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The study seeks to evaluate the influence of planning target volume (PTV) margins on plan parameters during inverse planning of brain metastases with the Gamma Knife treatment unit, considering various prescription isodose levels (PIL).
Material & Method:
CT scan images of a STEEV anthropomorphic phantom were transferred into the GAMMA PLAN Treatment Planning System. A target measuring a volume of 4·9cc was centrally contoured. Plans with a 0 mm volume margin at five prescription isodose levels from 50% to 70% at 5% increment were created. With 0.5 mm, 1 mm, 1.5 mm and 2 mm PTV margins, identical plans were regenerated. Adjustments were made to each plan when necessary to achieve same target coverage. One-way ANOVA test was used to analyse the influence of PTV margins on parameters including Selectivity[S], Gradient index [GI], V12, Paddick’s conformal index [PCI] and Treatment time [TI].
Results:
Margin addition resulted in PTV volume increase. The findings indicated that the PTV margin of 2.0 mm exhibited the highest mean selectivity of (0.93 ± 0.00), PCI (0.92 ± 0.01), GI (2.50 ± 0.04), V12 (16.17 ± 0.38) and treatment time (118.32 ± 2.91 min). The 0.0 mm PTV margin had the lowest mean value for all the parameters except for the treatment time (105.58 ± 3.48 min) which was slightly higher compared to the 0.5 mm PTV margin (M = 86.36 ± 4.13 min).
Conclusion:
Incremental increases in PTV margins for Gamma knife radiosurgery though a relatively controversial concept influence all dosimetric parameters, which may pose potential detrimental effects and thus need to be carefully evaluated for brain metastasis treatment.
This chapter introduces the class of autoregressive moving average models and discusses their properties in special cases and in general. We provide alternative methods for the estimation of unknown parameters and describe the properties of the estimators. We discuss key issues like hypothesis testing and model selection.
This chapter is written for the researcher who may encounter immunohistochemistry (IHC) in a slightly different context when compared to diagnostic applications. There are many moving parts to IHC assays, and this chapter covers all of the important aspects the researcher needs to consider when employing IHC for their projects. This objective is achieved by employing a request form for IHC services. The questions posed on the form build towards piecing together a protocol that is fit for purpose and can be used in many applications. Practical explanations about epitope retrieval, diluting antibodies from concentrates and the use of detection kits are provided. The need to block endogenous enzyme activity is also explained, as is the technique for antibody optimization. Borrowing the basic fundamental IHC protocol used in diagnostic histopathology, the researcher should be able to adopt and change parameters to suit their research applications.
Research into comparative syntax over the last four decades has revealed that, despite some quite considerable superficial differences, syntactic variation among different languages and varieties is not random, but is ultimately constrained by a small and finite set of principles and parameters, the number and nature of which can be successfully teased apart especially through the careful study of closely related languages and varieties where, all other things being equal, a particular parametric choice can be readily isolated. It is for this reason that investigations of parametric variation in the area of syntax have so often drawn on Romance data since empirical investigations of Romance morphosyntax, especially of non-standard varieties and dialects in more recent times, have uncovered a wealth of small-scale microvariation. Drawing on such examples as the variation found in subject clitic systems, auxiliary selection (variously driven by transitivity, mood, tense, and grammatical person), active participle agreement, the extent and distribution of verb movement, sentential negation, and C(omplementizer)-systems (e.g., dual/triple complementizer systems; V2; availability of V-to-C movement and focus fronting), this chapter provides a critical overview of the some of the principal dimensions of morphosyntactic parametric variation with the aim of identifying the nature of the choices involved and, in particular, the differences between macro-, meso-, micro-, and nanoparameters and how these are formally organized within the grammar, the interaction between these parameters both in diachrony and synchrony, and what the formal limits of such parametric variation are.
Many parameters are associated with IHC testing assays. With so many variables, it is quite easy to accumulate errors within the system. To make things more manageable, these considerations are categorized into three main groups. Pre-analytic aspects occur before the assay, analytic factors are concerned with the staining protocol and post-analytic elements relate to interpreting of results. It has also come to reason that any one variable can impact the reliability and consistency of the overall IHC assay. In this regard, standardization requirements have been enlisted to assist laboratories achieve optimal results. In addition, monitoring proficiency testing regimens and various organizations are in place to ensure high levels of standards are attained. All these endeavours are known as quality assurance and quality control measures. They are arranged under the overall umbrella of a facility’s quality management system.
