Susan G. Komen® (Komen) has invested nearly $1.1 billion in ground-breaking breast cancer research since 1982. As a patient-centered organization, Komen measures research funding impact beyond academic metrics in favor of economic value and societal effects. Here, we highlight an innovative approach to assessing the real-world impact of Komen-funded research by showing how Komen funding for pivotal studies and key personnel conducting research contributed to discovery and development of targeted therapy drugs approved to treat breast cancer by the United States Food and Drug Administration (FDA) between 2012 and 2023.

We utilized bibliometric analysis to work backwards through citations within pivotal Phase III clinical trial publications to identify earlier clinical trials, pre-clinical research, and basic research publications that supported development of each drug, evaluating each published study and contributing authors for Komen funding support.

All 19 targeted therapy drugs approved by the FDA between 2012 and 2023 were impacted at multiple phases along the drug development pipeline by Komen funding, including direct impacts in basic research (i.e., investments in projects) that supported target discovery, and impacts in support of key personnel who contributed to pivotal studies and clinical trials (i.e., investments in people) that led to approval.

Nonprofit and public sector research funding provide the foundation for the drug development pipeline. This paper highlights an innovative approach to assess the impact of research investments beyond traditional academic measures and underscores the significance of nonprofit, patient-centered organizations like Komen in driving drug development through supporting basic and applied research.

To estimate and improve Ukraine’s health sector’s preparedness to respond to radiation and nuclear emergencies.

Field expert assessments and analytical methods were used.

In September 2022, the WHO evaluation mission to Ukraine visited several critical regions to review the current state of health sector preparedness for a nuclear emergency and revealed many defects and items for improvement. The provision of radiation control equipment was considered for ambulance teams, admissions departments/emergency departments in designated hospitals, and tertiary level hospitals, and for National and Regional Public Health Laboratories. For cases of mass casualty, WHO procured 20 decontamination tents for the country. Training courses for medical specialists and decision-makers were launched.

The WHO mission was crucial in assessing the overall state of preparedness for CBRN threats and directing forces and resources to improve it. Donor assistance in the form of equipment for dosimetric monitoring and diagnostics of emergency-related disorders contributes to improving the preparedness of the health system of Ukraine to an adequate response to the threats of radiation and nuclear emergencies.

Efforts to reduce restrictive practices (RPs) in mental health care are growing internationally. Yet, inconsistent definitions and perspectives often challenge the consistent implementation and evaluation of reduction strategies. This study explored which scenarios different mental health stakeholders classify as RPs, examined the contextual factors influencing these classifications and compared classification patterns across clinicians, researchers, service users and family caregivers.

An international cross-sectional survey was conducted using a multilingual online questionnaire hosted on the Qualtrics platform. A total of 851 stakeholders participated, including clinicians (n = 517), service users (n = 80), family caregivers (n = 89) and researchers (n = 165). Participants were presented with 44 potential RP case scenarios and asked to rate whether each scenario should be classified as an RP using a four-point Likert scale (Definitely yes, Probably yes, Probably no, Definitely no). The scenarios were organized into 22 paired comparisons, each sharing the same core context but differing in specific details. Paired comparisons were analyzed one pair at a time, allowing us to identify classification patterns between the scenarios and isolate the effects of particular contextual factors using ordered logistic regression. Interaction analyses were then conducted to assess how classification patterns varied across stakeholder groups.

Substantial discrepancies exist both within and between stakeholder groups regarding whether a given action should be considered an RP or not. Physically visible actions were often identified as RPs across all groups, while less visible forms often went unrecognized. Contextual differences, such as the healthcare professional’s intention, duration of the action, methods used, presence or absence of consent, door-locking status, and the severity of anticipated harm to be prevented influenced whether a given action was classified as an RP. Service users classified more scenarios as RPs than other groups; however, their decisions were more context-sensitive, shifting notably even with minor changes in scenario details. Among the 22 paired scenarios compared, 13 (59.09%) showed significant differences (p < 0.01) within at least one stakeholder group and eight demonstrated differences between groups.

