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Manganese in health and disease

Published online by Cambridge University Press:  17 June 2025

Yingchen Wang ,
Jinyou Li ,
Jing Zhuang ,
Yinhang Wu ,
Jiang Liu  and
Shuwen Han
Yingchen Wang
Affiliation:
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, People’s Republic of China Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, People’s Republic of China Zhejiang-France United Laboratory of Integrated Traditional Chinese and Modern Medicine in Colorectal Cancer, Huzhou, Zhejiang, People’s Republic of China
Jinyou Li
Affiliation:
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, People’s Republic of China Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, People’s Republic of China Zhejiang-France United Laboratory of Integrated Traditional Chinese and Modern Medicine in Colorectal Cancer, Huzhou, Zhejiang, People’s Republic of China
Jing Zhuang
Affiliation:
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, People’s Republic of China Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, People’s Republic of China Zhejiang-France United Laboratory of Integrated Traditional Chinese and Modern Medicine in Colorectal Cancer, Huzhou, Zhejiang, People’s Republic of China
Yinhang Wu
Affiliation:
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, People’s Republic of China Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, People’s Republic of China Zhejiang-France United Laboratory of Integrated Traditional Chinese and Modern Medicine in Colorectal Cancer, Huzhou, Zhejiang, People’s Republic of China
Jiang Liu
Affiliation:
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, People’s Republic of China Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, People’s Republic of China Zhejiang-France United Laboratory of Integrated Traditional Chinese and Modern Medicine in Colorectal Cancer, Huzhou, Zhejiang, People’s Republic of China
Shuwen Han*
Affiliation:
Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang, People’s Republic of China Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, People’s Republic of China Zhejiang-France United Laboratory of Integrated Traditional Chinese and Modern Medicine in Colorectal Cancer, Huzhou, Zhejiang, People’s Republic of China ASIR (Institute - Association of intelligent systems and robotics), 14B rue Henri Sainte Claire Deville, 92500, Rueil-Malmaison, France
*
Corresponding author: Shuwen Han; Email: shuwenhan985@163.com
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Abstract

Manganese (Mn) is a crucial trace element that actively participates in a diverse array of physiological processes. Mn is maintained at appropriate levels in the body by absorption and excretion by the body. Dysregulation of Mn homeostasis can lead to a variety of diseases, especially the accumulation of Mn in the brain, resulting in toxic side effects. We reviewed the metabolism and distribution of Mn at multiple levels, including organ, cellular and sub-cell levels. Mitochondria are the main sites of Mn metabolism and energy conversion in cells. Enhanced Mn superoxide dismutase activity reduces mitochondrial oxidative stress and inhibits cancer development. In addition, Mn enhances anti-cancer immune responses through the cGAS–STING pathway. We introduced various delivery vectors for Mn delivery to cancer sites for Mn supplementation and anti-cancer immunity. This review aims to provide new research perspectives for the application of Mn in the prevention and treatment of human diseases, especially by enhancing anti-cancer immune responses to inhibit cancer progression.

Keywords

Trace elementsManganeseMitochondriacGAS–STINGManganese nanomaterialsCancer

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Type
Review Article
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Nutrition Research Reviews , First View , pp. 1 - 11
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© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

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