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Experiments have shown that ultrasound-stimulated microbubbles can translate through gel phantoms and tissues, leaving behind tunnel-like degraded regions. A computational model is used to examine the tunnelling mechanisms in a model material with well-defined properties. The high strain rates motivate the neglect of weak elasticity in favour of viscosity, which is taken to degrade above a strain threshold. The reference parameters are motivated by a 1 $\unicode{x03BC}$m diameter bubble in a polysaccharide gel tissue phantom. This is a reduced model and data are scarce, so close quantitative agreement is not expected, but tunnels matching observations do form at realistic rates, which provides validation sufficient to analyse potential mechanisms. Simulations of up to 100 acoustic cycles are used to track tunnelling over 10 bubble diameters, including a steady tunnelling phase during which tunnels extend each forcing cycle in two steps: strain degrades the tunnel front during the bubble expansion, and then the bubble is drawn further along the tunnel during its subsequent inertial collapse. Bubble collapse jetting is damaging, though it is only observed during a transient for some initial conditions. There is a threshold behaviour when the viscosity of the undamaged material changes the character of the inertial bubble oscillation. Apart from that, the tunnel growth rate is relatively insensitive to the high viscosity of the material. Higher excitation amplitudes and lower frequencies accelerate tunnelling. That acoustic radiation force, elasticity and bubble jetting are not required is a principal conclusion.
An asymptotic model for the flow of a highly viscous film coating the interior of a slippery, flexible tube is developed and studied. The model is valid for the axisymmetric flow of moderately thick films, and accounts for tube flexibility, wall damping, longitudinal tension, slip length and strength of base flow due either to gravity or airflow. In the absence of base flow, linear stability analysis shows the existence of one unstable mode; the presence of base flow allows for multiple unstable modes arising due to the Plateau–Rayleigh instability and elastic instability, with stronger base flow reducing the maximum growth rate. Numerical solutions in the absence of base flow show that slip decreases the amplitude of wall deformations and can significantly decrease the time to plug formation in weakly flexible or strongly damped tubes. For falling films, the impact of model parameters on the critical thickness required for plug formation was analysed by studying turning points in families of travelling-wave solutions; this thickness decreases with slip, flexibility and tension, while damping had a non-monotonic impact on critical thickness. In contrast to model solutions in rigid tubes, for flexible tubes the critical thickness cannot be made arbitrarily large through simply increasing the strength of the base flow. For air-driven films, both slip and flexibility increase the rate of film transport along the tube.
Let d be a positive integer, and let $\mathfrak {a}$ be an ideal of a commutative Noetherian ring R. We answer Hartshorne’s question on cofiniteness of complexes posed in Hartshorne (1970, Invent. Math. 9, 145–164) in the cases $\mathrm {dim}R=d$ or $\mathrm {dim}R/\mathfrak {a}=d-1$ or $\mathrm {ara}(\mathfrak {a})=d-1$, show that if $d\leqslant 2$, then a complex $X\in \mathrm {D}_\sqsubset (R)$ is $\mathfrak {a}$-cofinite if and only if each homology module $\mathrm {H}_i(X)$ is $\mathfrak {a}$-cofinite; if R is regular local, $\mathfrak {a}$ is perfect and $d\leqslant 2$, then $X\in \mathrm {D}(R)$ is $\mathfrak {a}$-cofinite if and only if every $\mathrm {H}_i(X)$ is $\mathfrak {a}$-cofinite; if $d\geqslant 3$, then $X\in \mathrm {D}_\sqsubset (R)$ is $\mathfrak {a}$-cofinite and $\mathrm {Ext}^j_R(R/\mathfrak {a},\mathrm {H}_i(X))$ is finitely generated for $j\leqslant d-2$ and $i\in \mathbb {Z}$ if and only if every $\mathrm {H}_{i}(X)$ is $\mathfrak {a}$-cofinite.
Dignity has been a notoriously elusive concept to philosophers. Nevertheless, in the realms of politics, law, and policymaking, appeals to dignity are frequent, and do not always align with the understandings most commonly endorsed by the philosophical literature. This paper considers how “dignity” is frequently appealed to in ethical arguments about the permissibility of abortion, and argues that the judicial decisions related to reproductive and LGBTQ+ rights over the past 30 years in the United States offer deep insights into the nature of “dignity” that philosophers and other theorists ought to pay attention to. These insights not only have profound implications for our understanding of the nature of “dignity,” but also for ethical analysis more broadly.
