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Genetic polymorphisms and lipoprotein responses to diets

Published online by Cambridge University Press:  19 December 2008

Stephanie Vincent ,
Richard Planells ,
Catherine Defoort ,
Marie-Christine Bernard ,
Mariette Gerber ,
Joanne Prudhomme ,
Philippe Vague  and
Denis Lairon
Stephanie Vincent
Affiliation:
Unité 476-Human Nutrition and Lipids at INSERM (National Institute of Health and Medical Research), 18 Avenue Mozart, 13009 Marseille, France
Richard Planells
Affiliation:
Unité 476-Human Nutrition and Lipids at INSERM (National Institute of Health and Medical Research), 18 Avenue Mozart, 13009 Marseille, France
Catherine Defoort
Affiliation:
Unité 476-Human Nutrition and Lipids at INSERM (National Institute of Health and Medical Research), 18 Avenue Mozart, 13009 Marseille, France
Marie-Christine Bernard
Affiliation:
CDPA, CHU Timone, Marseille, France
Mariette Gerber
Affiliation:
CRLC Val d'Aurelle, Montpellier, France
Joanne Prudhomme
Affiliation:
ORS, Marseille, France
Philippe Vague
Affiliation:
CDPA, CHU Timone, Marseille, France
Denis Lairon*
Affiliation:
Unité 476-Human Nutrition and Lipids at INSERM (National Institute of Health and Medical Research), 18 Avenue Mozart, 13009 Marseille, France
*
*Corresponding author: Denis Lairon, fax +33 4 91 75 15 62, email lairon@marseille.inserm.fr
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Abstract

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Résumé

Alors que l'alimentation de l'homme a beaucoup évoluée depuis ses origines, le génome humain est resté très stable. Pourtant, de très nombreux gènes ont des polymorphismes connus. En fait, on considère maintenant que les principales pathologies humaines (maladies cardiovasculaires, diabète, obésité et cancers) résultent d'une interaction entre des facteurs de succeptibilité génétique et des facteurs de l'environement, dont l'alimentation. Dans le domaine du métabolisme des lipoprotéines et des maladies cardiovasculaires, des polymorphimes de plusieurs gènes ont été identifiés et associés aux niveaux des paramètres lipidiques ou aà des réponses variables aux régimes, comme pour les apoprotéines (apo) E, B, A-IV et C-III, le LDL récepteur, la protéine microsomiale de transport (MTP), la protéine de liason des acides gras (FABP), la protéine de transport des esters de cholésterol (CETP), la lipoprotéine lipase ou la lipase hepatique. Nous réalisons une étude d'intervention à Marseille dans le but d'étudier l'interaction

Keywords

Human intervention studyMediterranean dietGene polymorphismsCardiovascular risk
Type
Symposium on ‘Nutrition in the post-genomic era’ Plenary session 3: Genetic variation and response to food
Information
Proceedings of the Nutrition Society , Volume 61 , Issue 4 , November 2002 , pp. 427 - 434
Copyright
Copyright © The Nutrition Society 2002

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