The final chapter reiterates the challenges posed by totalitarianism. By conducting coherent theoretical and empirical research into the origins and expansion of totalitarianism, this work strives to address these significant challenges that Mises warned about decades ago. This chapter summarizes the key insights drawn from both the empirical evidence and the theoretical framework of institutional genes that constitute a comprehensive methodological approach. The literature review distinguishes this book from other works in the fields of China studies, institutional analysis, and social science methodology. The two most extensive sections of the chapter examine the institutional genes and their evolution in Taiwan and in the former Soviet Union and Eastern Europe (FSU-EE). The former section sheds light on the pivotal role the institutional genes played in Taiwan’s transition from authoritarian rule to constitutional democracy, while the latter section explains the collapse of the totalitarian regimes in the FSU-EE countries and their divergent institutional transformations. The chapter also highlights the implications of the transitions in Taiwan and the FSU-EE countries for China’s future transformations.