Better evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD). One hallmark neurocognitive feature of ADHD is impaired inhibition, related to impulsivity. Given the high heritability of ADHD, the assessment of genetic background of impaired inhibition may contribute to our knowledge about the genetic background of the disorder.

In our study we investigated whether different forms of impulsivity (attentive, motor, and nonplanning) and polymorphisms in genes of the noradrenergic, serotonergic, and dopaminergic neurotransmission, i.e. dopamine transporter-1 (DAT1), cathecoloamin-O-metiltransferase (COMT), and serotonin receptor-1B (HTR1B genes show association.

208 aADHD patients diagnosed according to DSM-5 criteria from a clinical sample and 142 individuals from a population sample who screened positive for aADHD were included in the study. DNA samples were genotyped for the HTR-1B gene rs1321041 and the COMT gene rs4680 SNPs, moreover the DAT-1 VNTR polymorphism. Dimensional variables for impulsivity were compared between genotypes with the Generalized Linear Model procedure corrected for sex and age, using the PLINK 1.9 statistical software.

The 9 repeat polymorphism in DAT1 was associated with the severity of hyperactivity, moreover, all impulsivity factors. The A allele in COMT was associated with hyperactivity and better motor inhibition activity. In carriers of the G allele in HTR1B we detected significantly higher inattention scores and increased reaction time.

Our results support the putative role of the investigated genetic polymorphisms in the etiology of impulsivity. Nevertheless, these polymorphisms demonstrate a heterogeneous associations.

No significant relationships.

The term “two-eyed seeing” is spreading across North America as a concept for explanatory pluralism. The concept was brought into academic science by Albert Marshall, a M’iqmaq from Nova, Scotia, Canada. It speaks to the idea that indigenous knowledge is an equally valid way of conceptualizing a phenomenon as is contemporary science. Marshall’s famous example compares a traditional M’iqmaq story about the origins of the large tides in the Bay of Fundy with contemporary oceanographic geology findings and simulations.

We wanted to explore how this two-eyed seeing model could be applied to mental health to facilitate a dialogue between psychiatry and traditional cultural healers.

We reviewed the existing literature on two-eyed seeing within mental health care using PubMed, IndexMedicus, OneSearch, and Google Scholar. We presented a course on two-eyed seeing for indigenous mental health services and two-eyed seeing for addressing trauma in indigenous communities and surveyed the participants about the two-eyed seeing concept. We offered this course primarily to providers within indigenous communities and also for other interested counsellors.

Participants in our trainings were enthusiastic about the role of two-eyed seeing for improving communication among indigenous providers and patients and non-indigenous providers. Most indigenous counselors had not heard of two-eyed seeing and were quite enthusiastic about its affirming nature and how it gave them a basis for dialogue with non-indigenous practitioners.

Two-eyed seeing allows a rich dialogue between European-derived practitioners and indigenous people that enabls each to appreciate the other’s perspectives, leading to greater cooperation and collaborative treatment.

No significant relationships.

Syndemics are synergistically interacting epidemics (for example, the epidemics of substance use disorders and forced displacement) in a particular context with shared drivers such as pre-existing political, structural, social and health conditions. Policymakers may ask what the risks of and needs are for forcibly displaced people with regards to substance use disorder (SUD). Working from a syndemics framework, we would argue that multiple risk and resiliency factors relating to both forced displacement and SUD work synergistically, and impact more significantly upon some populations than others. These risk factors include structural inequality and racism, social deprivation, violence, homelessness, trauma, childhood adversity, and co-morbid physical and mental health disorders. Individuals may become vulnerable while experiencing displacement, during transition, settlement or resettlement, and also through their life across and across generations. In this perspective, our answers to policymakers becomes more nuanced. We may argue for integrated, multi-modal interventions, cross-disciplinary collaborations, cross-pollination of ideas and knowledge and embedding lived experience to bridge gaps and make use of limited resources in sustainable ways. This presentation will detail aspects of the application of a syndemic lens to the evidence base on SUD among forcibly displaced people and generate discussion on what scientists, clinicians and policymakers can and may do with these insights.

None Declared

Suicide is the third leading cause of death in adolescents (15-19 years). Physical pain is an important risk factor for suicidal thoughts and behaviors, especially in a delicate phase as adolescence.

