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In this introductory chapter to a book on the biophysical foundations and computational modeling of electric and magnetic signals in the brain, we give a brief summary of measurement techniques and modeling approaches in computational neuroscience.
It is common to study the electric activity of neurons by measuring the electric potential in the extracellular space of the brain. However, interpreting such measurements requires knowledge of the biophysics underlying the electric signals. Written by leading experts in the field, this volume presents the biophysical foundations of the signals as well as results from long-term research into biophysics-based forward-modeling of extracellular brain signals. This includes applications using the open-source simulation tool LFPy, developed and provided by the authors. Starting with the physical theory of electricity in the brain, this book explains how this theory is used to simulate neuronal activity and the resulting extracellular potentials. Example applications of the theory to model representations of real neural systems are included throughout, making this an invaluable resource for students and scientists who wish to understand the brain through analysis of electric brain signals, using biophysics-based modeling.
Chapter 6 summarizes new postulates of physicochemical mechanics and gives a simple but systematic derivation of all major transport and equilibrium relations.
Based on physicochemical mechanics, Chapter 10 discusses transport through artificial and biological membranes. It also describes simple biomimetic membranes,and their possible applications.
Based on physicochemical mechanics, Chapter 8 discusses complicated problems of multicomponent and thermodiffusion, and gives the generalizedFick’s law and generalized Onsagedr’s reciprocal relations.
Chapter 11 summarizes the major ideas of the book, and discusses their possible applications in more complex processes, such as biological evolution and social and economical phenomena.
Chapter 7 gives derivation of major laws of mechanochemstry, colloid chemistry, chemical kinetics of mono- and bimolecular reactions and electrochemistry.