Mental health stakeholders’ interpretations of RPs were often shaped not only by the inherent coercive nature of actions but also by the context in which they occurred and the professional role of the assessors. This underscores the need for harmonized definitions and classification frameworks for RPs, co-designed with diverse stakeholders. Addressing less visible forms of RPs in policy and clinical practice is also essential.

The link between problematic usage of the internet (PUI) and eating disorder symptoms is well-established. However, less is known about this association in the context of orthorexia nervosa (ON), an excessive preoccupation with healthy eating. This study aimed to investigate the relationship between PUI, including various problematic online behaviors, and ON tendency in a sample of US adults.

Three hundred adults completed an online survey via prolific (mean age = 37.40, 54.6% female). The survey included demographic questions, the ORTO-R to measure ON symptoms, and the Internet Severity and Activities Addiction Questionnaire (ISAAQ-10) to assess PUI and the extent of engagement in several online activities, such as gaming, shopping, social networking, cyberchondria, pornography, and cyberbullying.

Women had higher ORTO-R scores than men (p < .05). ISAAQ-10 scores predicted ORTO-R scores in a regression model (β = .375, p < .001) even after controlling for age, gender, and an eating disorder diagnosis. ON risk was associated with a high engagement in cyberchondria, researching healthy food choices on the internet, cyberbullying perpetration, and online shopping.

Results indicate that PUI is associated with ON symptoms even after considering other predictors. Maladaptive use of nutrition and medical-related resources may play a significant role in this association. However, it remains unclear whether exposure to this content increases ON risk or if people with ON symptoms seek this information online. The directionality of this relationship is an important area for future research.

We aimed to describe representative activities related to radiation risk management and community-based revitalization in Fukushima following the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident by chronological phase and provide an overview of effective recovery projects and future prospects.

We systematically reviewed projects and research on the FDNPP accident in PubMed. For convenience, we defined the first, second, and third phases as 2011-2014, 2015-2018, and 2019-2023, respectively. The main project, purpose, organization, core location, and validation in each phase after the disaster were briefly summarized.

We found that lessons learned from the FDNPP disaster have been continuously and professionally conveyed across generations, regions, and nations by effectively disseminating easy-to-understand information, avoiding any misunderstanding and prejudice. A continuous flow of scientists, researchers, and trainees from Japan and abroad to the affected areas will create a positive cycle of attracting people and residents, eventually accelerating recovery and contributing to the development of safe and vibrant communities in disaster-affected areas.

Continued efforts are required to enhance expertise at the field level, strengthen organizational capabilities, and promote international cooperation, thereby ensuring that a similar nuclear accident never happens again.

Provide a systematic overview of assessment approaches for treatment decisions after internal contamination with plutonium, americium, or curium and the efficacy of decorporation treatment with diethylenetriamine pentaacetate (DTPA) among humans and animals.

MEDLINE, EMBASE, and Cochrane Library were searched until December 06, 2023. Controlled experimental animal studies and human studies were eligible. Hand search of relevant reports continued until December 24, 2024. Risk of bias was assessed with the OHAT and JBI critical appraisal tools. Narrative synthesis was performed.

A total of 37 studies and 1 report were included. Two studies reported averted dose in humans following DTPA ranging from 150 μSv to 1.1 Sv, but the contribution of rapid contamination assessments to treatment decisions was unclear. Numerous outcomes across different treatment schedules and observation periods were studied in animal populations. Studies provided very low certainty evidence of positive treatment effects.

Whether rapid dose assessment contributes to timely treatment decisions could not be assessed with the limited amount of informative studies. In animal studies, DTPA treatment seems to be effective in reducing radiation burden and other proximal outcomes, but risk of bias is high. Evidence for humans is based on a small number of case studies where reductions in body burden have been reported.