisors than those with good physical health. Our findings suggest that community settings, such as voluntary associations, provide a unique platform for exchanging health advice and information among both close and distant network members.

Population ageing, increased immigration and strained public resources will challenge the future provision of formal older-age care. Despite growing diversity in older populations across Western countries, evidence on health-care utilization among older immigrants remains limited. Using full-population registry data from Norway (2011–2016) for individuals aged 60+, we examined transitions into home health care (HHC) and intensity of use (hours/day) by immigrant background. Across all country-of-origin groups, immigrants had lower odds of transitioning into HHC than natives, with differences narrowing as duration of residence increased. A broad socio-demographic patterning to HHC transitions generally held across the country background groupings. Higher transition likelihoods were observed for individuals with lower education, lower income, living alone, and residing in less urban areas. Childlessness was linked to higher relative transition propensities among natives and Nordic immigrants, but lower relative propensities among Western-origin and Eastern European immigrants. Among non-Western immigrants, childlessness appeared to have little influence on transition propensities. For HHC intensity, only non-Western immigrants received significantly fewer hours of care than natives. Subsequent analysis indicated that this difference was entirely contingent on living alone: Only non-Western immigrants living alone had significantly fewer hours of care than natives (living alone or otherwise). These findings highlight clear variation in HHC utilization by immigrant background and socio-demographic characteristics. Future research should investigate whether lower HHC use among older immigrants reflects reduced need or barriers to access. It will also be important to assess how compositional changes in the immigrant population may influence future patterns of HHC utilization.