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Whole grains protect against atherosclerotic cardiovascular disease

Published online by Cambridge University Press:  05 March 2007

James W. Anderson
James W. Anderson*
Affiliation:
Metabolic Research Group, VA Medical Center and University of Kentucky, (111C) Cooper Drive Room B402, Lexington, KY 40511, USA
*
Corresponding author: Professor James Anderson, fax +1 859 233 3832, jwandersmd@aol.com
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Abstract

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Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of death in most Western countries. Nutrition factors contribute importantly to this high risk for ASCVD. Favourable alterations in diet can reduce six of the nine major risk factors for ASCVD, i.e. high serum LDL-cholesterol levels, high fasting serum triacylglycerol levels, low HDL-cholesterol levels, hypertension, diabetes and obesity. Wholegrain foods may be one the healthiest choices individuals can make to lower the risk for ASCVD. Epidemiological studies indicate that individuals with higher levels (in the highest quintile) of whole-grain intake have a 29% lower risk for ASCVD than individuals with lower levels (lowest quintile) of whole-grain intake. It is of interest that neither the highest levels of cereal fibre nor the highest levels of refined cereals provide appreciable protection against ASCVD. Generous intake of whole grains also provides protection from development of diabetes and obesity. Diets rich in whole-grain foods tend to decrease serum LDL-cholesterol and triacylglycerol levels as well as blood pressure while increasing serum HDL-cholesterol levels. Whole-grain intake may also favourably alter antioxidant status, serum homocysteine levels, vascular reactivity and the inflammatory state. Whole-grain components that appear to make major contributions to these protective effects are: dietary fibre; vitamins; minerals; antioxidants; phytosterols; other phytochemicals. Three servings of whole grains daily are recommended to provide these health benefits.

Keywords

Atherosclerotic cardiovascular diseaseWhole grainsDietary fibre
Type
Session: Health effects of whole grains
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 1 , February 2003 , pp. 135 - 142
Copyright
Copyright © The Nutrition Society 2003

References

Albert, CM, Rifai, N, Stampfer, M, Ridker, P (2002) Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 105, 2595–2599.CrossRefGoogle ScholarPubMed
American Heart Association (2000) 2000 Heart and Stroke Statistical Update, pp. 1–32. Dallas, TX: American Heart Association.Google Scholar
Anderson, J (1983) Plant fiber and blood pressure. Annals of Internal Medicine 98, 842–846.CrossRefGoogle ScholarPubMed
Anderson, J (1985) High-fiber diets for obese diabetic men on insulin therapy: short-term and long-term effects. In Dietary Fiber and Obesity, 49–68 [Vahouny, GV, editors] New York: Alan R. Liss Inc.Google Scholar
Anderson, J (1995) Dietary fibre, complex carbohydrate and coronary artery disease. Canadian Journal of Cardiology 11 55G – 62GGoogle Scholar
Anderson, J (1999) Nutritional management of diabetes mellitus. In Modern Nutrition in Health and Disease, 9th ed.., pp.1365–1395 [Shils, ME, Olson, JA, Shike, M, editors] Baltimore, MD: Williams and Wilkins.Google Scholar
Anderson, J (2000) Dietary fiber prevents carbohydrate-induced hypertriglyceridemia. Current Atherosclerosis Reports 2, 536–541.CrossRefGoogle ScholarPubMed
