This article examines the siege of Gaza as a paradigmatic case of Achille Mbembe’s necropolitics, revealing how Gaza operates as a “laboratory of violence” where advanced military occupation, border control, and surveillance techniques are tested and exported. By tracing the intensifying militarization and orchestrated deprivation imposed on its population, this study demonstrates how colonial biopolitics embodied in strict movement restrictions, engineered food scarcity, and segregated medical care undermine human rights and perpetuate chronic vulnerability. These necropolitical practices obstruct key United Nations Sustainable Development Goals (SDGs), including SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-Being), and SDG 16 (Peace, Justice, and Strong Institutions), exposing moral and political contradictions within international frameworks committed to “leaving no one behind.” Yet the SDG rubric itself arose within a development discourse entangled with colonial power, making any assessment of Gaza’s “progress” by these indicators ethically and epistemically fraught. Gaza’s predicament exemplifies the destructive potential of protracted conflict and structural violence in derailing global development targets. This article reframes Gaza’s siege as both a localized humanitarian crisis and a global precedent with serious implications for international policy and human rights law. By situating Gaza as a focal point for understanding necropolitical governance, this study seeks to portray the urgency of policy interventions that move beyond rhetoric and have demonstrably challenged and mitigated such regimes in comparable contexts.