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This review intends to provide an overview of revealed preferences of decision-makers for recommendations of cancer drugs in health technology assessment (HTA) among the different agencies.
Methods
A systematic literature search was performed in MEDLINE and EMBASE databases from inception to July 2020. The studies were eligible for inclusion if they conducted a quantitative analysis of HTA’s previous decisions for cancer drugs. The factors with p-values below the significance level of .05 were considered as the statistically significant factors for HTA decisions.
Results
A total of nine studies for six agencies in Australia, Belgium, France, South Korea, the UK, and Canada were eligible to be included. From the univariable analysis, improvements in clinical outcomes and cost-effectiveness were found as significant factors for the agencies in Belgium, South Korea, and Canada. From the multivariable analysis, cost-effectiveness was found as a positive factor for the agencies in the UK, South Korea, and Canada. Few factors related to characteristics of disease and technology were found to be significant among the included agencies.
Conclusions
Despite the different drug reimbursement systems and the socioeconomic situations, cost-effectiveness and/or improvement on clinical outcomes seemed to be the most important factors for recommendations of cancer drugs among the agencies.
The introduction outlines the main argument of the book, its key concepts, analytical framework, methodology, and contributions. It begins by presenting the argument that Israeli foreign policy since the end of the Cold War, has revolved around three stances: entrenchment, unilateralism, and engagement. These foreign policy postures, which are an original contribution of the book, are unpacked and explained. The introduction goes on to describe the analytical framework that informs the book and accounts for Israeli foreign policy, depicted as three concentric circles: the decision-makers, the security network, and the contours imposed on foreign policymaking by national identity. The approach in this book is positioned in relation to the existing literature on Israeli foreign policy. The introduction ends with a note on sources, which outlines the dataset comprising the book, its qualitative methodology, and the approach to debating Israel in academia.
The chapter examines warnings relating to violent conflict and massive humanitarian crisis in Darfur, a region of Sudan. As a case of successful ‘crisis warning’ the 2004 Darfur crisis offers important lessons about persuasiveness, especially with regard to the role of senior officials as the chapter focuses on Andrew Natsios, then the administrator of the US Agency for International Development, and Mukesh Kapila, the UN Resident and Humanitarian Coordinator in Sudan. Drawing on extensive original research the chapter shows why these two officials had a variable persuasive impact over time and with different target organisations. The findings suggest that warner capacity and credibility are necessary if not always sufficient for achieving notice and acceptance. Receptivity factors played a facilitating role as they created an environment which was conducive for the warnings being accepted and which reinforced well-tailored warning messages. At the same time, the case shows that warning impact may depend on repeated attempts to get the message across, creativity in exploring alternative channels and routes, and a readiness among sources to take some career risks in order to achieve their intended goal eventually.