Anderson, J, Akanji, A (1991) Dietary fiber – an overview. Diabetes Care 14, 1126–1131.Google Scholar
Anderson, J, Allgood, L, Lawrence, A, Altringer, L, Jerdack, G, Hengehold, D (2000a) Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. American Journal of Clinical Nutrition 71, 472–479.CrossRefGoogle ScholarPubMed
Anderson, J, Allgood, L, Turner, C, Oelgten, P, Daggy, B (1999a) Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia. American Journal of Clinical Nutrition 70, 466–473.Google Scholar
Anderson, J, Bryant, CA (1986) Dietary fiber: diabetes and obesity. American Journal of Gastroenterology 81, 898–906.Google ScholarPubMed
Anderson, J, Chen, W, Sieling, B (1980) Hypolipidemic effects of high-carbohydrate, high-fiber diets. Metabolism 29, 551–558.CrossRefGoogle ScholarPubMed
Anderson, J, Deakins, DA, Floore, TL, Smith, BM, Whitis, SE (1990) Dietary fiber and coronary heart disease. Critical Reviews in Food Science and Nutrition 29, 95–147.CrossRefGoogle ScholarPubMed
Anderson, J, Gowri, M, Turner, J, Nichols, L, Diwadkar, V, Chow, C, Oelgten, P (1999b) Antioxidant supplementation effects on low-density lipoprotein oxidation for individuals with noninsulin dependent diabetes mellitus. Journal of the American College of Nutrition 18, 451–461.Google Scholar
Anderson, J, Gustafson, N (1988) Hypocholesterolemic effects of oat and bean products. American Journal of Clinical Nutrition 48, 749–753.CrossRefGoogle ScholarPubMed
Anderson, J, Hanna, TJ (1999) Impact of nondigestible carbohydrates on serum lipoproteins and risk for cardiovascular disease. Journal of Nutrition 129, 1457S–1466S.Google Scholar
Anderson, J, Hanna, TJ, Peng, X, Kryscio, R (2000b) Whole grain foods and heart disease risk. Journal of the American College of Nutrition 19, 291S–299S.CrossRefGoogle ScholarPubMed
Anderson, J, Johnstone, B, Cook-Newell, M (1995) Meta-analysis of effects of soy protein intake on serum lipids in humans. New England Journal of Medicine 333, 276–282.CrossRefGoogle Scholar
Anderson, J, Konz, EC (2001) Obesity and disease management: Effects of weight loss on co-morbid conditions. Obesity Research 9, 326S–334S.Google Scholar
Anderson, J, Riddell-Lawrence, S, Floore, T, Dillon, D, Oelgten, P (1991a) Bakery products lower serum cholesterol concentrations in hypercholesterolemic men. American Journal of Clinical Nutrition 54, 836–840.CrossRefGoogle ScholarPubMed
Anderson, J, Sieling, B (1980) High fiber diets for obese diabetic patients. Obesity/Bariatric Medicine 9, 109–113.Google Scholar
Anderson, J, Zeigler, J, Floore, T, Dillon, D, Wood, C, Oeltgen, P, Whitley, R (1991b) Metabolic effects of high-carbohydrate, highfiber diets for insulin-dependent diabetic individuals. American Journal of Clinical Nutrition 54, 936–943.CrossRefGoogle ScholarPubMed
Appel, L, Moore, T, Obarzanek, E, Vollmer, W, Svetkey, L, Sacks, F, Bray, G, Vogt, T, Cutler, J, Windhauser, M, Lin, P, Karanja, N (1997) A clinical trial of the effects of dietary patterns on blood pressure. New England Journal of Medicine 336, 1117–1124 DASH Collaborative Research GroupCrossRefGoogle ScholarPubMed
Ascherio, A, Rimm, EB, Giovannucci, EL, Colditz, GA, Rosner, B, Willett, WC, Sacks, F, Stampfer, MJ (1992) A prospective study of nutritional factors and hypertension among US men. Circulation 86, 1475–1484.CrossRefGoogle ScholarPubMed
Boushey, CJ, Beresford, SA, Omenn, GS, Motulsky, AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Journal of the American Medical Association 274, 1049–1057.Google Scholar
