This article considers the link between industrialization and social movement strategy. In the late nineteenth century, temperance organizations, rebuffed by Congress, won prohibition at the state level, especially in the American South and West. Simultaneously, lawmakers in the Reconstruction South and West built railroads to Midwestern rail hubs, which housed breweries and distilleries that shipped liquor by rail back into dry states. The Woman’s Christian Temperance Union and Anti-Saloon League lobbied dry state congressmen to ban this interstate liquor traffic through the 1890 Wilson Act and 1913 Webb-Kenyon Act and eventually sought a complementary national amendment prohibiting liquor manufacturing, sale, and transportation. As railroad expansion and advances in liquor manufacturing undermined the state-level dry regime, prohibitionists pushed for a nationwide ban, contrary to voters’ preferences. This case shows how interest groups adapted a new legislative strategy, partly in response to industrialization and interstate rail development at the turn of the twentieth century.