In March 1926, the USA saw its first production of an O’Casey play, when a version of Juno and the Paycock appeared at the Mayfair Theater in New York. The text was praised by two of the twentieth century’s most influential theatre reviewers, George Jean Nathan and Brooks Atkinson, who became major American supporters of O’Casey and his work. Their efforts were bolstered by the enthusiasm for O’Casey shown by the American director Paul Shyre. This chapter traces the development of O’Casey’s reputation in the USA, and examines a range of onstage versions of O’Casey’s plays in America, ranging from the introductory work of the 1920s to the 2019 O’Casey season at the Irish Repertory Theater in New York.