In addition to determination of proper ocular development, gross and histopathological exam of fetal eyes may be supportive or even mandatory for the diagnosis of certain inherited syndromes with ocular involvement and/or forensic evaluation. Fetal and infant eyes examination during the routine pediatric autopsy is often complicated by artifacts, which may be caused by either autolysis or incorrect sample manipulation and fixation. Thus proper technical execution of the postmortem eyes exam is pivotal for providing additional diagnostic information that would inform a final classification of an inherited syndrome. In turn, correct diagnosis will allow the appropriate parental genetic counseling with respect to future pregnancies. The fetal eyes autopsy is thus often critical for pediatric diagnostics and should be performed with great care [1, 2].