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Published online by Cambridge University Press: 21 November 2024
Primary lateral sclerosis is a sporadic form of neurodegenerative motor neuron disease that affects almost exclusively upper motor neurons. The pathophysiology of PLS is similar to amyotrophic lateral sclerosis, and results in the degeneration of corticospinal tracts, though almost completely spares the lower motor neurons. Demographically, PLS symptoms usually begin in the fifth or sixth decade of life and have no significant sex predominance.
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