The parametric approach to stress includes parameters (1) quantity sensitivity, (2) maximally binary or unbounded feet, (3) left or right branching and left or right strong, (4) direction of stress-tree construction, and (5) the word tree as left or right branching, Exemplification of this approach in Maranungku, Latvian, Warao, Eastern Cheemis, and Latin. Application to English as quantity sensitive with maximally binary feet that are left branching and left strong constructed from right to left with a right-branching word tree. It is necessary to allow some segments and syllables to be extrametrical prior to the application of the rules. Destressing rules are also required, with a convention of stray syllable adjunction. Most stress rules apply cyclically on stratum 1 of the phonology, with some noncyclic on stratum 2. Exceptions are to be accounted for by marking some items exceptions to certain rules; there is no need to assume stress in underlying representations.
The introduction outlines some important differences in approaches to literature and ethics. It goes on to situate the following work in relation to those differences. For example, we may be concerned principally with the literature (e.g., how to evaluate literary works morally) or the ethics (e.g., how to think in more nuanced ways about ethical problems in real life); this volume is concerned principally with the latter. More significantly, the study of ethics may be descriptive or normative. In other words, it may address what constitutes ethical thought or it may advocate a particular version of ethics. The book is divided into two parts. The first part treats descriptive ethics, seeking to isolate cross-cultural and transhistorical patterns in the relation between ethical attitudes, on the one hand, and structures of storytelling, on the other. The second part takes up normative ethics, focusing on an aspect of emotional response that is important in both ethics and literature – empathy.
The first chapter takes up the task of defining ethics, considered as a set of psychological structures and processes. In other work, I have argued that the three processes of categorization are, in distinct ways, consequential for our response to literature. Specifically, we make use of rule-defined categorization, prototype-defined categorization, and exemplar-defined categorization. In my descriptive account of ethics, all three types also enter importantly into our moral thought, feeling, and behavior. In connection with rule-based categorization, I argue that we have broad or fundamental ethical orientations that are guided by our various settings of parameters within general principles. These parameters concern such issues as what sorts of action or condition fall under the scope of morality. For example, there appears to be a broad division between people who are principally concerned with ending unjustified pleasure and people whose primary moral worries bear on undeserved pain. The first chapter explores this level of ethics.
Literary texts commonly manifest ethical attitudes. These may be represented in terms of distinct parameter settings within more widely held principles. The author is often not fully aware of the ethical views that guide his or her storytelling in this way. In addition, the implicit ethics of a work are often connected more specifically with its story genre – thus, its ethical prototype – such as the heroic usurpation story of Julius Caesar. More narrowly still, the ethical views represented in a work may have a generally trusting attitude toward the hero’s ethical self-presentation or may take a more skeptical view. I refer to the latter as a “critical ethics.” Critical ethics stresses the dissociation of a character’s rhetoric from his or her actual motivation. The second chapter develops some theoretical concepts along these lines. It goes on to concretize the first chapter’s relatively abstract treatment of ethical principles and parameters through an examination of the ethical concerns underlying characters’ judgments and behaviors in Julius Caesar.
We improve on and generalize a 1960 result of Maltsev. For a field F, we denote by
$H(F)$
the Heisenberg group with entries in F. Maltsev showed that there is a copy of F defined in
$H(F)$
, using existential formulas with an arbitrary non-commuting pair of elements as parameters. We show that F is interpreted in
$H(F)$
using computable
$\Sigma _1$
formulas with no parameters. We give two proofs. The first is an existence proof, relying on a result of Harrison-Trainor, Melnikov, R. Miller, and Montalbán. This proof allows the possibility that the elements of F are represented by tuples in
$H(F)$
of no fixed arity. The second proof is direct, giving explicit finitary existential formulas that define the interpretation, with elements of F represented by triples in
$H(F)$
. Looking at what was used to arrive at this parameter-free interpretation of F in
$H(F)$
, we give general conditions sufficient to eliminate parameters from interpretations.