Several studies investigated this association and the aim of this meta-analysis was to synthesize data in literature about this topic in adolescents (11-20 years).

We started from a systematic review published by Hinze and colleagues in 2019 and we searched on PubMed (January 2019-June 2020) studies comparing rates of suicidal outcomes (Suicidal Ideation, Suicide Plan, Attempt, Self-Harm: SI, SP, SA, SH) in individuals with any type of physical pain (head, back, neck, chest, stomach, abdomen, muscle, joint, arthritis) vs. those without it. Data were analyzed with Comprehensive Meta-Analysis software (CMA, version 3).

Of the 16 included studies, eleven focused on SI (68.8%), six (37.5%) on SA, four (25%) on SH and two (12.5%) on SP. Adolescents with physical pain were more likely to report SI (p < .001), SH (p < .001), SA (p = .004) and SP (p = .006). In all analyses, the between study heterogeneity was high. The presence of publication bias has been detected in SI (k≥10).

Results are in line with previous literature on this topic. Future research should investigate the specific impact of: acute vs. chronic pain; different types and intensities of pain; planned vs. impulsive action and therefore suicidal intent; role of psychological factors (in particular sensitivity and tolerance to physical pain).

A 12 month long mental health promotion pilot programme in Hungary, funded by the Norway Grants, will finish on 30th April 2017.

To launch six community mental health promotion centers (MHPCs) located in various economic environments, supervised by one Methodological Center plus expert teams and carrying out studies on the effectiveness of the launch of the system. The final recommendations will constitute a basis for setting up a national network for mental health promotion.

To develop a sustainable model for establishing a national network of MHPCs; to map and record the mental health problems and the stakeholders of the area; to find and assess the local best practices; and to raise public awareness in the following mental health problems: depression, suicide, stress and dementia.

(1) Models for inducing changes in the knowledge and attitudes upon mental health in the communities were reviewed in a systematic literature search. (2) Based on the results, a model of mental health promotion centers was outlined for problem identification, stakeholder mapping, assessing local best practices, organizing and supporting local networking activities for synergistic effects. (3) In the new MHPCs, on-site TTT education programme and organisational development have been in place. (4) The activities of the MHPCs have been monitored for knowledge transfer and attitude changes in the local networks. (5) Based on the results, recommendations are being made for the national extension of the model.

The first data ready for analysis will be available by April 2017.

The authors have not supplied their declaration of competing interest.

Taste perception is a complex phenomenon modulated by different factors, such as taste receptors and memory brain circuitry. The palatability of the food, that activates central reward pathways, also plays an important role in taste perception. It means that taste is able to influence the choice of food and then the eating behavior.

It's well known that people with anorexia nervosa (AN) have lower sensitivity to reward stimuli and recent studies have shown that altered function of taste neural circuitry may contribute to restricted eating in AN.

The aim of this study is to evaluate, in patients suffering from AN, the activation of the brain areas involved in taste perception and in central reward mechanisms to both pleasant and aversive taste stimuli and to correlate gustatory neural circuitry activity with eating behaviors, temperament measures and/or sensitivity to reward and to punishment.

12 underweight AN patients and 12 normal-weight healthy subjects underwent a functional MRI to measure brain areas activation to repeated stimuli of a pleasant taste, a sucrose solution, alternated with an aversive taste, a bitter solution, and a water taste.

Preliminary results showed, in patients with AN, a dysfunctional activation of brain areas involved in both taste perception and reward mechanisms following both the pleasant and aversive stimulus.

These results, if confirmed in future analyses, may improve our knowledge about the pathophysiological mechanism of AN.

The author has not supplied his declaration of competing interest.

In many countries suicide is one of the leading causes of death among children and adolescents. Identifying young people at risk and offering effective treatment is a major concern of mental health policies.

To look for the presence of suicidal thinking, plans and attempts in adolescents.

Measure the presence of suicidal tendencies having in mind possible correlation with psychological difficulties (measured by SDQ), level of depression, hopelessness and self-esteem of adolescents in one school sample.

The sample of adolescents at school have been offered to fill out CESD, Hopelessness scale for children, Rosenberg self-esteem scale, SDQ questionnaire and four item adopted questions about suicidal tendencies. All data has been analyzed by SPSS 14.0.

