Beyond the demographic factors of socio-economic disadvantage, inequality and unemployment, some occupations have been historically linked with higher rates of suicide deaths. These include: the armed forces, farmers, healthcare workers (including doctors), and “blue light” emergency workers, or “first responders,” for example, police, ambulance, rescue and fire personnel. Where available, the chapter draws upon systematic reviews and meta-analyses to discuss the evidence in specific occupational groups; the risk indicators and protective factors for suicide at individual, organisational and systemic level; and potential interventions over the course of a worker’s career. Understanding occupational risk factors over the career span from recruitment, self-selection and selection, through work environments and cultures, occupational trauma and stresses, could yield strategies for more generalisable suicide prevention at a population level as well as reducing rates in specific occupations.