Response to the unprecedented coronavirus disease 2019 (COVID-19) outbreak needs to be augmented in Texas, United States, where the first 5 cases were reported on March 6, 2020, and were rapidly followed by an exponential rise within the next few weeks. This study aimed to determine the ongoing trend and upcoming infection status of COVID-19 in county levels of Texas.
Methods:
Data were extracted from the following sources: published literature, surveillance, unpublished reports, and websites of Texas Department of State Health Services (DSHS), Natality report of Texas, and WHO Coronavirus Disease (COVID-19) Dashboard. The 4-compartment Susceptible-Exposed-Infectious-Removal (SEIR) mathematical model was used to estimate the current trend and future prediction of basic reproduction number and infection cases in Texas. Because the basic reproduction number is not sufficient to predict the outbreak, we applied the Continuous-Time Markov Chain (CTMC) model to calculate the probability of the COVID-19 outbreak.
Results:
The estimated mean basic reproduction number of COVID-19 in Texas is predicted to be 2.65 by January 31, 2021. Our model indicated that the third wave might occur at the beginning of May 2021, which will peak at the end of June 2021. This prediction may come true if the current spreading situation/level persists, i.e., no clinically effective vaccine is available, or this vaccination program fails for some reason in this area.
Conclusion:
Our analysis indicates an alarming ongoing and upcoming infection rate of COVID-19 at county levels in Texas, thereby emphasizing the promotion of more coordinated and disciplined actions by policy-makers and the population to contain its devastating impact.
Regression modelling involving heavy-tailed response distributions, which have heavier tails than the exponential distribution, has become increasingly popular in many insurance settings including non-life insurance. Mixed Exponential models can be considered as a natural choice for the distribution of heavy-tailed claim sizes since their tails are not exponentially bounded. This paper is concerned with introducing a general family of mixed Exponential regression models with varying dispersion which can efficiently capture the tail behaviour of losses. Our main achievement is that we present an Expectation-Maximization (EM)-type algorithm which can facilitate maximum likelihood (ML) estimation for our class of mixed Exponential models which allows for regression specifications for both the mean and dispersion parameters. Finally, a real data application based on motor insurance data is given to illustrate the versatility of the proposed EM-type algorithm.
Lamb live weight is one of the key drivers of profitability on sheep farms. Previous studies in Ireland have estimated genetic parameters for live weight and carcass composition traits using a multi-breed population rather than on an individual breed basis. The objective of the present study was to undertake genetic analyses of three lamb live weight and two carcass composition traits pertaining to purebred Texel, Suffolk and Charollais lambs born in the Republic of Ireland between 2010 and 2017, inclusive. Traits (with lamb age range in parenthesis) considered in the analyses were: pre-weaning weight (20 to 65 days), weaning weight (66 to 120 days), post-weaning weight (121 to 180 days), muscle depth (121 to 180 days) and fat depth (121 to 180 days). After data edits, 137 402 records from 50 372 lambs across 416 flocks were analysed. Variance components were derived using animal linear mixed models separately for each breed. Fixed effects included for all traits were contemporary group, age at first lambing of the dam, parity of the dam, a gender by age of the lamb interaction and a birth type by rearing type of the lamb interaction. Random effects investigated in the pre-weaning and weaning weight analyses included animal direct additive genetic, dam maternal genetic, litter common environment, dam permanent environment and residual variances. The model of analysis for post-weaning, muscle and fat depth included an animal direct additive genetic and litter common environment effect only. Significant direct additive genetic variation existed in all cases. Direct heritability for pre-weaning weight ranged from 0.14 to 0.30 across the three breeds. Weaning weight had a direct heritability ranging from 0.17 to 0.27 and post-weaning weight had a direct heritability ranging from 0.15 to 0.27. Muscle and fat depth heritability estimates ranged from 0.21 to 0.31 and 0.15 to 0.20, respectively. Positive direct correlations were evident for all traits. Results revealed ample genetic variation among animals for the studied traits and significant differences between breeds to suggest that genetic evaluations could be conducted on a per-breed basis.