In the sample of 768 adolescents (12-20yr, mean Age=17, 52) 22, 1% of them declared suicidal thinking, 3, 9% planed and 2, 2% attempted. About third of them didn’t find any reason for these tendencies. Females showed more suicidal tendencies but significantly only for thinking. Tobacco, alcohol and marihuana users have significantly more suicidality. Youths who declared more test anxiety have significantly more suicidal thinking. Significantly association is found between suicidal tendencies and psychological difficulties (emotional, conduct, hyperactivity and peers problems). Depression and high hopelessness also have significances. Suicidality is significantly higher in youths with normal self-esteem.

Suicidality is much presented in our sample and showed significantly association with substance use, psychological difficulties, hopelessness, depression and normal self-esteem.

Pregnancy represents a critical life stage for its physical and emotional changes. Maternal thoughts are often oriented to the worry to lose control on their body, and to their new physical shape. According to this, literature on eating disorder (ED) highlights how pregnancy is usually associated to a temporary interruption of the dysfunctional eating habits due to the move of concerns about the self and the body toward the caregiving of the baby.

The goal of the present study is to explore the impact of generalized difficulties in emotion regulation (as a stable trait) versus specific difficulties in emotion regulation (as pregnancy-related) in women with pre-pregnancy eating problems.

The sample is made by 15 women previously overweight and recruited during their 3^rd trimester of pregnancy. The following measures were administered: Difficulties in Emotion Regulation Scale (DERS), Eating Attitudes Test (EAT-26), Emotional Difficulties Specific to Pregnancy Scale (EDS), and the Adult Attachment Interview (AAI).

Preliminary findings have shown how higher scores on the DERS Impulse scale as well as higher difficulties in handling emotional states related to pregnancy (e.g. fear of the delivery) are associated to the existence of dysfunctional eating behaviors during the 3rd trimester.

Emotion regulation has emerged as a transversal skill during the life cycle. Difficulties in this area seem to represent a stable trait in the individual functioning, with the risk to affect the eating behaviors, as well as the health of the mother and the baby during pregnancy.

Facebook use among Teenagers has become a very common phenomenon. Its use can resuly in Facebook addiction .

To estimate the prevalence of problematic Facebook use among a sample of school-going adolescents.

This is a cross-sectional and descriptive study carried out among 110 school-going adolescenthe at 2 state colleges in Sidi Bouzid. We used a pre-established self-questionnaire containing 2 parts: a part exploring the socio-demographic data of the adolescent and a psychometric part: Bergen Facebook addiction Scale.

Study participants had a mean age of 14.4 years with extremes of 12 to 17 years. The sex ratio (M / F) (46/64) of the participants was 0.71.In our population, 13 students (11.8%) were smokers. Two students (1.8%) consumed alcohol. Cannabis use was noted in only one student.The majority of students (102), or 92.7%, had been online for more than a year.The daily Facebook connection time was more than 4 hours for 20.9%. Boredom was the number one reason for logging into Facebook for 82 students (74.5%) followed by curiosity for 45 students (40.9%). Fifteen students (13.6%) were addicted to Facebook (score> 10 on the Bergen Addiction Scale.

Facebook can be a useful and interesting tool to maintain and develop a network of relationships and create new ones. Its problematic use or addiction to Facebook has become a new scourge of public health. Faced with the negative impact of this addiction, It would be necessary to rationalize this use.

No significant relationships.

The purpose of this study was to assess the factors that influence attitudes of people neighbouring to residential care facilities that host chronic psychiatric patients formerly hospitalized in a psychiatric hospital, 2 years after their deinstitutionalization.

One member of at least 30 households neighbouring to 8 community-based psychiatric facilities (hostels and sheltered apartments) was interviewed by a group of specially trained social workers. The structured interview used was compiled specifically for the needs of this study.

Less than 25% of our sample had adequate knowledge of the term ‘deinstitutionalization’ and in particular people with higher education and that have been visited by a psychiatric resident. Nevertheless, their attitudes were in general positive. In a regression analysis, attitude towards deinstitutionalization was found to be positively correlated with having visited a psychiatric facility, years of education, and living near 4 out of the 8 psychiatric hostels [R-squared=0.20]. Female neighbours were generally more favourable, but this effect was only marginally significant. Attitude towards the psychiatric patient was best predicted by years of education, having visited a psychiatric hostel and living near 2 out of the 8 psychiatric hostels [R-squared=.21]. Age was generally negatively correlated with attitudes towards the patient [r=-0.23]. There were also significant differences among the attitudes of the various hostel neighbourhoods.

