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6077 results in Genomics, bioinformatics and systems biology

Page 301 of 304

  • Molecular analysis of Loop-tail, a mouse model of craniorachischisis

  • DIANNE GERRELLI, NICHOLAS GREENE, ANDREW J. COPP
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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  • How important are repetitive regions within developmentally relevant genes?

  • JOHN M. HANCOCK
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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  • Role of Hoxb-1 during hindbrain specification

  • M. STUDER, A. LUMSDEN, L. ARIZA-McNAUGHTON, A. BRADLEY, R. KRUMLAUF
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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  • Accelerated growth and testicular differentiation: which comes first?

  • U. MITTWOCH
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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  • Folate and protecting the fetus from environmental toxins

  • VALERIE SMELT, JASON POPE, HELEN MARDON, CHRIS REDMAN, EDITH SIM
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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  • The diversity of inherited parasites of insects: the male-killing agent of the ladybird beetle Coleomegilla maculata is a member of the Flavobacteria

  • GREGORY D. D. HURST, TANSY C. HAMMARTON, CLAUDIO BANDI, TAMSIN M. O. MAJERUS, DOMINIQUE BERTRAND, MICHAEL E. N. MAJERUS
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 1-6
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  • Many species of insects bear maternally inherited bacteria which contribute to the physiology and metabolism of their host whereas others bear inherited bacteria which are regarded as parasitic. Parasitic behaviours centre on disruption of the production, survival or fertility of male hosts, through which the microbe is not transmitted. One of the most common of these is early male-killing, where the bacteria kill male embryos they enter. The question arises as to why all inherited symbionts are not male-killers. The male-killing agents identified to date derive from two groups: the Proteobacteria and the Mollicutes. However, bacteria from other groups (Spirochaetes, Flavobacteria) are found to be inherited in insects, but contain no incidence of male-killing. We show here an association of male-killing with a bacterium from one of these groups. The bacterium causing male-killing behaviour in the ladybird Coleomegilla maculata is most closely related to Blattabacterium, a host-beneficial Flavobacteria found in cockroaches and some termites. This result indicates there is little if any taxonomic bar to the evolution of male-killing behaviour. This pattern severely contrasts with the evolution of two other parasitic symbiont behaviours, cytoplasmic incompatibility and the induction of host parthenogenesis, which have been found to be associated exclusively with bacteria from one group: Wolbachia. The result is briefly discussed in the light of the incidence of parasitic and beneficial cytoplasmic elements among insects.

  • Histone acetylation in mouse embryonic stem cells

  • LAURA O'NEILL, ANN M. KEOHANE, BRYAN TURNER
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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  • SHORT PAPER P element excision in Drosophila is stimulated by gamma-irradiation in transient embryonic assays

  • ALFRED M. HANDLER, SHEILACHU P. GOMEZ
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 75-78
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  • The influence of gamma-irradiation on P element excision and excision-site repair mechanisms was directly tested by embryonic somatic excision assays. Preblastoderm P[ry+, Δ2–3](99B) embryos, having a stable source of somatically active P transposase, were irradiated previous to injection with P excision indicator plasmids. Frequencies of precise or nearly precise P excision increased with gamma-ray doses ranging from 0·5 to 3·5 Gy. Higher doses resulted in frequencies close to that in unirradiated embryos, though considerable embryonic lethality was also evident at these doses. A direct positive interaction between gamma-irradiation and P element activity is concluded.

  • Three-dimensional studies of human craniofacial growth

  • ROBIN HENNESSY, PAUL O'HIGGINS, SAM COBB
  • Journal:
    Genetical Research / Volume 70 / Issue 1 / August 1997
    Published online by Cambridge University Press:
    01 August 1997, pp. 79-89
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Page 301 of 304