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Published online by Cambridge University Press: 21 November 2024
Well known for their excruciating pain, cluster headaches are a relatively rare and severe form of primary headache disorder, and more specifically, a type of trigeminal autonomic cephalgia. The pathogenesis of cluster headaches is thought to be different from that of migraine as PET scans have shown the activation of the posterior hypothalamus during cluster headache attacks, as opposed to the mesencephalic structures that become activated in migraine attacks. The involvement of the hypothalamus is thought to play a part in the circadian periodicity of the attacks experienced by individuals with cluster headaches.
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