This paper provides evidence for a kind of nominal licensing (Vergnaud licensing) in a number of morphologically caseless languages. Recent work on Bantu languages has suggested that abstract Case or nominal licensing should be parameterised (Diercks 2012, Van der Wal 2015a). With this is mind, we critically discuss the status of Vergnaud licensing in six languages lacking morphological case. While Luganda appears to systematically lack a Vergnaud licensing requirement, Makhuwa more consistently displays evidence in favour of it, as do all of the analytic languages that we survey (Mandarin, Yoruba, Jamaican Creole and Thai). We conclude that, while it seems increasingly problematic to characterise nominal licensing in terms of uninterpretable/abstract Case features, we nonetheless need to retain a (possibly universal) notion of nominal licensing, the explanation for which remains opaque.
A vigilance state is characterized by a particular activity state of the motorIautonomic and psychiclcognitive functional systems. S-W screening is possible through poly graphic monitoring of physiological variables and signals. Quantification of these signals introduces a set of parameters allowing the characterisation of the sleep (dys)function. There is no consensus regarding the choice or definition of these parameters. A particular cluster is presented and their informative value with respect to clinical practice and research is discussed.
We present generalized and unified families of (2n)-point and (2n — 1)-point p-ary interpolating subdivision schemes originated from Lagrange polynomial for any integers n ≥ 2 and p ≥ 3. Almost all existing even-point and odd-point interpolating schemes of lower and higher arity belong to this family of schemes. We also present tensor product version of generalized and unified families of schemes. Moreover error bounds between limit curves and control polygons of schemes are also calculated. It has been observed that error bounds decrease when complexity of the scheme decrease and vice versa. Furthermore, error bounds decrease with the increase of arity of the schemes. We also observe that in general the continuity of interpolating scheme do not increase by increasing complexity and arity of the scheme.
The high prevalence of anthelmintic-resistant gastrointestinal nematodes (GINs) throughout the world has led to the need for alternative worm control strategies. One of the possible substitutes to reduce the problems of drug resistance and residue is the evaluation/breeding of small ruminants for greater resistance to the GINs (organically produced), which in turn would be a helpful tool to predict the performance of an animal. At present, the existing diversity in the genetic potential to resist/tolerate GINs infection both within and between breeds has been validated. Successful selection of animals to define the genotype and identified resistance is related to the employed markers. A number of phenotypic traits such as faecal egg count (FEC), worm burden, serum antibodies, peripheral eosinophilia, packed cell volume, live weight, serum protein and albumin concentrations have been used for this purpose both in natural and artificial infections. Relatively resistant/tolerant animals have also been found to have mastocytosis, globule leucocytes, high levels of histamine and immunoglobulin (Ig) A and IgE concentrations. Of these traits, the principal and most practical measurement used to assess resistance status in animals undergoing similar parasite challenges is FEC. FEC has a positive/negative correlation with other biochemical, cellular and immunological parameters; however, the reliability of individual trial is often questioned and valuable information regarding the genetic makeup can be obtained from pooled data of a large number of trials and parameters. This paper covers all the aspects reported in the literature on various parameters considered to evaluate the resistance status of a range of small ruminant breeds.
The paper presents a meta-study of the kinematic, dynamic and electrical parameters for the PUMA 560 robot. Parameter values which have been reported in the literature are transformed into a single system of units and coordinates, and differences in the data and measurement techniques are discussed. New data have been gathered and are presented where the record was incomplete.
In this paper, nine adaptive control
algorithms are compared. The best two of them are tested
experimentally. It is shown that the Adaptive FeedForward Controller AFFC)
is well suited for learning the parameters of the dynamic
equation, even in the presence of friction and noise. The
resulting control performance is better than with measured parameters for
any trajectory in the workspace. When the task consists of
repeating the same trajectory, an adaptive look-up-table MEMory, introduced and
analyzed in this paper, is simpler to implement and results
in even better control performance.
This paper presents a new criterion based on prediction error which allows the estimation of the number of parameters as well as structures in statistical models. The criterion is valid for short and long samples alike. Unlike Akaike's earlier criterion, also based on prediction error, the criterion proposed here appears to produce consistent error estimates in ARMA processes.
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