Brown, B, Zhao, X-Q, Chait, A, Fisher, L, Cheung, M, Morse, J, Dowdy, A, Marino, E, Bolson, E, Alaupoviv, P, Frohlich, J, Albers, J (2001) Simvastatin and niacin, antioxidant vitamins, another combination for the prevention of coronary disease. New England Journal of Medicine 345, 1583–1592.CrossRefGoogle ScholarPubMed
Brown, L, Rosner, B, Willett, W, Sacks, F (1999) Cholesterollowering effects of dietary fiber: a meta-analysis. American Journal of Clinical Nutrition 69, 30–42.Google Scholar
Chandalia, M, Garg, A, Lutjohann, D, von Bergmann, K, Grundy, S, Brinkley, L (2000) Beneficial effects of high dietary fiber intake in patients with Type 2 diabetes mellitus. New England Journal of Medicine 342, 1392–1398.CrossRefGoogle ScholarPubMed
Cleveland, LE, Moshfegh, AJ, Albertson, AM, Goldman, JD (2000) Dietary intake of whole grains. Journal of the American College of Nutrition 19, 331S–338S.CrossRefGoogle ScholarPubMed
Despres, J-P, Lamarche, B, Mauriege, P (1996) Hyperinsulinemia as an independent risk factor for ischemic heart disease. New England Journal of Medicine 334, 952–957.CrossRefGoogle ScholarPubMed
Duncan, KH, Bacon, JA, Weinsier, RL (1983) The effects of high and low energy density diets on satiety, energy intake, and eating time of obese and nonobese subjects. American Journal of Clinical Nutrition 37, 763–767.Google Scholar
Ford, E, Giles, W, Dietz, W (2002) Prevalence of the metabolic syndrome among US adults. Journal of the American Medical Association 287, 356–359.CrossRefGoogle ScholarPubMed
Fraser, GE, Sabate, J, Beeson, WL, Strahan, TM (1992) A possible protective effect of nut consumption on risk of coronary heart disease. Archives of Internal Medicine 152, 1416–1424.CrossRefGoogle ScholarPubMed
Fukagawa, NK, Anderson, J, Young, VR, Minaker, KL (1990) High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults. American Journal of Clinical Nutrition 52, 524–528.CrossRefGoogle ScholarPubMed
Fung, T, Rimm, E, Spiegelman, D, Rifai, N, Tofler, G, Willett, W, Hu, F (2001) Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. American Journal of Clinical Nutrition 73, 61–67.Google Scholar
Gey, K, Moser, U, Jordan, P, Stahelm, H, Eichholzer, M, Ludin, E (1993) Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiologic update with special attention to carotene and vitamin C. American Journal of Clinical Nutrition 57, 787S–797S.Google Scholar
Ginsberg, H (1997) Is hypertriglyceridemia a risk factor for atherosclerotic cardiovascular disease: a simple question with a complicated answer. Annals of Internal Medicine 126, 912–914.CrossRefGoogle ScholarPubMed
Gowri, MS, Van der Westhuyzen, DR, Bridges, SR, Anderson, J (1999) Decreased protection by HDL from poorly controlled type 2 diabetic subjects against LDL oxidation may be due to the abnormal composition of HDL. Arteriosclerosis, Thrombosis and Vascular Biology 9, 2226–2233.Google Scholar
He, J, Whelton, PK (1999) Effect of dietary fiber and protein intake on blood pressure: a review of epidemiologic evidence. Clinical and Experimental Hypertension 21, 785–796.CrossRefGoogle ScholarPubMed
Honore, EK, Williams, JK, Anthony, MS, Clarkson, TB (1997) Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertility and Sterility 67, 148–154.CrossRefGoogle ScholarPubMed
Jacobs, D, Meyer, K, Kushi, L, Folsom, A (1998) Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study. American Journal of Clinical Nutrition 68, 248–257.Google Scholar
