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The partitioning of squared Eucliean distance between two vectors in M-dimensional space into the sum of squared lengths of vectors in mutually orthogonal subspaces is discussed and applications given to specific cluster analysis problems. Examples of how the partitioning idea can be used to help describe and interpret derived clusters, derive similarity measures for use in cluster analysis, and to design Monte Carlo studies with carefully specified types and magnitudes of differences between the underlying population mean vectors are presented. Most of the example applications presented in this paper involve the clustering of longitudinal data, but their use in cluster analysis need not be limited to this arena.
Research in psychology is experiencing a rapid increase in the availability of intensive longitudinal data. To use such data for predicting feelings, beliefs, and behavior, recent methodological work suggested combinations of the longitudinal mixed-effect model with Lasso regression or with regression trees. The present article adds to this literature by suggesting an extension of these models that—in addition to a random effect for the mean level—also includes a random effect for the within-subject variance and a random effect for the autocorrelation. After introducing the extended mixed-effect location scale (E-MELS), the extended mixed-effect location-scale Lasso model (Lasso E-MELS), and the extended mixed-effect location-scale tree model (E-MELS trees), we show how its parameters can be estimated using a marginal maximum likelihood approach. Using real and simulated example data, we illustrate how to use E-MELS, Lasso E-MELS, and E-MELS trees for building prediction models to forecast individuals’ daily nervousness. The article is accompanied by an R package (called mels) and functions that support users in the application of the suggested models.
Millsap and Meredith (1988) have developed a generalization of principal components analysis for the simultaneous analysis of a number of variables observed in several populations or on several occasions. The algorithm they provide has some disadvantages. The present paper offers two alternating least squares algorithms for their method, suitable for small and large data sets, respectively. Lower and upper bounds are given for the loss function to be minimized in the Millsap and Meredith method. These can serve to indicate whether or not a global optimum for the simultaneous components analysis problem has been attained.
A multivariate reduced-rank growth curve model is proposed that extends the univariate reducedrank growth curve model to the multivariate case, in which several response variables are measured over multiple time points. The proposed model allows us to investigate the relationships among a number of response variables in a more parsimonious way than the traditional growth curve model. In addition, the method is more flexible than the traditional growth curve model. For example, response variables do not have to be measured at the same time points, nor the same number of time points. It is also possible to apply various kinds of basis function matrices with different ranks across response variables. It is not necessary to specify an entire set of basis functions in advance. Examples are given for illustration.
A number of methods for the analysis of three-way data are described and shown to be variants of principal components analysis (PCA) of the two-way supermatrix in which each two-way slice is “strung out” into a column vector. The methods are shown to form a hierarchy such that each method is a constrained variant of its predecessor. A strategy is suggested to determine which of the methods yields the most useful description of a given three-way data set.
Reliability captures the influence of error on a measurement and, in the classical setting, is defined as one minus the ratio of the error variance to the total variance. Laenen, Alonso, and Molenberghs (Psychometrika 73:443–448, 2007) proposed an axiomatic definition of reliability and introduced the RT coefficient, a measure of reliability extending the classical approach to a more general longitudinal scenario. The RT coefficient can be interpreted as the average reliability over different time points and can also be calculated for each time point separately. In this paper, we introduce a new and complementary measure, the so-called RΛ, which implies a new way of thinking about reliability. In a longitudinal context, each measurement brings additional knowledge and leads to more reliable information. The RΛ captures this intuitive idea and expresses the reliability of the entire longitudinal sequence, in contrast to an average or occasion-specific measure. We study the measure’s properties using both theoretical arguments and simulations, establish its connections with previous proposals, and elucidate its performance in a real case study.
Behavioral science researchers have shown strong interest in disaggregating within-person relations from between-person differences (stable traits) using longitudinal data. In this paper, we propose a method of within-person variability score-based causal inference for estimating joint effects of time-varying continuous treatments by controlling for stable traits of persons. After explaining the assumed data-generating process and providing formal definitions of stable trait factors, within-person variability scores, and joint effects of time-varying treatments at the within-person level, we introduce the proposed method, which consists of a two-step analysis. Within-person variability scores for each person, which are disaggregated from stable traits of that person, are first calculated using weights based on a best linear correlation preserving predictor through structural equation modeling (SEM). Causal parameters are then estimated via a potential outcome approach, either marginal structural models (MSMs) or structural nested mean models (SNMMs), using calculated within-person variability scores. Unlike the approach that relies entirely on SEM, the present method does not assume linearity for observed time-varying confounders at the within-person level. We emphasize the use of SNMMs with G-estimation because of its property of being doubly robust to model misspecifications in how observed time-varying confounders are functionally related to treatments/predictors and outcomes at the within-person level. Through simulation, we show that the proposed method can recover causal parameters well and that causal estimates might be severely biased if one does not properly account for stable traits. An empirical application using data regarding sleep habits and mental health status from the Tokyo Teen Cohort study is also provided.
