Climate change is one of the main global challenges of the 21st century due to its consequences for the environment, the economy and health. Given that human behaviour exists at the forefront of many of the environmental issues we face, it is crucial to effectively measure pro-environmental behaviours (PEB). Stanley et al. (2021) proposed the PEB Scale (PEBS), a bifactorial measure including eight items asking about personal behaviours and eight collective actions that revealed good psychometric properties. To the best of our knowledge, there is no instrument that validly assesses these parameters in the general Portuguese population.

To analyze the psychometric properties of the Portuguese version of PEBS and to explore its relationship with individual factors.

A community sample of 599 Portuguese adults (64.6% women; mean age=34.40±16.18) answered to the Portuguese preliminary version of PEBS and to the validated instruments: Climate Change Distress and Impairment Scale/CC-DIS, Big3 Perfectionism Scale–Short version/BTPS-SF, HEXACO-60 and Toronto and Coimbra Prosocial Behaviour Questionnaire/ProBeQ. SPSS 29 and AMOS-29 were used for Exploratory Factor Analysis (EFA; with a subsample of n=291) and Confirmatory Factor Analysis (CFA; n=308), respectively.

EFA revealed a 3-factor solution with an explained variance of 60.52% confirmed by parallel analysis. With CFA, fit indices were found to be acceptable for first and second-order models (X²/df=4,0741; CFI =.8638; TLI=.8382; GFI=.8515; RMSEA= .0887, p<.001). Cronbach’s alphas were of .871 for the total scale (16 items), .857 for F1 (Collective actions/CA; 5 items), .832 for F2 (Personal behaviours/PB; 8 items) and .736 for F3 (Political actions/PA; 3 items). PEBS correlated with CC-DIS (r=.48 with total PEBS, r=.42 with CA and PB and r=.21 with PA, p<.01), ProBeQ (r=.24 with total PEBS, r=.12 with CA, r=.37 with PB and r=-.14 with PA, p<.01), Narcissistic Perfectionism (r=.08, p<.05 with CA and r=.20, p<.01 with PA), Honesty-Humility (r=-.15, p<.01 with PA), Emotionality (r=-.12, p<.01 with PB and r=.09, p<.05 with PA), Extraversion (r=.09, p<.05 with CA and r=.12, p<.01 with PA), Agreeableness (r=.11 with total PEBS, r=.12 with CA and r=.14 with PA, p<.01) and Conscientiousness (r=.09, p<.05 with total PEBS). When the correlated variables were inserted as predictors in linear multiple regression models where CA, PB and PA were dependent variables, they explained 19.8% (R2=.198), 24.6% (R2=.246) and 14.9% (R2=.149) of their variance, respectively (all p<.001).

PEBS shows adequate psychometric properties, therefore, it can be used to measure PEB in the Portuguese population, namely, to analyze the efficacy of pro-climate interventions and campaigns. These initiatives should take into consideration the role of individual factors (such as personality traits) in PEB.

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Access to employment is a significant challenge in adulthood, particularly for autistic individuals. Accommodations, both in the workplace and during selection processes, are essential to support the inclusion of this population in the labor market. Given the dynamic nature of support needs, understanding the specific characteristics and needs of autistic individuals is necessary to provide reasonable adjustments. However, this process becomes more complex when individuals do not disclose their autism diagnosis, hindering organizations’ ability to identify and address their needs.

To identify accommodations that support the employment of autistic young adults in Chile.

Semi-structured interviews were conducted with 12 autistic young adults with job interview experience in Chile. Participants, residing across five regions, were selected through theoretical sampling. Data were analyzed using content analysis in alignment with the principles of Grounded Theory by Glaser and Strauss. Ethical approval was obtained from the Universidad de O’Higgins Ethics Committee, and all participants provided informed consent.

While accommodations are deemed necessary by autistic individuals, they are seldom requested due to concerns that such requests may imply reduced competence, potentially lowering employment prospects. Participants in this study highlighted key dimensions essential for support, including procedural adjustments (advance preparation, privacy, and flexibility), interpersonal approaches (empathy and respect for diversity), and sensory accommodations (specific sensory considerations and clear, literal communication). Additionally, virtual interview formats were viewed positively, as they facilitate the fulfillment of certain sensory needs.

This study reveals a tendency among autistic individuals not to request accommodations during job-seeking processes, despite recognizing their necessity. Promoting professional practices based on updated, inclusive knowledge is essential for developing employment processes that effectively support autistic individuals.