Jacobs, D, Meyer, K, Kushi, L, Folsom, A (1999) Is whole grain intake associated with reduced total and cause-specific death rates in older women? The Iowa Women's Health Study. American Journal of Public Health 89, 322–329.Google Scholar
Jacques, H, Gascon, A, Arul, J, Boudreau, A, Lavigne, C, Bergeron, J (1999) Modified milk fat reduces plasma triacylglycerol concentrations in normolipidemic men compared with regular milk fat and nonhydrogenated margarine. American Journal of Clinical Nutrition 70, 983–991.Google Scholar
Jenkins, D, Kendall, C, Vuksan, V (2000) Viscous fibers, health claims, and strategies to reduce cardiovascular disease. American Journal of Clinical Nutrition 71, 401–402.CrossRefGoogle ScholarPubMed
Jenkins, D, Wolever, T, Taylor, R, Barker, H, Fielden, H, Baldwin, J, Bowling, A, Newman, H, Jenkins, A, Goff, D (1981) Glycemic index of foods: a physiologic basis for carbohydrate exchange. American Journal of Clinical Nutrition 34, 362–366.Google Scholar
Jha, P, Flather, M, Lonn, E, Farkouh, M, Yusuf, S (1995) The antioxidant vitamins and cardiovascular disease. Annals of Internal Medicine 123, 860–872.Google Scholar
Juntunen, KS, Mazur, WM, Liukkonen, KH, Uehara, M, Poutanen, KS, Adlercreutz, HC, Mykkanen, HM (2000) Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women. British Journal of Nutrition 84, 839–846.CrossRefGoogle ScholarPubMed
Kang, S-S, Wong, PW, Malinow, M (1992) Hyperhomocysti (e)nemia as a risk factor for occlusive vascular disease. Annual Review of Nutrition 12, 279–298.CrossRefGoogle Scholar
Kannel, W (1996) Blood pressure as a cardiovascular risk factor. Journal of the American Medical Association 275, 1571–1576.CrossRefGoogle ScholarPubMed
Krauss, R, Eckel, R, Howard, B, Appel, L, Daniels, S, Deckelbaum, R, Erdman, J, Kris-Etherton, P, Goldberg, I, Kotchen, T, Lichtenstein, A, Mitch, W, Mullis, R, Robinson, K, Wylie-Rosett, J, St, Jeor, S, Suttie, J, Tribble, D, Bazzarre T (2000) AHA Guidelines Revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 102, 2296–2311.CrossRefGoogle ScholarPubMed
Liu, S, Manson, JE, Stampfer, MJ, Rexrode, KM, Hu, FB, Rimm, EB, Willett, WC (2000) Whole grain consumption and risk of ischemic stroke in women: A prospective study. Journal of the American Medical Association 284, 1534–1540.CrossRefGoogle ScholarPubMed
Liu, S, Stampfer, M, Hu, F, Giovannucci, E, Rimm, E, Manson, J, Hennekens, C, Willett, W (1999) Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study. American Journal of Clinical Nutrition 70, 412–419.Google Scholar
Ludwig, D, Pereira, M, Kroenke, C, Hilner, J, Van Horn, L, Slattery, M, Jacobs, D Jr (1999) Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. Journal of the American Medical Association 282, 1539–1546.CrossRefGoogle ScholarPubMed
McCully, K (1969) Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. American Journal of Pathology 56, 111–128.Google Scholar
MacDougall, AJ, Selvendran, RR (2001) Chemistry, architecture, and composition of dietary fiber from plant cell walls. In Handbook of Dietary Fiber, pp.281–319 [Cho, SS, Dreher, ML, editors] New York: Marcel Dekker, Inc.CrossRefGoogle Scholar
McIntosh, G, Whyte, J, McArthur, R, Nestel, P (1991) Barley and wheat foods: influence on plasma cholesterol concentrations in hypercholesterolemic men. American Journal of Clinical Nutrition 53, 1205–1209.Google Scholar
Manson, J, Willett, W, Stampfer, M, Colditz, G, Hunter, D, Hankinson, S, Hennekens, C, Speizer, F (1995) Body weight and mortality among women. New England Journal of Medicine 333, 677–685.CrossRefGoogle ScholarPubMed