The social relations model (SRM) is commonly used in the analysis of interpersonal judgments and behaviors that arise in groups. The SRM was developed only for use with cross-sectional data. Here, we introduce an extension of the SRM to longitudinal data. The social relations growth model represents a person’s repeated SRM judgments of another person as a function of time. We show how the model’s parameters can be estimated using restricted maximum likelihood, and how the effects of covariates on interindividual and interdyad variability in growth can be computed. An example is presented to illustrate the suggested approach. We also present the results of a small simulation study showing the suitability of the social relations growth model for the analysis of longitudinal SRM data.
Piecewise growth mixture models are a flexible and useful class of methods for analyzing segmented trends in individual growth trajectory over time, where the individuals come from a mixture of two or more latent classes. These models allow each segment of the overall developmental process within each class to have a different functional form; examples include two linear phases of growth, or a quadratic phase followed by a linear phase. The changepoint (knot) is the time of transition from one developmental phase (segment) to another. Inferring the location of the changepoint(s) is often of practical interest, along with inference for other model parameters. A random changepoint allows for individual differences in the transition time within each class. The primary objectives of our study are as follows: (1) to develop a PGMM using a Bayesian inference approach that allows the estimation of multiple random changepoints within each class; (2) to develop a procedure to empirically detect the number of random changepoints within each class; and (3) to empirically investigate the bias and precision of the estimation of the model parameters, including the random changepoints, via a simulation study. We have developed the user-friendly package BayesianPGMM for R to facilitate the adoption of this methodology in practice, which is available at https://github.com/lockEF/BayesianPGMM. We describe an application to mouse-tracking data for a visual recognition task.
A new measure for reliability of a rating scale is introduced, based on the classical definition of reliability, as the ratio of the true score variance and the total variance. Clinical trial data can be employed to estimate the reliability of the scale in use, whenever repeated measurements are taken. The reliability is estimated from the covariance parameters obtained from a linear mixed model. The method provides a single number to express the reliability of the scale, but allows for the study of the reliability’s time evolution. The method is illustrated using a case study in schizophrenia.
Confirmatory factor analysis is considered from a Bayesian viewpoint, in which prior information on parameter is incorporated in the analysis. An iterative algorithm is developed to obtain the Bayes estimates. A numerical example based on longitudinal data is presented. A simulation study is designed to compare the Bayesian approach with the maximum likelihood method.
A direct method in handling incomplete data in general covariance structural models is investigated. Asymptotic statistical properties of the generalized least squares method are developed. It is shown that this approach has very close relationships with the maximum likelihood approach. Iterative procedures for obtaining the generalized least squares estimates, the maximum likelihood estimates, as well as their standard error estimates are derived. Computer programs for the confirmatory factor analysis model are implemented. A longitudinal type data set is used as an example to illustrate the results.
Over-time, repeated measures, or longitudinal data are terms referring to repeated measurements of the same variables within the same unit (e.g., person, family, team, company). Longitudinal data come from many sources, including self-reports, behaviors, observations, and physiology. Researchers collect repeated measures for a variety of reasons, such as wanting to model change in a process over time or wanting to increase measurement reliability. Whatever the reason for data collection, longitudinal methods pose unique challenges and opportunities. This chapter has three main goals: (1) to help researchers consider design decisions when developing a longitudinal study, (2) to describe the different decisions researchers have to make when analyzing longitudinal data, and (3) to consider the unique properties of longitudinal designs that researchers should be aware of when designing and analyzing longitudinal studies. We aim to provide a comprehensive overview of the major issues that researchers should consider, and we also point to more extensive resources.
Commonly occurring mental health disorders have been well studied in terms of epidemiology, presentation, risk factors and management. However, rare or uncommon mental health disorders and events are harder to study. One way to do this is active surveillance. This article summarises how the Royal College of Psychiatrists Child and Adolescent Psychiatry Surveillance System was developed, as well as the key studies that have used the system and their impact, to make the case for a wider international surveillance unit for child and adolescent psychiatry. Keeping this surveillance active in different populations across the globe will add to existing knowledge and understanding of these uncommon disorders and events. This will in turn help in developing better frameworks for the identification and management for these disorders and events. It will also facilitate the sharing of ideas regarding current methodology, ethics, the most appropriate means of evaluating units and their potential applications.
