Workplace harassment is one of the main psychosocial risks, leading to suffering at work or a lack of well-being. It can compromise one’s sense of safety and dignity and leave lasting scars on mental health.

Determine the prevalence of workplace harassment in healthcare environments and evaluate its impact on mental health.

This is across-sectional study conducted among health professionals at an University Hospital in Tunisia. Data was collected using a pre-established synoptic form on the social and professional characteristics of the participants. Workplace harassment was assessed using the LIPT questionnaire.

Of the 500 healthcare workers included in this study period, 362 respended to the questionnaire representing a response rate of 72.4%. The average age of the participants was 37.3±8.71 years, with women predominating (59.4%). The majority of participants were paramedical staff (54.4%). Of the participants, 101 (27.9%) had at least one comorbidity. The most common medical conditions were hypertension (10.5%). As for psychiatric history, which was present in 21.8% of participants, depression was the most common pathology (53.1%). The prevalence of harassment was 19.9%. Both men and women were harassed in 47.9% of cases, 66.7% by their hierarchical superior, and 72.2% by their colleagues. Our results show that 27.4% of subjects reporting palpitations were harassed, compared with 14.8% in the group without palpitations (p=0.003). Similarly, the frequency of harassment was significantly higher in participants with a lump in the throat. Subjects with fatigue were also significantly more harassed than subjects without this complaint (25.5% vs. 12%, p=0.002). Anxiety and competition problems were 4.27 (CI95%(2.3-7.91), p<0.001) and 4.41 (CI95%(2.32-8.39), p<0.001) times more frequent in people suffering harassment.

The prevalence of harassment among health professionals is not negligible, and the repercussions of this phenomenon are frequent. Given the extent of this emerging concept, preventive measures must be proposed and studied in order to put an end to its harmful effects.

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Attachment styles, developed through early life interactions, influence how individuals perceive relationships and manage stress. Medical students often exhibit insecure attachment styles, which are linked to increased psychological distress.

The primary aim of this study is to explore the extent to which resilience influences the connection between attachment styles and general psychological well-being among medical students.

This cross-sectional study was conducted at New Giza University in Cairo, Egypt, and involved 437 medical students. Participants completed self-report surveys measuring attachment styles, resilience, and psychological distress. The survey instruments included the Relationship Questionnaire (RQ) for attachment styles, the General Health Questionnaire (GHQ-12) for psychological distress (where a lower GHQ-12 score indicates less psychological distress), and the Connor–Davidson Resilience Scale (CD-RISC-10) for resilience. Participants were grouped into four attachment styles: secure (SA), fearful avoidant (FA), anxious preoccupied (AP), and dismissive avoidant (DA).

The sample’s mean age was 20.32 years (SD = 2.09). Females comprised 69.6% of the cohort, and single students made up 80.1% of the whole cohort. The distribution of attachment styles across females and males differed significantly (p < 0.0001, χ² = 25.7), with DA being more prevalent in males compared to females (28.6% and 13.2%, respectively). GHQ-12 median scores were similar between genders (p = 0.23), while CD-RISC-10 scores differed (p = 0.002), with males having a higher median (28).

Median scores of GHQ-12 and CD-RISC-10 differed significantly across groups of attachment styles (p < 0.0001 and p = 0.0002, respectively). AP and FA had the highest GHQ-12 medians (15), while AP had the lowest CD-RISC-10 median (25).

A negative correlation between CD-RISC-10 and GHQ-12 scores was significant in the whole cohort (p < 0.0001, r = -0.3227), with FA showing the strongest correlation (p < 0.0001, r = -0.3292, CI: -0.4714 to -0.1704) and other groups showing similar reuslts (figures 1, 2 and 3).

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The findings underscore the critical role of resilience in buffering against the psychological impacts of insecure attachment among medical students. Approaches targeting resilience enhancement could serve as a valuable intervention target to mitigate psychological distress and improve well-being in this high-risk attachment styles. Future research is recommended to develop and test resilience-focused interventions tailored to medical students with insecure attachment styles, which may help reduce burnout and promote mental health in medical training environments.

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Consensual non-monogamous relationships (CNM) are characterized by a diversity of approaches to intimate relationships, diverging from the traditional monogamous model and exploring new possibilities. CNM relationships include forms such as polyamory, open relationships, and swinging. There are no official and systematic epidemiological data on CNM relationships in Italy; however, these relationships have recently gained more visibility due to social media, support groups, and open discussions about relationship diversity that are slowly emerging in a country whose culture is traditionally influenced by Catholicism and conservative social norms.

Most research focuses on discrimination against individuals involved in CNM, while the factors underlying people’s engagement in such relationships are overlooked. This study aims to investigate predictors of willingness to engage and actual engagement in CNM among Italian emerging adults. Specifically, based on the Theory of Planned Behavior (Ajzen, 1991), we examined the role of perceived social norms and perceived behavioral control, as well as other predictors already tested in previous research.