None Declared

Organic solvent-induced psychosyndromes (OSP) constitute a major occupational health concern, particularly in industrial sectors involving frequent use of chemical products. This neurotoxic disorder can have significant consequences on workers’ health and their ability to maintain professional activity.

This study aims to analyze the epidemiological, clinical, and occupational characteristics of organic solvent-induced psychosyndromes diagnosed in the workplace, as well as to evaluate their impact on work fitness.

A retrospective study was conducted based on medical records collected at the Institute of Occupational Health and Safety (ISST) in Tunisia during a period of 5 years from 2019 until 2024. Socio-professional data, risk factors, diagnoses, progression, and fitness decisions were analyzed with a focus on OSP cases. The severity of the psychosyndrome was assessed using the Raleigh classification and the WHO criteria.

The study identified 11 cases of organic solvent-induced psychosyndromes. The average age of patients was 41 years. The gender distribution showed 6 women and 5 men.

The professional sectors were distributed as follows: chemical industry (n=4), textile industry (n=3), electronics (n=2), and other sectors (n=2).

The main solvents involved were xylene (n=7), toluene (n=6), hexane (n=5), and cyclohexane (n=4), with multiple exposures in 8 cases. The average duration of occupational exposure before diagnosis was 14 years ranging from 5 to 30 years. An ineffectiveness of protective measures was found in 6 patients.

The most frequently reported symptoms included memory disorders (n=9), attention disorders (n=8), and mood disorders (n=7).

The most common type of psychosyndrome was type 2B (n=8).

Regarding work fitness, nine cases required removal from solvent exposure, including six through job transfer and three through workplace accommodation. Two cases were declared unfit for their current position.

This study highlights the impact of organic solvent-induced psychosyndromes on workers’ health and emphasizes the need for better protective measures, early screening, and regular medical monitoring.

None Declared

Psychiatric disorders in the workplace represent a major challenge for occupational medicine, affecting workers’ health and their professional capacity.

The study aims to analyze the socio-professional characteristics, risk factors, clinical evolution, and work fitness of patients with psychiatric disorders in the workplace.

A retrospective analytical study was conducted on 62 medical files from the Institute of Health and Safety at Work (ISST) in Tunisia, covering the period 2023-2024. Sociodemographic, professional, medical data, and fitness decisions were extracted. Descriptive statistical analyses were performed to identify significant correlations.

The study included 62 cases. The average age was 44 years. The sex ratio was 0.8.

The most represented sectors were industry (29%), healthcare (24%), and education (11%). Depressive syndrome was the most frequent diagnosis (55%), followed by anxiety disorders (29%) and bipolar disorder (10%). Psychosis was found in 6% of cases.

A significant correlation between the industrial sector and the prevalence of depressive syndrome was found (p<0.01).

The predominant occupational risk factors included stress (51.6%), shift work (22.6%), and exposure to chemicals (16.1%). A positive correlation was observed between exposure to chemicals and the onset of anxiety disorders (p=0.03).

Analysis of fitness decisions showed that 41.9% of cases were deemed fit with accommodations, 29% temporarily unfit, 19.4% fit without restriction, and 9.7% permanently unfit.

This study highlights the high prevalence of psychiatric disorders in the workplace and their significant impact on work fitness. The results underscore the importance of implementing targeted prevention strategies to preserve workers’ mental health and maintain their professional fitness.

None Declared

Increased sick leave among educators can detrimentally impact students’ productivity, and academic achievement. It remains unknown whether the number of sick days taken by educators in the preceding school year correlates with the prevalence or severity of psychological problems among educators in the subsequent school year.

This study aimed to examine the number of self-reported sick days taken by educators in three Canadian provinces during the 2021/2022 academic year and its association with measures of stress, burnout, low resilience, depression, and anxiety during the 2022/2023 school year.

Data was collected from educators in three Canadian provinces, Alberta, Nova Scotia, and Newfoundland and Labrador, from September 1, 2022, to August 30, 2023. The Maslach Burnout Inventory-Educator Survey (MBI-ES), the Brief Resilience Scale (BRS), and the Perceived Stress Scale were used to assess burnout, resilience, and stress, respectively. Likely Generalized Anxiety Disorder (GAD) and likely Major Depressive Disorder (MDD) were assessed using the Generalized Anxiety Disorder-7 and Patient Health Questionnaire-9 scales, respectively. Statistical analysis was conducted using SPSS version 28.

