Published online by Cambridge University Press: 21 November 2024
Characterized by lingual, facial, and oromandibular spasms, Meige syndrome, named after French neurologist Henri Meige who first described it in 1910, disproportionately affects women and with an onset typically in their 50s. Oromandibular spasms along with blepharospasm are prominent as these patients most commonly experience forced jaw opening or closure, protrusion of the tongue, lip retraction or pursing, and platysma spasm, though can also have bruxism and/or jaw deviation. Much more rarely, these patients can develop torticollis as well as limbs and truncal dystonias that can produce tremor. Though the majority of cases are idiopathic, ~25% have been found to be linked to the use of long-term neuroleptic medications. Ongoing research is looking into potential associations with genetic mutations and other movement disorders.
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