Apart from education, age, and gender the most important factors in influencing attitudes towards deinstitutionalization and patients are local. Choice of favourable locations for psychiatric facilities and cultivation of a positive neighbourhood climate are important.

The Adolescent Day Treatment Program (ADTP) established in Summer 2000 in Calgary, Alberta, Canada provides multi-disciplinary non-residential day treatment for mentally disturbed youth aged 13 to 18 years who suffer from moderate to severe forms of mental health disorders that do not to require hospitalization or as a step-down from hospitalization. the treatment approach includes pharmaco-therapy, psychiatric consultation, psycho-educational groups, individual, group and family therapy, occupational and recreational therapy and school board-operated educational programming.

Data descriptions and repeated measure analyses included variables representing demographics, length of stay, diagnoses, admission and discharge problem severity, goal achievement ratings, and Children's Global Assessment Scale (CGAS).

Significant improvement was observed over the course of treatment in the majority of patients in outcome measures (problem severity and goal achievement) and CGAS. Follow-up of a sub-sample of those served indicates that function at the time of discharge best predicts adaptation at the time of follow-up.

Day treatment appears to be effective and clinical effects persists at the time of follow-up and are predicted primarily by discharge function.

We aimed to study HMGB1, pro- and antioxidant status alongside with T cells phenotype and Th1 and Th17 proinflammatory cytokine profiles in depressed patient. We also investigated the glucocorticoid response.

Blood was collected from patients diagnosed with recurrent depressive disorder (rDD) (N = 15) and from healthy controls (N = 19). We measuredplasma hydrogen peroxide (H2O2) and reduced glutathione (GSH), malondialdehyde (MDA) levels as well as SOD1, GPx, GR activities in red blood cells. HO1 and NOX4 levels in plasma were also assayed. IL-2, IL-6, IL-8, IFN-g, TNF-a, IL-17, HMGB1, neopterin and cortisol were analyzed in sera. Further, we examined surface phenotype expression of T regulatory and T effector cells with flow cytometer. The glucocorticoid response was measured by dexamethasone-induced inhibition of IL-6 produced by LPS-stimulated peripheral blood.

We observed pro- and antioxidant imbalance in depressed patients expressed by significant changes in the enzyme activities, increased MDA, decreased GSH, increased H2O2. Shifted Th1/Th17 cytokine ratios, increased Treg/Teffector cells ratio and increased levels of neopterin were also detected. Moreover, we revealed a distinct role of HMGB1 in maintaining cytokine and Treg/Teffector cells balance in depressed patients. HMGB1 remained also in relation with oxidant potential of the blood. The important role of IL-17 and inhibitory effect of MDA on glucocorticoids response was also revealed.

Strong immunomodulatory role of HMGB1 might be related to the change of its activity caused by redox imbalance in depressed patients. The shifted immune balance alongside with prooxidative environment modulates glucocorticoid response in these patients.

To develop a toolkit (QuIRC) for assessing the living conditions, care and human rights of people with long term mental illness in psychiatric and social care facilities.

The QuIRC was developed by research partners across ten countries: UK; Germany; Spain; Czech Republic; Bulgaria; Italy; Netherlands; Poland; Greece and Portugal. Its content was informed by triangulation of the evidence on critical components of care collated from: a review of care standards in each country; an international literature review; and Delphi exercises. Its final format was agreed by an international panel of rehabilitation and recovery experts. QuIRC scores were compared against service users’ quality of life, autonomy, experiences of care and markers of recovery to assess whether the QuIRc could provide a proxy-assessment of the unit’s promotion of service users’ autonomy and Recovery.

The finalised tool was used to interview managers from 21 units throughout Germany. One hundred and eighty-eight service users were also interviewed. QuIRC domain ratings were compared by facility type and with service user assessments. The QuIRC’s ability to deliver assessments relevant to Germany’s established systems of change at local, regional and national level will be discussed.