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10164 results in Genetics

Page 478 of 509

  • Identification of H-Y epitopes in Smcy

  • D. SCOTT, I. EHRMANN, P. ELLIS, E. SIMPSON, M. MITCHELL
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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  • cDNA libraries from single human preimplantation embryos

  • JAMES ADJAYE, ROBERT DANIELS, MARILYN MONK
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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  • Pervasive effects of P element mutagenesis on body size in Drosophila melanogaster

  • DOROTHY B. CURRIE, TRUDY F. C. MACKAY, LINDA PARTRIDGE
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 19-24
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  • A set of Drosophila melanogaster was generated, all derived from a common isogenic base stock and each with a single new P element insert on the second or third chromosome. The lines were scored for their body size, measured as thorax length. P inserts were associated with highly significant effects on body size, although the genotypes of the construct and of the control prevented deduction of the direction of mutant effects. In addition to mutant effects on the thorax length of both sexes, there were also highly significant sex-specific effects. Pleiotropic effects of inserts affecting body size on viability and bristle number, as ascertained in a separate study of these lines (Lyman et al., 1996), were weak. Insertional mutagenesis is potentially a powerful tool for investigating the genes involved in size-control in Drosophila, but the technique requires fine tuning for use on polygenic and fitness-related traits.

  • Detection of disturbed folate metabolism in mouse embryos developing neural tube defects

  • ANGELEEN FLEMING, ANDREW J. COPP
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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  • Differential display analysis of dissected mouse somites

  • RAJEEV GUPTA, DENNIS SUMMERBELL, PETER W. J. RIGBY
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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  • The relationship between the rate of transposition and transposable element copy number for copia and Doc retrotransposons of Drosophila melanogaster

  • ELENA G. PASYUKOVA, SERGEY V. NUZHDIN, DMITRY A. FILATOV
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 1-11
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  • We present data on the relationship between the rate of transposition and copy number in the genome for the copia and Doc retrotransposons of Drosophila melanogaster. copia and Doc transposition rates were directly measured in sublines of the isogenic 2b line using individual males or females, respectively, with a range of copia copy numbers from 49 to 103 and Doc copy numbers from 112 to 235 per genome. Transposition rates varied from 3×10−4 to 2×10−2 for copia and from 2×10−4 to 2×10−3 for Doc. A positive relationship between transposition rate and copy number was found both for copia and for Doc when the data were analysed across all the 2b individuals; no significant correlation was found when the data were analysed across the subline means for both retrotransposons tested. Overall, correlation between copia and Doc transposition rate and their copy number in the genome, if any, was not negative, which would be expected if transposable elements (TEs) self-regulate their copy number. Thus, for copia and Doc no evidence for self-regulation was provided, and at least for these two TEs this hypothesis is not favoured for explaining the maintenance of the stable copy number that is characteristic for natural populations. The transposition rate of copia was measured twice, and a strong positive correlation between copy number and transposition rate both across individuals and subline means was found in 1994, while in 1995 no correlation was found. This fact is in agreement with the hypothesis that a positive correlation between the rate of transposition and TE copy number may be a default starting point for future host–TE coevolution.

  • Induction of ectopic cartilage by misexpression of Sox9 in chicken embryos

  • CHRIS HEALY, DAFE UWANOGHO, PAUL SHARPE
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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  • Fishing upstream of Myf5

  • OLIVER COUTELLE, DENNIS SUMMERBELL, PETER W. J. RIGBY
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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  • Mutation analysis of mottled mice

  • PAMELA CUNLIFFE, VIVIENNE REED, WALTER MASSON, YVONNE BOYD
  • Journal:
    Genetical Research / Volume 72 / Issue 1 / August 1998
    Published online by Cambridge University Press:
    01 August 1998, pp. 59-72
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Page 478 of 509