Participants completed an online questionnaire examining factors such as gender, sexual orientation, willingness to engage in CNM relationships (WECNM; Moors et al., 2015; 6 items), avoidant and anxious attachment style (ECR-S; Wei et al., 2007; 12 items), erotophilia (ATP; Johnson et al., 2015; 5 items), social norms (PSN; custom scale, 4 items), perceived behavioral control in CNM relationships (PBC; custom scale, 2 items). Data were analyzed using SPSS, applying multiple linear regression.

The sample consists of 667 emerging adults (Mage = 23.29; age range: 18 – 30) with diverse sexual orientations and gender identities. Of these, 535 participants are involved in monogamous relationships, 65 in polyamorous, and 67 in open relationships. In line with our hypotheses, results show that social norms, perceived behavioral control, non-heterosexual orientation, and cisgender male identity are significant predictors of both the willingness to engage in and the commitment to consensual non-monogamous relationships. Avoidant attachment style, as well as erotophilia, predict the predisposition but not the actual commitment to CNM.

The results contribute to a deeper understanding of CNM relationships in the Italian context by identifying some individual and social factors related to openness and involvement in CNM relationships. This provides preliminary evidence of the utility of the Theory of Planned Behavior in understanding this type of relationship. Moreover, the significant number of individuals involved or interested underscores the importance of considering relationship diversity in future research and social policies, with the aim of promoting greater acceptance and inclusion.

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Psychiatry focuses on disorders of affect, behavior, and cognition (ABC), with half of all psychiatric disorders emerging by age 14 and three-quarters by age 24. Disorders are categorized into four types: Type 1 (affective disorders like depression and anxiety), Type 2 (behavioral disorders like ADHD and ODD), Type 3 (developmental disorders like mental retardation and speech/language issues), and Type 4 (dysfunctional disorders, including psychotic illnesses and mood disorders). These categories—emotional, behavioral, cognitive, and dysfunctional—form the ABCD framework in child psychiatry.

The study aimed to categorize childhood and adolescent mental and behavioral disorders into four groups: developmental, disruptive, emotional, and dysfunctional. It also sought to examine intra- and inter-group comorbidities, and analyze the clinical variables of these groups and their comorbidities by age and sex.

This was an observational cross-sectional study conducted at Gauhati Medical College Hospital (GMCH), Guwahati, Assam, from September 7, 2018, to September 6, 2019. Existing diagnostic systems do not distinguish between child/adolescent and adult mental health, and there is a lack of a unified “common language” for childhood and adolescent mental and behavioral disorders. The study aimed to address this gap, particularly in the local geo-cultural context, where data for a new classificatory system is scarce. Participants included children and adolescents admitted to the Child Psychiatry Unit or attending the Child Guidance Clinic. Demographic (age, sex) and clinical variables (ICD-10 diagnoses) were studied, with diagnoses categorized into types 1–4.

Total sample size was 137. Adolescents (ten to 18 years of age) were almost double in numbers to that of children (below ten years of age). Boys outnumbered girls. Adolescents were more than children in both among girls and boys (even the single third gender was an adolescent). Most of the children and adolescents were having type 3 disorders, followed by type 1 and type 2 disorders. While majority had type 3 disorders below ten years of age (children), type 1 disorders were highest in the adolescents. Type 1 and type 3 disorders were almost equally distributed among girls, while boys predominantly had type 3 disorders. Within group comorbidity was maximum with type 3 disorders. Across group comorbidity was found mostly in type 2-type 3 disorders.

John Lennon “imagined” of having no countries and no religion too; thus, there will be nothing to kill and die for! Bono of U2 wanted to be there “where the streets have no name”! Likewise, we too dream of a land for child and adolescent psychiatry where if we cannot live without names then let us at least have a few and simple ones: ABCD!

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The association between prenatal acetaminophen exposure and the development of Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) remains a subject of considerable debate. Despite extensive research, the evidence regarding this relationship is conflicting.

To perform a systematic review and meta-analysis of studies comparing the incidence of ADHD and ASD in patients that were either exposed or not exposed to acetaminophen prenatally.

We systematically searched Pubmed, Embase and Cochrane Central for eligible studies up until August 2024. Only studies which included participants with a medical diagnosis of ADHD/ASD and reported acetaminophen exposure as a binary measure were included. Available summary data was extracted from published reports and pooled with a random-effects model using odds ratios (OR) with 95% confidence intervals (CI). Hazard ratios (HR) adjusted for potential confounding factors were used for sensitivity analyses. All statistical analyses were conducted utilizing Review Manager 5.4.1. PROSPERO iD:CRD42024587662.

We included five studies with a total of 2,647,536 patients with ADHD (150,741) / ASD (63,726), of whom 271,126 were exposed to acetaminophen prenatally and 2,376,410 were not exposed. Prenatal acetaminophen exposure was associated with an increased risk of developing ADHD (OR 1.30; 95% CI 1.17 to 1.45; p<0.01; I2 = 73%; Figure 1) and ASD (OR 1.17; 95% CI 1.14 - 1.20; p<0.01; I2 = 0%; Figure 2). Sensitivity analyses revealed that acetaminophen exposure during the third trimester of pregnancy was associated with an increased risk of ADHD (HR 1.26; 95% CI 1.07 to 1.47; p<0.01; I2 = 0%; Figure 3), but not during first (HR 1.10; 95% CI 0.97 to 1.26; p=0.13; I2 = 0%; Figure 3) and second (HR 1.07; 95% CI 0.95 to 1.19; p=0.26; I2 = 0%; Figure 3) trimesters.

