The reviewed literature indicates that, even in industrialisedcountries, the nutrition of mature and aged subjects is ofteninadequate (because of deficiency or excess), which may lead topremature or pathological senescence.
Recent nutritional research on ageing laboratory animals shows thatdietary restriction may be the most effective procedure to achievealong and disease-free life span, probably owing to a betterprotection against mitochondria-linked oxygen stress. Likewise, theexperimental and clinical work from many laboratories, including ourown, indicates that age-dependent changes in the cardiovascular andimmune systems are linked to oxygen stress and that an adequateintake of dietary antioxidants may protect those systems againstchronic degenerative syndromes in the physiopathology of whichreactive oxygen species (ROS) play a key role.
The extant data indicate that the antioxidant vitamins C and E arecentrally involved in defending the above two systems against ROSattack. Moreover, recent research suggests that theglutathione-related thiolic antioxidants, thiazolidine carboxylicacid (thioproline) and N-acetylcysteine, as well asthe phenolic liposoluble ‘co-antioxidants’ of Curcuma longa, mayhave a significant protective effect against age-relatedatherogenesis and immune dysfunction.
Key messages from this paper are the following. (1) It is generallyaccepted that oxygen free radicals released in metabolic reactionsplay a key role in the physiopathology of ‘normal ageing’ and ofmany age-related degenerative diseases. (2) Consumption of adequatelevels of antioxidants in the diet is essential in order to preservehealth in old age. (3) A certain degree of protection againstatherogenesis and immune dysfunction may be achieved by preventingvitamin E deficiency and an excessive oxidation of theglutathione-supported thiol pool.