This article investigates the evolving dynamics of global scientific production and collaboration from 2000 to 2022, focusing on the impact of geopolitical changes on academic freedom and international research collaboration. Historically dominated by Western liberal democracies, the global scientific landscape has seen a significant shift with the rise of emerging economies, particularly within the BRICS group. This transition reflects broader changes in wealth distribution and scientific output, with China emerging as the largest scientific system. The analysis employs bibliometric indicators and political metrics, including the V-Dem’s Liberal Democracy Index and the Academic Freedom Index, to assess changes in scientific output, academic freedom, and international collaboration. Results reveal a decline in academic freedom and liberal democracy in major science-producing countries, coinciding with increased scientific output from nations with lower academic freedoms. The study also examines international collaboration patterns, highlighting a shift away from traditional Western partners towards increased collaboration within the BRICS group. This shift is particularly evident in the growing partnerships between China, India and Russia. Despite the increased scientific output from these countries, Western countries, particularly the USA and European nations, remain pivotal in global scientific networks. In summary, the findings suggest a move towards a more multipolar scientific world, where the balance of power is shifting away from traditional Western hegemony. However, this shift comes with significant challenges, particularly concerning the erosion of academic freedom in many of the expanding scientific regions.