763 subscribers completed all the demographic, professional questions, and clinical scales, giving a response rate of 39.91%. Of these, there were 94 (12.3%) males and 669 (87.7%) females. Educators who reported taking 11 or more sick days in the previous academic year were at least three times more likely to exhibit high stress, emotional exhaustion, likely GAD, low resilience, and likely MDD than educators with no sick days during the preceding year. Similarly, educators with 11 or more sick days had significantly higher mean scores on the GAD-7 scale, the PHQ-9 scale, the PSS-10, the MBI Emotional Exhaustion subscale, and the MBI Depersonalization subscale than those with zero sick days.

This study demonstrates a significant association between sick days and the prevalence and severity of high stress, low resilience, burnout, anxiety, and depression among educators. Short-term sick leave can escalate into long-term absences without adequate support for teachers. Governments and policymakers in the education sector must foster a supportive environment that enables teachers to thrive and effectively perform their professional role without taking prolonged sick days, which can undermine student learning and achievement.

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Suicide Crisis Syndrome (SCS) is an acute suicidal state characterized by feelings of entrapment, affective disturbances, loss of cognitive control, hyperarousal, and social withdrawal. It has been demonstrated that SCS predicted suicidal behavior post discharge and that could help identifying high risk patients (Galynker I. Oxford University Press 2023; Yaseen ZS et al. Suicide Life Threat Behav Aug 2019;49(4):1124-1135). Until today, there is no valid consensus on which medication class is more effective in reducing the acute symptoms of SCS, which often accompany suicidal patients.

The present study aims to evaluate medication response to SCS along hospitalization into a psychiatric unit and to determine if certain drug classes can alleviate SCS symptoms.

The sample consisted of 133 participants, aged 18 to 85, recruited across four Mount Sinai Health System hospitals in New York City, USA and admitted to the psychiatric units for suicidal behavior in the past week. Patients were assessed at intake and discharge with the Suicide Crisis Syndrome -Checklist (SCS-C) to evaluate the presence of SCS symptoms. Administered medication were divided into 5 classes: antipsychotics, antidepressants, mood stabilizers, benzodiazepines and opioids.

Looking at administered medications, descriptive analysis showed an overall decrease in mean SCS-C scores from intake to discharge with antipsychotics and opioids being associated with greater SCS symptoms reduction throughout hospitalization. On the other hand, participants taking antidepressants, mood stabilizers or benzodiazepines did not show different SCS-C results than participants who were not administered these medications.

Our results are preliminary and to gain a clearer perspective a larger sample size would be needed. Nonetheless, antipsychotics drugs given their broad psychopharmacological properties might be able to address the difficult and heterogeneous symptomatology of suicidal patients, especially loss of cognitive control aspect of the SCS. Given that opioids are used to treat emotional pain, they may be an effective treatment for symptoms of SCS as well. These results highlight the need for further studies and randomized clinical trials to adequately assess the effectiveness and safety of these medications in treating SCS.

None Declared

Migraine is one of the leading neurological causes of disability worldwide with a significant impact on all aspects of life, despite the high prevalence and debilitating effects migraine remains underestimated in Sudan. This study aims to measure the prevalence of migraine among medical students at a Sudanese University.

This study aims to measure the prevalence of migraine among medical students from the University of Science and Technology Faculty of Medicine, Omdurman, Sudan.

This descriptive cross-sectional study was carried out between June and August 2024 involving 283 medical students enrolled in the University of Science and Technology, data was collected online and ID-Migraine was used to screen for migraine and R programming language for statistical computation and graphics was used to analyze the data.

The prevalence of migraine was 41% and females were more affected than males. The most reported trigger factor was irregular sleep 84%, with rest being the most used method for relief 43% and the majority of migraine-positive students 46% mentioned their academic performance was moderately affected.

This study found a high prevalence of migraine among medical students enrolled in the University of Science and Technology, with female students being more affected and significant impact on academic performance.

None Declared

This study examines the frequency and underlying mechanisms of antidepressant discontinuation syndrome (ADS) in patients receiving SSRI therapy who subsequently experience viral infections such as influenza or COVID-19. Clinical observations suggest that viral infections may diminish the efficacy of SSRIs, potentially triggering ADS even without changes in dosage.

To assess the prevalence of ADS symptoms among patients undergoing SSRI treatment during viral infections and to explore potential biological mechanisms behind this interaction.

A sample of 84 individuals was recruited from a large Russian-language forum for users of antidepressants. Data on ADS symptoms onset and exacerbation during viral infections were collected using a survey based on the DESS scale. Inclusion criteria for ADS were the new appearance or worsening of withdrawal symptoms specifically during the viral illness.

A significant portion of the cohort reported ADS symptoms. Key findings included dizziness (62%), increased anxiety (40%), mood instability (57%), sleep disturbances (65%), and memory impairment (40%). Notably, brain zaps were observed in 63% of patients, identifying this symptom as distinct to ADS rather than typical viral symptomatology.

