Africa’s mental health burden is rising owing to population growth, ageing and a severe shortage of professionals – just 1.4 per 100 000 population versus the global average of 9 per 100 000. This article outlines insights from the first African School of Psychiatry (held in Agadir, 2024), highlighting key challenges and solutions. Culturally sensitive care, integrating traditional practices and religious beliefs, is essential. Strategies include telepsychiatry, primary care integration, mental health literacy (especially for youth), caregiver training, and research into epidemiology and genetics to address Africa’s unique psychiatric profiles. The article calls for innovative, localised approaches, increased funding and global collaboration to move beyond Western models. Policymakers and professionals must act to transform mental healthcare for Africa’s specific needs.