Mendelsohn, M, Karas, R (1999) The protective effects of estrogens on the cardiovascular system. New England Journal of Medicine 340, 1801–1811.CrossRefGoogle ScholarPubMed
Meyer, K, Kushi, L, Jacobs, D, Slavin, J, Sellers, T, Folsom, A (2000) Carbohydrates, dietary fiber, and incidence of type 2 diabetes in older women. American Journal of Clinical Nutrition 71, 921–930.Google Scholar
Mickelsen, O, Makdani, DD, Cotton, RH, Titcomb, ST, Colmey, JC, Gatty, R (1979) Effects of a high fiber bread diet on weight loss in college-age males. American Journal of Clinical Nutrition 32, 1703–1709.Google Scholar
Miller, H, Rigelhop, F, Marquart, L, Prakash, A, Kanter, M (2000) Whole-grain products and antioxidants. Cereal Foods World 45, 59–63.Google Scholar
Morris, J, Marr, J, Clayton, D (1977) Diet and heart: a postscript. British Medical Journal 2, 1307–1314.Google Scholar
Navab, M, Berliner, J, Watson, A, Hama, S, Territo, M, Lusis, A, Shih, D, Van Lenten, B, Frank, J, Demer, L, Edwards, P, Fogelman, A (1996) The Yin and Yang of oxidation in the development of the fatty streak. Arteriosclerosis, Thrombosis and Vascular Biology 16, 831–842.Google Scholar
Nestel, PJ, Yamashita, T, Sasahara, T, Pomeroy, S, Dart, A, Komesaroff, P, Own, A, Abbey, M (1997) Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arteriosclerosis, Thrombosis and Vascular Biology 17, 3392–3398.CrossRefGoogle Scholar
Olson, B, Anderson, S, Becker, M, Anderson, J, Hunninghake, D, Jenkins, D, LaRosa, J, Rippe, J, Roberts, D, Stoy, D, Summerbell, C, Truswell, A, Wolever, T, Morris, D, Fulgoni, V (1997) Psylliumenriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol in hypercholesterolemic adults: results of a meta-analysis. Journal of Nutrition 127, 1973–1980.Google Scholar
Park, E, Hellerstein, M (2000) Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. American Journal of Clinical Nutrition 71, 412–433.Google Scholar
Pereira, M, Jacobs, D Jr, Pins, J, Raatz, SK, Gross, MD, Slavin, J & Seaquist, ER (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. American Journal of Clinical Nutrition 75, 848–855.Google Scholar
Raines, EW, Ross, R (1995) Biology of atherosclerotic plaque formation: possible role of growth factors in lesion development and the potential impact of soy. Journal of Nutrition 125, 624S–630S.Google Scholar
Reaven, G (1988) Role of insulin resistance in human disease. Diabetes 37, 1595–1607.Google Scholar
Regal, JF, Fraser, DG, Weeks, CE, Greenberg, NA (2000) Dietary phytoestrogens have anti-inflammatory activity in a guinea pig model of asthma. Experimental Biology and Medicine 223, 372–378.Google Scholar
Regnstrom, J, Nilsson, J, Strom, K, Bavenholm, P, Tornvall, P, Hamsten, A (1996) Inverse relationship between concentration of vitamin E and severity of coronary artery disease. American Journal of Clinical Nutrition 63, 377–385.Google Scholar
Reis, S, Gloth, S, Blumenthal, R, Resar, J, Zacur, H, Gerstenblith, G, Brinker, J (1994) Ethinyl estradiole acutely attenuates abnormal coronary vasomotor responses to acetyl choline in postmenopausal women. Circulation 89, 52–60.Google Scholar
Rimm, E, Stampfer, M, Ascherio, A, Giovannucci, E, Colditz, G, Willett, W (1993) Vitamin E consumption and the risk of coronary heart disease in man. New England Journal of Medicine 328, 1450–1456.Google Scholar