A 103 km2 aerial lidar survey of Dzibanche/Kaanu’l, Mexico, reveals the city’s settlement to be more populous and well-organized than previously thought. The sprawling settlement incorporated the early center of Ichkabal in a network of smaller peri-urban civic-ceremonial nodes. The density and complexity of the Kaanu’l settlement is consistent with its extraordinary political reach as a multiregional hegemonic state. The city and settlement grew to their maximum extent during the Early Classic period until AD 630. The lidar-derived data show that Dzibanche may have had the largest monumental zone and highest population density in the Maya Lowlands at that time. The Early Classic layout was unaltered by later construction, allowing us to document a well-developed system of causeways connecting an urban center and peripheral plaza groups with surrounding settlements and agricultural fields. The spatial organization and interconnectedness of this Early Classic settlement suggests a greater level of urban planning for optimal flow of goods and people across urban and peri-urban zones than previously thought.
Historical analysis of Ghana’s late colonial mine communities has been extensive and overwhelmingly dominated by organised and politically active male mineworkers. Questions regarding the linkages between formal and informal mining actors and cultural ideas in the broader mine communities have remained inadequately explored. This article makes a timely investigation by critically analysing a range of governmental and corporate archival documents and situating the discussion within the context of expansive literature on Asante, and complemented by oral histories. It centres on the Asante/Akan term “kankyema”—a sociocultural phenomenon which women transformed towards economic ends to navigate the late colonial political economy’s mining income disruptions. The article argues for the essential need to centre marginalised voices in understanding diverse agencies in African mining history and for a deeper reflection on the potentialities of contextual sociocultural ideas—notably, how marginalised actors invoke and evoke their capacities over different times.
Pulmonary embolism is said to be more common in clozapine-treated patients than either in patients treated with other antipsychotics or in the general population.
Aims
To explore clinical features and outcomes of clozapine-related pulmonary embolism in the UK.
Method
We studied UK Yellow Card reports recorded as clozapine-related respiratory, thoracic and mediastinal disorders, 1990–2022.
Results
Of 474 unique reports of people with clozapine-associated pulmonary embolism, 339 (59% male) remained after applying strict exclusion criteria. Of these, 164 patients (48%) died. The mean clozapine dose was 336.7 (range 25–1000) mg d−1 (N = 126). There was no difference in dose between the fatal and non-fatal outcomes. The median age at onset of pulmonary embolism was 45 years (range 21–82 years; N = 309). The median duration of clozapine treatment until onset was 2.9 years (range 2 days–22.7 years; N = 306). Sixty-five (39%) non-fatal and 36 (22%) fatal emboli occurred within 1 year of treatment. People who died were more likely to be obese (adjusted odds ratio 2.61; 95% CI 1.44–4.91) and to be noted as sedentary (adjusted odds ratio 6.07; 95% CI 1.58, 39.9). The 3 year moving average of cases was 0–5 per year, 1990–1999, 26 in 2010 and 16 in 2022. There was no change in the proportion of deaths by year of report (p = 0.41).
Conclusions
Clozapine-related pulmonary embolism is a significant concern with a high fatality rate. This risk necessitates a proactive approach to not only prevention, but also early recognition and management.
We investigate theoretically the breakup dynamics of an elasto-visco-plastic filament surrounded by an inert gas. The filament is initially placed between two coaxial disks, and the upper disk is suddenly pulled away, inducing deformation due to both constant stretching and capillary forces. We model the rheological response of the material with the Saramito–Herschel–Bulkley (SHB) model. Assuming axial symmetry, the mass and momentum balance equations, along with the constitutive equation, are solved using the finite element framework PEGAFEM-V, enhanced with adaptive mesh refinement with an underlying elliptic mesh generation algorithm. As the minimum radius decreases, the breakup dynamics accelerates significantly. We demonstrate that the evolution of the minimum radius, velocity and axial stress follow a power-law scaling, with the corresponding exponent depending on the SHB shear-thinning parameter, $n$. The scaling exponents obtained from our axisymmetric simulations under creeping flow are verified through asymptotic analysis of the slender filament equations. Our findings reveal three distinct breakup regimes: (a) elasto-plastic, (b) elasto-plasto-capillary, both with finite-time breakup for $n\lt 1$, and (c) elasto-plasto-capillary with no finite-time breakup for $n=1$. We show that self-similar solutions close to filament breakup can be achieved by appropriate rescaling of length, velocity and stress. Notably, the effect of the yield stress becomes negligible in the late stages of breakup due to the local dominance of high elastic stresses. Moreover, the scaling exponents are independent of elasticity, resembling the breakup behaviour of finite extensible viscoelastic materials.
