We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
Published online by Cambridge University Press: 21 November 2024
The most common form of muscular dystrophy in adults, myotonic dystrophy (MD) is an autosomal dominant neuromuscular disease caused by the trinucleotide expansion of CTG repeats. The location of these CTG repeats differs between types of MD with the chromosome 19 gene DMPK (dystrophia-myotonica protein kinase) being the culprit gene in myotonic dystrophy type 1 (DM-1 aka Steinert’s disease), and the chromosome 3 gene ZnFP9 (zinc finger protein 9) being the culprit gene in myotonic dystrophy type 2 (DM-2). A greater number of CTG repeats predicts an earlier onset of disease.
To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.