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In this systematic review and meta-analysis, prenatal acetaminophen exposure was significantly associated with risk of developing ADHD and ASD, especially if exposure occurs in the third trimester of pregnancy.

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Social deficits are a significant impairment in adult ASD, leading to difficulties in socio-emotional cognition, communication, and relationships. Effective social skills interventions are crucial during the transition to adulthood. The UCLA PEERS® (Program for the Education and Enrichment of Relational Skills) for young adults is a prominent and well-researched intervention, implemented in over eighty countries and translated into numerous languages. This program includes concurrent sessions for young adults and their parents, aiming to improve social skills and reduce ASD-related social issues

The current study aimed to test the effectiveness of a culturally adapted Persian -translated version of PEERS® for young adults with ASD without intellectual disabilities.

Three psychiatrists and two psychologists underwent PEERS® training and translated the manual into Farsi, adapting it culturally for Iran. Twenty-four young adults with ASD and their parents participated in the study, randomly assigned to a treatment group or a control group. Inclusion criteria were males aged 18-30 years with an ASD diagnosis, predominant social difficulties, motivation to participate, and a family member acting as a social coach. Exclusion criteria included intellectual disability, major psychiatric conditions, and significant verbal or literacy difficulties.

Participants attended 16 weekly 90-minute group sessions, covering topics like conversations, humor, electronic communication, dating etiquette, conflict management, and bullying. Sessions were led by a PEERS-certified psychologist and an assistant behavioral coach. Weekly meetings were held to align session content and address potential issues.

The culturally adapted Persian -translated version of PEERS® was perceived as beneficial by young adults with ASD and their caregivers, improving social skills and quality of life. However, quantitative measures did not show significant changes, indicating a need for further refinement and investigation to achieve measurable improvements in social functioning.

While qualitative feedback indicates that both young adults with ASD and their caregivers found the caregiver-assisted social skills intervention to be beneficial in improving social skills and overall quality of life, the quantitative measures did not show significant changes. This suggests that while the intervention may have positive perceptual impacts, further refinement and investigation are needed to achieve measurable improvements in social functioning.

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Rehospitalization is common in psychosis, often due to poor adherence to antipsychotic treatments. Long-acting injectable antipsychotics (LAIs), particularly paliperidone palmitate 6-month (PP6M), have shown promise in improving adherence and reducing relapses compared to monthly or quarterly formulations . Rapid initiation of PP6M during hospitalization may further optimize post-discharge outcomes and enhance the therapeutic adherence, minimizing the risk of a new outbreak, reducing the impact of rehospitalization and improving patients’ quality of life.

To evaluate clinical outcomes and treatment adherence in schizophrenia and other psychotic disorders after rapid PP6M initiation during psychiatric hospitalization.

A retrospective analysis of 24 hospitalized patients diagnosded with schizophrenia and other psychotic disorders treated with PP6M within 7–10 days was conducted. Treatment adherence, follow-up attendance, and adverse effects were evaluated using McNemar’s test for statistical analysis.

Patients had a mean age of 36.8 years (SD=10.85), 64% were male, with an average of 2 prior hospitalizations (SD=3.16) in the past two years. Previously, 57% were on monthly LAIs. Post-discharge, 83% attended follow-ups. Antipsychotic monotherapy increased by 27% (p = .10) to 59%, while attendance at over 80% of appointments improved by 47% (p ≤ .001). Akathisia was reported in 25% of patients.

PP6M significantly improves adherence by simplifying treatment regimens. Increased follow-up attendance (47%) and greater use of monotherapy reflect better patient outcomes. These findings align with prior evidence on the efficacy of LAIs in preventing relapses. Rapid initiation of PP6M can reduce rehospitalizations and optimize hospital resources. The low incidence of akathisia (25%) supports its safety and tolerability for long-term use.

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Previous research suggests that motivational factors relate to psychosocial functioning in SZ, both concurrently (Tobe et al. Compr Psychiat 2016; 65 103-109) and at follow-up (Fervaha et al. Acta Psychiat Scand 2014; 130 290-299). Importantly, no study has examined the influence of baseline motivation on the rate of change in response to rehabilitation

1. 1. To study the relationship between baseline measures of motivation/ effort with psychosocial functioning at follow-up

2. 2. To examine if motivation/ effort predict individual change in psychosocial functioning

Participants

Table 1 summarizes the sample characteristics

Figures 1 and 2 show individuals slopes for PSP and FAST, with a thick red line representing the average group slopes. For both PSP and FAST, models with only time as the independent variable and random intercepts indicated that time was a significant predictor (PSP: t=10.65, p<.0001; FAST: t =-6.13, p<.0001).