The study indicates a high prevalence of ADS symptoms in patients continuing SSRI therapy during viral infections, likely influenced by neuroinflammatory responses and cytokine release, along with tryptophan depletion driven by interferon activity. These insights underscore the importance of vigilance and potentially adapting SSRI management strategies during periods of viral illness to mitigate ADS effects.

None Declared

Parkinson’s disease (PD) is the second most common neuropsychiatric disorder, affecting approximately 6.1 million people worldwide. Its incidence has increased over the last two decades, with a higher rate observed in industrialized countries, suggesting that pollution and social isolation may contribute. Some studies even identify loneliness as an independent risk factor. PD is characterized by a slow progression of disability, often lasting decades, with significant impact on both individuals and caregivers. In addition to its hallmark motor symptoms (rigidity, bradykinesia, and tremor), neuropsychiatric symptoms are now better understood, and some researchers have also identified social symptoms.

Our aim is to describe the social symptoms of PD and assess the impact of these symptoms on patients’ quality of life.

A narrative literature review was conducted through bibliographic research in the PubMed and Google Scholar databases, using the terms “Parkinson’s disease,” “social symptoms,” and “social impact.”

The so-called social symptoms arise from various changes that occur in PD, affecting both the verbal and non-verbal components of communication. “Facial masking” results from facial muscle bradykinesia, leading to a diminished ability to produce facial expressions. Research has shown that individuals with PD have a reduced capacity to modulate emotional expressions, which are crucial for eliciting empathy and facilitating social interactions. Additionally, patients demonstrate difficulties in recognizing emotions, possibly due to a dysfunctional theory of mind (Embodied Simulation Theory). Reduced prosody leads to monotonous, emotionless speech, which contributes to negative self-perception and a feeling of impaired communication abilities. Furthermore, in more advanced stages of PD, there appears to be a deficit in interpreting prosody.

These factors contribute to stigma, dehumanization, and social isolation among PD patients, with significant consequences for their quality of life, which has been demonstrated in several studies.

Social symptoms, though often overlooked, are prevalent in PD and substantially reduce patients’ quality of life. It is crucial to further investigate these symptoms and develop interventions to mitigate their impact.

None Declared

The Convalescence Unit provides semi-open inpatient care during the subacute phases of psychiatric illness, with the goal of restructuring and reorganizing the personality after a crisis or relapse.

The main objective is to observe the profile of patients admitted to the Convalescence Unit who could benefit from this type of resource.

A retrospective, observational study was conducted by collecting and analyzing data in 2019, which 61 patients were admitted in this resource. The profile of patients during the year 2019 was analyzed.

Of a total of 61 patients, 47 were referred from the Brief Hospitalization Unit (UHB), 11 from the Mental Health Team (ESM), and 3 from other facilities. By gender, there were 38 women and 23 men. The average age was 44.16 years. Regarding the type of admission, 29 were voluntary and 32 involuntary. Seventeen patients had been readmitted from previous years. The diagnoses were: 10 patients with bipolar disorder, 14 with schizophrenia, 6 with substance-induced psychosis, 2 with schizoaffective disorder, 10 with anxiety-depressive syndrome, 5 with dysthymia, 2 with obsessive-compulsive disorder, 7 with delusional disorder, and 6 with personality disorders. Of these patients, 58 received therapeutic discharge, 1 voluntary discharge, and 2 were transferred to other facilities. Regarding marital status, 43 were single, 7 married, 4 widowed, and 7 divorced. The average length of stay was 48.56 days.

As for the profile of patients admitted to the Convalescence Unit, it is not possible to determine a statistically significant pattern. However, we observed that most are women with severe mental health disorders. Notably, the majority are single, suggesting less family support, and a high percentage are admitted involuntarily, often from the UHB, to extend their stay for the management of subacute conditions in a more controlled environment. This helps ensure adherence to treatment, which is both difficult and crucial for a favorable outcome in these patients.

None Declared

Acute confusional state is usually the main diagnosis we encounter in hospitalized older adults. Its incidence increases in parallel with age. Often underdiagnosed. The main characteristics are alteration in the level of consciousness and/or attention, cognitive impairment (disorientation or reduction in memory), relatively rapid onset and fluctuations. As clinical manifestations there is usually disorganization of thought, perceptual disorders, hyper or hypoactivity, alteration of sleep rhythm and alteration of mood.

