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This chapter details the epidemiology, route of spread, prevalence, incubation period and at-risk groups relating to human adenoviruses. It gives information on symptoms, laboratory diagnosis, treatment, prophylaxis and infection control.
This chapter provides details of serological tests which can be used to detect viral antibodies or antigens in serum, saliva or urine (e.g. ELISA, EIA, IF, CFT, HAI, neutralisation, Western blot, line immunoassays and avidity tests). It details the utility of each test.
This paper retrospectively analysed the prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) in some parts of China. Between January 2013 and December 2019, we collected 4,145 respiratory samples, including pharyngeal swabs and alveolar lavage fluid. The highest PCR-positive rate of M. pneumoniae was 74.5% in Beijing, the highest resistance rate was 100% in Shanghai, and Gansu was the lowest with 20%. The highest PCR-positive rate of M. pneumoniae was 74.5% in 2013, and the highest MRMP was 97.4% in 2019; the PCR-positive rate of M. pneumoniae for adults in Beijing was 17.9% and the MRMP was 10.48%. Among the children diagnosed with community-acquired pneumonia (CAP), the PCR-positive and macrolide-resistant rates of M. pneumoniae were both higher in the severe ones. A2063G in domain V of 23S rRNA was the major macrolide-resistant mutation, accounting for more than 90%. The MIC values of all MRMP to erythromycin and azithromycin were ≥ 64 μg/ml, and the MICs of tetracycline and levofloxacin were ≤ 0.5 μg/ml and ≤ 1 μg/ml, respectively. The macrolide resistance varied in different regions and years. Among inpatients, the macrolide-resistant rate was higher in severe pneumonia. A2063G was the common mutation, and we found no resistance to tetracycline and levofloxacin.
This chapter provides an overview of the antiviral drugs currently available, including maraviroc, aciclovir, penciclovir, ganciclovir, amantadine, zydovudine, adefovir, ribavirin, indinavir , oseltamivir, zanamivir, interferon alpha, rituximab , palivizumab, cidofovir, brincidofovir, foscarnet, remdesivir and paxlovid with an indication of their modes of action for treating virus infections, including HIV, herpes viruses, respiratory viruses, HBV, HCV, CMV, adenoviruses , BK, EBV (especially for PTLD), RSV, poxviruses and SARS-CoV-2.
This chapter deals with Occupational Health and how to protect healthcare workers from acquiring infections (e.g. HAV, HBV, HIV, HCV, VZV, influenza, Covid-19, measles, mumps, rubella, polio, TB, diphtheria, meningococcal infection and tetanus) while at work. It describes how healthcare workers can be protected by providing pre-exposure vaccinations and post-exposure treatments, as well as discussing responses to outbreaks and routes of infection.
This chapter details the epidemiology, route of spread, prevalence, incubation period and at-risk groups relating to EBV. It provides information on symptoms, laboratory diagnosis, treatment, prophylaxis and infection control.
This chapter details the epidemiology, route of spread, prevalence, incubation period and at-risk groups relating to hepatitis B and D viruses. It gives information on symptoms, laboratory diagnosis, treatment, prophylaxis and infection control.
This chapter details the eye diseases (conjunctivitis, keratitis, retinitis and scleritis) caused by viruses and other organisms (adenoviruses, enteroviruses, HSV, measlesvirus, influenzaviruses, VZV, CMV, Toxoplasma gondii, molluscum contagiosum, papillomaviruses and HHV8). It details symptoms, epidemiology, diagnosis and treatment.
This chapter details the epidemiology, route of spread, prevalence, incubation period and at-risk groups relating to rhinoviruses. It gives information on symptoms, laboratory diagnosis, treatment, prophylaxis and infection control.
This chapter details the symptoms relating to the organisms which cause encephalitis and meningitis (HSV, VZV, enteroviruses, mumps virus). It gives information on laboratory diagnosis and treatment.
This chapter details the epidemiology, route of spread, prevalence, incubation period and at-risk groups relating to hMPV. It gives information on symptoms, laboratory diagnosis, treatment, prophylaxis and infection control.
This chapter provides a basic introduction to virology, dealing with the history of viruses, taxonomy, virus replication stages (attachment, entry, uncoating, transcription, translation, assembly and release). It also deals with the immune response to viruses, including innate immune response, adaptive immunity, cell-mediated response, antibody-mediated response, viral pathogenesis, viral tropisms, viral spread, viral persistence, viral virulence and host factors.
This chapter deals with how infection control procedures can be used to minimise the spread of viral infections transmitted via the respiratory, gastrointestinal, blood-borne, sexual, vertical and vector-borne routes. It also details infection control strategies in hospitals and in the community via universal precautions, respiratory precautions, enteric precautions and those for highly dangerous pathogens. Post-exposure prophylaxis and management of outbreaks is also discussed along with a list of notifiable infections.
This chapter details the epidemiology, route of spread, prevalence and incubation periods of viruses causing respiratory symptoms (adenoviruses, SARS-CoV-2, enteroviruses, influenza, HMPV, parainfluenzaviruses, RSV, rhinoviruses). It gives information on symptoms, laboratory diagnosis, treatment, prophylaxis and infection control.
This chapter details the epidemiology, route of spread, prevalence, animal hosts relating to viral haemorrhagic fever (Lassa fever, Marburg disease, Ebola, Crimean-Congo haemorrhagic fever, dengue haemorrhagic fever, HFRS, hantaviruses). It gives information on symptoms, laboratory diagnosis, treatment and infection control.
This chapter details to genital tract and sexually transmitted infections (HSV, VZV, Treponema pallidum, papillomaviruses, poxviruses, HIV, HBV, C. trachomatis, LGV). It gives information on symptoms, laboratory diagnosis, management, treatment, prophylaxis and infection control.