Baseline motivation/ effort → follow-up psychosocial functioning

No significant correlations were found for neither PSP scores (QLS: ρ=-.018, S=2343.3, p=.93, IMI: P=.23, t=1.09, p=.28, effort: ρ=.001, S=2297.3, p=.99) nor FAST scores (QLS: ρ=-.16, S=2674.9, p=.45, IMI: P=-.02, t=-0.09, p=.92, effort: ρ=.07, S=2128, p=.72).

Motivation → change in psychosocial functioning

For PSP, the interaction model (Table 2) shows that the interaction of effort and timepoint significantly predicts PSP scores

Figure 1. Individual slopes for PSP scores

Figure 2. Individual slopes for FAST scores

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Patients showed an improvement after rehabilitation. Effort can explain this trend. Finally, unlike previous studies, basal motivation did not predict follow-up psychosocial functioning

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In recent years, the concept of Self/Other distinction (SOD),the ability to differentiate one’s own body, actions and mental states from those of others,has recieved increasing interest. Studies that have explored SOD in psychiatric or neurodevelopmental disorders generally used static images or movies that progressively morph from one’s own face to another’s. However, these paradigms may be insufficient for SOD assessment given the centrality of embodiment in the pathophysiology of these disorders.The new Alter Ego double mirror paradigm was developped to specifically explore SOD under greater ecological conditions.This innovative device allows the progressive morphing of one’s own face to that of another between two subjects physically facing each other on either side of the device.

Two pilot studies were conducted to investigate self-recognition and self/other distinction respectively in adolescents with Anorexia nervosa (AN) and Autism Spectrum Disorder (ASD) compared with matched healthy controls through a self/other face identification task using the “Alter Ego” TM double mirror system.

Participants had to watch a double mirror in which their own face was gradually morphed into the face of an unfamiliar other (self-to-other) or vice versa (other-to-self), requiring them to indicate at which point they judged the morph to look more like their own face than the other’s face.Two judgment criteria were used: 1) M1: Threshold at which the subject starts recognizing his own face during the other-to-self morphing sequence 2) M2: Threshold at which the subject starts recognizing the other’s face during the self-to-other morphing sequence. For participants with AN, in a second part, SOD was reassessed during five different sensorimotor tasks aimed at increasing body self-consciousness.

Compared to controls, participants with ASD and AN showed an earlier self recognition in the other-to-self direction and a delayed other recognition in the self-to-other direction. Moreover, contrasting with controls, in ASD and AN participants, the critical threshold for switching between self and other varied with the direction of morphing. Finally, when participants with AN were seated with a backrest and footrest reinforcing the median axis of their body, the self-recognition threshold (M1) increased significantly approaching that of controls.

The preliminary results of these studies uncovered novel findings showing first behavioral evidence of impaired self/other distinction in individuals with ASD and AN through an embodied face-recognition paradigm. These results confirm the interest of the Alter Ego double mirror paradigm for the study of alterations in self-consciousness and Self/Other Distinction as a transosographic dimension common to various neurodevelopmental or psychiatric disorders.

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Sleep disturbances are common among individuals with bipolar disorder (BD) and may be present even during euthymic phases and significantly impact illness course and quality of life. This preliminary analysis is part of BEGIN (The Bipolar Exposome-Gene Interaction Naturalistic study.

Here, we analyze the relationship between subjective sleep disturbances and various lifestyle and environmental factors in BD patients.

Eighty-seven patients diagnosed with BD (Mean age = 50.7 years, SD = 13.6; 44.7% female; Mean BMI = 26.9, SD = 4.61) all in a three-month euthymic phase, were recruited. At baseline, participants completed lifestyle questionnaires covering diet, light exposure, and time spent indoors, alongside assessments of clinical history and circadian rhythms using the BRIAN scale. Sleep quality was assessed through the Pittsburgh Sleep Quality Index (PSQI, with a cutoff >5 for sleep problems) and the Epworth Sleepiness Scale (ESS, with a cutoff >10 indicating excessive daytime sleepiness). Sociodemographic, clinical, and environmental factors were compared between BD patients with and without sleep disturbances.

Based on ESS scores, patients with excessive daytime sleepiness had significantly higher overall circadian rhythm disruptions, as indicated by the BRIAN total score (p = 0.049). A negative correlation emerged between excessive daytime sleepiness and age at first hospitalization (r = -0.36, p = 0.003). Disrupted eating patterns, reflected in the BRIAN eating subscale, also correlated with excessive daytime sleepiness (r = 0.27, p = 0.027). Based on PSQI scores tobacco smoking was positively associated with poor sleep quality (r = 0.42, p = 0.013), while more time spent with artificial light from electronic devices (r = -0.29, p = 0.019), and less time spent indoors (r = 0.39, p = 0.001) correlated with worse sleep quality. Patients experiencing poor sleep also showed less consistency in social routines (BRIAN social score, p = 0.028).

These preliminary findings suggest that sleep disturbances in BD patients may be intricately linked to lifestyle and environmental factors, such as circadian rhythm disruptions, smoking, and exposure to artificial light. These results highlight the importance of considering environmental and lifestyle modifications to support sleep quality in BD. Future longitudinal analyses will be essential to clarify causal pathways and develop targeted interventions that address circadian and lifestyle factors in managing BD.