Early worsening of plasma lipid levels (EWL; ≥5% change after 1 month) induced by at-risk psychotropic treatments predicts considerable exacerbation of plasma lipid levels and/or dyslipidaemia development in the longer term.
Aims
We aimed to determine which clinical and genetic risk factors could predict EWL.
Method
Predictive values of baseline clinical characteristics and dyslipidaemia-associated single nucleotide polymorphisms (SNPs) on EWL were evaluated in a discovery sample (n = 177) and replicated in two samples from the same cohort (PsyMetab; n1 = 176; n2 = 86).
Results
Low baseline levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides, and high baseline levels of high-density lipoprotein cholesterol (HDL-C), were risk factors for early increase in total cholesterol (P = 0.002), LDL-C (P = 0.02) and triglycerides (P = 0.0006), and early decrease in HDL-C (P = 0.04). Adding genetic parameters (n = 17, 18, 19 and 16 SNPs for total cholesterol, LDL-C, HDL-C and triglycerides, respectively) improved areas under the curve for early worsening of total cholesterol (from 0.66 to 0.91), LDL-C (from 0.62 to 0.87), triglycerides (from 0.73 to 0.92) and HDL-C (from 0.69 to 0.89) (P ≤ 0.00003 in discovery sample). The additive value of genetics to predict early worsening of LDL-C levels was confirmed in two replication samples (P ≤ 0.004). In the combined sample (n ≥ 203), adding genetics improved the prediction of new-onset dyslipidaemia for total cholesterol, LDL-C and HDL-C (P ≤ 0.04).
Conclusions
Clinical and genetic factors contributed to the prediction of EWL and new-onset dyslipidaemia in three samples of patients who started at-risk psychotropic treatments. Future larger studies should be conducted to refine SNP estimates to be integrated into clinically applicable predictive models.
Western Australia's response to the COVID-19 pandemic was swift and effective in implementing public health protections and preventing the spread of the virus for the first 2 years. However, healthcare staff continued to be at increased risk of mental health concerns.
Aims
To investigate the longitudinal patterns of post-traumatic stress symptoms (PTSS), depression and anxiety among healthcare workers in Western Australia, and the risk and protective factors associated with changes in status during the first wave.
Method
Participants comprised 183 healthcare staff working at tertiary hospitals and major clinics across Perth, for whom longitudinal data were available. Questionnaire data were collected before Western Australia's first major COVID-19 community wave in early 2022 and following the first wave in late 2022. Online surveys comprised validated measures assessing psychological symptoms, risk and protective factors, and original measures of workplace factors.
Results
Overall rates of PTSS, depression and anxiety remained stable across the two assessment points. However, latent growth models revealed that those with lower PTSS, depression or anxiety symptoms at baseline reported a larger increase in symptoms over time, and those with higher symptoms at baseline had a smaller decline over time, indicating a ‘catch-up’ effect. Workplace stressors, sleep difficulties and trauma exposure were key risk factors for changes in psychological symptoms from baseline, and workplace and social supports played protective roles.
Conclusions
Improvements in systemic workplace factors are needed to support healthcare workers’ mental health during periods of acute stress, even in settings with high levels of emergency preparedness.
The COVID-19 pandemic has disproportionately affected women's mental health. However, most evidence has focused on mental illbeing outcomes, and there is little evidence on the mechanisms underlying this unequal impact.
Aims
To investigate gender differences in the long-term trajectories of life satisfaction, how these were affected during the pandemic and the role of time-use differences in explaining gender inequalities.
Method
We used data from 6766 (56.2% women) members of the 1970 British Cohort Study (BCS70). Life satisfaction was prospectively assessed between the ages of 26 (1996) and 51 (2021) years, using a single question with responses ranging from 0 (lowest) to 10 (highest). We analysed life satisfaction trajectories with piecewise latent growth curve models, and investigated whether gender differences in the change in the life satisfaction trajectories with the pandemic were explained by self-reported time spent doing different paid and unpaid activities.
Results
Women had consistently higher life satisfaction than men before the pandemic (Δintercept,unadjusted = 0.213, 95% CI 0.087–0.340; P = 0.001) and experienced a more accelerated decline with the pandemic onset (Δquad2,unadjusted = −0.018, 95% CI −0.026 to −0.011; P < 0.001). Time-use differences did not account for the more accelerated decrease in women's life satisfaction levels with the pandemic (Δquad2,adjusted = −0.016, 95% CI −0.031 to −0.001; P = 0.035).
