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Neuropeptide-like signaling in the microbiota-gut-brain axis

Published online by Cambridge University Press:  15 July 2019

Sergueï O. Fetissov Open the ORCID record for Sergueï O. Fetissov [Opens in a new window]
Sergueï O. Fetissov*
Affiliation:
Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Inserm UMR1239, University of Rouen Normandy, Institute for Research and Innovation in Biomedicine (IRIB), 76130 Mont-Saint-Aignan, France. Serguei.Fetissov@univ-rouen.fr
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Abstract

For gut microbiota to influence behavior, microorganisms should be able to interfere with specific brain neurochemical circuitries. Understanding these molecular mechanisms is a key task in the new microbiota-gut-brain field. Recent studies have revealed that one major mechanistic link is the modulation of neuropeptide signaling by homologous bacterial proteins acting both directly and indirectly via production of neuropeptide-reactive immunoglobulins.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e70
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Copyright
Copyright © Cambridge University Press 2019 

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Footnotes

1.

The author is a founder and scientific advisor of TargEDys SA.

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