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Psychological and behavioural symptoms are an inherent part of neurodegenerative diseases such as Alzheimer’s disease and other dementias or Parkinson’s disease. Despite the growing research on the subject, there are still large gaps in knowledge about their origin, pathophysiology, diagnosis and treatment. In recent years, various initiatives have been carried out in Spain to improve knowledge, especially on the most controversial issues, of various aspects such as Alzheimer’s disease from the point of view of Psychiatry, the use of antipsychotic drugs or depression in neurodegenerative diseases. The presentation will include data on these national initiatives and will address in more detail two studies using Delphi methodology referring to depression in neurodegenerative diseases. The first one addressed depression in the context of Alzheimer’s disease and other dementias in 53 controversial items regarding risk factors, signs and symptoms, diagnosis and treatment. The second one addresses depression in Parkinson’s disease in 49 controversial issues about the aetiopathological mechanisms, clinical features and connections with motor and non-motor symptoms, diagnostic criteria, and therapeutic options. In both cases, in addition to trying to shed light on etiological and clinical aspects, specific advice is provided on the choice of antidepressant treatment and the particularities linked to its prescription.

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Treatment motivation is very important in the treatment of alcohol and substance use disorders. The evaluation of motivation, which is seen as the first step in addiction treatment, will also help understand the person’s interest and compliance with treatment. The lack of motivation of the person during the treatment process causes treatment abandonment and relapses.

An important issue in the treatment of alcohol use disorder is the trust of the person in the treatment. It is also important for the addict to have someone around him who has benefited from treatment, which is very important in terms of treatment compliance. With the influence of a person who has benefited from addiction treatment, the likelihood of applying for treatment and benefiting from treatment increases in a “snowball” manner.

The aim of this study was to evaluate whether people who are treated for alcohol use disorder have a treatment motivation for those around them. It was aimed to examine whether the people who have been treated are important in increasing the trust in treatment for other patients.

The study included cases who applied to the Seferihisar State Hospital Psychiatry Outpatient Clinic with complaints of alcohol use. The sociodemographic information form was filled out during the individuals’ first applications. The participants were asked whether there were people around them who had received inpatient treatment for alcohol use disorder at the hospital where the study was conducted, and the individuals were then administered the Readiness for Change and Desire for Treatment Scale (SOCRATES), Treatment Motivation Questionnaire (TMQ), and Alcohol Use Disorders Identification Test (AUDIT). The individuals were given the standard treatment recommended in our country’s treatment guidelines for the diagnosis of alcohol use disorder. The individuals participating in the study were interviewed at 1 month, 2 months and 3 months after starting treatment. The individuals’ answers and the decrease in the frequency and amount of alcohol use were recorded.

The rate of treatment attendance is 2.7 times higher for people who have received treatment for alcohol use disorder in their circle.

The rate of treatment confidence in treatment is 4.1 times higher for people who have received treatment for alcohol use disorder in their circle.

The frequency and amount of alcohol use has decreased more for people who have received treatment for alcohol use disorder in their circle.

It has been determined that those who are surrounded by people who have received treatment for alcohol use disorder have higher levels of treatment confidence and compliance. The assistance of these people to those around them can play an important role in increasing the success of addiction treatment.

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The nature-based therapeutic perspective includes: green therapy, blue therapy, animal-assisted therapy, and natural landscape therapy. Until now researchers haven’t clearly recognized underlying mechanisms of nature-related mental health well-being.

The study aimed to clarify the relationships between experienced nature connectedness (NC) and social connectedness (SC) before and after blue nature based intervention and mental health (WHO-5, PHQ-4)

Study group included 54 adults (Mean = 30.6; SD 13,2). Participants completed semi-structured questionnaires before and after blue interventions (one week high sea sailing under supervision of two psychologists). The questionaire measured following variables: nature connectedness, social connectedness, well-being, and mental health.

Results showed a significant increase in social and nature connectedness as well as in mental well-being after the blue interventions. Full results will be shown on the e-poster.

The mental health and wellbeing benefits of contact with nature are becoming increasingly recognized in psychology and medicine. The findings support hypothesis that nature connectedness and social connectedness increased after nature based interventions, and therefore they seem to be important factors conected with mental health.

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The COVID-19 pandemic has placed immense psychological pressure on healthcare workers (HCWs) worldwide. In addition to the physical risks of infection, HCWs have faced high levels of anxiety due to their proximity to the virus, overwork, and the challenges of providing care in an ever-evolving environment. These psychological effects are expected to persist well beyond the initial phase of the pandemic.

This study explores the long-term impact of COVID-19 on both anxiety and depression among HCWs and identifies the main contributing factors.