Behavioral and psychological symptoms of dementia (BPSD) describes a heterogeneous group of behavioral or mood disturbances, such as agitation, anxiety, depression, psychosis, or sleep disorders. They are universal and are present in dementia of any etiology and can be observed in any phase of the disease. They are considered multifactorial and are characterized by a recurrent or sporadic course.

68-year-old female patient who went to the hospital due to the presentation of symptoms that had been going on for 3 months (memory lapses, insomnia and irritability) that had intensified in recent days, leading to the appearance of visual hallucinations, episodes of disconnection from the environment, their language becomes impoverished and a disintegrated and incoherent speech appears with difficulty in naming.

Propose differential diagnosis between confusional syndrome and psychological and behavioral symptoms of dementia.

Analytical: elevation of acute phase reactants.

Cranial CT: no findings that justify the diagnostic suspicion.

Neurology: despite the sudden onset of the symptoms, they rule out performing LP, given the unremarkable nature of the rest of the complementary tests.

It was decided to admit him to mental health to study the condition. The evolution is characterized by a fluctuating picture while the acute phase reactants begin to gradually increase, D-Dimer: 5500 and an ECG with an S1Q3T3 pattern. CT angiography is requested (ruling out PET)

Finally, after evaluation by neurology in which new analysis is requested along with urine and culture (+ for C.Glabrata) due to fever peak, lumbar puncture and cranial MRI (small acute ischemic lesions). Finally, it was decided to admit him to neurology with targeted treatment, resulting in resolution of the condition.

Confusional syndrome with a subacute course of etiology under study.

BPSD of dementia are multifactorial and include different neurobiological factors, as well as environmental, social and psychological factors. They generally have a recurrent or sporadic character and can appear in all phases of any type of dementia, although they do not usually occur acutely. Therefore, it is important not to lose sight of carrying out complementary tests and a multidisciplinary approach, given that psychopathology of acute-subacute onset should not make us forget to rule out an acute confusional state.

None Declared

Burnout is a work-related syndrome characterized by emotional exhaustion, depersonalization, and a reduced sense of personal accomplishment. It is particularly prevalent among physicians and it is associated with various personal and occupational risk factors. This study aims to assess the prevalence of burnout and its predictors among physicians across different specialties at Sultan Qaboos University Hospital (SQUH).

to assess the prevalence of burnout and its predictors among physicians across different specialties at Sultan Qaboos University Hospital (SQUH).

A cross-sectional study was conducted from October 2023 to January 2024 involving Omani and non-Omani physicians from all specialties at SQUH, Muscat, Oman. Data were collected via an electronic and paper-based survey that included the Oldenburg Burnout Inventory and a sociodemographic questionnaire. Stepwise regression analysis was used to identify independent predictors of burnout.

A total of 353 physicians participated, yielding a response rate of 79%. The prevalence of burnout was 56.7% (n = 200). The majority of respondents were male 56.4%, with 88.4% being married and 66.3% having one to four children. Of the participants, 45% were consultants or senior consultants, and 70% had been practicing for over ten years. Independent predictors of burnout included male gender [OR 1.62 (1.01-2.59), p = 0.007], older age [OR 1.12 (0.66-1.89), p = 0.02], less than 6 hours of sleep per night [OR 2.57 (1.62-4.10), p < 0.001], administrative responsibilities [OR 2.75 (1.41-5.34), p = 0.015], and involvement in research activities [OR 3.75 (1.77-7.95), p = 0.036].

The high prevalence of burnout among physicians at SQUH highlights the need for targeted interventions to mitigate burnout and its associated negative impacts. Addressing the identified risk factors is essential for promoting physician well-being and optimizing healthcare delivery.

None Declared

This study aimed to identify the big five personality factors among cybercrime victims in Jordan and to investigate the differences in the level of the big five personality factors due to the type of crime, gender, age, and educational level. The descriptive analytical approach was used. The study sample consisted of (515) cybercrime victims in Jordan. To achieve the aims of the study, the five major factor scale was used, and its reliability and validity were checked.

Study Objectives:

1. 1. ersonality traits of cybercrime victims in Jordan.

2. 2. The differences in the Big Five personality traits of cybercrime victims based on the type of cybercrime.

3. 3. whether Big Five personality traits among cybercrime victims varied significantly with regard to gender, age, and educational status of respondents.

Study Tool: The Big Five Personality Traits Scale

This study used The Big Five Personality Traits Scale (Costa & McCrae, 1992) . In its original configuration, the scale consisted of 60 items or questions.

