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7 - Nanoscale biomemory device composed of recombinant protein variants

from Part I - Electronic components

Published online by Cambridge University Press:  05 September 2015

By
Ajay Kumar Yagati ,
Junhong Min  and
Jeong Woo Choi
Edited by
Sandro Carrara  and
Krzysztof Iniewski
Ajay Kumar Yagati
Affiliation:
Sogang University
Junhong Min
Affiliation:
Chung-Ang University
Jeong Woo Choi
Affiliation:
Sogang University
Sandro Carrara
Affiliation:
École Polytechnique Fédérale de Lausanne
Krzysztof Iniewski
Affiliation:
Redlen Technologies Inc., Canada
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Summary

Abstract

Recent research in nanobioelectronic devices has opened up a new wave ofenthusiasm in revolutionizing electronic circuit design, marking thebeginning of a new era for biomimicry phenomena to advance into high-densitylogic and memory applications. This chapter describes the formation anddevelopment of a protein-based biomemory device composed of recombinantprotein variants, together with some experimental results on protein filmformation with various readout mechanisms for constructing future memorydevices. To elucidate the concept of the memory device, a redox protein inwhich cysteine residues were incorporated by recombinant technology wasimmobilized on a gold electrode surface. Application of the correctpotentials then causes carrier trapping or detrapping in protein films tooccur, as shown by the electrochemical measurements, thus performing thememory function. The chapter also summarizes recent research on nanoscalebiomemory devices, considering first the basic nature of thewrite-once-read-many (WORM) characteristics. The concept of WORM is thenextended to multi-bit storage of protein variants and towards development ofa nanoscale biomemory device. The fact that these developed devices,operating at very low voltages, can be patterned and addressed locally, andalso have good stability with excellent reversibility, makes them apromising platform for non-volatile memory devices.

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Type
Chapter
Information
Handbook of Bioelectronics
Directly Interfacing Electronics and Biological Systems
 , pp. 86 - 102
Publisher: Cambridge University Press
Print publication year: 2015

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