This cross-sectional study was conducted among HCWs infected with SARS Cov-2 between January and August 2022. Sociodemographic and professional data were extracted from participants’ medical records. Anxiety and depression were evaluated using the GAD-7 (Generalized Anxiety Disorder) and PHQ-9 (Patient Health Questionnaire) scales, respectively, through phone interviews conducted at least one year after their last COVID-19 infection

This study included a total of 184 healthcare workers (HCWs). The mean age of the participants was 41.93 years (± 8.6), with 95.1% being over 30 years old. Women comprised 81.4% of the cohort, and the majority of participants were nurses (45.7%), followed by administrative staff (20.1%). The median occupational seniority was 16 years. Notably, 28.3% of HCWs were employed in COVID-19 wards. Anxiety symptoms were reported by 92.9% of participants, with 17.3% experiencing mild anxiety, and 38.5% severe anxiety. Depression was prevalent in 69.1% of HCWs, with 27.2% presenting mild symptoms, and 24.5% experiencing moderate to severe depression. Female HCWs and those aged over 40 were significantly more likely to report symptoms of anxiety and depression (p < 0.001). Furthermore, HCWs with pre-existing conditions, such as diabetes, as well as those directly exposed to COVID-19 patients, exhibited significantly higher anxiety and depression scores. Nurses demonstrated particularly elevated levels of psychological distress, especially those working in COVID-19 wards.

The COVID-19 pandemic has had a profound and lasting psychological impact on healthcare workers, with anxiety and depression levels remaining elevated long after the acute phase of the crisis. This study emphasizes the need for targeted psychological support interventions. Addressing the mental health needs of HCWs is crucial not only for their well-being but also for ensuring the ongoing efficacy and resilience of the healthcare workforce in times of crisis. Further research is warranted to explore long-term impacts and effective strategies for mental health support in this population.

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Resilience is the capacity to bounce back from adversity, and this concept has been extensively studied across various populations, especially those facing significant stress. In this context, Tunisian women have recently encountered multiple challenges related to balancing professional and family responsibilities, which require them to demonstrate strong resilience. Recent literature has highlighted a strong link between social support and resilience.

This study aims to explore the impact of social support on the psychological resilience of Tunisian women.

This cross-sectional study surveyed Tunisian women aged 18 and above using an online questionnaire between June and August 2024. Familial and professional characteristics were collected through a structured survey. Social support was measured using the Multidimensional Scale of Perceived Social Support (MSPSS), and psychological resilience was assessed with the 25-item Connor-Davidson Resilience Scale (CD-RISC 25).

Data from 695 Tunisian women (mean age = 36.72 ± 12.23 years) revealed diverse backgrounds: 24.7% were students, 35.3% worked in the public sector, 21.2% were self-employed, and 14.7% were unemployed. In terms of marital status, 42.9% were single, 49.2% married, and 5.6% divorced, with 8.5% living alone, 75.7% in nuclear families, 10.4% in extended families, and 5.5% in shared housing; additionally, 50.6% had children. The average resilience score was 68.26 ± 14.09, with 26.3% exhibiting low resilience. Social support scores were as follows: familial support (20.06 ± 6.38), friend support (18.17 ± 6.47), significant other support (21.2 ± 6.22), and overall social support (59.42 ± 15.26). Significant associations were found between resilience and marital status (p = 0.019), with married women showing lower rates of low resilience (21.3%) than single women (31.9%). Women with children also demonstrated higher resilience (p = 0.002), while employment status had a notable impact (p = 0.005), with low resilience rates highest among unemployed women (36.3%) and lowest among public sector workers (19.6%). Resilience positively correlated with social support across all sources: familial (p < 0.001, r = 0.269), friend (p < 0.001, r = 0.260), significant other (p < 0.001, r = 0.289), and overall social support (p < 0.001, r = 0.338).

Our findings underscore the crucial role of social support and family connections in enhancing the psychological resilience of Tunisian women. Therefore, targeted social interventions are needed to support women experiencing loneliness or lacking social networks, aiming to strengthen their resilience and overall well-being.

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For patients with schizophrenia, effective treatment of early episodes may improve long-term outcomes, reduce the risk of relapse, and limit functional impairment.

To evaluate the efficacy and safety of brexpiprazole versus placebo in adult and adolescent patients with early-episode schizophrenia.

Data were analyzed from four Phase 3, 6-week, randomized, double-blind, placebo-controlled trials: three in adults (Clinical Trials.gov: NCT01396421 [Vector], NCT01393613 [Beacon], NCT01810380 [Lighthouse]), and one in adolescents (NCT03198078 [Study 331-10-234]). For the trials in adults, patients aged 18–65 were randomized to placebo (total N=531), brexpiprazole (total N=1,093; 0.25, 1, 2 or 4 mg/day, or 2–4 mg/day, depending on the trial), or quetiapine extended-release (N=154; active reference in one trial). For the trial in adolescents, patients aged 13–17 were randomized to placebo (N=104), brexpiprazole 2–4 mg/day (N=110), or aripiprazole (N=102; active reference). Mean baseline Positive and Negative Syndrome Scale (PANSS) Total scores indicated that adult and adolescent patients were of similar disease severity. In all four trials, the primary efficacy endpoint was change from baseline to Week 6 in PANSS Total score. In this post hoc analysis, early-episode schizophrenia was defined as age 13–35, and ≤5 years’ duration of illness. Data from the four trials were pooled and compared between brexpiprazole 2–4 mg/day (FDA-recommended target dose in adults and adolescents) and placebo. Efficacy outcomes were analyzed using least squares (LS) mean change from baseline (mixed model for repeated measures). Safety was also evaluated.