Item Characteristics of the Assessments Scale: 1.Internal Construct Validity. Internal consistency was checked using Cronbach’s alpha. The Cronbach’s alpha reliability coefficient was 0.701to 0.818, which was above 0.70; therefore, it is acceptable. Scoring of the scale: A 5-point Likert scale was employed .The second question was approached with One-way ANOVA. The third question was addressed via MANOVA.

The results show that the level of extraversion and openness factors came at a high level, while the conscientiousness, agreeableness, and neuroticism factors came at a moderate level. Also, the results found that there were no differences due to the type of crime in the neuroticism factor and there were differences in the factors (extraversion in favor of device hacking crime, openness in favor of unwanted sexual crime, conscientiousness, and agreeableness in favor of identity theft crime). Also, the results show that there are differences in the factors (neuroticism, extraversion, and openness) due to gender in favor of females, and due to age in the factors (neuroticism, acceptability, and conscientiousness) in favor of less than 30 years, and the level of education in the openness factor in favor of a secondary class or less, while in the acceptability factor in favor of a bachelor, while in the scientific factor in favor of postgraduate students.

Actions should be taken against cybercrimes, which include:

• - More education about cybercrimes and how to use internet in a safe way.

• - Supervision of people who are still not efficient in using technology and close supervision of the way that teenagers are using high technology devices.

• - Trainings should be done to start protecting people from such crimes.

None Declared

Patients with breast cancer have a higher incidence of psychiatric symptoms and mental illness compared to those without a cancer history. Breast cancer survivors often experience increased depression, anxiety, neurocognitive and sexual dysfunction, sleep disorders, stress-related conditions, and other psychiatric issues. Psychopharmacological intervention plays a key role in managing both comorbid mental illness and cancer-related symptoms caused by the disease or its treatment. However, there is limited scientific evidence regarding the specificities of psychotropic drug prescriptions in patients undergoing antineoplastic therapy.

Considering the specificities of this population (greater physical fragility, polypharmacy) and the limited scientific evidence on the subject, the aim of this work is to review the literature on the use of psychotropic drugs—antidepressants, anxiolytics, antipsychotics, mood stabilizers, and psychostimulants—in the treatment of psychiatric symptoms and cancer-related symptoms in this patient population, with a particular emphasis on psychopharmacological-antineoplastic drug interactions.

A non-systematic literature review using PubMed as the database.

In patients undergoing tamoxifen treatment, the use of psychotropic drugs that have inhibitory properties on cytochrome P450 (CYP2D6), the enzyme responsible for its metabolism into its active form (endoxifen) should be avoided. This specificity limits the use of strong inhibitors of this enzyme, such as some selective serotonin reuptake inhibitors—fluoxetine, paroxetine, and fluvoxamine. In the use of antipsychotics, the preference for drugs less associated with hyperprolactinemia should be considered when managing these patients. Commonly used mood stabilizers, such as lithium and valproic acid, do not interact with the most commonly used antineoplastic drugs in breast cancer, and are frequently used in this population safely, requiring the same monitoring as in the general population.

The need for pharmacological management of psychiatric symptoms or illnesses in the breast cancer population is a reality for which there is still little information in the available scientific literature. It is crucial that the use of psychotropic drugs is carefully monitored due to the potential pharmacological interactions with antineoplastic treatments, which may alter the efficacy or increase the toxicity of the drugs. For this reason, the present review is important and can enrich clinical practice. Collaboration between psychiatrists and oncologists is essential to optimize treatment and improve the quality of life for these patients.

None Declared

Total laryngectomy is a major surgical procedure involving the complete removal of the larynx, often necessary to treat severe conditions such as laryngeal cancer. Although this operation is often life-saving, it leads to significant and often disabling consequences that impact mental health, including increased levels of anxiety and depression.

Determine the prevalence of anxiety and depression among a group of patients who have undergone total laryngectomy and to investigate the factors associated with their occurrence.

This is a descriptive cross-sectional study with an analytical aim conducted over a period of 6 months from December 2021 to June 2022, involving patients followed for laryngeal cancer who had undergone total laryngectomy at the Otolaryngology department of Hospital Tahar Sfar Mahdia. Anxiety and depression were assessed using the Hamilton Anxiety Rating Scale and the Beck Depression Inventory , respectively.

A total of 40 patients participated in the study. The average age was 62±9 years, with a population consisting of 100% males. A score greater than 20 indicating the presence of anxiety symptoms was noted in 50% of patients. Depression was noted in 78% of patients, with moderate intensity in 42% and severe in 25% of cases. We found that shorter postoperative follow-up was associated with greater anxiety symptoms (p=0.005). However, other factors such as diabetes and impact on social life could be related to anxiety, though no statistically significant associations were found. Regarding depressive symptoms, only the presence of postoperative complications was statistically related to moderate or severe depressive symptoms (p=0.004) in our study. Other factors such as radiotherapy and impact on work might be related to depressive symptoms, although no statistically significant associations were found.