This article examines the intellectual and interventionist trajectory of American popular writer and commentator Robert Reich from his early 1980s advocacy of “industrial policy” to his time as US Secretary of Labor in the 1990s. It argues that Reich is an interesting figure to consider through the lens of “interventionist knowledges” because, although he draws selectively on social scientific data and knowledge, his syntheses of these things are more rooted in mythic thinking than in disciplined analysis. This article recounts the history of a failed bill, the Reemployment Act of 1994, to examine how Reich and those around him drew on and interpreted existing social scientific data to construct an idea of “the New Economy” and what, they claimed, it meant for national human capital policy. This article suggests that mythic visions of society and economy possibly play a large role in policy-making and issues advocacy.
In air-entraining flows, there is often strong turbulence beneath the free surface. We consider the entrainment of bubbles at the free surface by this strong free-surface turbulence (FST). Our interest is the entrainment size distribution (per unit free surface area) $I(a)/A_{\textit{FS}}$, for bubbles with radius $a$ greater than the capillary scale ($\approx 1.3\ \mathrm{mm}$ for air–water on Earth), where gravity dominates surface tension. We develop a mechanistic model based on entrained bubble size being proportional to the minimum radius of curvature of the initial surface deformation. Using direct numerical simulation of a flow that isolates entrainment by FST, we show that, consistent with our mechanism, $I(a)/A_{\textit{FS}} = C_I \, g^{-3} \varepsilon ^{7/3} (2 a)^{-14/3}$, where $g$ is gravity, and $\varepsilon$ is the turbulence dissipation rate. In the limit of negligible surface tension, $C_I\approx 3.62$, and we describe how $C_I$ decreases with increasing surface tension. This scaling holds for sufficiently strong FST such that near-surface turbulence is nearly isotropic, which we show is true for turbulent Froude number ${\textit{Fr}}^2_T = \varepsilon /u_{\textit{rms}} g \gt 0.1$. While we study FST entrainment in isolation, our model corroborates previous numerical results from shear-driven flow, and experimental results from open-channel flow, showing that the FST entrainment mechanism that we elucidate can be important in broad classes of air-entraining flows.
The present study investigated the cross-national measurement invariance of a 10-item Youth Externalizing Problems Screener (YEPS) on a sample of 17,489 adolescents from 32 countries. The original one-factor and two-factor models of YEPS were found to provide a poor fit to the data in most countries. Following the removal of two semantically overlapping items and the inclusion of correlated error terms, adequate model fit was obtained in 31 of 32 countries. Measurement invariance testing of an abbreviated 8-item YEPS (YEPS-SF) supported configural invariance. Partial scalar invariance was achieved only after freely estimating numerous parameters. The alignment analysis revealed that 22% of parameters were non-invariant across countries. South Africa, Hungary, and India showed the largest number of non-invariant parameters, whereas the lowest number was detected in several European countries. These findings highlight the potential of the YEPS-SF for use within individual countries and the challenge of developing cross-culturally comparable measures, suggesting that cultural adaptations may be necessary.
Two expert groups on global health from Norway and Denmark have recently made important strides in reenergizing the debate on the role of the Nordic countries in global health. Their tailored recommendations — emphasizing core values of human rights, equity, accountability, and local ownership alongside health security — have proven influential at a time when new forms of international collaboration in global health are urgently needed.
Why has political representation by Scheduled Castes in post-colonial India failed to improve the lives of the vast majority of this population? One common answer rests on the assumption that caste inequality is upheld by dominant social groups who effectively resist progressive state policy. Others point to the institution of joint electorates: though constituencies are reserved for Scheduled Caste legislators, Scheduled Caste voters form a minority within them; the representatives thus elected are chosen primarily by others, and precisely because they will not challenge the status quo, it is said. But neither of these explanations, I argue, can adequately account for the minimal effects of Scheduled Caste representation, because both imagine states as confronting a distinct realm—‘society’—with pregiven interest groups that are then represented in legislatures. Instead, an examination of how state actions themselves govern, produce, and reproduce caste groups and intercaste relations is required. The argument is illustrated through episodes from the career of Dr Sathiavani Muthu, who sought to address injustices suffered by Scheduled Castes in Tamil Nadu from the late 1950s through to the 1980s. Muthu’s skill, diligence, and commitment make her an ideal representative, and Tamil Nadu as a state ought to provide a best-case scenario for the success of such an actor, given the scholarly consensus regarding its good governance and the pervasion of its society with a progressive ideology. An analysis of why her efforts nevertheless produced little fruit reveals pervasive deficiencies in current models of political representation.