The post hoc early-episode schizophrenia sample comprised 292 patients treated with brexpiprazole 2–4 mg, and 190 treated with placebo (analyzed for safety), of whom 289 and 187 were analyzed for efficacy, respectively. The post hoc efficacy sample comprised 19.3% of the corresponding efficacy sample of the adult trials (pooled), and 98.1% of the corresponding efficacy sample of the adolescent trial. In the post hoc efficacy sample, mean (standard deviation) baseline age was 22.4 (6.6) in the brexpiprazole group and 20.5 (6.6) in the placebo group, and baseline PANSS Total scores were 97.9 (13.5) and 100.4 (14.2), respectively. The LS mean (standard error) change from baseline to Week 6 in PANSS Total score was -21.4 (1.1) with brexpiprazole, and -17.8 (1.4) with placebo (p=0.042). The overall incidence of treatment-emergent adverse events (TEAEs) was 50.7% with brexpiprazole, and 46.3% with placebo. The TEAE with the highest incidence in the brexpiprazole group was akathisia (6.5%; placebo, 2.1%).

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In this post hoc analysis of patients with early-episode schizophrenia, brexpiprazole was associated with greater improvement in schizophrenia symptoms than placebo. No new safety observations were made.

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Eating disorders are a group of mental illnesses determining general health consequences. Several studies suggest that social media influence body image concerns, considered the core of eating disorder pathology. Thin idealization has become an increasing cultural focus, leading young people to pursue body image as a symbol of success.

Aim of this study is to assess the quality and quantity of Social Network (SN) use and their influence on body uneasiness in individuals with Disordered Eating Behaviours (DEB) or Eating Disorders(ED)

69 individuals suffering from Disordered Eating Behaviours (Grazing, Sweeteating, Food Addiction) or Eating Disorders (Night Eating Syndrome, Anorexia nervosa, Bulimia nervosa or Binge eating disorder) were enrolled. Mean age was 34 (SD ±11,33), mean BMI 28,68 (SD ±12,23). 93% of individuals were females. 20,29% (14) of the sample suffered from ED and 79,71% (55) from DEB. A social network self-administered questionnaire was used to investigate which SN was most used and what contents were most shown in users’ feed; domains investigated by the questionnaire are reported in fig. 1

Questionnaire analysis allowed to investigate individuals preferences about social media use and the kind of contents they consumed the most. The data showed the most frequently used social network are Facebook (42%), Instagram (33%) and Tiktok (22%). Healthy and/or fit contents were frequently displayed on SN feed 57.9% (40), but only 26,08% (18) of users were influenced in their lifestyle and food habits. 39,13% (27) of the individuals also felt like this kind of contents increased their sense of body uneasiness.

The study emphasize that 42,85% of the individuals diagnosed with an ED answered that SN content influenced their lifestyle and 71,42% that it increased their feeling of body uneasiness. In individuals with DEB only 21,8% were influenced in their lifestyle and 30,9% describe a worsening of their body uneasiness, as is shown in Tab.1.Tab 1

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Social media contents about health, diet and sport impact on individuals body image, diet and body uneasiness, mostly in individuals diagnosed with ED. This evidence stresses the importance to take into account every component of ED and DEB for a global approach to individuals including an assessment on interests, hobbies and use of social media.

None Declared

Though glutamate modulators have been increasingly used with some success in cases of OCD resistant to SRIs, there is limited data on the use of ketamine in OCD. There is one study on the use of multiple ketamine infusions in SRI-resistant OCD, but no studies have yet compared the effectiveness of multiple infusions of ketamine with multiple infusions of an active comparator agent. Benzodiazepines are commonly prescribed for OCD despite the lack of recommendations. The current study was a hospital-based prospective, single-blind, randomised controlled trial conducted over a period of one and a half years to compare the effectiveness of multiple infusions of ketamine with those of midazolam.

To look into the immediate effects of ketamine infusion in terms of reduction in illness severity in OCD treatment non-responders in comparison to midazolam infusion.

To determine the time-point associated with the largest change in symptom severity in patients receiving repeated ketamine infusions in comparison to midazolam infusions.

To determine the overall proportion of response of OCD treatment non-responders to ketamine infusions in comparison to midazolam infusions.

In a hospital setting, we compared the effectiveness of 6 sessions of ketamine infusions (0.5 mg/kg body weight) with that of 6 sessions of midazolam infusions (0.045 mg/kg body weight), given on alternate days on a Monday-Wednesday-Friday schedule, in 30 patients with treatment non-responding OCD. Assessments were made using rating scales: DY-BOCS, MADRS, HAM-A, CADSS and SAFTEE.