Total laryngectomy has undeniable repercussions on the mental health of patients. Medical and social support is essential to help them better cope with this disability.

None Declared

Total laryngectomy, as a major surgical intervention, leads to significant changes both physically and psychologically. The observed alterations include communication difficulties, adjustments to new breathing methods, and often a lengthy and complex rehabilitation process. These changes can deeply impact social interactions, autonomy, and the emotional well-being of the individuals affected.

To assess quality of life in patients who have undergone total laryngectomy, and to investigate the factors associated with its impairment.

This was a cross-sectional descriptive study with an analytical aim conducted over a period of 6 months, from December 2021 to June 2022, involving patients followed for laryngeal cancer who had undergone total laryngectomy at the Otorhinolaryngology department of Tahar Sfar Mahdia Hospital. Quality of life was assessed using the SF-36 in its validated Arabic version. Referring to Lean’s threshold value, it is accepted that a mean score < 66.7 indicates an impairment in quality of life.

A total of 40 patients participated in the study. The mean age was 62±9 years, and the population was 100% male. Quality of life assessment revealed that 87% of patients had scores below 66.7, attesting to impaired quality of life. A study of the mean scores per dimension on the SF36 revealed the following rates of impairment, in descending order: 100% for physical pain (D3), 97% for psychological health (D8), 95% for life and relationships with others (D6), 87% for vitality (D5) and limitations due to psychological state (D7), 72% for perceived health (D4), 55% for physical activity (D1) and 22% for limitations due to physical state (D2). In univariate analysis, rural origin (p=0.015), low socio-economic level (p=0.023), the existence of discomfort with eating (p=0.002), the existence of pain (p=0.008) and long hospital stay (p=0.056) were associated with impaired quality of life in our study population.

It is crucial to recognize and address these challenges holistically. Multidisciplinary approaches, including voice rehabilitation, psychological support, and social assistance, play an essential role in improving the quality of life for total laryngectomy patients.

None Declared

Cancer prehabilitation has emerged as a pivotal strategy for the augmentation of patients’ comprehensive well-being, encompassing physical, psychological, and functional aspects while improving their quality of life. The profound impact of breast cancer on patients and their family caregivers emphasizes the critical need for interventions addressing their holistic well-being.

In this portion of the study, researchers intend to develop two psychological-based prehabilitation modules within a larger investigation targeting to address the quality of life as well as relationship quality among breast cancer patients and their family caregivers. The deliberate involvement of the family caregiver proposed here is based on the belief that the well-being of an individual is interconnected with his/her community.

Guided by the Allostatic Model and Systems Theory, these modules are tailored to mitigate the negative effects associated with breast cancer with a systemic perspective in mind. Leveraging on Sidek’s Module Development Model, the first module (PreCARE) targets breast cancer patients, while the second (PreCARE Plus) extends its focus to patients and their family caregivers. The content validity of these modules is rigorously assessed through consultation with six experts across mental health, oncology, rehabilitation, and radiology disciplines. The study aims to look at the aspects of content validity of the developed modules through the content validity index (CVI).

The CVI for both PreCARE and PreCARE Plus modules were high (above 0.83) with values of 0.92 and 0.93 respectively. The findings also yielded high S-CVI for both modules with values of 0.98 (PreCARE) and 0.96 (PreCARE Plus).

These crafted psychological-based prehabilitation modules proposed to revolutionize oncological care in Malaysia by empowering healthcare professionals in the oncology setting to enhance the psychological and physical well-being of breast cancer patients and their family caregivers. Their potential impact underscores the importance of integrating systemic-inspired interventions into comprehensive cancer care paradigms.

None Declared

Common psychiatric disorders in oncological patients include depression, anxiety, delirium, sexual dysfunctions, adjustment and sleep disorders, affecting 30%–40% of those diagnosed. The incidence is even higher in advanced cancer stages. Despite the profound impact on quality of life, these issues are often underdiagnosed and undertreated. While effective management includes both pharmacological and nonpharmacological interventions, psychologists are rarely involved in palliative care, as doctors tend to focus primarily on physical symptoms overlooking the emotional and existential suffering these patients endure.

The aim of this study was to determine the frequency of clinical psychologist involvement in the care of palliative cancer patients.