Ripsin, CM, Keenan, JM, Jacobs, DR, Elmer, PJ, Welch, RR, Van Horn, L, Liu, K, Turnbull, WH, Thye, FW, Kestin, M, Hegsted, M, Davidson, DM, Davidson, MH, Dugan, LD, Demark-Wahnefried, W, Beling, S (1992) Oat products and lipid lowering. Journal of the American Medical Association 267, 3317–3325.CrossRefGoogle ScholarPubMed
Ross, R (1999) Atherosclerosis is an inflammatory disease. American Heart Journal 138, S419–S420.Google Scholar
Rubins, H, Robins, S, Collins, D, Fye, C, Anderson, J, Elam, M, Faas, F, Linares, E, Schaefer, E, Schectman, G, Wilk, T, Wittes, J (1999) Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. New England Journal of Medicine 341, 410–418.Google Scholar
Russ, C, Atkinson, R (1985) A comprehensive outpatient weight reduction program: dietary patterns, psychological considerations, and treatment principles. Nutrition Reports International 32, 193–198.Google Scholar
Sacks, FM, Svetkey, LP, Vollmer, WM, Appel, LJ, Bray, GA, Harsha, D, Obarzanek, E, Conlin, PR, Miller, ER, Simons-Morton, D, Karanja, N, Pao-Hwa, L (2001) Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. New England Journal of Medicine 344, 3–10.CrossRefGoogle ScholarPubMed
Sadowska-Krowicka, H, Mannick, EE, Oliver, PD, Sandoval, M, Zhang, XJ, Eloby-Childess, S, Clark, DA, Miller, MJS (1998) Genistein and gut inflammation: role of nitric oxide. Experimental Biology and Medicine 217, 351–357.Google Scholar
Salmeron, J, Ascherio, A, Rimm, E, Colditz, G, Spiegelman, D, Jenkins, D, Stampfer, M, Wing, A, Willett, W (1997a) Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 20, 545–550.Google Scholar
Salmeron, J, Manson, JE, Stampfer, MJ, Coldtiz, GA, Wing, AL, Willet, WC (1997b) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Journal of the American Medical Association 277, 472–477.Google Scholar
Selhub, J, Jacques, P, Bostom, A, D'Agostino, R, Wilson, P, Belanger, A, O'Leary, D, Wolf, P, Schaefer, E, Rosenberg, I (1995) Association between plasma homocysteine concentrations and extracranial carotid-artery disease. New England Journal of Medicine 332, 286–291.CrossRefGoogle Scholar
Slavin, J, Jacobs, D, Marquart, L (1997) Whole-grain consumption and chronic disease: protective mechanisms. Nutrition and Cancer 27, 14–21.Google Scholar
Stampfer, M, Hennekens, C, Manson, J, Colditz, G, Rosner, B, Willett, W (1993) Vitamin E consumption and the risk of coronary disease in women. New England Journal of Medicine 328, 1444–1449.CrossRefGoogle ScholarPubMed
Stampfer, M, Malinow, M (1995) Can lowering homocysteine levels reduce cardiovascular disease?. New England Journal of Medicine 332, 328–329.CrossRefGoogle Scholar
Subbiah, M (1998) Mechanisms of the cardioprotection of estrogens. Experimental Biology and Medicine 217, 23–52.Google Scholar
Truswell, A (2002) Cereal grains and coronary heart disease. European Journal of Clinical Nutrition 56, 1–14.Google Scholar
Vinik, AI, Jenkins, DJA (1988) Dietary fiber in management of diabetes. Diabetes Care 11, 160–173.CrossRefGoogle ScholarPubMed
Welch, GN, Loscalzo, J (1998) Homocysteine and atherothrombosis. New England Journal of Medicine 338, 1042–1050.CrossRefGoogle ScholarPubMed
Wilcox, JN, Blumenthal, BF (1995) Thrombotic mechanism in atherosclerosis: potential impact of soy proteins. Journal of Nutrition 125, 631S–638S.Google Scholar
Williams, JK, Clarkson, TB (1998) Dietary soy isoflavones inhibit in-vivo constrictor responses of coronary arteries to collagen-induced platelet activation. Coronary Artery Disease 9, 759–764.CrossRefGoogle ScholarPubMed
Zilversmit, D (1979) Atherogenesis: a postprandial phenomenon. Circulation 60, 473–485.CrossRefGoogle ScholarPubMed