At 1 hour and 4 hours after the 1st ketamine infusion, 26% of patients achieved treatment response, while none in the midazolam group did so at these time points (Figures 1 and 2). Maximum symptom reduction occurred after the 1st infusion. By the 6th infusion, 40% of ketamine patients achieved treatment response, compared to 20% in the midazolam group. At 4 weeks after the last infusion, only 1 patient (6%) in the ketamine group maintained treatment response, with none in the midazolam group. Overall, the result indicates that the ketamine group showed significant improvement compared to the midazolam group (F=1.541, p=0.048) with a medium effect size (η2=0.056) (Fugure 3). There were no statistically significant differences between the two groups in terms of overall reductions in MADRS.

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Ketamine, though modest in action, is superior to midazolam. Our findings lie between those of 2 prior studies—that by Bloch et al. (2012), who showed it to be largely ineffective, and that of Rodriguez et al. (2013), who found that half of their participants continued to show response even 1 week after the infusion. The differential overall improvement in DY-BOCS in the ketamine group over the midazolam group was independent of the reductions in depressive symptoms.

None Declared

Given the increasing rates of antipsychotic use in multiple psychiatric conditions, greater attention to the assessment, monitoring and documentation of their side effects is warranted. While significant attention has been provided to metabolic side effect monitoring, comparatively little is known about how clinicians screen for, document and monitor their motor side effects (i.e. parkinsonism, akathisia, dystonia and tardive dyskinesia (TD), collectively “extrapyramidal symptoms” or EPS).

This review aims to systematically assess the literature for insights into current trends in EPS monitoring practices within various mental health settings globally.

In line with our preregistered protocol (PROSPERO: CRD42023482372), we systematically searched the OVID Medline, PubMed, Embase, CINAHL and PsycINFO databases for studies published from 1998 to present day. Figure 1 shows a detailed flowchart of the selection process. Included studies were assessed for quality using a modified version of the Quality Improvement Minimum Criteria Set (QI-MQCS) and findings summarized using narrative synthesis. All stages of the review process are reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.

A total of 22 studies met our inclusion criteria. Studies occurred in varied settings and employed a range of study designs. The APA and NICE guidelines were most commonly used to guide practice. Baseline monitoring rates in adult settings ranged from 0 to 54%, and 3.7 to 100% in child & adolescent settings. In studies reassessing EPS monitoring rates following practice improvement initiatives, virtually all demonstrated benefits. Screening processes and instruments varied, ranging from standardized rating scales (such as the AIMS for TD screening) to locally developed tools. In some studies, no structured tool was identified. Monitoring rates were higher when structured processes and tools were used.

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This review demonstrates significant heterogeneity in clinical practice for the screening, documentation, and monitoring of EPS in patients prescribed antipsychotic medication in mental health settings globally. Adherence to existing guidelines was found to be poor in most settings, with practice improvements observed in virtually all settings where quality improvement initiatives were implemented. The best improvements were seen to occur after services introduced structured EPS screening tools with regular education on their use.

R. Aubry: None Declared, T. Hastings: None Declared, M. Morgan: None Declared, J. Hastings: None Declared, M. Bolton: None Declared, M. Grummell: None Declared, R. Shorr: None Declared, S. Killeen: None Declared, C. Coyne: None Declared, M. Solmi Consultant of: MS has received honoraria/has been a consultant for AbbVie, Angelini, Lundbeck, Otsuka.

Bipolar disorders (BD) are among the most impairing of pediatric psychiatric disorders. Even though BD symptoms may begin in adolescence, they are frequently not diagnosed until adulthood. BD screening tests could aid diagnostic assessment in paediatric populations and are supported by The International Society for Paediatric Bipolar Disorders Task Force and empirical evidence.

This review synthesizes the evidence on the accuracy of BD symptom screening tests in distinguishing bipolar disorders from other psychiatric conditions or healthy cases in pediatric populations. Additionally, it examines a wide range of potential moderators that may influence diagnostic accuracy.

A systematic search was conducted across three databases (1980–2022), supplemented by searches of grey literature, citation chaining, and author contact. Data from relevant studies were combined using meta-analysis. A multilevel model was used to account for nested effect sizes, with 31 potential moderators tested in both univariate and multivariate models.

2,281 records were identified; 1712 titles-and-abstracts records were screened; 114 records were full-text screened; and 28 studies were included. The meta-analysis was based on all s=28 studies, 40 independent samples, k=115 effect sizes, and n=11,464 participants. Meta-analytic results showed that BD symptom index tests have high diagnostic accuracy in pediatric populations (g = 1.300; 95% CI: 0.982 - 1.619; p < .001) (see Fig. 1). Accuracy varied based on the comparison group, test content, test informant, and the specific scale or subscale used.

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Screening tests focusing on mania-related symptoms, caregiver reports, and psychiatric comparison groups demonstrate clinical value in identifying pediatric BD. Also, other informants and symptom content combinations may not reliably identify pediatric BD. Importantly, tests derived from studies using psychiatric comparison groups, represent BD symptom non-specificity and BD symptom overlap with other disorders (eg. ADHD and depression), providing external validity and clinical utility. Screening tests with high accuracy and clinically useful are the GBI-73-P, MDQ-A-P and the YMRS-P.

None Declared