We performed a single centre cross-sectional study of patients with metastatic or locally advanced, inoperable cancer who were hospitalized at the University Clinical Centre Maribor every first Wednesday of October between 2017 and 2023. Patient records were retrieved from the hospital’s electronic medical database. Data extraction included demographic information, clinical details, and whether a clinical psychologist was consulted by the treating physician. We also aimed to identify the reasons for consultation when applicable.

Out of the 600 patients, 342 (57.0%) were male, and 258 (43.0%) were female. Their ages ranged from 30 to 95 years, with a mean age of 67.9 ± 11.1 years and a median age of 68 years. Only 1.3% (8 patients) had a clinical psychologist involved in their care through a doctor-initiated consultation while most (592 patients or 98.7%) did not. Anxiety-related concerns were the most common reasons for consulting a psychologist, with 4 patients addressing these issues: 1 patient expressed a fear of dying, another feared the pain, a third had concerns about potential side effects of therapy, especially infertility, and the fourth presented general anxiety. Additionally, 1 patient expressed suicidal ideations. Unfortunately, the reason for consulting was not available for 3 patients.

Our study shows the underutilization of clinical psychologists in the care of palliative cancer patients, with only a small part receiving psychological support despite the known prevalence of psychiatric disorders in this population. Given the comorbidity of depression, anxiety and other psychiatric disorders among these patients, integrating mental health professionals into palliative care teams is crucial for enhancing their overall quality of life and emotional well-being.

None Declared

Substance use and substance use disorders are widespread among cancer patients, throughout the complex course of the disease. Besides the fact that the use of some substances predisposes individuals to cancer, substance use can also develop after a cancer diagnosis. The latter becomes more concerning by the significant use of opioids in the context of cancer pain management. In addition, individuals with cancer may use substances in an attempt to cope with psychological distress or poorly controlled physical symptoms – “chemical coping”.

In this work, we intend to do a review on the prevalence and impact of substance abuse in oncological population.

Our research will focus on papers of the last 10 year, indexed in Pubmed. We will summarize the most relevant data for clinical practice.

The use of substances in cancer patients is extremely heterogeneous. Not all of the situations constitute a Substance Use Disorder categorized in the diagnostic manuals used in psychiatry. Nevertheless, substance abuse always represents a causal agent in the deterioration of clinical and functional state of cancer patients.

According to studies, cancer patient care services do not assess patients substance abuse patterns or risk in an assertive and systematic manner. Moreover, there are no specific guidelines for the approach and treatment of cancer patients with addictive disorders.

Some authors also emphasize that the stigma associated with patients with substance dependences can difficult their access to health care and delay the diagnosis of neoplastic diseases or prevent them from undergoing treatment, which is often prolonged.

As a conclusion, we highlight that further studies are needed in this population, with more attention to the interaction between substance use and worse clinical progression. Furthermore, we remind the increasingly need for multidisciplinary teams to approach these patients - from oncology to psychiatry. There should be a greater investment in training these teams, as it can significantly improve the treatment and prognosis of these patients.

None Declared

Lung cancer is one of the most frequent forms of cancer worldwide. Its prevalence has increased substantially the last decades. About 85% of all cases are non-small-cell lung cancer, which can be further divided in other subtypes. The use of targeted therapies and immune check-point inhibitors in the last years has improved survival, such is the case of tyrosin-kinasa inhibitors as lorlatinib. This molecule can reduce neoplastic growth when ALK rearrangement is present.

To review the literature about psychiatric adverse effects of lorlatinib.

A narrative review of the evidence was performed. The search was focused on described psychiatric adverse effects in patients with lung cancer who have received lorlatinib as antineoplastic agent.

We report the case of a 54-year-old man with lung adenocarcinoma stage IV ALK+ diagnosed in 2024. Suprarenal metastases were found. He started antineoplastic treatment with lorlatinib as first line agent during hospitalization, with a dose of 100mg per day. Three months later, the patient experienced anxiety and impulse phobias of aggressive content which led to an intense psychological distress and behavioural repercussion (avoidance, overcompensation). He consulted because of these symptoms and the dose of lorlatinib was reduced to 75mg per day by his oncologist. By the time he was evaluated in Psychiatry Service, the symptoms had improved but remained present. Low doses of aripiprazole were prescribed as symptomatic treatment (2,5mg per day) with great results manifested one week later.

Most common adverse effects of tyrosin-kinasa inhibitors are fatigue, gastrointestinal symptoms, skin reactions or edema, among others. Although neuropsychiatric adverse effects are infrequent, they can occur and induce significative impairment and emotional distress. It’s important to recognize these other symptoms, especially on new drugs, and know how to approach them properly.

None Declared