Conclusions
Our study shows pronounced gender inequalities in the impact of the pandemic on the long-term life satisfaction trajectories of adults in their 50s, with women losing their pre-pandemic advantage over men. Self-reported time-use differences did not account for these inequalities. More research is needed to tackle gender inequalities in population mental health.
Compulsory mental health treatment has increased globally. In Scotland, compulsory treatment for >28 days is permitted under hospital- and community-based compulsory treatment orders. Community-based compulsory treatment has not been shown to lead to improved outcomes, and scrutiny of their use is needed.
Aims
To describe the trend, duration and demographic characteristics of compulsory treatment orders in Scotland over a 14-year period.
Method
We conducted a retrospective analysis of order use in Scotland from 1 January 2007 to 31 December 2020, focusing on the (a) number and demographic characteristics of those treated, (b) duration, (c) extensions beyond the 6-month review point and (d) characteristics of new versus continued orders.
Results
The number of individuals on a community-based order increased by 118% (571 v. 1243) from 2007 to 2020, compared with a 16% increase (1316 v. 1532) for hospital-based orders. Of orders starting in 2007, 57.3% were extended, compared with 43.7% in 2020. The median duration was 6 months for first-time orders and 9 months for subsequent orders, which were longest for males (median 11 months); those of African, Caribbean or Black (median 11 months), Asian (median 11 months) and mixed ethnicity (median 10 months); and individuals from the most deprived communities (median 10 months).
Conclusions
There has been a marked rise of community-based compulsory treatment orders in Scotland. If existing trends continue, there will be more people receiving care under community-based orders than hospital-based orders, fundamentally changing the nature of involuntary treatment. Further work needs to explore associations between demographic and diagnostic characteristics on order duration.
Stressors across the lifespan are associated with the onset of major depressive disorder (MDD) and increased severity of depressive symptoms. However, it is unclear how lifetime stressors are related to specific MDD subtypes. The present study aims to examine the relationships between MDD subtypes and stressors experienced across the lifespan while considering potential confounders.
Methods
Data analyzed were from the Zone d’Épidémiologie Psychiatrique du Sud-Ouest de Montréal (N = 1351). Lifetime stressors included childhood maltreatment, child–parent bonding, and stressful life events. Person-centered analyses were used to identify the clusters/profiles of the studied variables and multinomial logistic regression analyses were performed to examine the relationships between stressors and identified MDD subtypes. Intersectional analysis was applied to further examine how distal stressors interact with proximal stressors to impact the development of MDD subtypes.
Results
There was a significant association between proximal stressors and melancholic depression, whereas severe atypical depression and moderate depression were only associated with some domains of stressful life events. Additionally, those with severe atypical depression and melancholic depression were more likely to be exposed to distal stressors such as childhood maltreatment. The combinations of distal and proximal stressors predicted a greater risk of all MDD subtypes except for moderate atypical depression.
Conclusions
MDD was characterized into four subtypes based on depressive symptoms and severity. Different stressor profiles were linked with various MDD subtypes. More specific interventions and clinical management are called to provide precision treatment for MDD patients with unique stressor profiles and MDD subtypes.
Edited by
Jeremy Koster, Max Planck Institute for Evolutionary Anthropology, Leipzig,Brooke Scelza, University of California, Los Angeles,Mary K. Shenk, Pennsylvania State University
Scientific disciplines are characterized by cultures of practice that shape how research is conducted. The conventional research designs of studies by human behavioral ecologists entail both pros and cons. This chapter considers alternatives that would allow human behavioral ecologists to marshal the empirical evidence that is needed for convincing answers to long-standing debates. In particular, the chapter advocates for greater emphasis on long-term, individual-based field research. Data acquired via prospective panel studies can be used to examine the dynamic processes that unfold over long periods of time, including life span and intergenerational processes. Remedies are needed to the structural obstacles that limit the implementation of prospective panel studies, including logistical and funding constraints. The chapter also addresses the disadvantageous academic research culture that incentivizes scientists to pursue status and prestige instead of research objectives with greater long-term value. Methods to support longitudinal research are discussed, including approaches to data management and data analysis. The chapter concludes by highlighting opportunities for rising generations of human behavioral ecologists to reshape the culture of research practice in order to advance principled, ethical, and compelling approaches to the comparative study of human behavior.